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1. 发明授权

US5648951A Movable optical head integrally incorporated with objective lens and hologram element 失效
标题翻译：整体结合物镜和全息元件的可移动光学头
公开(公告)号：US5648951A
公开(公告)日：1997-07-15
申请号：US415764
申请日：1995-04-03
申请人： Makoto Kato , Yoshiaki Komma , Shin-ichi Kadowaki , Yoshikazu Hori , Seiji Nishino , Tetsuo Saimi
发明人： Makoto Kato , Yoshiaki Komma , Shin-ichi Kadowaki , Yoshikazu Hori , Seiji Nishino , Tetsuo Saimi
IPC分类号： G02B5/18 , G02B5/32 , G02B27/00 , G11B7/09 , G11B7/12 , G11B7/13 , G11B7/135 , G11B7/00
CPC分类号： G11B7/131 , G02B27/0037 , G02B27/4238 , G02B27/4277 , G02B5/1819 , G02B5/1857 , G02B5/32 , G11B7/094 , G11B7/123 , G11B7/1353 , G11B7/0912
摘要： Disclosed is a compact optical pick-up head apparatus suitable for mass-production, which comprises a light radiation source, an element composed of photodetector split into a plurality of regions and integrated on the same base, an objective lens for focusing a beam from the above source on an optical disk, a blazed hologram integrated to the support member of the lens, a means for driving the support member to which the objective lens and blazed hologram are integrated in response to an output as servo signal output from the photodetector which receives a diffracted beam produced in such a manner that a return beam reflected or diffracted by the optical disk is incident on the objective lens integrated with the above hologram. The optical pickup apparatus according to the present invention employs a region-split-type phase hologram in which a pair of Flesnel zone plate-like patterns, by which a plurality of diffraction wavefronts having a different focus and the same diffraction order are produced outside an optical-axis, are non-superimposedly formed. The above hologram can be blazed with a pinpoint accuracy by lithography using a few mask patterns synthesized by a computer, and further a more preferably blazing can be realized by the combination of the ion beam etching and the lithography. Accordingly, not only noise caused by an unnecessary diffracted beam component but also the offset of a servo signal can be restrained and the size of the objective lens can be reduced by the integration of the entire optical system, which greatly contributes to the superminiaturization of an optical head.
摘要翻译：公开了一种适用于批量生产的紧凑型光学拾取头装置，其包括光辐射源，由分离成多个区域并集成在同一基底上的光电检测器构成的元件，用于将来自在光盘上的源极上，与透镜的支撑构件集成的闪耀的全息图，用于驱动支撑构件的装置，物镜和闪耀的全息图响应于作为从接收到的光电检测器输出的伺服信号的输出而被集成到该支撑构件上以使得由光盘反射或衍射的返回光束入射到与上述全息图集成的物镜上的方式产生的衍射光束。根据本发明的光学拾取装置采用区域分割型相位全息图，其中一对Flesnel区域板状图案，其中具有不同焦点和相同衍射级的多个衍射波前在外部产生光轴不叠加地形成。通过使用由计算机合成的几个掩模图案通过光刻可以使上述全息图以精确的准确度闪耀，并且还可以通过离子束蚀刻和光刻的组合来实现更好的燃烧。因此，不仅可以抑制由不必要的衍射光束分量引起的噪声，而且可以抑制伺服信号的偏移，并且可以通过整个光学系统的整合来减小物镜的尺寸，这极大地有助于使光头。

