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1. 发明授权

US4877733A Glucose dehydrogenase and its production 失效
标题翻译：葡萄糖脱氢酶及其生产
公开(公告)号：US4877733A
公开(公告)日：1989-10-31
申请号：US42655
申请日：1987-04-28
申请人： Mamoru Takahashi , Shigeyuki Imamura , Masaki Takada
发明人： Mamoru Takahashi , Shigeyuki Imamura , Masaki Takada
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , Y10S435/911
摘要： Glucose dehydrogenase having the following biochemial properties:(a) enzymatic action: catalyzes a reaction which generates glucono-.delta.-lactone and reduced NADP from glucose and NADP;(b) substrate specificity: has substrate specificity on glucose and no substrate specificity on 2-deoxyglucose;(c) optimum pH: pH 6-8,(d) optimum temperature: approximately 55.degree. C.,(e) pH-stability: stable at pH 6.0-7.5,(f) molecular weight: 11.times.10.sup.4 .+-.11000,(g) Km-value: 2.6.times.10.sup.-3 .+-.2.6.times.10.sup.-4 M(glucose) 4.2.times.10.sup.-6 35 4.2.times.10.sup.-7 M(NADP) and(h) isoelectric point: 4.9.+-.0.5,comprises culturing a glucose dehydrogenase-producing microorganism Cryptococcus uniguttulatus Y 0033 FERM P-8709, now FERM BP-1352 in a nutrient medium and isolating glucose dehydrogenase thus produced from the cultured medium.
摘要翻译：具有以下生物化学性质的葡萄糖脱氢酶：（a）酶促作用：催化从葡萄糖和NADP产生葡萄糖酸-δ-内酯和还原的NADP的反应; （b）底物特异性：对葡萄糖具有底物特异性，对2-脱氧葡萄糖没有底物特异性; （c）最适pH：pH 6-8，（d）最适温度：约55℃，（e）pH稳定性：pH 6.0-7.5稳定，（f）分子量：11×10 4 +/- 11000，（g ）Km值：2.6×10 -3 +/- 2.6×10 -4 M（葡萄糖）4.2×10-635 4.2×10-7M（NADP）和（h）等电点：4.9 +/- 0.5，包括培养产生葡萄糖脱氢酶微生物隐球酵母Y 0033 FERM P-8709，现在是营养培养基中的FERM BP-1352，并从培养基中分离出葡萄糖脱氢酶。

2. 发明授权

US4985360A Novel bilirubin oxidase which has a substrate specifity to bilirubin, but not to biliverdin, catechol and hemin 失效
标题翻译：新型胆红素氧化酶，其具有对胆红素的底物特异性，但不对胆红素，儿茶酚和血红素
公开(公告)号：US4985360A
公开(公告)日：1991-01-15
申请号：US204868
申请日：1988-06-10
申请人： Mamoru Takahashi , Shigeyuki Imamura , Masaki Takada
发明人： Mamoru Takahashi , Shigeyuki Imamura , Masaki Takada
IPC分类号： C12N9/06 , C12N9/02 , C12Q1/26 , C12R1/80
CPC分类号： C12Y103/03005 , C12N9/001 , C12Q1/26 , Y10S435/933
摘要： A novel bilirubin oxidase is provided having a substrate specificity for bilirubin but not to, at least, biliverdin, catechol and hemin and which catalyzes the enzyme reaction between two moles of bilirubin and one mole of oxygen to yield two moles of biliverdin and two moles of water. A process is also provided for the production of said novel bilirubin oxidase, which comprises cultivating a bilirubin oxidase-producing fungus of the genus Penicillium in a culture medium and collecting the bilirubin oxidase from the culture mixture. A method of determining the content of bilirubin in a sample to be analyzed is further provided which comprises contacting the sample with the bilirubin oxidase to convert bilirubin in the sample into biliverdin and determining the amount of biliverdin formed or the amount of oxygen consumed therefor, as well as a method for removing bilirubin contained in a sample to be analyzed, which comprises contacting the sample with said novel bilirubin oxidase.

