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1. 外观设计

USD469527S1 Pharmacological inhaler 失效
标题翻译：药理吸入器
公开(公告)号：USD469527S1
公开(公告)日：2003-01-28
申请号：US29133793
申请日：2000-12-07
申请人： Manfred Keller , Thomas Eggimann
设计人： Manfred Keller , Thomas Eggimann
IPC分类号： A61M11/00 , A61M15/00 , A61M15/06 , A61M16/00 , G06M1/16
CPC分类号： A61M15/0086 , A61M11/002 , A61M15/0025 , A61M15/0045 , A61M15/0065 , A61M15/0068 , A61M15/0076 , A61M15/008 , A61M15/0091 , A61M2016/0039 , A61M2202/064 , A61M2205/215 , A61M2205/825 , G06M1/163

2. 发明授权

US07131441B1 Inhaler for multiple dosed administration of a pharmacological dry powder 有权
标题翻译：多剂量给药药物干粉的吸入器
公开(公告)号：US07131441B1
公开(公告)日：2006-11-07
申请号：US09570107
申请日：2000-05-12
申请人： Manfred Keller , Thomas Eggimann
发明人： Manfred Keller , Thomas Eggimann
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0026 , A61M15/0045 , A61M15/0068 , A61M15/007 , A61M15/0076 , A61M15/0086 , A61M2202/064 , A61M2205/825 , G06M1/083 , G06M1/22
摘要： An inhaler for multiple dosed administration of a pharmacological dry powder has a housing with a mouthpiece fitted thereon and a removable protective cap that covers the mouthpiece prior to removal. The mouthpiece may be fitted with or without lip grooves, which aid a user in the positioning and manipulation of the inhaler. The inhaler includes a dosing slide, a carriage, a dosing cavity and a valve shield, all of which are arranged within the housing. Removal of the protective cap initiates dosing, which consists of a dose of a pharmacological dry powder being received in the dosing cavity and then transported to the mouthpiece by means of the dosing slide. Only upon application of a defined minimum intensity of inhalation is the shutter moved by the suctioned valve shield, resulting in the release of the dose for inhalation.
摘要翻译：用于多剂量给药药理学干粉的吸入器具有安装在其上的接口的外壳和在移除之前覆盖接口管的可移除的保护帽。吸嘴可以安装有或没有唇槽，这有助于使用者定位和操纵吸入器。吸入器包括定量滑块，滑架，计量腔和阀屏蔽件，所有这些都布置在壳体内。保护帽的移除开始给药，其由在剂量腔中接收的一定剂量的药物干燥粉末组成，然后通过定量给药载体输送到吸口。只有在施加了限定的最小吸入强度后，通过抽吸的阀屏才能移动活门，导致吸入剂量的释放。

3. 发明授权

US06182655B2 Inhaler for multiple dosed administration of a pharmacological dry powder 失效
标题翻译：多剂量给药药物干粉的吸入器
公开(公告)号：US06182655B2
公开(公告)日：2001-02-06
申请号：US09077387
申请日：1998-05-28
申请人： Manfred Keller , Thomas Eggimann
发明人： Manfred Keller , Thomas Eggimann
IPC分类号： A61M1500
CPC分类号： A61M15/0086 , A61M11/002 , A61M15/0025 , A61M15/0045 , A61M15/0065 , A61M15/0068 , A61M15/0076 , A61M15/008 , A61M15/0091 , A61M2016/0039 , A61M2202/064 , A61M2205/215 , A61M2205/825 , G06M1/163
摘要： An inhaler for multiple dosed administration of a pharmacological dry powder consists externally of a housing (100,150) and of a protective cap (950) which can be removed from a special mouthpiece (900) fitted on the housing. Arranged on the inside there are a slide rail (200), a dosing slide (300), a shutter (400), a carriage (500), a funnel arrangement (600), a counter device (700), a valve shield (800) and a valve guide (850). Removal of the protective cap (950) initiates the dosing, with a dose received in the dosing cavity (302) being transported to the mouth-piece (900) by means of the dosing slide (300). Only upon application of a defined minimum intensity of inhalation is the shutter (400) moved by the suctioned valve shield (800), as a result of which the dose is released for inhalation. Completed with an electronic module and a controllable nozzle, all inhalation-relevant data can be recorded and the flow conditions regulated.
摘要翻译：用于多剂量给药药物干粉的吸入器由外壳（100,150）和保护盖（950）外部组成，其可以从装配在外壳上的特殊接口（900）移除。在内侧设置有滑轨（200），配料滑块（300），快门（400），滑架（500），漏斗装置（600），计数器装置（700），阀屏蔽 800）和阀引导件（850）。保护帽（950）的去除启动剂量，在剂量腔（302）中接收的剂量通过定量给药载玻片（300）输送到口件（900）。只有当施加了限定的最小吸入强度时，由抽吸阀屏蔽（800）移动的快门（400），结果释放剂量用于吸入。完成了电子模块和可控喷嘴，可以记录所有吸入相关数据，并调节流量条件。