2. 发明授权

US5301182A Optical pickup head 失效
标题翻译：光学拾音头
公开(公告)号：US5301182A
公开(公告)日：1994-04-05
申请号：US868939
申请日：1992-04-16
申请人： Yoshiaki Komma , Seiji Nishino , Yoshikazu Hori
发明人： Yoshiaki Komma , Seiji Nishino , Yoshikazu Hori
IPC分类号： G11B7/09 , G11B7/135 , G11B7/00
CPC分类号： G11B7/1362 , G11B7/1353
摘要： An optical pickup head for operating on an information recording medium includes a light source for emitting a light beam. A transparent base plate has opposite surfaces formed with a semitransparent film and a hologram respectively. The semitransparent film is exposed to the light beam emitted from the light source, and reflects a portion of the light beam emitted from the light source. The portion of the light beam which is reflected by the semitransparent film forms a forward light beam. A condenser optical system serves to focus the forward light beam on the information recording medium. The forward light beam is reflected at the information recording medium, and forms a backward light beam. The backward light beam successively passes through the condenser optical system, the semitransparent film, and the transparent base plate, and then reaches the hologram. The hologram generates a backward +1-order diffraction light beam from the backward light beam. A plurality of photodetectors serve to receive the +1-order diffraction light beam and to convert the received +1-order diffraction light beam into corresponding electric signals respectively.
摘要翻译：用于在信息记录介质上操作的光学拾取头包括用于发射光束的光源。透明基板分别具有形成半透明膜和全息图的相对表面。半透明膜暴露于从光源发射的光束，并且反射从光源发射的光束的一部分。由半透明膜反射的光束部分形成正向光束。聚光器光学系统用于将前向光束聚焦在信息记录介质上。正向光束在信息记录介质上被反射，形成反向光束。后向光束依次通过聚光系统，半透明膜和透明基板，然后到达全息图。全息图从后向光束产生反向+ 1级的衍射光束。多个光电探测器用于接收+ 1级衍射光束并将接收到的+1级衍射光束分别转换为相应的电信号。

3. 发明授权

US5062098A Optical pick-up device having holographic element 失效
标题翻译：具有全息元件的光学拾取装置
公开(公告)号：US5062098A
公开(公告)日：1991-10-29
申请号：US259704
申请日：1988-10-19
申请人： Yoshikazu Hori , Makoto Kato
发明人： Yoshikazu Hori , Makoto Kato
IPC分类号： G11B7/135
CPC分类号： G11B7/1353
摘要： An optical pick-up device includes a semiconductor laser for emitting a laser beam, a focusing lens for focusing the laser beam emitted from the laser onto the surface of an optical medium, a holographic optical element having an anisotropic refractive index and located between the laser and the focusing lens, and a photodetector for receiving a diffracted laser beam from the holographic optical element. The holographic optical element, which may be formed of a liquid crystal or a lithium niobate crystal, transmits therethrough in an undiffracted manner the laser beam emitted from the semiconductor laser and diffracts only the reflected laser beam which has reflected off of the optical medium.
摘要翻译：光学拾取装置包括用于发射激光束的半导体激光器，用于将从激光器发射的激光束聚焦到光学介质的表面上的聚焦透镜，具有各向异性折射率并位于激光器之间的全息光学元件和聚焦透镜，以及用于接收来自全息光学元件的衍射激光束的光电检测器。可以由液晶或铌酸锂晶体形成的全息光学元件以非衍射的方式从半导体激光器发射的激光束透射，并且仅衍射已经从光学介质反射的反射的激光束。

4. 发明申请

US20080312228A1 PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF 审中-公开
标题翻译：吡嗪类化合物及其医疗用途
公开(公告)号：US20080312228A1
公开(公告)日：2008-12-18
申请号：US12053133
申请日：2008-03-21
申请人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
发明人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/496 , A61P35/00
CPC分类号： C07D471/04 , A61K31/519 , C07C275/30 , C07C275/50 , C07C2601/16 , C07D239/545 , C07D239/553 , C07D239/62 , C07D471/16 , C07D487/04 , C07F9/53
摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要翻译：本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

