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1. 发明授权

US06407060B1 Method for enhancing functional recovery following central nervous system ischemia or trauma 失效
标题翻译：增强中枢神经系统缺血或创伤后功能恢复的方法
公开(公告)号：US06407060B1
公开(公告)日：2002-06-18
申请号：US08828281
申请日：1997-03-21
申请人： Marc F. Charette , Seth P. Finklestein
发明人： Marc F. Charette , Seth P. Finklestein
IPC分类号： A61K3800
CPC分类号： A61K38/1875
摘要： The present invention provides methods and compositions for treatment of mammals afflicted with an ischemic or traumatic injury of the central nervous system. The present invention capitalizes in part upon the discovery that administration of a morphogen to such a mammal provides significant improvement in central nervous system function, even when administered after central nervous system tissue has been damaged. The methods involve the administration of dimeric proteins defined as morphogens, inducers of these morphogens, or agonists of the corresponding morphogen receptors, or implantation of cells stimulated by exposure to the morphogens. The proteins defined as morphogens comprise a structurally and functionally distinct family within the TGF-&bgr; superfamily. Osteogenic protein-1 (OP-1) is considered to be an exemplary and preferred member of this morphogen family.
摘要翻译：本发明提供了治疗患有中枢神经系统的缺血性或创伤性损伤的哺乳动物的方法和组合物。本发明部分地利用了这样的发现：即使在中枢神经系统组织被损坏后施用形态发生剂给这种哺乳动物提供了中枢神经系统功能的显着改善。所述方法包括给予定义为形态发生剂的二聚体蛋白质，这些形态发生剂的诱导剂或相应的形态发生受体的激动剂，或通过暴露于形态发生体刺激的细胞的植入。定义为形态发生蛋白的蛋白质在TGF-β超家族中包含结构和功能上不同的家族。成骨蛋白-1（OP-1）被认为是该形态发生家族的典型和优选的成员。

2. 发明授权

US06399569B1 Morphogen treatments for limiting proliferation of epithelial cells 失效
标题翻译：用于限制上皮细胞增殖的形态治疗
公开(公告)号：US06399569B1
公开(公告)日：2002-06-04
申请号：US08461113
申请日：1995-06-05
申请人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
发明人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
IPC分类号： A61K3818
CPC分类号： G01N33/6872 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , G01N2800/06 , A61K2300/00
摘要： Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
摘要翻译：公开了用于维持哺乳动物胃肠道腔内衬的完整性的方法和组合物，包括（1）限制上皮细胞增殖，（2）抑制溃疡性病变形成，（3）抑制通常与溃疡性疾病相关的炎症，和（4 ）刺激溃疡性病变的修复和管腔组织的再生。方法和组合物包括治疗有效量的如本文所定义的形态发生素。

3. 发明授权

US07060680B2 Morphogen treatments for limiting proliferation of epithelial cells 失效
公开(公告)号：US07060680B2
公开(公告)日：2006-06-13
申请号：US10050050
申请日：2002-01-15
申请人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
发明人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang , Engin Ozkaynak , John E. Smart
IPC分类号： A61K38/18 , C07K14/51
CPC分类号： G01N33/6872 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , G01N2800/06 , A61K2300/00
摘要： Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.

4. 发明授权

US5376636A Method for promoting tissue repair and regeneration using PDGF and glucocorticoids 失效
标题翻译：使用PDGF和糖皮质激素促进组织修复和再生的方法
公开(公告)号：US5376636A
公开(公告)日：1994-12-27
申请号：US849931
申请日：1992-03-12
申请人： Robert B. Rutherford , Marc F. Charette
发明人： Robert B. Rutherford , Marc F. Charette
IPC分类号： A61K38/22 , A61K31/57 , A61K38/18 , A61K45/06 , A61P1/02 , A61P43/00 , A61K37/36
CPC分类号： A61K38/1858
摘要： Disclosed is a method for the regeneration of tissue, the treatment of external wounds and the treatment of periodontal disease comprising applying to the affected tissue an effective amount of a composition comprised of platelet-derived growth factor (PDGF) and an anti-inflammatory compound. The presence of the anti-inflammatory compound potentiates the activity of PDGF in stimulating cell growth, thereby enhancing tissue regeneration and/or wound healing.
摘要翻译：公开了一种用于组织再生，外部伤口治疗和牙周病治疗的方法，包括向受影响的组织施用有效量的由血小板衍生生长因子（PDGF）和抗炎化合物组成的组合物。抗炎化合物的存在增强PDGF在刺激细胞生长中的活性，从而增强组织再生和/或伤口愈合。