4. 发明申请

US20090232744A1 Macrolide compositions having improved taste and stability 审中-公开
标题翻译：具有改善的味道和稳定性的大环内酯组合物
公开(公告)号：US20090232744A1
公开(公告)日：2009-09-17
申请号：US12380378
申请日：2009-02-26
申请人： Manfred Keller , Evy Corbanie
发明人： Manfred Keller , Evy Corbanie
IPC分类号： A61K9/12 , A61K31/7048 , A61K31/7028
CPC分类号： A61K9/0078 , A61K31/7028 , A61K31/7048 , A61K47/12
摘要： The invention provides an aqueous pharmaceutical composition for administration as an aerosol to the respiratory tract, nose or oropharyngeal region comprising (i) a macrolide having a poor taste and poor chemical stability in aqueous solution; (ii) at least one salt selected from the group consisting of sodium gluconate, sodium aspartate, sodium acetate, sodium lactate, sodium succinate, sodium maleate, magnesium gluconate, magnesium aspartate, magnesium citrate, magnesium acetate, magnesium lactate, magnesium succinate, and magnesium maleate; or mixtures thereof and (iii) a taste-masking agent different from said salt; wherein (a) the concentration of said macrolide in the composition is in the range of about 0.25 wt.-% to about 15 wt.-%; (b) the molar ratio of said macrolide:said salt is in the range from about 1:0.5 to about 1:100; (c) the pH of the composition is in the range of about 3 to 9; and (d) the osmolality of the composition is in the range of about 150 mOsmol/kg to about 1500 mOsmol/kg. The invention further provides a method of generating an aerosol, preferably by means of a nebuliser, which uses such an aqueous pharmaceutical composition. The macrolide may be used alone or in combination with other drugs. The composition is suitable to treat inflammatory disorders and/or infections of the respiratory tract. It has an improved taste and stability.
摘要翻译：本发明提供一种用于作为气溶胶施用于呼吸道，鼻或口咽区域的水性药物组合物，其包含（i）具有差的味道和在水溶液中的化学稳定性差的大环内酯类; （ii）至少一种选自葡萄糖酸钠，天冬氨酸钠，乙酸钠，乳酸钠，琥珀酸钠，马来酸钠，葡糖酸镁，天冬氨酸镁，柠檬酸镁，乙酸镁，乳酸镁，琥珀酸镁和马来酸镁或其混合物和（iii）不同于所述盐的掩味剂; 其中（a）所述大环内酯在组合物中的浓度在约0.25重量％至约15重量％的范围内; （b）所述大环内酯：所述盐的摩尔比在约1:0.5至约1:100的范围内; （c）组合物的pH在约3至9的范围内; 和（d）组合物的重量摩尔渗透压浓度在约150mOsmol / kg至约1500mOsmol / kg的范围内。本发明还提供了一种产生气雾剂的方法，优选通过使用这种水性药物组合物的雾化器。大环内酯可以单独使用或与其他药物组合使用。该组合物适用于治疗炎症性疾病和/或呼吸道感染。它具有改善的味道和稳定性。

