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1. 发明授权

US08008014B2 Capture, recapture, and trapping of molecules with a nanopore 有权
公开(公告)号：US08008014B2
公开(公告)日：2011-08-30
申请号：US12286787
申请日：2008-10-02
申请人： Marc H. Gershow , Jene A. Golovchenko , Daniel Branton
发明人： Marc H. Gershow , Jene A. Golovchenko , Daniel Branton
IPC分类号： C12Q1/68 , C12M1/00 , G01N15/06 , C07H21/04
摘要： In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure.

2. 发明授权

US08273532B2 Capture, recapture, and trapping of molecules with a nanopore 有权
标题翻译：用纳米孔捕获，重新捕获和捕获分子
公开(公告)号：US08273532B2
公开(公告)日：2012-09-25
申请号：US12286787
申请日：2008-10-02
申请人： Marc H. Gershow , Jene A. Golovchenko , Daniel Branton
发明人： Marc H. Gershow , Jene A. Golovchenko , Daniel Branton
IPC分类号： C12Q1/68 , C12M1/00 , G01N15/06 , C07H21/04
CPC分类号： C12Q1/6825 , C12Q1/6869 , G01N33/48721 , C12Q2565/631 , C12Q2565/607
摘要： In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure.
摘要翻译：在分子分析系统中，提供了包括纳米孔和第一和第二流体储层的结构。两个储存器通过纳米孔流体连接。连接检测器以检测纳米孔的分子物质易位，从两个流体储存器中的一个到两个流体储存器中的另一个。连接控制器以产生控制信号以在纳米孔上产生条件以诱导分子种类在易位纳米孔之后至少一次地转移纳米孔。这使得分子分析方法能够通过分子物质在被结构分离的两个流体储存器之间的结构中的纳米孔中多次转位。

3. 发明申请

US20090136958A1 Capture, recapture, and trapping of molecules with a nanopore 有权
标题翻译：用纳米孔捕获，重新捕获和捕获分子
公开(公告)号：US20090136958A1
公开(公告)日：2009-05-28
申请号：US12286787
申请日：2008-10-02
申请人： Marc H. Gershow , Jene A. Golovchenko , Daniel Branton
发明人： Marc H. Gershow , Jene A. Golovchenko , Daniel Branton
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6825 , C12Q1/6869 , G01N33/48721 , C12Q2565/631 , C12Q2565/607
摘要： In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure.
摘要翻译：在分子分析系统中，提供了包括纳米孔和第一和第二流体储层的结构。两个储存器通过纳米孔流体连接。连接检测器以检测纳米孔的分子物质易位，从两个流体储存器中的一个到两个流体储存器中的另一个。连接控制器以产生控制信号以在纳米孔上产生条件以诱导分子种类在易位纳米孔之后至少一次地转移纳米孔。这使得分子分析方法能够通过分子物质在被结构分离的两个流体储存器之间的结构中的纳米孔中多次转位。

4. 发明申请

US20110159601A1 STUDY OF POLYMER MOLECULES AND CONFORMATIONS WITH A NANOPORE 有权
标题翻译：聚合物分子的研究与纳米聚合物的合成
公开(公告)号：US20110159601A1
公开(公告)日：2011-06-30
申请号：US12961021
申请日：2010-12-06
申请人： Jene A. Golovchenko , Jiali Li , Derek Stein , Marc H. Gershow
发明人： Jene A. Golovchenko , Jiali Li , Derek Stein , Marc H. Gershow
IPC分类号： G01N33/00
CPC分类号： G01N33/50 , C12Q1/6811 , G01N33/48721 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , C12Q2563/143 , C12Q2565/629 , C12Q2565/631 , C12Q2565/133
摘要： The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
摘要翻译：本发明的特征在于评估聚合物构象的方法，例如用于确定多种聚合物的构象分布并检测结合或变性事件。该方法使用聚合物例如核酸穿过的纳米孔。当聚合物穿过纳米孔时，纳米孔的传输性质的测量产生聚合物构象的数据。

