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1. 发明申请

US20150160152A1 ELECTRODE FOR SUPEROXIDE ANION AND SENSOR INCLUDING THE SAME 审中-公开
标题翻译：用于超氧化物阴离子和包括其的传感器的电极
公开(公告)号：US20150160152A1
公开(公告)日：2015-06-11
申请号：US14531666
申请日：2014-11-03
申请人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Masuhide Ishikawa , Katsuya Eguchi , Tomohiro Kobayashi , Satoshi Tsutsui , Yuujirou Toyoda
发明人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Masuhide Ishikawa , Katsuya Eguchi , Tomohiro Kobayashi , Satoshi Tsutsui , Yuujirou Toyoda
IPC分类号： G01N27/333 , C25D5/00
CPC分类号： G01N27/3335 , C25D5/00
摘要： An electrode for superoxide anions characterized by comprising a conductive component and, superimposed on a surface thereof, a film resulting from electrolytic polymerization of a metal thiofurylporphyrin/axial ligand complex; and a sensor for measuring a superoxide anion concentration including the same. The electrode for superoxide anions, by virtue of not only the excellent performance of electrode provided with the metal porphyrin complex polymer film, but also the presence of the axial ligand, can prevent poisoning by a catalyst poison such as hydrogen peroxide. Accordingly, in any of in vitro or in vivo environments, this electrode for superoxide anions enables detection of superoxide anion radicals without suffering any influence from a catalyst poison such as hydrogen peroxide. Moreover, quantitative assay of superoxide anions can be performed by the use of this electrode for superoxide anion in combination with a counter electrode or a reference electrode. Thus, this electrode for superoxide anions can find wide applicability in various fields.
摘要翻译：一种超氧化物阴离子的电极，其特征在于包括导电成分，并且在其表面上叠加由金属硫代卟啉/轴配体络合物的电解聚合得到的膜; 以及用于测量包含该超氧化物阴离子浓度的超氧化物阴离子浓度的传感器。超氧化物阴离子电极不仅具有金属卟啉复合聚合物膜的电极的优异性能，而且还具有轴配体的存在，可以防止催化剂毒物如过氧化氢的中毒。因此，在任何体外或体内环境中，这种超氧化物阴离子电极能够检测超氧阴离子自由基，而不会受到诸如过氧化氢等催化剂毒物的任何影响。此外，超氧阴离子的定量测定可以通过将该电极与对电极或参比电极结合使用来实现超氧阴离子。因此，这种超氧阴离子电极可以在各个领域得到广泛的应用。

2. 发明申请

US20120145562A1 ELECTRODE FOR SUPEROXIDE ANION AND SENSOR INCLUDING THE SAME 审中-公开
标题翻译：用于超氧化物阴离子和包括其的传感器的电极
公开(公告)号：US20120145562A1
公开(公告)日：2012-06-14
申请号：US13270608
申请日：2011-10-11
申请人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Masuhide Ishikawa , Katsuya Eguchi , Tomohiro Kobayashi , Satoshi Tsutsui , Yuujirou Toyoda
发明人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Masuhide Ishikawa , Katsuya Eguchi , Tomohiro Kobayashi , Satoshi Tsutsui , Yuujirou Toyoda
IPC分类号： G01N27/333 , G01N27/26
CPC分类号： G01N27/3335 , C25D5/00
摘要： An electrode for superoxide anions which contains a conductive component and, superimposed on a surface thereof, a film resulting from electrolytic polymerization of a metal thiofurylporphyrin/axial ligand complex; and a sensor for measuring a superoxide anion concentration including the same. The electrode for superoxide anions can prevent poisoning by a catalyst poison such as hydrogen peroxide. Accordingly, in any of in vitro or in vivo environments, this electrode for superoxide anions enables detection of superoxide anion radicals without suffering any influence from a catalyst poison such as hydrogen peroxide. Moreover, quantitative assay of superoxide anions can be performed with this electrode for superoxide anion in combination with a counter electrode or a reference electrode. Thus, this electrode for superoxide anions can find wide applicability in various fields.
摘要翻译：一种超氧阴离子的电极，其包含导电成分，并且在其表面上叠加由金属硫卟啉/轴配位体络合物的电解聚合得到的膜; 以及用于测量包含该超氧阴离子浓度的超氧化物阴离子浓度的传感超氧化物阴离子电极可以防止催化剂毒物如过氧化氢中毒。因此，在任何体外或体内环境中，这种超氧化物阴离子电极能够检测超氧阴离子自由基，而不会受到诸如过氧化氢等催化剂毒物的任何影响。此外，超氧化物阴离子的定量测定可以用该电极进行，其中超氧阴离子与对电极或参比电极组合。因此，这种超氧阴离子电极可以在各个领域得到广泛的应用。