3. 发明授权

US4346173A Process for the production of acyl-Coenzyme A oxidase 失效
标题翻译：制备酰基辅酶A氧化酶的方法
公开(公告)号：US4346173A
公开(公告)日：1982-08-24
申请号：US201123
申请日：1980-10-27
申请人： Shigeru Ikuta , Shigeyuki Imamura , Hidehiko Ishikawa , Kazuo Matsuura , Masaki Takada , Hideo Misaki
发明人： Shigeru Ikuta , Shigeyuki Imamura , Hidehiko Ishikawa , Kazuo Matsuura , Masaki Takada , Hideo Misaki
IPC分类号： C12N9/02
CPC分类号： C12Y103/03006 , C12N9/001 , C12R1/06 , C12R1/645 , C12R1/66 , C12R1/865 , Y10S435/83 , Y10S435/911 , Y10S435/913 , Y10S435/942
摘要： A process for the production of acyl-Coenzyme A oxidase, comprises culturing an acyl-Coenzyme A-oxidase-producing microorganism belonging to genus Macrophomina, genus Cladosporium, genus Aspergillus, genus Monascus, genus Saccharomyces or genus Arthrobacter in a nutrient medium, and isolating the thus-formed acyl-CoA oxidase therefrom. The preferred species of microorganism are Macrophomina phaseoli ATCC 14383, Cladosporium resinae IFO 6367, Aspergillus candidus M-4815 FERM-P No. 5226, Monascus sp. M-4800 FERM-P No. 5225, Saccharomyces cerevisiae Y 0036 FERM-P No. 5174, and Arthrobacter sp. B-720 FERM-P No. 5224, respectively.
摘要翻译：一种制备酰基辅酶A氧化酶的方法，包括在营养培养基中培养属于巨噬细胞，枝孢霉属，曲霉属，红曲霉属，酿酒酵母属或节杆菌属的酰基辅酶A氧化酶微生物，由此形成的酰基辅酶A氧化酶。微生物的优选种类是Macrophomina phaseoli ATCC 14383，Cladosporium resinae IFO 6367，Aspergillus candidus M-4815 FERM-P No.5226，Monascus sp。 M-4800 FERM-P No.5225，酿酒酵母Y 0036 FERM-P No.5174和节杆菌属（Arthrobacter sp。 B-720 FERM-P No. 5224。

4. 发明授权

US4482707A Aminoglycoside antibiotic saccharocins 失效
标题翻译：氨基糖苷类抗生素糖酵解
公开(公告)号：US4482707A
公开(公告)日：1984-11-13
申请号：US447967
申请日：1982-12-08
申请人： Hideo Sakakibara , Shuzo Satoi , Masashi Awata , Hitoshi Sagai , Mitsuo Hayashi , Naoki Muto , Masaki Takada
发明人： Hideo Sakakibara , Shuzo Satoi , Masashi Awata , Hitoshi Sagai , Mitsuo Hayashi , Naoki Muto , Masaki Takada
IPC分类号： C07H15/224 , C12P19/48 , C07H15/22 , C12P19/44
CPC分类号： C07H15/224 , C12P19/48
摘要： Antibiotic saccharocins of the formula ##STR1## wherein R is hydrogen (saccharocin) or hydroxyl (3'-oxysaccharocin) are produced by culturing a microorganism belonging to the genus Saccharopolyspora, for example Saccharopolyspora sp. AC 3440 FERM-P No. 6238, in a conventional nutrient medium, and separating the thus-produced saccharocins from the cultured medium. The noval saccharocins exhibit anti-bacterial activity against Gram negative bacteria.
摘要翻译：通过培养属于Saccharopolyspora属的微生物（例如Saccharopolyspora sp。）来制备其中R是氢的（Saccharocin）或羟基（3'-氧基蔗糖）的式“IMAGE”的抗生素糖酵母。 AC3440FERM-P No.6238，在常规营养培养基中，并从培养基中分离由此产生的蔗糖。诺瓦克糖酵母显示抗革兰氏阴性细菌的抗细菌活性。