5. 发明授权

US08969091B2 Study of polymer molecules and conformations with a nanopore 有权
标题翻译：研究聚合物分子和与纳米孔的构象
公开(公告)号：US08969091B2
公开(公告)日：2015-03-03
申请号：US13766231
申请日：2013-02-13
申请人： Jene A. Golovchenko , Jiali Li , Derek Stein , Marc H. Gershow
发明人： Jene A. Golovchenko , Jiali Li , Derek Stein , Marc H. Gershow
IPC分类号： G01N33/50 , G01N33/00 , C12Q1/68 , G01N33/487
CPC分类号： G01N33/50 , C12Q1/6811 , G01N33/48721 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , C12Q2563/143 , C12Q2565/629 , C12Q2565/631 , C12Q2565/133
摘要： The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
摘要翻译：本发明的特征在于评估聚合物构象的方法，例如用于确定多种聚合物的构象分布并检测结合或变性事件。该方法使用聚合物例如核酸穿过的纳米孔。当聚合物穿过纳米孔时，纳米孔的传输性质的测量产生聚合物构象的数据。

6. 发明授权

US08394640B2 Study of polymer molecules and conformations with a nanopore 有权
公开(公告)号：US08394640B2
公开(公告)日：2013-03-12
申请号：US12961021
申请日：2010-12-06
申请人： Jene A. Golovchenko , Jiali Li , Derek Stein , Marc H. Gershow
发明人： Jene A. Golovchenko , Jiali Li , Derek Stein , Marc H. Gershow
IPC分类号： G01N33/00
CPC分类号： G01N33/50 , C12Q1/6811 , G01N33/48721 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , C12Q2563/143 , C12Q2565/629 , C12Q2565/631 , C12Q2565/133
摘要： The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

7. 发明授权

US07846738B2 Study of polymer molecules and conformations with a nanopore 有权
标题翻译：研究聚合物分子和与纳米孔的构象
公开(公告)号：US07846738B2
公开(公告)日：2010-12-07
申请号：US10918959
申请日：2004-08-16
申请人： Jene A. Golovchenko , Jiali Li , Derek Stein , Marc H. Gershow
发明人： Jene A. Golovchenko , Jiali Li , Derek Stein , Marc H. Gershow
IPC分类号： G01N33/00
CPC分类号： G01N33/50 , C12Q1/6811 , G01N33/48721 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , C12Q2563/143 , C12Q2565/629 , C12Q2565/631 , C12Q2565/133
摘要： The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
摘要翻译：本发明的特征在于评估聚合物构象的方法，例如用于确定多种聚合物的构象分布并检测结合或变性事件。该方法使用聚合物例如核酸穿过的纳米孔。当聚合物穿过纳米孔时，纳米孔的传输性质的测量产生聚合物构象的数据。

8. 发明授权

US08470408B2 Carbon nanotube synthesis for nanopore devices 有权
公开(公告)号：US08470408B2
公开(公告)日：2013-06-25
申请号：US12286849
申请日：2008-10-02
申请人： Daniel Branton , Jene A. Golovchenko , Slaven Garaj , Dimitar M. Vlassarev , El-Hadi S. Sadki
发明人： Daniel Branton , Jene A. Golovchenko , Slaven Garaj , Dimitar M. Vlassarev , El-Hadi S. Sadki
IPC分类号： D01F9/12 , C40B50/14 , C23C16/00 , B05D3/00
CPC分类号： B81C1/00182 , G01N33/48721
摘要： In a process for fabricating a nanopore device, at least one carbon nanotube catalyst region is formed on a structure. A plurality of nanopores is formed in the structure at a distance from the catalyst region that is no greater than about an expected length for a carbon nanotube synthesized from the catalyst region. Then at least one carbon nanotube is synthesized from the catalyst region. This fabrication sequence enables the in situ synthesis of carbon nanotubes at the site of nanopores, whereby one or more nanotubes articulate one or more nanopores without requiring manual positioning of the nanotubes.

