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1. 发明授权

US06500449B2 Intraocular transplantation of encapsulated cells 有权
公开(公告)号：US06500449B2
公开(公告)日：2002-12-31
申请号：US09775325
申请日：2001-02-01
申请人： Marc Abitbol , Yves Uteza , Maurice Menasche , Carine Bossard , Loïc Van Den Berghe , Sébastian Bonnel , Hervé Prats , Jiri Honiger , Martin Neuner-Jehle
发明人： Marc Abitbol , Yves Uteza , Maurice Menasche , Carine Bossard , Loïc Van Den Berghe , Sébastian Bonnel , Hervé Prats , Jiri Honiger , Martin Neuner-Jehle
IPC分类号： A61F200
CPC分类号： A61K9/0051
摘要： Compositions and methods for reducing ocular diseases by implanting in an eye of a subject a composition comprising encapsulated cells which produce polypeptides, more particularly polypeptides that exhibit neurotrophic and/or anti-angiogenic activity. The encapsulation prevents the entry of host immune cells in the microcapsule while permitting the release of the polypeptide outside of the microcapsule.

2. 发明授权

US06267954B1 Intraocular transplantation of encapsulated cells 失效
标题翻译：囊内细胞的眼内移植
公开(公告)号：US06267954B1
公开(公告)日：2001-07-31
申请号：US09449293
申请日：1999-11-24
申请人： Marc Abitbol , Yves Uteza , Maurice Menasche , Carine Bossard , Loïc Van Den Berghe , Sébastien Bonnel , Hervé Prats , Jiri Honiger , Martin Neuner-Jehle
发明人： Marc Abitbol , Yves Uteza , Maurice Menasche , Carine Bossard , Loïc Van Den Berghe , Sébastien Bonnel , Hervé Prats , Jiri Honiger , Martin Neuner-Jehle
IPC分类号： A01N6300
CPC分类号： A61K9/0051
摘要： Compositions and methods for reducing ocular diseases by implanting in an eye of a subject a composition encapsulated cells which produce polypeptides, more particularly polypeptides that exhibit neurotrophic and/or anti-anglogenic activity. The encapsulation prevents the entry of host immune cells in the microcapsule while permitting the release of the polypeptide outside of the microcapsule.
摘要翻译：通过在受试者的眼睛中植入产生多肽的组合物包封的细胞，更具体地表现出神经营养和/或抗疟原虫活性的多肽来减少眼部疾病的组合物和方法。该封装防止宿主免疫细胞进入微胶囊，同时允许多肽在微胶囊外释放。

3. 发明授权

US06663894B2 Intraocular transplantation of encapsulated cells 失效
公开(公告)号：US06663894B2
公开(公告)日：2003-12-16
申请号：US09775174
申请日：2001-02-01
申请人： Marc Abitbol , Yves Uteza , Maurice Menasche , Carine Bossard , Loic Van Den Berghe , Sebastian Bonnel , Hervé Prats , Jiri Honiger , Martin Neuner-Jehle
发明人： Marc Abitbol , Yves Uteza , Maurice Menasche , Carine Bossard , Loic Van Den Berghe , Sebastian Bonnel , Hervé Prats , Jiri Honiger , Martin Neuner-Jehle
IPC分类号： A61K914
CPC分类号： A61K9/0051
摘要： Compositions and methods for reducing ocular diseases by implanting in an eye of a subject a composition comprising encapsulated cells which produce polypeptides, more particularly polypeptides that exhibit neurotrophic and/or anti-angiogenic activity. The encapsulation prevents the entry of host immune cells in the microcapsule while permitting the release of the polypeptide outside of the microcapsule.

4. 发明授权

US09192296B2 Multifunctional ophthalmic measurement system 有权
标题翻译：多功能眼科测量系统
公开(公告)号：US09192296B2
公开(公告)日：2015-11-24
申请号：US12674432
申请日：2008-08-21
申请人： Marc Abitbol , Ian Melnick , Ran Yam , Haggai Herman
发明人： Marc Abitbol , Ian Melnick , Ran Yam , Haggai Herman
IPC分类号： A61B3/10 , A61B3/107
CPC分类号： A61B3/107 , A61B3/1005 , A61B3/1015
摘要： A wavefront measurement system, for measurement of aberrations in the eye, and for measurement of the topography of the cornea of the eye. The system differs from previously available systems in that the wavefront measurement of the eye's aberrations can be performed as a function of eye accommodation. Furthermore, methods for reducing corneal reflection are described. Additionally, the use of a very short focal length Hartman Shack lenslet array enables a very wide range of low order aberrations, up to ±25 diopters, to be measured without any refocusing or motion of the system. Also, methods are described for enabling the presence of defects within the eye to be determined using the aberration measurement system. Another embodiment captures the pupil centering position without any projected illumination pattern being used, so that a subsequent accurate centering and focusing procedure can commence at the initially captured position, thus reducing measurement time.
摘要翻译：波前测量系统，用于测量眼睛中的像差，以及用于测量眼睛角膜的形态。该系统与先前可用的系统不同，因为眼睛像差的波前测量可以作为眼睛调节的功能来执行。此外，描述了减少角膜反射的方法。另外，使用非常短的焦距Hartman Shack小透镜阵列能够测量非常宽范围的低阶像差，高达±25屈光度，无需系统的任何重新聚焦或运动。此外，描述了使用像差测量系统来确定眼睛内的缺陷的存在的方法。另一个实施例捕获瞳孔定心位置而没有使用任何投影照明图案，使得随后的准确定心和聚焦程序可以在初始捕获的位置开始，从而减少测量时间。

