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1. 发明申请

US20110104753A1 Soluble Recombinant Influenza Antigens 有权
标题翻译：可溶性重组流感抗原
公开(公告)号：US20110104753A1
公开(公告)日：2011-05-05
申请号：US13001111
申请日：2009-07-07
申请人： Manon Couture , Nathalie Landry , Louis-Philippe Vezina , Michéle Dargis
发明人： Manon Couture , Nathalie Landry , Louis-Philippe Vezina , Michéle Dargis
IPC分类号： C12P21/00 , C07K14/11 , C07H21/00 , C12N15/82 , C12N5/10
CPC分类号： C12N15/8257 , A61K39/00 , A61K39/12 , A61K39/145 , C07K14/005 , C07K2319/50 , C07K2319/70 , C07K2319/73 , C07K2319/735 , C12N2760/16122 , C12N2760/16134
摘要： The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal. The invention is also directed to nucleic acids encoding the rHA of the invention, as well as vectors and chimeric constructs comprising the nucleic acid. Methods of producing the rHA are also provided. The rHA described herein may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：本发明提供了包含血凝素胞外域和寡聚化结构域的重组可溶性三聚体血凝素（rHA）蛋白。 rHA产生为可溶性同三聚物，并且还可以包含信号肽和/或内质网（ER）保留信号。本发明还涉及编码本发明的rHA的核酸，以及包含该核酸的载体和嵌合构建体。还提供了生产rHA的方法。本文所述的rHA可用于制定流感疫苗，或可用于富集现有疫苗。

2. 发明授权

US08771703B2 Soluble recombinant influenza antigens 有权
标题翻译：可溶性重组流感抗原
公开(公告)号：US08771703B2
公开(公告)日：2014-07-08
申请号：US13001111
申请日：2009-07-07
申请人： Manon Couture , Nathalie Landry , Louis-Philippe Vezina , Michéle Dargis
发明人： Manon Couture , Nathalie Landry , Louis-Philippe Vezina , Michéle Dargis
IPC分类号： A61K39/145 , A61K39/00 , C12N15/82 , C12N15/79 , C12N15/84 , C12N15/44 , C12N15/62 , C12N15/90 , C12N5/10 , C07K14/005
CPC分类号： C12N15/8257 , A61K39/00 , A61K39/12 , A61K39/145 , C07K14/005 , C07K2319/50 , C07K2319/70 , C07K2319/73 , C07K2319/735 , C12N2760/16122 , C12N2760/16134
摘要： The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal. The invention is also directed to nucleic acids encoding the rHA of the invention, as well as vectors and chimeric constructs comprising the nucleic acid. Methods of producing the rHA are also provided. The rHA described herein may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：本发明提供了包含血凝素胞外域和寡聚化结构域的重组可溶性三聚体血凝素（rHA）蛋白。 rHA产生为可溶性同三聚物，并且还可以包含信号肽和/或内质网（ER）保留信号。本发明还涉及编码本发明的rHA的核酸，以及包含该核酸的载体和嵌合构建体。还提供了生产rHA的方法。本文所述的rHA可用于制定流感疫苗，或可用于富集现有疫苗。

3. 发明申请

US20100239610A1 INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT 审中-公开
标题翻译：包含在植物中生产的HEMAGGLUTININ的流感病毒样颗粒（VLPS）
公开(公告)号：US20100239610A1
公开(公告)日：2010-09-23
申请号：US12669033
申请日：2008-07-11
申请人： Marc-André D'Aoust , Manon Couture , Frédéric Ors , Sonia Trépanier , Pierre-Olivier Lavoie , Michéle Dargis , Louis-Philippe Vézina , Nathalie Landry
发明人： Marc-André D'Aoust , Manon Couture , Frédéric Ors , Sonia Trépanier , Pierre-Olivier Lavoie , Michéle Dargis , Louis-Philippe Vézina , Nathalie Landry
IPC分类号： A61K39/145 , C07H21/04 , C07K14/11 , A61P31/16 , C12N7/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/517 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55583 , A61K2039/58 , C07K14/005 , C12N7/00 , C12N15/8257 , C12N15/8258 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：提供了在植物或植物的一部分内合成流感病毒样颗粒（VLP）的方法。该方法包括在植物中表达流感HA并通过尺寸排阻色谱法进行纯化。本发明还涉及包含流感HA蛋白和植物脂质的VLP。本发明还涉及编码流感HA以及载体的核酸。 VLP可用于制定流感疫苗，或可用于丰富现有疫苗。