5. 发明授权

US07507709B2 Synergistic effects of OP/BMP morphogens and GDNF/NGF neurotrophic factors 失效
标题翻译： OP / BMP形态发生和GDNF / NGF神经营养因子的协同作用
公开(公告)号：US07507709B2
公开(公告)日：2009-03-24
申请号：US11083512
申请日：2005-03-18
申请人： Marc F. Charette , Ted Ebendal , David C. Rueger
发明人： Marc F. Charette , Ted Ebendal , David C. Rueger
IPC分类号： A61K38/18 , C07K14/48 , C07K14/51
CPC分类号： A61K38/185 , A61K38/1875 , A61K2300/00
摘要： OP/BMP morphogen may be combined with GDNF/NGF neurotrophic factors to promote the survival or growth, or inhibit the death or degeneration, of mammalian cells, particularly neural cells, which express OP/BMP-activated serine/threonine kinase receptors and GDNF/NGF-activated tyrosine kinase receptors. Also disclosed are methods for the treatment of such cells, including treatments for mammals afflicted with, or at imminent risk of, damage or injury to, such cells, as well as new pharmaceutical preparations for such treatments.
摘要翻译： OP / BMP形态发生可以与GDNF / NGF神经营养因子结合，以促进哺乳动物细胞，特别是表达OP / BMP激活的丝氨酸/苏氨酸激酶受体和GDNF / NGF的神经细胞的存活或生长或抑制死亡或变性， NGF激活的酪氨酸激酶受体。还公开了用于治疗这种细胞的方法，包括用于对这种细胞造成伤害或即将遭受损伤或损伤的哺乳动物的治疗以及用于这种治疗的新药物制剂。

6. 发明授权

US5972884A Morphogen treatment of gastrointestinal ulcers 失效
标题翻译：形态治疗胃肠道溃疡
公开(公告)号：US5972884A
公开(公告)日：1999-10-26
申请号：US461397
申请日：1995-06-05
申请人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang
发明人： Charles M. Cohen , Marc F. Charette , Thangavel Kuberasampath , David C. Rueger , Hermann Oppermann , Roy H. L. Pang
IPC分类号： A01N1/02 , A61F2/00 , A61K6/00 , A61K38/00 , A61K38/18 , A61L27/22 , A61L27/24 , C07K14/51 , C07K16/22
CPC分类号： C07K16/22 , A61K38/1875 , A61L27/227 , A61L27/24 , C07K14/51 , A61F2310/00365 , G01N2500/10 , G01N2800/06
摘要： Disclosed are methods and compositions for maintaining the integrity of the gastrointestinal tract luminal lining in a mammal, including (1) limiting epithelial cell proliferation, (2) inhibiting ulcerative lesion formation, (3) inhibiting inflammation normally associated with ulcerative diseases, and (4) stimulating the repair of ulcerative lesions and the regeneration of the luminal tissue. The methods and compositions include a therapeutically effective amount of a morphogen as defined herein.
摘要翻译：公开了用于维持哺乳动物胃肠道腔内衬的完整性的方法和组合物，包括（1）限制上皮细胞增殖，（2）抑制溃疡性病变形成，（3）抑制通常与溃疡性疾病相关的炎症，和（4 ）刺激溃疡性病变的修复和管腔组织的再生。方法和组合物包括治疗有效量的如本文所定义的形态发生素。

7. 发明授权

US5013653A Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage 失效
标题翻译：将铰链区引入融合蛋白以促进切割的产物和方法
公开(公告)号：US5013653A
公开(公告)日：1991-05-07
申请号：US462297
申请日：1989-12-28
申请人： James S. Huston , Marc F. Charette , Charles M. Cohen , Roberto Crea , Peter C. Keck , Hermann Oppermann , David C. Rueger , Richard J. Ridge
发明人： James S. Huston , Marc F. Charette , Charles M. Cohen , Roberto Crea , Peter C. Keck , Hermann Oppermann , David C. Rueger , Richard J. Ridge
IPC分类号： C07K14/485 , C07K14/575 , C07K14/585 , C12N15/62
CPC分类号： C07K14/485 , C07K14/575 , C07K14/585 , C12N15/62 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/50 , C07K2319/75
摘要： Disclosed is a method for the isolation and purification of polypeptides expressed in host cells by recombinant DNA techniques. A fused polypeptide is produced containing a desired polypeptide fused to additional amino acids. The additional amino acids define a leader sequence having properties exploitable in purification, a hinge region, and a cleavage site. The hinge region is cysteine-free and has a secondary structure which serves to expose the cleavage site to a selected endopeptidase. The method of the invention involves the production of a fused polypeptide which may be efficiently isolated by exploiting the properties of the leader sequence, and then efficiently cleaved at the cleavage site in an appropriate aqueous environment by virtue of the influence of the hinge on the cleavage agent/cleavage site reaction and other properties of the fused polypeptide.
摘要翻译：公开了通过重组DNA技术分离和纯化在宿主细胞中表达的多肽的方法。产生融合的多肽，其含有与另外的氨基酸融合的所需多肽。另外的氨基酸定义具有在纯化中可利用的性质，铰链区和切割位点的前导序列。铰链区域是无半胱氨酸的并且具有用于将切割位点暴露于所选择的内肽酶的二级结构。本发明的方法涉及产生融合多肽，其可以通过利用前导序列的性质而有效分离，然后由于铰链对切割的影响，在合适的水性环境中的切割位点处有效地切割试剂/裂解位点反应和融合多肽的其他性质。