5. 发明申请

US20110273669A1 MULTIFUNCTIONAL OPTHALMIC MEASUREMENT SYSTEM 有权
标题翻译：多功能对位测量系统
公开(公告)号：US20110273669A1
公开(公告)日：2011-11-10
申请号：US12674432
申请日：2008-08-21
申请人： Marc Abitbol , Ian Melnick , Ran Yam , Haggai Herman
发明人： Marc Abitbol , Ian Melnick , Ran Yam , Haggai Herman
IPC分类号： A61B3/107 , A61B3/00
CPC分类号： A61B3/107 , A61B3/1005 , A61B3/1015
摘要： A wavefront measurement system, for measurement of aberrations in the eye, and for measurement of the topography of the cornea of the eye. The system differs from previously available systems in that the wavefront measurement of the eye's aberrations can be performed as a function of eye accommodation. Furthermore, methods for reducing corneal reflection are described. Additionally, the use of a very short focal length Hartman Shack lenslet array enables a very wide range of low order aberrations, up to ±25 diopters, to be measured without any refocusing or motion of the system. Also, methods are described for enabling the presence of defects within the eye to be determined using the aberration measurement system. Another embodiment captures the pupil centering position without any projected illumination pattern being used, so that a subsequent accurate centering and focusing procedure can commence at the initially captured position, thus reducing measurement time.
摘要翻译：波前测量系统，用于测量眼睛中的像差，以及用于测量眼睛角膜的形态。该系统与先前可用的系统不同，因为眼睛像差的波前测量可以作为眼睛调节的功能来执行。此外，描述了减少角膜反射的方法。另外，使用非常短的焦距Hartman Shack小透镜阵列能够测量非常宽范围的低阶像差，高达±25屈光度，无需系统的任何重新聚焦或运动。此外，描述了使用像差测量系统来确定眼睛内的缺陷的存在的方法。另一个实施例捕获瞳孔定心位置而没有使用任何投影照明图案，使得随后的准确定心和聚焦程序可以在初始捕获的位置开始，从而减少测量时间。

6. 发明授权

US5784282A Method and apparatus for identifying the position in three dimensions of a movable object such as a sensor or a tool carried by a robot 失效
标题翻译：用于识别诸如由机器人携带的传感器或工具的可移动物体的三维位置的方法和装置
公开(公告)号：US5784282A
公开(公告)日：1998-07-21
申请号：US381999
申请日：1995-06-08
申请人： Marc Abitbol , Jean-Luc Maillart
发明人： Marc Abitbol , Jean-Luc Maillart
IPC分类号： B25J13/08 , B25J9/16 , B25J9/18 , G01B11/00 , G05B19/19 , G05D3/12 , G06T7/00 , G05B19/18 , G06F19/00 , G06G7/64 , G06G7/66
CPC分类号： G06T7/0018 , B25J9/1692 , G01B11/002 , G06T7/004 , G05B2219/39057
摘要： A method and apparatus for identifying the position of an object that is movable in a determined three-dimensional zone by means of a video camera (20) or the like mounted on the movable object (14), the camera (20) being capable of being swivelled to sight targets (22) disposed around the movable object (14) and to enable the position and the orientation of said object to be determined accurately by triangulation. The invention is particularly applicable to accurately determining the position and the orientation of a sensor or a tool mounted on a robot.
摘要翻译： PCT No.PCT / FR94 / 00687 Sec。 371日期：1995年6月8日 102（e）日期1995年6月8日PCT提交1994年6月10日PCT公布。出版物WO94 / 29774 日期1994年12月22日一种用于通过安装在可移动物体（14）上的摄像机（20）或相机（14）来识别在确定的三维区域中可移动的物体的位置的方法和装置， 20）能够旋转到设置在可移动物体（14）周围的瞄准器（22）上，并且能够通过三角测量精确地确定所述物体的位置和方位。本发明特别适用于准确地确定安装在机器人上的传感器或工具的位置和方向。