3. 发明申请

US20080289960A1 Electrode for Superoxide Anion and Sensor Including the Same 审中-公开
标题翻译：超氧阴离子电极及其传感器
公开(公告)号：US20080289960A1
公开(公告)日：2008-11-27
申请号：US10592469
申请日：2004-03-12
申请人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Masuhide Ishikawa , Katsuya Eguchi , Tomohiro Kobayashi , Satoshi Tsutsui , Yuujirou Toyoda
发明人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Masuhide Ishikawa , Katsuya Eguchi , Tomohiro Kobayashi , Satoshi Tsutsui , Yuujirou Toyoda
IPC分类号： G01N27/26
CPC分类号： G01N27/3335 , C25D5/00
摘要： An electrode for superoxide anions characterized by comprising a conductive component and, superimposed on a surface thereof, a film resulting from electrolytic polymerization of a metal thiofurylporphyrin/axial ligand complex; and a sensor for measuring a superoxide anion concentration including the same. The electrode for superoxide anions, by virtue of not only the excellent performance of electrode provided with the metal porphyrin complex polymer film, but also the presence of the axial ligand, can prevent poisoning by a catalyst poison such as hydrogen peroxide. Accordingly, in any of in vitro or in vivo environments, this electrode for superoxide anions enables detection of superoxide anion radicals without suffering any influence from a catalyst poison such as hydrogen peroxide. Moreover, quantitative assay of superoxide anions can be performed by the use of this electrode for superoxide anion in combination with a counter electrode or a reference electrode. Thus, this electrode for superoxide anions can find wide applicability in various fields.
摘要翻译：一种超氧化物阴离子的电极，其特征在于包括导电成分，并且在其表面上叠加由金属硫代卟啉/轴配体络合物的电解聚合得到的膜; 以及用于测量包含该超氧化物阴离子浓度的超氧化物阴离子浓度的传感器。超氧化物阴离子电极不仅具有金属卟啉复合聚合物膜的电极的优异性能，而且还具有轴配体的存在，可以防止催化剂毒物如过氧化氢的中毒。因此，在任何体外或体内环境中，这种超氧化物阴离子电极能够检测超氧阴离子自由基，而不会受到诸如过氧化氢等催化剂毒物的任何影响。此外，超氧阴离子的定量测定可以通过将该电极与对电极或参比电极结合使用来实现超氧阴离子。因此，这种超氧阴离子电极可以在各个领域得到广泛的应用。

4. 发明申请

US20050077192A1 Electrode for active oxygen species and sensor using the electrode 审中-公开
标题翻译：用于活性氧的电极和使用电极的传感器
公开(公告)号：US20050077192A1
公开(公告)日：2005-04-14
申请号：US10498359
申请日：2002-12-19
申请人： Makoto Yuasa , Masahiko Abe , Aritomo Yamaguchi , Asako Shiozawa , Masuhide Ishikawa , Katsuya Eguchi , Shigeru Kido
发明人： Makoto Yuasa , Masahiko Abe , Aritomo Yamaguchi , Asako Shiozawa , Masuhide Ishikawa , Katsuya Eguchi , Shigeru Kido
IPC分类号： A61B5/00 , C08G61/12 , C08G73/06 , C11D3/00 , C11D3/20 , C11D3/50 , G01N27/30 , G01N27/49 , G01N33/49 , G01N27/48
CPC分类号： G01N27/3335 , A61B5/1473 , C11D3/0015 , C11D3/2093 , C11D3/50 , G01N27/3271 , G01N33/4925
摘要： An electrode for active oxygen species comprising a conductive component with a polymer membrane of a metal porphyrin complex formed on the surface is disclosed. The electrode for active oxygen species can detect active oxygen species such as superoxide anion radicals, hydrogen peroxide, and .OH and other active radical species (NO, ONOO—, etc.) in any environment including in vivo environment as well as in vitro environment. The electrode thus can be used for specifying various diseases and examining active oxygen species in food or in water such as tap water and sewage water.
摘要翻译：公开了一种用于活性氧物质的电极，其包含在表面上形成的具有金属卟啉络合物的聚合物膜的导电组分。用于活性氧的电极可以在包括体内环境以及体外环境的任何环境中检测活性氧，如超氧阴离子自由基，过氧化氢和.OH等活性自由基（NO，ONOO-等）。因此，电极可以用于指定各种疾病并检查食物或水中的活性氧，例如自来水和污水。