4. 发明申请

US20100310604A1 RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ 审中-公开
标题翻译：转基因植物中生产的重组流感病毒样芽孢杆菌（VLPS）表达HEMAGGLUTININ
公开(公告)号：US20100310604A1
公开(公告)日：2010-12-09
申请号：US12863772
申请日：2009-01-12
申请人： Marc-André D'Aoust , Manon Couture , Frédéric Ors , Sonia Trépanier , Pierre-Olivier Lavoie , Michéle Dargis , Louis-Philippe Vézina , Nathalie Landry
发明人： Marc-André D'Aoust , Manon Couture , Frédéric Ors , Sonia Trépanier , Pierre-Olivier Lavoie , Michéle Dargis , Louis-Philippe Vézina , Nathalie Landry
IPC分类号： A61K39/145 , C07H21/04 , C07K14/11 , A01H5/00 , A61P31/16 , A01H1/00
CPC分类号： C12N15/8258 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55583 , A61K2039/55588 , A61K2039/58 , C07K14/005 , C07K2319/02 , C07K2319/03 , C12N7/00 , C12N9/90 , C12N15/8257 , C12N2760/16022 , C12N2760/16122 , C12N2760/16123 , C12N2760/16133 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16234 , C12Y503/04001 , G06F9/505 , G06F2209/508
摘要： A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：提供了在植物或植物的一部分内合成流感病毒样颗粒（VLP）的方法。该方法包括在植物中表达流感HA并通过尺寸排阻色谱法进行纯化。本发明还涉及包含流感HA蛋白和植物脂质的VLP。本发明还涉及编码流感HA以及载体的核酸。 VLP可用于制定流感疫苗，或可用于丰富现有疫苗。

5. 发明授权

US09492528B2 Influenza virus-like particles (VLPS) comprising hemagglutinin 有权
标题翻译：包含血凝素的流感病毒样颗粒（VLPS）
公开(公告)号：US09492528B2
公开(公告)日：2016-11-15
申请号：US13003570
申请日：2009-07-02
申请人： Marc-Andre D'Aoust , Manon Couture , Frédéric Ors , Sonia Trepanier , Pierre-Olivier Lavoie , Michèle Dargis , Louis-Philippe Vezina , Nathalie Landry
发明人： Marc-Andre D'Aoust , Manon Couture , Frédéric Ors , Sonia Trepanier , Pierre-Olivier Lavoie , Michèle Dargis , Louis-Philippe Vezina , Nathalie Landry
IPC分类号： A61K39/145 , C12N15/82 , C12N7/04 , C12N15/44 , C07K14/005 , C12N7/00 , A61K39/12 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/517 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55583 , A61K2039/58 , C07K14/005 , C12N7/00 , C12N15/8257 , C12N15/8258 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein of type A/California/04/09 and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA of type A/California/04/09 as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：提供了在植物或植物的一部分内合成流感病毒样颗粒（VLP）的方法。该方法包括在植物中表达A / California / 04/09型流感病毒HA，并通过大小排阻色谱法纯化。本发明还涉及包含A / California / 04/09型流感HA蛋白和植物脂质的VLP。本发明还涉及编码A / California / 04/09型流感病毒的核酸以及载体。 VLP可用于制定流感疫苗，或可用于丰富现有疫苗。