7. 发明授权

US06786602B2 Aberration correction spectacle lens 有权
标题翻译：畸变修正眼镜
公开(公告)号：US06786602B2
公开(公告)日：2004-09-07
申请号：US10159167
申请日：2002-05-31
申请人： Marc Abitbol
发明人： Marc Abitbol
IPC分类号： A61B300
CPC分类号： G02C7/02 , A61F2/1637 , A61F2240/002 , G02C7/027 , G02C7/028 , G02C2202/02 , G02C2202/22
摘要： A novel method for the design and construction of a spectacle lens for the correction of human vision, including the correction of high order aberrations. The lens enables the provision of super-normal vision using spectacles. Different lenses are described for use at a partial or a fuller field of view. The method applies corrective measures based on data obtained from high order wave front measurements of the subject's eye. According to one method, the Modulation Transfer Function (MTF) of the overall eye and lens optical system is optimized. According to another method, the optimization is performed on the wavefront of the overall eye and lens optical system. Both methods use weighted functions in the optimization procedure. This method of high order aberration correction is also applicable for the design of contact lenses and intra-ocular lenses, and for the execution of refractive eye surgery.
摘要翻译：一种用于设计和构造用于矫正人类视觉的眼镜片的新颖方法，包括校正高阶像差。该镜头能够使用眼镜提供超正常视力。不同的镜头被描述为在部分或更全面的视场中使用。该方法基于从受试者眼睛的高阶波前测量获得的数据应用校正措施。根据一种方法，优化了整个眼睛和镜片光学系统的调制传递函数（MTF）。根据另一种方法，对整个眼睛和镜片光学系统的波前执行优化。两种方法在优化过程中使用加权函数。这种高阶像差校正方法也适用于隐形眼镜和眼内透镜的设计以及执行屈光眼手术。

8. 发明授权

US06692127B2 Spectacles fitting system and fitting methods useful therein 失效
标题翻译：眼镜配件系统及其中适用的方法
公开(公告)号：US06692127B2
公开(公告)日：2004-02-17
申请号：US09859603
申请日：2001-05-17
申请人： Marc Abitbol , Ran Sasson , Ofer Mosenzon
发明人： Marc Abitbol , Ran Sasson , Ofer Mosenzon
IPC分类号： A61B304
CPC分类号： G02C13/003 , G02C13/005 , G06Q30/0641
摘要： A spectacles fitting system including a wide-view imaging system operative to provide a wide-view of a client's face, a 3D image processor operative to generate first 3D information describing the client's physical features, a virtual try-on unit operative to receive the digital 3D representation of the client's face and a digital 3D representation of a spectacle frame, to virtually mount the spectacle frame onto the client's face and to generate second 3D information describing frame/facial fit, and a lens fitter operative to receive the first 3D information and the second 3D information and to generate therefrom at least one parameter for face-and-frame customized manufacture and cutting of the lens.
摘要翻译：一种眼镜配合系统，包括可用于提供客户脸部的宽视角的宽视角成像系统，可操作以产生描述客户的物理特征的第一3D信息的3D图像处理器，可操作以接收数字的虚拟试用单元客户脸部的3D表示和眼镜架的数字3D表示，将眼镜架虚拟地安装在客户端的脸上，并产生描述框架/面部贴合的第二3D信息，以及可操作以接收第一3D信息的镜片装配器，以及第二3D信息，并从中产生至少一个用于面镜定制制造和切割镜片的参数。

9. 发明授权

US06685934B1 Recombinant adenoviruses coding for basic fibroblast growth factors (BFGF) 失效
标题翻译：编码碱性成纤维细胞生长因子（BFGF）的重组腺病毒
公开(公告)号：US06685934B1
公开(公告)日：2004-02-03
申请号：US08718482
申请日：1996-10-09
申请人： Jacques Mallet , Michel Perricaudet , Emmanuelle Vigne , Frédéric Revah , Marc Abitbol , Paul Roustan
发明人： Jacques Mallet , Michel Perricaudet , Emmanuelle Vigne , Frédéric Revah , Marc Abitbol , Paul Roustan
IPC分类号： A01N6300
CPC分类号： C12N15/86 , A61K38/1825 , A61K48/00 , C07K14/503 , C12N2710/10343
摘要： Recombinant adenoviruses comprising a heterologous DNA sequence coding for basic blast growth factors (bFGF), preparation and uses thereof for the treatment and/or prevention of neurodegenerative diseases.
摘要翻译：重组腺病毒，其包含编码基础胚芽生长因子（bFGF）的异源DNA序列，其用于治疗和/或预防神经变性疾病的制备及其用途。

10. 发明授权

US06154969A Holding assembly for lens measuring device 有权
标题翻译：镜头测量装置的组装
公开(公告)号：US06154969A
公开(公告)日：2000-12-05
申请号：US420400
申请日：1999-10-18
申请人： Marc Abitbol , Yair Tal
发明人： Marc Abitbol , Yair Tal
IPC分类号： G01M11/00 , G02C13/00 , A61B3/10
CPC分类号： G02C13/001
摘要： A holding assembly for holding spectacles, having an adjustable grip for fitting around a pair of spectacles. The adjustable grip is slidably mounted to allow alignment one after the other of each lens along a single predetermined axis perpendicular to the plane of the lens, such that the aligned lens has a clear line of sight to a lens measuring device.
摘要翻译：用于保持眼镜的保持组件，具有用于安装在一副眼镜周围的可调节把手。可调节的手柄被可滑动地安装，以允许每个透镜的另一个沿垂直于透镜的平面的单个预定轴线对准，使得对准的透镜具有到透镜测量装置的清晰视线。

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