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1. 发明授权

US3978210A Antibiotic aculeacins 失效
标题翻译：抗生素ACULEACINS
公开(公告)号：US3978210A
公开(公告)日：1976-08-31
申请号：US556190
申请日：1975-03-06
申请人： Kimio Mizuno , Tetsuo Matsuda , Katsumi Asano , Akira Yagi , Masaki Takada , Tetsu Saito , Minoru Toriya , Shuzo Satoi , Kazuo Matsuura
发明人： Kimio Mizuno , Tetsuo Matsuda , Katsumi Asano , Akira Yagi , Masaki Takada , Tetsu Saito , Minoru Toriya , Shuzo Satoi , Kazuo Matsuura
IPC分类号： A01N63/04 , A61K36/06 , C07G11/00 , C12P1/02 , C12P21/00 , A61K35/70
CPC分类号： C07G11/00 , Y10S435/913
摘要： A family of antibiotics active against pathogenic yeasts and fungi comprises aculeacin-A, -B, -C, -D, -E, -F, and -G. These are produced from cultured broth of Aspergillus aculeatus FERM-P 2324.

2. 发明授权

US4254256A Amino sugar compound 失效
标题翻译：氨基糖化合物
公开(公告)号：US4254256A
公开(公告)日：1981-03-03
申请号：US968697
申请日：1978-12-12
申请人： Masaru Otani , Tetsu Saito , Shuzo Satoi , Junzo Mizoguchi , Naoki Muto
发明人： Masaru Otani , Tetsu Saito , Shuzo Satoi , Junzo Mizoguchi , Naoki Muto
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/715 , A61P3/08 , A61P3/10 , C07H15/203 , C07H15/22 , C12P19/26 , C12P19/46 , A61K31/73 , C07H5/06
CPC分类号： C12R1/465 , C07H15/22 , C12P19/26
摘要： An amino sugar compound represented by the general formula: ##STR1## (wherein m is an integer of 0 to 8, n is an integer of 1 to 8 and m+n is an integer of 1 to 8) has strong glycosidase inhibiting action and is produced by culturing an amino sugar compound producing microorganisms belonging to Streptomyces.
摘要翻译：由以下通式表示的氨基糖化合物：其中m为0〜8的整数，n为1〜8的整数，m + n为1〜 8）具有强的糖苷酶抑制作用，通过培养产生属于链霉菌属的微生物的氨基糖化合物而产生。

3. 发明授权

US4291021A Novel macrolide antibiotics and preparation thereof 失效
标题翻译：新型大环内酯类抗生素及其制备方法
公开(公告)号：US4291021A
公开(公告)日：1981-09-22
申请号：US37846
申请日：1979-05-10
申请人： Masaru Otani , Shuzo Satoi , Naoki Muto , Tetsu Saito , Tadashiro Fujii , Seiji Katsumata , Mitsuo Hayashi , Masaru Ono
发明人： Masaru Otani , Shuzo Satoi , Naoki Muto , Tetsu Saito , Tadashiro Fujii , Seiji Katsumata , Mitsuo Hayashi , Masaru Ono
IPC分类号： A23K20/195 , C07H17/08 , C12P1/06 , C12P19/60 , A61K35/74
CPC分类号： C07H17/08 , A23K20/195 , C12P1/06 , Y10S435/867
摘要： A novel microorganism species belonging to the genus Micromonospora, i.e. Micromonospora sp. A 11725 is found to be capable of producing novel macrolide antibiotics A 11725 I, A 11725 II and A 11725 III. Novel antibiotics A 11725 Ia and A 11725 IIa are also found to be derived by chemical modification of the antibiotics A 11725 I and A 11725 II, respectively. All of these antibiotics or salts thereof exhibit excellent antibacterial and anti-mycoplasmal activities against various microorganisms such as Staphylococcus or Mycoplasma, and therefore useful for various purposes including medicaments.
摘要翻译：属于小单孢菌属的微生物物种，即小单孢菌属（Micomonospora sp。 A 11725被发现能够生产新型大环内酯类抗生素A 11725 I，A 11725 II和A 11725 III。还发现新抗生素A 11725 Ia和A 11725 IIa通过分别对抗生素A 11725 I和A 11725 II进行化学修饰而得到。所有这些抗生素或其盐对葡萄球菌或支原体等各种微生物表现出优异的抗菌和抗支原体活性，因此可用于包括药物在内的各种目的。