5. 发明授权

US07351825B2 Cyclopropane compounds and pharmaceutical use thereof 失效
标题翻译：环丙烷化合物及其药物用途
公开(公告)号：US07351825B2
公开(公告)日：2008-04-01
申请号：US11011773
申请日：2004-12-15
申请人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafumi Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
发明人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafumi Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
IPC分类号： C07D265/00 , C07D295/00 , C07D237/00 , C07D409/00 , C07D411/00 , C07D217/00 , C07D211/00 , C07D213/00 , C07D271/00 , C07D413/00 , C07D498/00 , C07D277/00 , C07D257/00 , C07D233/00 , C07D231/00 , C07D207/00 , C07D333/00 , C07D307/00 , C07D303/00 , C07D309/00 , C07D311/00
CPC分类号： C07C311/29 , C07C311/13 , C07C311/20 , C07C311/22 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07C2603/08 , C07C2603/18 , C07C2603/30 , C07D205/04 , C07D207/48 , C07D209/44 , C07D211/58 , C07D211/96 , C07D213/18 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/82 , C07D217/08 , C07D231/12 , C07D233/64 , C07D237/12 , C07D239/22 , C07D243/08 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/107 , C07D277/26 , C07D277/36 , C07D277/82 , C07D295/26 , C07D307/79 , C07D307/91 , C07D333/18 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/62 , C07D401/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）的环丙烷化合物：其中R 1 是 - （CH 2）2 -X-（CH 2）n - SUP> 1等，其中m和n相同或不同，并且各自为0至6，X为单键等，而A 1为取代的C _{3-14个烃环基等; R 2和R 3相同或不同，并且各自为氢原子， - （CH 2）2 N 其中p和q为 - （CH 2）2 - - - - CH 2 - 相同或不同，并且各自为0至6，X 1为单键等，而A 2为任选取代的C 3-14烷基，烃环等; R 4是-CO 2 R 9等，其中R 9是氢原子等。 ; 和R 20和R 21相同或不同，各自为氢原子， - （CH 2 CH 2）m 12 其中m12和m12（其中m12和m12）相同或不同，各自为0至6，X 12为单键等，R 30为氢原子等; 或其前药或其药学上可接受的盐。}

6. 发明授权

US5897790A Field-emission electron source and method of manufacturing the same 失效
标题翻译：场发射电子源及其制造方法
公开(公告)号：US5897790A
公开(公告)日：1999-04-27
申请号：US995839
申请日：1997-12-22
申请人： Keisuke Koga , Yoshikazu Hori , Takehito Yoshida , Yuka Yamada
发明人： Keisuke Koga , Yoshikazu Hori , Takehito Yoshida , Yuka Yamada
IPC分类号： H01J9/02 , B44C1/22
CPC分类号： H01J9/025 , H01J2201/30426
摘要： A withdrawn electrode is formed on a silicon substrate with intervention of upper and lower silicon oxide films each having circular openings corresponding to regions in which cathodes are to be formed. Tower-shaped cathodes are formed in the respective openings of the upper and lower silicon oxide films and of the withdrawn electrode. Each of the cathodes has a sharply tapered tip portion having a radius of 2 nm or less, which has been formed by crystal anisotropic etching and thermal oxidation process for silicon. The region of the silicon substrate exposed in the openings of the upper and lower silicon oxide films and the cathode have their surfaces coated with a thin surface coating film made of a material having a low work function.
摘要翻译：引出电极形成在硅衬底上，介于上和下氧化硅膜之间，每个氧化硅膜具有对应于其中将形成阴极的区域的圆形开口。在上下氧化硅膜和引出电极的各个开口中形成塔状阴极。每个阴极具有通过晶体各向异性蚀刻和硅的热氧化工艺形成的具有2nm或更小半径的尖锐尖端部分。暴露在上，下氧化硅膜和阴极的开口中的硅衬底的区域的表面涂覆有由具有低功函数的材料制成的薄表面涂膜。

7. 发明申请

US20070149517A1 3,4-DIHYDROBENZOXAZINE COMPOUNDS AND INHIBITORS OF VANILLOID RECEPTOR SUBTYPE 1 (VRI) ACTIVITY 有权
标题翻译：丹酚酸受体亚型1（VRI）活性的3,4-二氢苯并恶唑化合物和抑制剂
公开(公告)号：US20070149517A1
公开(公告)日：2007-06-28
申请号：US11616962
申请日：2006-12-28
申请人： Yoshihisa Koga , Shinji Yata , Takayuki Yamasaki , Tatsuya Matsumoto , Masahiro Sakata , Wataru Kondo , Yoshikazu Hori
发明人： Yoshihisa Koga , Shinji Yata , Takayuki Yamasaki , Tatsuya Matsumoto , Masahiro Sakata , Wataru Kondo , Yoshikazu Hori
IPC分类号： A61K31/538 , C07D265/36
CPC分类号： C07D413/04 , C07D413/14
摘要： A 3,4-dihydrobenzoxazine compound of the present invention is represented by the following formula [1] (wherein X is a nitrogen atom or CR3; R1 is a hydrogen atom or a halogen atom; R2 is a C1-6 alkoxy group which may be substituted with the same or different 1 to 5 substituents selected from a halogen atom and a hydroxyl group; and R3 is a halogen atom. However, R1 is a halogen atom when X is CR3). This compound is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, etc.
摘要翻译：本发明的3,4-二氢苯并恶嗪化合物由下式[1]表示（其中X为氮原子或CR 3，R 1为氢原子或卤素原子; R 2是可被相同或不同的1至5个选自卤素原子和羟基的取代基取代的C 1-6烷氧基; 3是卤素原子，但当X是CR 3时，R 1是卤素原子。该化合物可有效治疗涉及到香草素受体亚型1（VR1）活性的疾病，如疼痛等。