9. 发明授权

US07582490B2 Controlled fabrication of gaps in electrically conducting structures 有权
标题翻译：控制导电结构间隙的制造
公开(公告)号：US07582490B2
公开(公告)日：2009-09-01
申请号：US10767102
申请日：2004-01-29
申请人： Jene A. Golovchenko , Gregor M. Schürmann , Gavin M. King , Daniel Branton
发明人： Jene A. Golovchenko , Gregor M. Schürmann , Gavin M. King , Daniel Branton
IPC分类号： H01L21/00 , C23C14/00 , G01N35/08 , G01N35/00 , H01L29/78
CPC分类号： G01N33/48721 , Y10T436/11 , Y10T436/12
摘要： A method for controlling a gap in an electrically conducting solid state structure provided with a gap. The structure is exposed to a fabrication process environment conditions of which are selected to alter an extent of the gap. During exposure of the structure to the process environment, a voltage bias is applied across the gap. Electron tunneling current across the gap is measured during the process environment exposure and the process environment is controlled during process environment exposure based on tunneling current measurement. A method for controlling the gap between electrically conducting electrodes provided on a support structure. Each electrode has an electrode tip separated from other electrode tips by a gap. The electrodes are exposed to a flux of ions causing transport of material of the electrodes to corresponding electrode tips, locally adding material of the electrodes to electrode tips in the gap.
摘要翻译：一种用于控制具有间隙的导电固态结构中的间隙的方法。该结构暴露于制造工艺环境条件，其条件被选择以改变间隙的程度。在将结构暴露于工艺环境中时，跨越间隙施加电压偏置。在工艺环境暴露期间测量跨越间隙的电子隧道电流，并且基于隧道电流测量在工艺环境暴露期间控制工艺环境。一种用于控制设置在支撑结构上的导电电极之间的间隙的方法。每个电极具有通过间隙与其它电极尖端分离的电极头。电极暴露于离子通量，导致电极的材料传输到相应的电极尖端，将电极的材料局部地添加到间隙中的电极尖端。

10. 发明申请

US20120234679A1 Nanometric Material Having a Nanopore Enabling High-Sensitivity Molecular Detection and Analysis 审中-公开
标题翻译：具有纳米孔的纳米材料实现高灵敏度分子检测和分析
公开(公告)号：US20120234679A1
公开(公告)日：2012-09-20
申请号：US13419383
申请日：2012-03-13
申请人： Slaven Garaj , Jene A. Golovchenko , Daniel Branton
发明人： Slaven Garaj , Jene A. Golovchenko , Daniel Branton
IPC分类号： G01N27/447 , G01N27/453 , B82Y5/00 , B82Y30/00 , B82Y99/00
摘要： There is provided a substantially bare, self-supported single-layer graphene membrane including a nanopore extending through a thickness of the graphene membrane from a first to a second membrane surface opposite the first graphene membrane surface. A connection from the first graphene membrane surface to a first reservoir provides, at the first graphene membrane surface, a species in an ionic solution to the nanopore, and a connection from the second graphene membrane surface to a second reservoir is provided to collect the species and ionic solution after translocation of the species and ionic solution through the nanopore from the first graphene membrane surface to the second graphene membrane surface. An electrical circuit is connected on opposite sides of the nanopore to measure flow of ionic current through the nanopore in the graphene membrane.
摘要翻译：提供了基本上裸露的自支撑单层石墨烯膜，其包括从第一至第二膜表面延伸穿过石墨烯膜的厚度的纳米孔，所述第一膜表面与第一石墨烯膜表面相对。从第一石墨烯膜表面到第一储存器的连接在第一石墨烯膜表面处提供离子溶液中的物质到纳米孔，并且提供从第二石墨烯膜表面到第二储存器的连接以收集物种和离子溶液在物种和离子溶液通过纳米孔从第一石墨烯膜表面转移到第二石墨烯膜表面之后。电路连接在纳米孔的相对侧，以测量通过石墨烯膜中的纳米孔的离子电流的流动。

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