4. 发明授权

US07405051B2 Method of screening antiplatelet agents 失效
标题翻译：筛选抗血小板药的方法
公开(公告)号：US07405051B2
公开(公告)日：2008-07-29
申请号：US10333844
申请日：2001-10-31
申请人： Jun Takasaki , Mitsuyuki Matsumoto , Masazumi Kamohara , Tetsu Saito , Takahide Ohishi , Takatoshi Soga
发明人： Jun Takasaki , Mitsuyuki Matsumoto , Masazumi Kamohara , Tetsu Saito , Takahide Ohishi , Takatoshi Soga
IPC分类号： G01N33/53 , G01N33/567 , G01N33/566 , C12Q1/68 , C12N5/00 , C12N5/06 , C07K1/00
CPC分类号： G01N33/566 , G01N33/6872 , G01N2333/726 , G01N2500/00
摘要： A screening tool for an antiplatelet agent wherein the tool is a human ADP receptor P2TAC protein, a variation functionally equivalent thereto, or a homologous protein thereof, and a screening tool for an antiplatelet agent wherein the tool is a transformant which is transformed with an expression vector comprising a DNA encoding the protein and is expressing the polypeptide are disclosed. Further, a method for detecting an ADP receptor P2TAC ligand, antagonist, or agonist by using the screening tool for an antiplatelet agent, and a method for screening an antiplatelet agent by the detecting method are disclosed.
摘要翻译：用于抗血小板剂的筛选工具，其中所述工具是人ADP受体P2T蛋白，与其功能等同的变体或其同源蛋白，以及用于抗血小板剂的筛选工具，其中所述工具是公开了用包含编码该蛋白质并正在表达多肽的DNA的表达载体转化的转化体。此外，公开了通过使用抗血小板剂的筛选工具检测ADP受体P2TACAC配体，拮抗剂或激动剂的方法以及通过检测方法筛选抗血小板剂的方法。

5. 发明授权

US07341849B2 Polynucleotides encoding SREB1 receptor 有权
标题翻译：编码SREB1受体的多核苷酸
公开(公告)号：US07341849B2
公开(公告)日：2008-03-11
申请号：US10898329
申请日：2004-07-26
申请人： Mitsuyuki Matsumoto , Toru Sugimoto , Jun Takasaki , Masazumi Kamohara , Tetsu Saito , Masato Kobayashi
发明人： Mitsuyuki Matsumoto , Toru Sugimoto , Jun Takasaki , Masazumi Kamohara , Tetsu Saito , Masato Kobayashi
IPC分类号： C12P23/00 , C12N15/00 , C12N5/00 , C12N1/20 , C12Q1/16
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K14/723
摘要： This invention belongs to the genetic engineering field, and provides novel G protein-coupled receptor family proteins SREB1, SREB2 and SREB3 expressed in the central nervous system, genes coding for these proteins, screening methods using these proteins and so on. As one of the methods for obtaining the G protein-coupled receptor proteins of the present invention, RT-PCR is carried out using mRNA extracted from human or rat brain tissue or brain-derived cells as the template and using two primers interposing the entire portion or a part of the G protein-coupled receptor protein translation region, thereby obtaining cDNA corresponding to the G protein-coupled receptor protein or a part thereof, and the cDNA is integrated into an appropriate expression vector and expressed in a host cell.
摘要翻译：本发明属于遗传工程领域，提供了在中枢神经系统中表达的新型G蛋白偶联受体家族蛋白SREB1，SREB2和SREB3，编码这些蛋白质的基因，使用这些蛋白质的筛选方法等。作为获得本发明的G蛋白偶联受体蛋白质的方法之一，使用从人或大鼠脑组织或脑源性细胞提取的mRNA作为模板，使用插入整个部分的两个引物进行RT-PCR 或G蛋白偶联受体蛋白质翻译区的一部分，从而获得对应于G蛋白偶联受体蛋白或其一部分的cDNA，并将cDNA整合到合适的表达载体中并在宿主细胞中表达。