8. 发明申请

US20060014768A1 Pyrimidine compound and medical use thereof 有权
标题翻译：嘧啶化合物及其医疗用途
公开(公告)号：US20060014768A1
公开(公告)日：2006-01-19
申请号：US11150792
申请日：2005-06-10
申请人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
发明人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
IPC分类号： A61K31/513 , C07D405/02
CPC分类号： C07D471/04 , A61K31/519 , C07C275/30 , C07C275/50 , C07C2601/16 , C07D239/545 , C07D239/553 , C07D239/62 , C07D471/16 , C07D487/04 , C07F9/53
摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要翻译：本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

9. 发明授权

US5502314A Field-emission element having a cathode with a small radius 失效
标题翻译：具有半径小的阴极的场发射元件
公开(公告)号：US5502314A
公开(公告)日：1996-03-26
申请号：US269676
申请日：1994-07-01
申请人： Yoshikazu Hori
发明人： Yoshikazu Hori
IPC分类号： H01J1/304 , H01J9/02 , H01L29/06 , H01J1/46 , H01L29/04 , H01L29/12
CPC分类号： H01J1/3042 , H01J9/025
摘要： The invention is a field-emission element that is fabricated by forming an elevated surface and a base surface on a conductive substrate or a semiconductor substrate by applying a photolithographic process and an etching process, and making these surfaces cross at a step with an acute angle between the two surfaces. The intersection of the elevated surface with the step form a cathode having a radius of curvature of less than 20 nm. A gate electrode formed on the base electrode but insulated therefrom is disposed at a distance less than 1 .mu.m from said cathode by controlling the distance by the thickness of an etching protection mask. The field-emission element enables electrons to be emitted from the cathode when a voltage less than 150V is applied between the cathode and the gate electrode.
摘要翻译：本发明是通过应用光刻工艺和蚀刻工艺在导电衬底或半导体衬底上形成升高的表面和基底表面而制成的场致发射元件，并使这些表面以锐角在两个表面之间。升高的表面与台阶的交点形成具有小于20nm的曲率半径的阴极。通过将距离除以蚀刻保护掩模的厚度，将形成在基极上但与之绝缘的栅电极设置在距离阴极小于1μm的距离处。当在阴极和栅电极之间施加小于150V的电压时，场发射元件使得能够从阴极发射电子。

10. 发明授权

US4496951A Hyperbolic navigation receiver 失效
标题翻译：双曲线导航接收机
公开(公告)号：US4496951A
公开(公告)日：1985-01-29
申请号：US336327
申请日：1981-12-31
申请人： Kazuo Tsukada , Yoshiharu Kanzaki , Yoshikazu Hori
发明人： Kazuo Tsukada , Yoshiharu Kanzaki , Yoshikazu Hori
IPC分类号： G01S1/10 , G01S1/30 , G01S5/10 , H03L7/23
CPC分类号： G01S1/026 , G01S1/306 , H03L7/23
摘要： A hyperbolic navigation receiver locates ships, and the like, by phase-locking the output signal of the voltage-controlled oscillator or voltage-controlled phase shifter of respectively provided tracking loop filters corresponding to the incoming signals from a master and slave station. The voltage-controlled oscillator or voltage-controlled phase shifter is caused to produce an output signal which is a multiple frequency of the incoming signal. Phase discrimination of the output signals is undertaken without the use of a multiplier.
摘要翻译：双曲线导航接收器通过锁定相应于来自主站和从站的输入信号的分别提供的跟踪环路滤波器的压控振荡器或电压控制移相器的输出信号来定位船舶等。使压控振荡器或压控移相器产生作为输入信号的多个频率的输出信号。在不使用乘法器的情况下进行输出信号的相位辨别。

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