6. 发明申请

US20110191915A1 INFLUENZA VIRUS IMMUNIZING EPITOPE 有权
标题翻译：流感病毒免疫抗体
公开(公告)号：US20110191915A1
公开(公告)日：2011-08-04
申请号：US13054452
申请日：2009-07-15
申请人： Manon Couture , Louis-Philippe Vezina , Nathalie Landry
发明人： Manon Couture , Louis-Philippe Vezina , Nathalie Landry
IPC分类号： A01H5/00 , C12N15/63 , C12P21/00 , C07K2/00 , A61K39/145 , C12N5/10 , A61P37/04 , A61P31/16
CPC分类号： C12N15/8257 , A61K39/12 , A61K39/145 , A61K2039/517 , A61K2039/5258 , A61K2039/543 , C07K16/1018 , C12N7/00 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151 , C12N2760/16223 , C12N2760/16234 , C12N2760/16251
摘要： A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of a novel influenza HA protein in plants and its purification The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding improved influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：提供了在植物或植物的一部分内合成流感病毒样颗粒（VLP）的方法。该方法包括在植物中表达新型流感HA蛋白及其纯化本发明还涉及包含流感HA蛋白和植物脂质的VLP。本发明还涉及编码改进的流感HA以及载体的核酸。 VLP可用于制定流感疫苗，或可用于丰富现有疫苗。

7. 发明授权

US09546375B2 Influenza virus immunizing epitope 有权
标题翻译：流感病毒免疫表位
公开(公告)号：US09546375B2
公开(公告)日：2017-01-17
申请号：US13054452
申请日：2009-07-15
申请人： Manon Couture , Louis-Philippe Vezina , Nathalie Landry
发明人： Manon Couture , Louis-Philippe Vezina , Nathalie Landry
IPC分类号： A61K39/145 , C12N15/82 , C12N15/79 , C12N15/44 , C12N15/62 , C07K16/10 , C12N7/00 , A61K39/12 , A61K39/00
CPC分类号： C12N15/8257 , A61K39/12 , A61K39/145 , A61K2039/517 , A61K2039/5258 , A61K2039/543 , C07K16/1018 , C12N7/00 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151 , C12N2760/16223 , C12N2760/16234 , C12N2760/16251
摘要： A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of a novel influenza HA protein in plants and its purification The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding improved influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：提供了在植物或植物的一部分内合成流感病毒样颗粒（VLP）的方法。该方法包括在植物中表达新型流感HA蛋白及其纯化本发明还涉及包含流感HA蛋白和植物脂质的VLP。本发明还涉及编码改进的流感HA以及载体的核酸。 VLP可用于制定流感疫苗，或可用于丰富现有疫苗。

8. 发明申请

US20110293650A1 INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ 有权
标题翻译：包含HEMAGGLUTININ的流感病毒颗粒（VLPS）
公开(公告)号：US20110293650A1
公开(公告)日：2011-12-01
申请号：US13003570
申请日：2009-07-02
申请人： Marc-Andre D'Aoust , Manon Couture , Frédéric Ors , Sonia Trepanier , Pierre-Olivier Lavoie , Michèle Dargis , Louis-Philippe Vezina , Nathalie Landry
发明人： Marc-Andre D'Aoust , Manon Couture , Frédéric Ors , Sonia Trepanier , Pierre-Olivier Lavoie , Michèle Dargis , Louis-Philippe Vezina , Nathalie Landry
IPC分类号： A61K39/145 , C12N15/82 , A01H1/06 , A61P31/16 , A01H5/00 , C07K14/11 , A61P37/00 , C07H21/04 , C07K1/14
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/517 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55583 , A61K2039/58 , C07K14/005 , C12N7/00 , C12N15/8257 , C12N15/8258 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein of type A/California/04/09 and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA of type A/California/04/09 as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：提供了在植物或植物的一部分内合成流感病毒样颗粒（VLP）的方法。该方法包括在植物中表达A / California / 04/09型流感病毒HA，并通过大小排阻色谱法纯化。本发明还涉及包含A / California / 04/09型流感HA蛋白和植物脂质的VLP。本发明还涉及编码A / California / 04/09型流感病毒的核酸以及载体。 VLP可用于制定流感疫苗，或可用于丰富现有疫苗。