6. 发明申请

US20050136484A1 Method for screening agents for the treatment of diabetes 有权
标题翻译：用于治疗糖尿病的筛选剂的方法
公开(公告)号：US20050136484A1
公开(公告)日：2005-06-23
申请号：US10975367
申请日：2004-10-29
申请人： Takahide Ohishi , Jun Takasaki , Mitsuyuki Matsumoto , Tetsu Saito , Masazumi Kamohara , Takatoshi Soga , Shigeru Yoshida , Yoshitaka Ueda
发明人： Takahide Ohishi , Jun Takasaki , Mitsuyuki Matsumoto , Tetsu Saito , Masazumi Kamohara , Takatoshi Soga , Shigeru Yoshida , Yoshitaka Ueda
IPC分类号： A61K38/00 , A61P3/10 , A61P43/00 , C07K14/705 , C07K14/72 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/12 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , C07K14/723
摘要： A convenient screening tool and a convenient screening method for obtaining an agent for treating diabetes, a pharmaceutical composition for treating diabetes, and a process for manufacturing the pharmaceutical composition are disclosed. The screening tool is a G protein-coupled receptor, a variation functionally equivalent thereto, or a homologous polypeptide thereof which promotes insulin secretion under a high glucose concentration by activation, or cells transformed with an expression vector comprising a polynucleotide encoding the above polypeptide and expressing the polypeptide.
摘要翻译：公开了一种方便的筛选工具和用于获得治疗糖尿病的药物的方便的筛选方法，用于治疗糖尿病的药物组合物和制备该药物组合物的方法。筛选工具是G蛋白偶联受体，功能上等同于其的变异体，或其通过活化促进高葡萄糖浓度下的胰岛素分泌的同源多肽，或用包含编码上述多肽的多核苷酸的表达载体转化的细胞，并表达多肽。

7. 发明授权

US4870171A 1-Substituted alkyl-2-oxo-1,2-dihydroquinoxaline derivatives 失效
标题翻译： 1-取代的烷基-2-氧代-1,2-二氢喹喔啉衍生物
公开(公告)号：US4870171A
公开(公告)日：1989-09-26
申请号：US235733
申请日：1988-08-22
申请人： Masao Yaso , Yukio Suzuki , Eiichi Honda , Kensuke Shibata , Hiroyuki Kinoshita , Noriyasu Takayanagi , Tetsu Saito , Eiichi Hayashi
发明人： Masao Yaso , Yukio Suzuki , Eiichi Honda , Kensuke Shibata , Hiroyuki Kinoshita , Noriyasu Takayanagi , Tetsu Saito , Eiichi Hayashi
IPC分类号： A61K31/495 , A61P9/12 , A61P25/02 , C07D241/44
CPC分类号： C07D241/44
摘要： A compound of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl, R.sup.2 is hydrogen, lower alkoxy or halogen, and A is lower alkylene, or a pharmacologically acceptable salt thereof, has sympatholytic .alpha.-receptor blocking activity and is useful for the treatment of hypertension.

8. 发明授权

US07662775B2 Method for screening agents for the treatment of diabetes 有权
标题翻译：用于治疗糖尿病的筛选剂的方法
公开(公告)号：US07662775B2
公开(公告)日：2010-02-16
申请号：US10975367
申请日：2004-10-29
申请人： Takahide Ohishi , Jun Takasaki , Mitsuyuki Matsumoto , Tetsu Saito , Masazumi Kamohara , Takatoshi Soga
发明人： Takahide Ohishi , Jun Takasaki , Mitsuyuki Matsumoto , Tetsu Saito , Masazumi Kamohara , Takatoshi Soga
IPC分类号： A61K38/00 , A61K51/00 , C07K1/00 , C07K14/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/723
摘要： The invention relates to a convenient screening tool for identifying an agent for treating diabetes. The screening tool is a G protein-coupled receptor, a variant of the G protein-coupled receptor, or a homolog of the G protein-coupled receptor, which promotes insulin secretion under a high glucose concentration by activation. The invention also relates to cells transformed with an expression vector comprising a polynucleotide encoding and expressing the screening tool. The invention provides a convenient screening method for identifying an agent for treating diabetes, pharmaceutical compositions comprising the agent, and a process for manufacturing the pharmaceutical composition.
摘要翻译：本发明涉及用于鉴定用于治疗糖尿病的药剂的方便的筛选工具。筛选工具是G蛋白偶联受体，G蛋白偶联受体的变体或G蛋白偶联受体的同系物，其通过活化促进高葡萄糖浓度下的胰岛素分泌。本发明还涉及用包含编码和表达筛选工具的多核苷酸的表达载体转化的细胞。本发明提供了用于鉴定用于治疗糖尿病的药剂的方便的筛选方法，包含该药剂的药物组合物和用于制备该药物组合物的方法。

