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    • 1. 发明授权
    • Method for enhancing functional recovery following central nervous system ischemia or trauma
    • 增强中枢神经系统缺血或创伤后功能恢复的方法
    • US06407060B1
    • 2002-06-18
    • US08828281
    • 1997-03-21
    • Marc F. CharetteSeth P. Finklestein
    • Marc F. CharetteSeth P. Finklestein
    • A61K3800
    • A61K38/1875
    • The present invention provides methods and compositions for treatment of mammals afflicted with an ischemic or traumatic injury of the central nervous system. The present invention capitalizes in part upon the discovery that administration of a morphogen to such a mammal provides significant improvement in central nervous system function, even when administered after central nervous system tissue has been damaged. The methods involve the administration of dimeric proteins defined as morphogens, inducers of these morphogens, or agonists of the corresponding morphogen receptors, or implantation of cells stimulated by exposure to the morphogens. The proteins defined as morphogens comprise a structurally and functionally distinct family within the TGF-&bgr; superfamily. Osteogenic protein-1 (OP-1) is considered to be an exemplary and preferred member of this morphogen family.
    • 本发明提供了治疗患有中枢神经系统的缺血性或创伤性损伤的哺乳动物的方法和组合物。 本发明部分地利用了这样的发现:即使在中枢神经系统组织被损坏后施用形态发生剂给这种哺乳动物提供了中枢神经系统功能的显着改善。 所述方法包括给予定义为形态发生剂的二聚体蛋白质,这些形态发生剂的诱导剂或相应的形态发生受体的激动剂,或通过暴露于形态发生体刺激的细胞的植入。 定义为形态发生蛋白的蛋白质在TGF-β超家族中包含结构和功能上不同的家族。 成骨蛋白-1(OP-1)被认为是该形态发生家族的典型和优选的成员。