5. 发明授权

US08114803B2 Catalyst material and process for preparing the same 失效
标题翻译：催化剂材料及其制备方法
公开(公告)号：US08114803B2
公开(公告)日：2012-02-14
申请号：US11883479
申请日：2006-02-03
申请人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Hiroshi Ikkanda , Ken Tanaka , Yuichi Iai , Masakuni Yamamoto , Shigeru Kido , Hidetaka Nishikoori , Tetsuo Nagami , Naoko Iwata
发明人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Hiroshi Ikkanda , Ken Tanaka , Yuichi Iai , Masakuni Yamamoto , Shigeru Kido , Hidetaka Nishikoori , Tetsuo Nagami , Naoko Iwata
IPC分类号： B01J21/00 , B01J23/00 , B01J25/00 , B01J29/00 , B01J31/00 , B01J37/00 , B01J27/24 , B01J21/04 , B01J23/02 , C08F4/02 , C08F4/60
CPC分类号： B01J31/182 , B01J31/1805 , B01J31/181 , B01J37/0219 , B01J2531/0216 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/845 , H01M4/8647 , H01M4/8652 , H01M4/8668 , H01M4/8673 , H01M4/9008 , H01M4/921 , H01M4/926 , H01M2008/1095
摘要： This invention provides a catalyst material comprising a conductive material coated with a polynuclear complex molecule derived from at least two types of heteromonocyclic compounds and a catalyst metal coordinated to the coating layer of the polynuclear complex molecule, and a catalyst material comprising a conductive material coated with a polynuclear complex molecule derived from a heteromonocyclic compound and a catalyst metal, which is a composite of a noble metal and a transition metal, coordinated to the coating layer of the polynuclear complex molecule. Such catalyst material of the invention has excellent catalytic performance and serviceability as, for example, an electrode of fuel cells.
摘要翻译：本发明提供一种催化剂材料，其包含涂覆有衍生自至少两种异单环化合物的多核络合物分子的导电材料和与多核络合物分子的涂层配位的催化剂金属，以及催化剂材料，其包含涂覆有衍生自杂多环化合物的多核络合物分子和与多核配合物分子的被覆层配位的贵金属和过渡金属的复合体的催化剂金属。本发明的这种催化剂材料具有优异的催化性能和适用性，例如燃料电池的电极。

6. 发明申请

US20080269184A1 Niosome Having Metal Porphyrin Complex Embedded Therein, Process For Producing The Same And Drug With The Use Thereof 审中-公开
标题翻译：具有金属卟啉复合物的Niosome，其制造方法与其使用相同和药物
公开(公告)号：US20080269184A1
公开(公告)日：2008-10-30
申请号：US10591658
申请日：2004-03-04
申请人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Yukihiro Hanyuu , Kazunori Kasahara , Masayasu Komuro
发明人： Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Yukihiro Hanyuu , Kazunori Kasahara , Masayasu Komuro
IPC分类号： A61K31/555 , C07D487/22 , A61P35/04 , A61P3/00 , A61P29/00 , A61P25/00
CPC分类号： A61K9/1272 , A61K9/0019 , A61K31/409 , A61K31/555 , A61K45/06
摘要： A niosome having a metalloporphyrin complex embedded therein comprising a cationized metalloporphyrin complex and a niosome-forming substance. The niosome having a metalloporphyrin complex embedded therein has an SOD activity, can interact with superoxide anionic radicals (O2−.) as a target, and can reduce these radicals without fail. The niosome having a metalloporphyrin complex embedded therein can reach cells in living bodies such as cancer cells due to properties of a niosome. Therefore, the niosome having a metalloporphyrin complex embedded therein can exhibit an excellent effect of treating cancer by reducing O2-. in cancer cells. In addition, since the effect is selective, the niosome can be used as a novel anticancer agent without side effects. Moreover, the niosome having a metalloporphyrin complex embedded therein can be retained in the blood while exhibiting a superior antioxidation effect. The niosome can thus protect living bodies from hindrance brought about by active oxygen species.
摘要翻译：具有嵌入其中的金属卟啉络合物的组合物包含阳离子化金属卟啉络合物和形成niosome的物质。嵌入其中的金属卟啉络合物的组合物具有SOD活性，可与超氧化物阴离子自由基（O 2 O 2）作为靶，并且可以不失败地减少这些基团。具有嵌入其中的金属卟啉复合物的组合物可以由于niosome的性质而到达活体内的细胞，例如癌细胞。因此，嵌入其中的金属卟啉复合物的组合物可以通过减少O2-表现出优异的治疗癌症的效果。在癌细胞中。此外，由于效果是选择性的，所以可以用作新型抗癌剂而没有副作用。此外，具有嵌入其中的金属卟啉复合物的组合物可以保留在血液中，同时具有优异的抗氧化作用。因此，保护活体可以保护活体免受活性氧引起的阻碍。