5. 发明授权

US4357425A Process for producing L-amino acid oxidase 失效
标题翻译：生产L-氨基酸氧化酶的方法
公开(公告)号：US4357425A
公开(公告)日：1982-11-02
申请号：US256901
申请日：1981-04-23
申请人： Eiichi Yoshino , Hidehiko Ishikawa , Fumitaka Inoue , Masaki Takada , Hideo Misaki
发明人： Eiichi Yoshino , Hidehiko Ishikawa , Fumitaka Inoue , Masaki Takada , Hideo Misaki
IPC分类号： C12N9/06 , C12R1/645
CPC分类号： C12N9/0022 , Y10S435/911
摘要： L-amino acid oxidase is obtained by culturing a microorganism which can produce L-amino acid oxidase and belongs to the genus Colletotrichum, e.g. Colletotrichum sp. M5073, deposition number FERMP 5441, in a culturing medium and recovering the oxidase from cells of the microorganism.
摘要翻译：通过培养可产生L-氨基酸氧化酶并属于Colletotrichum属的微生物获得L-氨基酸氧化酶，例如， Colletotrichum sp。 M5073，沉积编号FERMP 5441，并在微生物的细胞中回收氧化酶。

6. 发明授权

US3978210A Antibiotic aculeacins 失效
标题翻译：抗生素ACULEACINS
公开(公告)号：US3978210A
公开(公告)日：1976-08-31
申请号：US556190
申请日：1975-03-06
申请人： Kimio Mizuno , Tetsuo Matsuda , Katsumi Asano , Akira Yagi , Masaki Takada , Tetsu Saito , Minoru Toriya , Shuzo Satoi , Kazuo Matsuura
发明人： Kimio Mizuno , Tetsuo Matsuda , Katsumi Asano , Akira Yagi , Masaki Takada , Tetsu Saito , Minoru Toriya , Shuzo Satoi , Kazuo Matsuura
IPC分类号： A01N63/04 , A61K36/06 , C07G11/00 , C12P1/02 , C12P21/00 , A61K35/70
CPC分类号： C07G11/00 , Y10S435/913
摘要： A family of antibiotics active against pathogenic yeasts and fungi comprises aculeacin-A, -B, -C, -D, -E, -F, and -G. These are produced from cultured broth of Aspergillus aculeatus FERM-P 2324.

7. 发明授权

US4749571A Physiologically-active novel substance "Aldostatin" and production method thereof 失效
标题翻译：生理活性新物质“Aldostatin”及其生产方法
公开(公告)号：US4749571A
公开(公告)日：1988-06-07
申请号：US16327
申请日：1987-02-19
申请人： Satoshi Yaginuma , Akira Asahi , Masaki Takada
发明人： Satoshi Yaginuma , Akira Asahi , Masaki Takada
IPC分类号： A61K36/06 , A61K31/195 , A61K38/00 , A61P3/08 , A61P3/10 , A61P43/00 , C07C233/47 , C07G99/00 , C12N9/99 , C12P1/02 , C12P13/04 , C12R1/645 , A61K35/70
CPC分类号： C12R1/645 , C12P13/04
摘要： A physiologically-active novel substance "aldostatin" having an estimated molecular formula of C.sub.20 H.sub.20 N.sub.2 O.sub.8 is produced by culturing an aldostatin-producing microorganism of the Pseudeurotium, for example, the Pseudeurotium zonatum M4109 strain. Aldostatin inhibits the aldose reductase activity and as a consequence, avoids abnormal accumulation of sorbitol, galactitol, etc. It is therefore effective for the treatment of chronic complications such as cataract, retinopathy and neuropathy caused by diabetes renalis.
摘要翻译：具有估计分子式为C20H2ON2O8的生理活性的新型物质“醛糖抑制素”是通过培养Pseudeurotium的产生aldostatin的微生物，例如Pseudeurotium zonatum M4109菌株产生的。醛固酮抑制醛糖还原酶活性，从而避免山梨糖醇，半乳糖醇等异常积累。因此，治疗慢性并发症如白内障，视网膜病变和糖尿病肾病引起的神经病变是有效的。