5. 发明申请

US20090025713A1 Nebulised Antibiotics for Inhalation Therapy 审中-公开
标题翻译：用于吸入治疗的雾化抗生素
公开(公告)号：US20090025713A1
公开(公告)日：2009-01-29
申请号：US12223735
申请日：2007-02-08
申请人： Manfred Keller , Aslihan Akkar
发明人： Manfred Keller , Aslihan Akkar
IPC分类号： A61K9/12 , A61K47/38 , A61K47/36 , A61K47/40 , A61P11/00
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/4709 , A61K31/496 , A61K31/535 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/6951 , B82Y5/00 , Y02A50/473 , Y02A50/478
摘要： The present invention provides pharmaceutical aerosols which are useful for the prevention or treatment of infectious diseases of the airways, such as the lungs, the bronchi, or the sinunasal cavities. The aerosols comprise an active agent selected from the group of quinolone antibiotics. Also disclosed are liquid and solid compositions suitable for being converted into the aerosols, and kits comprising such compositions.
摘要翻译：本发明提供了可用于预防或治疗气道如肺，支气管或鼻腔的传染病的药用气溶胶。气溶胶包含选自喹诺酮类抗生素的活性剂。还公开了适于转化成气溶胶的液体和固体组合物，以及包含这种组合物的试剂盒。

6. 发明授权

US07173712B2 Method and device for increasing the long-term operational reliability of a fiber optic interferometer 有权
标题翻译：提高光纤干涉仪长期运行可靠性的方法和装置
公开(公告)号：US07173712B2
公开(公告)日：2007-02-06
申请号：US10485579
申请日：2002-07-26
申请人： Manfred Keller
发明人： Manfred Keller
IPC分类号： G01C19/72
CPC分类号： G01C19/721
摘要： A method for increasing the long-term operational reliability of a fiber optic interferometer. Noise in a detector output signal is set to a desired value by correcting the detector light power. Detector light power is corrected by varying a light source current of a light source of the interferometer. A change in the light source power results. It is thereby possible to increase both the reliability and useful life of the interferometer.
摘要翻译：一种提高光纤干涉仪长期运行可靠性的方法。通过校正检测器光功率将检测器输出信号中的噪声设置为期望值。通过改变干涉仪的光源的光源电流来校正检测器光功率。导致光源功率的变化。从而可以提高干涉仪的可靠性和使用寿命。

7. 发明申请

US20050244339A1 Pharmaceutical aerosol composition 有权
标题翻译：药物气溶胶组成
公开(公告)号：US20050244339A1
公开(公告)日：2005-11-03
申请号：US11106999
申请日：2005-04-14
申请人： Jurgen Jauernig , Frank-Christophe Lintz , Manfred Keller , Ingo Friedrich
发明人： Jurgen Jauernig , Frank-Christophe Lintz , Manfred Keller , Ingo Friedrich
IPC分类号： A61K9/00 , A61K9/107 , A61K9/127 , A61K9/19 , A61L9/04
CPC分类号： A61K9/1075 , A61K9/0078 , A61K9/127 , A61K9/19
摘要： Sterile compositions for administration as aerosols are described. They contain an active agent which is poorly water-soluble, a non-ionic surfactant acomponent and a phospholipid component. The compositions are suitable for oral or nasal inhalation, but also for topical or oromucosal administration. They are particulary useful for the efficient pulmonary administration of poorly soluble corticosteroids and can be aerosolized with common nebulizers.
摘要翻译：描述了作为气溶胶施用的无菌组合物。它们含有水溶性差的活性剂，非离子表面活性剂组分和磷脂组分。所述组合物适用于口服或鼻吸入，也适用于局部或粘膜粘膜给药。它们对于有效的肺部给药难溶性皮质类固醇是特别有用的，并且可以用普通喷雾器进行雾化。