7. 发明申请

US20090048096A1 Porphyrin-based electrode catalyst 审中-公开
标题翻译：卟啉类电极催化剂
公开(公告)号：US20090048096A1
公开(公告)日：2009-02-19
申请号：US11920152
申请日：2006-05-10
申请人： Naoko Iwata , Tetsuo Nagami , Hidetaka Nishikoori , Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Mizuki Kitao , Takuya Imai , Shigeru Kido
发明人： Naoko Iwata , Tetsuo Nagami , Hidetaka Nishikoori , Makoto Yuasa , Kenichi Oyaizu , Aritomo Yamaguchi , Mizuki Kitao , Takuya Imai , Shigeru Kido
IPC分类号： B01J31/18
CPC分类号： H01M4/9008 , B01J31/1815 , B01J37/086 , B01J2531/845 , C07D487/22 , H01M4/9083
摘要： This invention provides a macrocyclic-organic-compound-based catalyst for reducing oxygen having high oxygen-reducing activity. This oxygen-reducing catalyst comprises a conductive support and, supported thereon, a porphyrin complex represented by formula (I): wherein Rs each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a halogen atom, an amino group, a hydroxyl group, a nitro group, a phenyl group, or a cyano group or adjacent Rs together form a methylene chain having 2 to 6 carbon atoms or aromatic ring; R's each independently represent a thienyl group; and M represents a metal atom selected from the group consisting of Cu, Zn, Fe, Co, Ni, Ru, Pb, Rh, Pd, Pt, Mn, Sn, Au, Mg, Cd, Al, In, Ge, Cr, and Ti, provided that M may bind to a halogen atom, an oxygen atom, —OH, a nitrogen atom, NO, or ═CO.
摘要翻译：本发明提供了一种用于还原具有高氧还原活性的氧的大环 - 有机 - 化合物基催化剂。该氧还原催化剂包括导电载体，并在其上负载由式（I）表示的卟啉络合物：其中R 5各自独立地表示氢原子，具有1至6个碳原子的烷基，卤素原子，氨基，羟基，硝基，苯基或氰基或相邻的Rs一起形成具有2至6个碳原子的亚甲基或芳香环; R各自独立地表示噻吩基; 并且M表示选自Cu，Zn，Fe，Co，Ni，Ru，Pb，Rh，Pd，Pt，Mn，Sn，Au，Mg，Cd，Al，In，Ge，Cr，和Ti，条件是M可以与卤素原子，氧原子，-OH，氮原子，NO或-CO结合。

8. 发明申请

US20050008687A1 Metal-porphyrin-complex-embedded liposomes, production process thereof, and medicines making use of the same 审中-公开
标题翻译：金属 - 卟啉 - 复合物嵌入的脂质体，其制备方法和使用其的药物
公开(公告)号：US20050008687A1
公开(公告)日：2005-01-13
申请号：US10788263
申请日：2004-03-01
申请人： Makoto Yuasa , Noriyoshi Matsukura , Aritomo Yamaguchi , Hiroyoshi Kawakami , Shoji Nagaoka , Masahiko Abe , Hitoshi Takebayashi , Aiko Horiuchi , Akihiko Ogata , Takeshi Sakaya
发明人： Makoto Yuasa , Noriyoshi Matsukura , Aritomo Yamaguchi , Hiroyoshi Kawakami , Shoji Nagaoka , Masahiko Abe , Hitoshi Takebayashi , Aiko Horiuchi , Akihiko Ogata , Takeshi Sakaya
IPC分类号： A61K9/127 , A61K31/409 , A61K31/4439 , A61K31/555
CPC分类号： A61K31/409 , A61K9/127 , A61K31/4439 , A61K31/555
摘要： An metalloporphyrin-complex-embedded liposome, comprising a cationic metalloporphyrin complex and a lipid having liposome forming ability is disclosed. As metalloporphyrin-complex-embedded liposomes according to the present invention act on superoxide anion radicals (O2−), and can surely lower their concentration, they can exhibit superb effects for the treatment of cancers and have excellent characteristics as antioxidants.
摘要翻译：公开了包含阳离子金属卟啉络合物和具有脂质体形成能力的脂质的金属卟啉 - 复合物嵌入的脂质体。由于根据本发明的金属卟啉 - 复合物嵌入的脂质体作用于超氧化物阴离子自由基（O 2 - ），并且可以确定地降低它们的浓度，它们对于治疗癌症表现出极好的效果，并且具有作为抗氧化剂的优异特征。