9. 发明申请

US20090318377A1 MEDICAGENIC ACID SAPONIN AND USES THEREOF 审中-公开
标题翻译：药用酸性痤疮及其用途
公开(公告)号：US20090318377A1
公开(公告)日：2009-12-24
申请号：US12373476
申请日：2007-07-13
申请人： Louis-Philippe Vezina , Nathalie Landry , Joelle Pelletier , Sylvain Savard
发明人： Louis-Philippe Vezina , Nathalie Landry , Joelle Pelletier , Sylvain Savard
IPC分类号： A61K31/704 , A61P3/06
CPC分类号： A61K31/575 , A23L33/105 , A61K31/704
摘要： A cholesterol-lowering preparation comprising medicagenic acid saponin is disclosed. The amount of medicagenic acid saponin in the preparation is greater than 50% by weight to produce the cholesterol-lowering effect in an animal. A method of purifying a preparation of at least 30% medicagenic acid saponin is also disclosed. The preparation may be purified from alfalfa plants and used as a treatment for lowering cholesterol and triglycerides in an animal, in particular a human.
摘要翻译：公开了包含药用皂苷的降胆固醇制剂。制剂中的药用植物皂苷的量大于50重量％，以在动物中产生降低胆固醇的作用。还公开了一种纯化至少30％的药用植物皂苷的制剂的方法。该制剂可以从苜蓿植物中纯化并用作降低动物，特别是人类中的胆固醇和甘油三酸酯的治疗剂。

10. 发明授权

US6030818A Bacterial mass production of taxanes and paclitaxel 失效
标题翻译：紫杉烷和紫杉醇的细菌大量生产
公开(公告)号：US6030818A
公开(公告)日：2000-02-29
申请号：US995960
申请日：1997-12-22
申请人： Michel Page , Nathalie Landry , Maurice Boissinot , Marie-Claude Helie , Mario Harvey , Martin Gagne
发明人： Michel Page , Nathalie Landry , Maurice Boissinot , Marie-Claude Helie , Mario Harvey , Martin Gagne
IPC分类号： C12P15/00 , C12P17/02 , C12N1/20
CPC分类号： C12P17/02 , C12P15/00
摘要： The present invention relates to a method of obtaining different biologically pure cultures of bacteria isolated from different species of Taxus such as Taxus canadensis. T. brevifolia, T. baccata, T. cuspidata, and T. hunnewelliana, wherein the bacteria produce in vitro taxanes and paclitaxel, and wherein the bacteria are of the genus Sphingomonas, Bacillus, Pantoea or Curtobacterium. Also, the present invention relates to a method of a bacterial mass production of at least one taxane or paclitaxel. There is also disclosed a novel bacterial taxane. The present invention also relates to the use of different biologically pure cultures of bacteria isolated from different species of Taxus, wherein the bacteria are able to biotransform pro-taxanes. There is also provided a process for improving taxanes and paclitaxel production of taxanes and paclitaxel producing bacteria which include culturing bacteria in the presence of a mutagenic agent for a period a time sufficient to allow mutagenesis. There is disclosed two new mutated bacteria which have an increased yield of pro-taxane biotransformation.
摘要翻译：本发明涉及从不同种类的红豆杉（Taxus canadensis）分离得到的细菌的不同生物纯培养物的方法。 T. brevifolia，T.cuspidata和T. hunnewelliana，其中细菌在体外产生紫杉烷和紫杉醇，其中细菌是鞘氨醇单胞菌属，芽孢杆菌属，泛菌属或曲霉属。另外，本发明涉及细菌大量生产至少一种紫杉烷或紫杉醇的方法。还公开了一种新型细菌紫杉烷。本发明还涉及从不同种类的红豆杉分离的细菌的不同生物纯培养物的用途，其中细菌能够生物转化前紫杉烷。还提供了一种改善紫杉烷类和紫杉醇生产细菌的紫杉烷类和紫杉醇生产的方法，其包括在致突变剂存在下培养细菌足以允许诱变的时间。已经公开了两种新的突变细菌，其具有增加的前紫杉烷生物转化产率。

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