9. 发明申请

US20090215868A1 Therapeutic Medicament for Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, and Pulmonary Hypertension 审中-公开
标题翻译：慢性阻塞性肺疾病（COPD），囊性纤维化和肺动脉高压治疗药物
公开(公告)号：US20090215868A1
公开(公告)日：2009-08-27
申请号：US11794167
申请日：2006-01-12
申请人： Kunimiki Otsu , Tetsu Saito , Takefumi Gemba
发明人： Kunimiki Otsu , Tetsu Saito , Takefumi Gemba
IPC分类号： A61K31/711 , C07H21/04 , A61K48/00
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K31/7088 , A61K31/713 , C12N15/113 , C12N2310/13
摘要： The present invention provides a prophylactic, therapeutic or ameliorative medicament for chronic obstructive pulmonary disease (COPD), cystic fibrosis or pulmonary hypertension. More specifically, the present invention provides: (1) a prophylactic, therapeutic or ameliorative medicament for chronic obstructive pulmonary disorder (COPD), cystic fibrosis or pulmonary hypertension, having an NF-κB decoy as the active ingredient thereof; (2) the NF-κB decoy is an oligonucleotide containing the binding sequence GGGRHTYYC (where R represents either A or G; Y represents either C or T; and H represents either A, C or T); (3) an oligonucleotide wherein the NF-κB binding sequence is GGGATTTCCC or GGGACTTTCC; (4) an oligonucleotide wherein the NF-κB decoy is represented by SEQ ID NO:3; (5) the NF-κB decoy is a double-stranded oligonucleotide; (6) the NF-κB decoy is administered in the form of a fine powder; and (7) the NF-κB decoy fine powder is a dry powder.
摘要翻译：本发明提供了用于慢性阻塞性肺疾病（COPD），囊性纤维化或肺动脉高压的预防，治疗或改善药物。更具体地，本发明提供：（1）具有NF-κB诱饵作为其活性成分的用于慢性阻塞性肺病（COPD），囊性纤维化或肺动脉高压的预防，治疗或改善药物; （2）NF-κB诱饵是含有结合序列GGGRHTYYC（其中R表示A或G; Y表示C或T; H表示A，C或T）的寡核苷酸; （3）NF-κB结合序列为GGGATTTCCC或GGGACTTTCC的寡核苷酸; （4）其中NF-κB诱饵由SEQ ID NO：3表示的寡核苷酸; （5）NF-κB诱饵是双链寡核苷酸; （6）NF-κB诱饵以细粉末的形式施用; 和（7）NF-κB诱饵细粉是干粉。

10. 发明授权

US5760177A Lipopolysaccharide binding protein and process for producing the same 失效
标题翻译：脂多糖结合蛋白及其制备方法
公开(公告)号：US5760177A
公开(公告)日：1998-06-02
申请号：US393058
申请日：1995-02-23
申请人： Sadaaki Iwanaga , Shunichiro Kawabata , Tetsu Saito
发明人： Sadaaki Iwanaga , Shunichiro Kawabata , Tetsu Saito
IPC分类号： A61K9/08 , A61K38/00 , C07K1/22 , C07K14/00 , C07K14/435 , G01N33/579 , G01N33/92 , A61K39/385
CPC分类号： C07K14/43509 , A61K38/00 , Y10S530/82
摘要： The invention provides a lipopolysaccharide (LPS) binding protein isolated from horseshoe crab. The LPS binding protein is isolated by (i) extracting the hemocyte membrane fraction of horseshoe crab with a polyethylene glycol ether type nonionic surface active agent in the presence of Ca ions, (ii) combining the extract with immobilized LPS under conditions that permit the LPS binding protein to bind the immobilized LPS to produce an LPS-LPS binding protein complex, and (iii) harvesting the LPS binding protein released from the complex in the presence of a chelating agent. The isolated LPS binding protein has a molecular weight of about 27,000 daltons as determined by SDS polyacrylamide gel electrophoresis and is operative to bind a lipopolysaccharide endotoxin. Accordingly, the isolated LPS binding protein can be used for detecting endotoxin and/or removing endotoxin from an injectable medicine.
摘要翻译：本发明提供从马蹄蟹分离的脂多糖（LPS）结合蛋白。通过（i）在Ca离子存在下用聚乙二醇醚型非离子表面活性剂提取鲎的血细胞膜级分，分离LPS结合蛋白，（ii）在允许LPS的条件下将提取物与固定的LPS组合结合蛋白质以结合固定的LPS以产生LPS-LPS结合蛋白复合物，和（iii）在螯合剂存在下从复合物中收获释放的LPS结合蛋白。通过SDS聚丙烯酰胺凝胶电泳测定，分离的LPS结合蛋白具有约27,000道尔顿的分子量，并且可操作地结合脂多糖内毒素。因此，分离的LPS结合蛋白可用于从可注射药物中检测内毒素和/或除去内毒素。

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