9. 发明申请

US20090246601A1 PROCESS FOR PREPARING CATALYST MATERIAL 审中-公开
标题翻译：制备催化材料的方法
公开(公告)号：US20090246601A1
公开(公告)日：2009-10-01
申请号：US12282060
申请日：2007-03-09
申请人： Naoko Iwata , Makoto Yuasa , Kenichi Oyaizu , Ken Tanaka , Yuichi Iai , Masakuni Yamamoto , Shinichi Sasaki , Shigeru Kido
发明人： Naoko Iwata , Makoto Yuasa , Kenichi Oyaizu , Ken Tanaka , Yuichi Iai , Masakuni Yamamoto , Shinichi Sasaki , Shigeru Kido
IPC分类号： H01M4/86 , H01M4/88
CPC分类号： C25D9/02 , H01M4/9008 , H01M4/9075 , H01M4/9083 , H01M4/92 , H01M4/925 , H01M4/926
摘要： The present invention is intended to provide a catalyst material that supports active species densely, thereby having higher catalytic performance and serviceability as, for example, an electrode for fuel cells. To achieve the above object, the present invention provides a process for preparing a catalyst material, including: an electrochemical polymerization step of electrochemically polymerizing a heteromonocyclic compound so that the surface of a conductive material is coated with polynuclear complex molecules derived from the heteromonocyclic compound; and a metallation step of coordinating a catalytic metal to the coating layer of the polynuclear complex molecules, characterized in that the potential applied in the electrochemical polymerization is 0.8 to 1.5 V.
摘要翻译：本发明旨在提供一种致密地支持活性物质的催化剂材料，从而具有比如燃料电池用电极更高的催化性能和适用性。为了实现上述目的，本发明提供一种制备催化剂材料的方法，包括：电化学聚合步骤，使异单环化合物电化学聚合，使得导电材料的表面被衍生自异单环化合物的多核复合分子包被; 以及将催化金属配位到多核络合物分子的被覆层的金属化步骤，其特征在于，在电化学聚合中施加的电位为0.8〜1.5V。

10. 发明申请

US20100015506A1 CATALYST MATERIAL AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：催化材料及其制备方法
公开(公告)号：US20100015506A1
公开(公告)日：2010-01-21
申请号：US12523879
申请日：2008-01-22
申请人： Naoko Iwata , Makoto Yuasa , Kenichi Oyaizu , Ken Tanaka , Yuichi Iai , Masakuni Yamamoto , Shinichi Sasaki , Shigeru Kido
发明人： Naoko Iwata , Makoto Yuasa , Kenichi Oyaizu , Ken Tanaka , Yuichi Iai , Masakuni Yamamoto , Shinichi Sasaki , Shigeru Kido
IPC分类号： H01M4/00 , B01J31/18 , B01J31/00
CPC分类号： H01M4/921 , H01M4/9008 , H01M4/9075 , H01M4/9083 , H01M4/925 , H01M4/926
摘要： A catalyst material that bears active species densely, thereby having higher catalytic performance and serviceability, for example, as an electrode for fuel cells. A catalyst material, wherein a conductive material whose surface physically adsorbs a polymerizable ligand having an electrochemically polymerizable heterocycle and an electron-withdrawing group bonded to the heterocycle or is coated with polynuclear complex molecules formed by electrochemical polymerization of the polymerizable ligand having an electrochemically polymerizable heterocycle and an electron-withdrawing group bonded to the heterocycle. A catalytic metal is coordinated to the adsorption layer of the polymerizable ligand having an electrochemically polymerizable heterocycle and an electron-withdrawing group bonded to the heterocycle, or to the coating layer of the polynuclear complex molecules.
摘要翻译：作为燃料电池用电极，具有活性物质密实地具有较高催化性能和适用性的催化剂材料。一种催化剂材料，其中表面物理吸附具有电化学可聚合杂环的可聚合配体和与该杂环键合的吸电子基团的导电材料，或涂覆有由具有电化学可聚合杂环的可聚合配体的电化学聚合形成的多核络合物分子和与杂环键合的吸电子基团。催化金属与可聚合配体的吸附层配位，其具有结合到杂环的电化学可聚合杂环和吸电子基团，或与多核络合物分子的涂层配位。

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