8. 发明授权

US06475467B1 Medicinal aerosol formulations 有权
标题翻译：药用气雾剂
公开(公告)号：US06475467B1
公开(公告)日：2002-11-05
申请号：US09744798
申请日：2001-04-20
申请人： Manfred Keller , Kurt Herzog , Rudi Müller-Walz , Holger Kraus
发明人： Manfred Keller , Kurt Herzog , Rudi Müller-Walz , Holger Kraus
IPC分类号： A61K912
CPC分类号： A61K9/008 , A61K9/124 , A61K47/22
摘要： The use of solid, pharmaceutically acceptable salts of cromoglycic acid and/or nedocromil as carriers in a therapeutically and prophylactically inefficacious amount in suspension aerosol formulations of pharmaceutical active compounds improves the dispersion properties, increases the chemical and physical stability of moisture-sensitive active compounds, makes possible a more accurate dosage, in particular even of low-dose active compounds, and as a rule permits the abandonment of surface-active agents.
摘要翻译：在治疗和预防无效量的药物活性化合物的悬浮气雾剂制剂中使用色甘酸和/或奈多罗米的固体药学上可接受的盐作为载体改善了分散性能，提高了湿敏性活性化合物的化学和物理稳定性，使得可能更准确的剂量，特别是甚至低剂量活性化合物，并且通常允许放弃表面活性剂。

9. 发明授权

US4973227A Method of producing a vacuum 失效
标题翻译：制造真空的方法
公开(公告)号：US4973227A
公开(公告)日：1990-11-27
申请号：US367025
申请日：1989-06-16
申请人： Otto Bernauer , Clemens Halene , Manfred Keller
发明人： Otto Bernauer , Clemens Halene , Manfred Keller
IPC分类号： B01J3/00 , C01B3/00 , F04B37/02
CPC分类号： F04B37/02
摘要： A method of producing a vacuum in a volume of a hollow body which has at least one outlet opening for the gaseous atmosphere present therein, the method includes the following steps: introducing at least about 3 g/dm.sup.3 of evacuation volume of a metal hydride into the hollow body so as to take up less than about 5% of the volume 3. The metal hydride comprises a hydride forming alloy of the formulaTi(V.sub.1-a-b Fe.sub.a Al.sub.b).sub.xy Mn.sub.z,wherein1
摘要翻译：一种在具有至少一个气体气氛出口的中空体的体积中产生真空的方法，该方法包括以下步骤：将至少约3g / dm 3的金属氢化物排空体积引入空心体以便占据体积3的小于约5％。金属氢化物包括式Ti（V1-ab FeaAlb）xyMnz的氢化物形成合金，其中1 = = 0 0 z 。将金属氢化物加热到使氢化物中释放大量气态氢的温度，进行加热步骤，使中空体的加热温度不超过约500℃。用从氢化物释放的气态氢冲洗体积，从而在释放之前更换体积中存在的气体气氛; 关闭中空体的出口; 冷却空心体; 并用氢化物形成合金吸收气态氢。

10. 发明授权

US4707606A Proportional counter for detecting surface contaminations 失效
标题翻译：用于检测表面污染物的比例计数器
公开(公告)号：US4707606A
公开(公告)日：1987-11-17
申请号：US658114
申请日：1984-10-05
申请人： Manfred Keller
发明人： Manfred Keller
IPC分类号： H01J47/00 , H01J47/06 , G01T1/18
CPC分类号： H01J47/06 , H01J47/002
摘要： Proportional counters for the detection and measurement of radioactive surface contaminations are provided with at least two flat window faces enclosing an angle and being formed by a thin foil spread or stretched by a framework including thin rods arranged along the inner edges of contacting window faces, to which rods the foil may be adhered. A perforated lattice or grid cage serves in particular to protect the thin window against any contact, the cage provides for a spacing of about double rod thickness between the framework and the controlled surface. Preferred is a polygonal and in particular hexagonal lattice whose grid wires or strips do not lie in the main scanning direction. Particularly convenient for checking pipelines are, for example, cylindrical measuring probes comprising window foils extending over and perhaps adhered to a circularly arranged frame of thin rods.
摘要翻译：用于检测和测量放射性表面污染物的比例计数器设置有至少两个平坦的窗口面，其包围一角度，并且由薄片展开形成，薄的薄片由包括沿着接触窗面的内边缘布置的细棒的框架延伸或拉伸，哪个棒可以粘附。穿孔格栅或格栅笼特别用于保护薄窗不受任何接触，保持架在框架和受控表面之间提供约双重杆厚度的间隔。优选的是多边形，特别是其网格线或条不位于主扫描方向的六边形格子。检查管道特别方便的是例如圆柱形测量探针，其包括延伸并可能粘附到圆形的细棒框架上的窗口箔。

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