8. 发明授权

US07105638B1 Product and process for the production, isolation, and purification of recombinant polypeptide 失效
标题翻译：用于生产，分离和纯化重组多肽的产物和方法
公开(公告)号：US07105638B1
公开(公告)日：2006-09-12
申请号：US08014096
申请日：1993-02-04
申请人： James S. Huston , Marc F. Charette , Charles M. Cohen , Roberto Crea , Peter C. Keck , Hermann Oppermann , David C. Rueger , Richard J. Ridge
发明人： James S. Huston , Marc F. Charette , Charles M. Cohen , Roberto Crea , Peter C. Keck , Hermann Oppermann , David C. Rueger , Richard J. Ridge
IPC分类号： C07K16/46
CPC分类号： C07K14/485 , C07K14/575 , C07K14/585 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/50 , C07K2319/75 , C12N15/62
摘要： Disclosed is a method for the isolation and purification of polypeptides expressed in host cells by recombinant DNA techniques. A fused polypeptide is produced containing a desired polypeptide fused to additional amino acids. The additional amino acids define a leader sequence having properties exploitable in purification, a hinge region, and a cleavage site. The hinge region is cysteine-free and has a secondary structure which serves to expose the cleavage site to a selected endopeptidase. The method of the invention involves the production of a fused polypeptide which may be efficiently isolated by exploiting the properties of the leader sequence, and then efficiently cleaved at the cleavage site in an appropriate aqueous environment by virtue of the influence of the hinge on the cleavage agent/cleavage site reaction and other properties of the fused polypeptide.
摘要翻译：公开了通过重组DNA技术分离和纯化在宿主细胞中表达的多肽的方法。产生融合的多肽，其含有与另外的氨基酸融合的所需多肽。另外的氨基酸定义具有在纯化中可利用的性质，铰链区和切割位点的前导序列。铰链区域是无半胱氨酸的并且具有用于将切割位点暴露于所选择的内肽酶的二级结构。本发明的方法涉及产生融合多肽，其可以通过利用前导序列的性质而有效分离，然后由于铰链对切割的影响，在合适的水性环境中的切割位点处有效地切割试剂/裂解位点反应和融合多肽的其他性质。

9. 发明授权

US5759815A Production of platelet derived growth factor (PDGF) an muteins thereof 失效
标题翻译：生产血小板衍生生长因子（PDGF）的突变蛋白
公开(公告)号：US5759815A
公开(公告)日：1998-06-02
申请号：US686550
申请日：1991-05-06
申请人： Marc F. Charette , Zita A. Babickas , Hermann Oppermann
发明人： Marc F. Charette , Zita A. Babickas , Hermann Oppermann
IPC分类号： C07K14/49 , C12N15/18
CPC分类号： C07K14/49 , C07K2319/00
摘要： Native, analog, and mutein species of A and B chains of platelet derived growth factor are produced in prokaryotes, purified, combined, and modified in vitro to produce various active AA, AB, and BB PDGF dimers.
摘要翻译：在原核生物中产生血小板衍生生长因子的A和B链的天然，类似物和突变蛋白，在体外纯化，组合和修饰以产生各种活性AA，AB和BB PDGF二聚体。

10. 发明授权

US5234908A Method of treating gastrointestinal ulcers with platelet derived growth factor 失效
标题翻译：用血小板衍生生长因子治疗胃肠溃疡的方法
公开(公告)号：US5234908A
公开(公告)日：1993-08-10
申请号：US866822
申请日：1992-04-10
申请人： Sandor Szabo , Marc F. Charette
发明人： Sandor Szabo , Marc F. Charette
IPC分类号： A61K38/18
CPC分类号： A61K38/1858
摘要： Disclosed is a method for treating ulcers of the gastrointestinal tract in a mammal which includes administering to the mammal a therapeutically effective amount of Platelet-Derived Growth Factor (PDGF) to the gastrointestinal tract of the mammal.
摘要翻译：公开了一种治疗哺乳动物胃肠道溃疡的方法，其包括向哺乳动物施用治疗有效量的血小板衍生生长因子（PDGF）给哺乳动物的胃肠道。

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