8. 发明授权

US4732910A Enzyme Inhibiting substance 失效
标题翻译：酶抑制物质
公开(公告)号：US4732910A
公开(公告)日：1988-03-22
申请号：US843003
申请日：1986-03-24
申请人： Satoshi Yaginuma , Akira Asahi , Masaki Takada , Mitsuo Hayashi , Kiyofumi Fukukawa
发明人： Satoshi Yaginuma , Akira Asahi , Masaki Takada , Mitsuo Hayashi , Kiyofumi Fukukawa
IPC分类号： A61K31/335 , A61K31/336 , A61P29/00 , A61P37/08 , A61P43/00 , C07D303/48 , C12N9/99 , C12P17/02 , C12R1/645 , A61K31/355
CPC分类号： C12P17/02 , C07D303/48
摘要： A substance is provided which has strong enzyme inhibitory activity against thiol proteases such as papain, ficin, bromelain, etc. and which is represented by the following formula: ##STR1## (wherein R is a hydrogen atom or a hydroxyl group), its pharmaceutically acceptable salt or hydrate.
摘要翻译：提供了对硫羟蛋白酶如木瓜蛋白酶，蓖麻蛋白，菠萝蛋白酶等具有强的酶抑制活性的物质，其由下式表示：其中R是氢原子或羟基，其药学上可接受的盐或水合物。

9. 发明授权

US4801697A Physiologically active substance TPI and production thereof 失效
标题翻译：生理活性物质TPI及其生产
公开(公告)号：US4801697A
公开(公告)日：1989-01-31
申请号：US847312
申请日：1986-04-02
申请人： Satoshi Yaginuma , Masashi Awata , Masaki Takada , Kenji Kinoshita
发明人： Satoshi Yaginuma , Masashi Awata , Masaki Takada , Kenji Kinoshita
IPC分类号： C07H15/203 , C07H15/00 , A61K31/715
CPC分类号： C07H15/203
摘要： A compound of the formula ##STR1## wherein R is .beta.-D-glucopyranosyl, .beta.-D-galactopyranosyl, 6'-O-acetyl-.beta.-D-glucopyranosy or 6'-O-acetyl-.beta.-D-galactopyranosyl, or a pharmaceutically acceptable salt thereof, has bronchodilator, cardiac activity, smooth muscle relaxant activity and hormone excretion stimulant activity. It can be produced by culturing a microorganism belonging to the genus Nodulisporium and adapted to produce the compound in a culture medium, and isolating the produced compound from the cultured medium. The microorganism can be Nodulisporium sp. M5220 FERM P-8133. The compounds have inhibitory activity on cyclic-adenosine-3',5'-monophosphate phosphodiesterase.
摘要翻译：其中R是β-D-吡喃葡萄糖基，β-D-吡喃半乳糖基，6'-O-乙酰基-β-D-吡喃葡萄糖或6'-O-乙酰基-β-D-吡喃半乳糖基的式其药学上可接受的盐具有支气管扩张剂，心脏活性，平滑肌松弛剂活性和激素排泄兴奋剂活性。可以通过培养属于Nodulisporium属的微生物并适于在培养基中生产化合物，并从培养基中分离生成的化合物来制备。微生物可以是Nodulisporium sp。 M5220 FERM P-8133。该化合物对环腺苷-3'，5'-单磷酸磷酸二酯酶具有抑制活性。

10. 发明授权

US4517296A Antibiotic acmimycin and its production 失效
标题翻译：抗生素acmimycin及其生产
公开(公告)号：US4517296A
公开(公告)日：1985-05-14
申请号：US530668
申请日：1983-09-09
申请人： Hideo Sakakibara , Masashi Awata , Shuzo Satoi , Naoki Mutoh , Masaki Takada , Mitsuo Hayashi
发明人： Hideo Sakakibara , Masashi Awata , Shuzo Satoi , Naoki Mutoh , Masaki Takada , Mitsuo Hayashi
IPC分类号： C07D493/04 , A61K31/35 , A61K35/74 , A61P31/04 , C07H15/224 , C12P1/06 , C12P17/18 , C12R1/465 , C07D323/04
CPC分类号： C07H15/224
摘要： Antibiotic acmimycin of the formula ##STR1## is active against Gram positive and Gram negative bacteria. It is produced by culturing the microorganism Streptomyces sp. AC4559 FERM P-6445, and isolating the above compound from the cultured medium.
摘要翻译：具有下式的抗生素阿米霉素对革兰氏阳性和革兰氏阴性菌具有活性。它是通过培养微生物链霉菌（Streptomyces sp。 AC4559 FERM P-6445，并从培养基中分离上述化合物。

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