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1. 发明授权

US06605433B1 Mitochondrial dosimeter 有权
标题翻译：线粒体剂量计
公开(公告)号：US06605433B1
公开(公告)日：2003-08-12
申请号：US09525906
申请日：2000-03-15
申请人： Makiko Fliss , David Sidransky , Jin Jen , Komelia Polyak , Bert Vogelstein , Kenneth W. Kinzler
发明人： Makiko Fliss , David Sidransky , Jin Jen , Komelia Polyak , Bert Vogelstein , Kenneth W. Kinzler
IPC分类号： C12Q168
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： Mitochondrial mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition.
摘要翻译：线粒体突变作为人与环境污染物接触的产物发生。线粒体突变在体液中容易检测到。体液中线粒体突变的测量可用作剂量计来监测对环境污染物的暴露。线粒体突变也可以在癌症患者中检测到。含有突变体线粒体序列的探针和引物可用于监测患者状况。

2. 发明申请

US20090124795A1 Mitochondrial Dosimeter 审中-公开
标题翻译：线粒体剂量计
公开(公告)号：US20090124795A1
公开(公告)日：2009-05-14
申请号：US12100706
申请日：2008-04-10
申请人： Makiko Fliss , David Sidransky , Jin Jen , Kornelia Polyak , Bert Vogelstein , Kenneth W. Kinzler
发明人： Makiko Fliss , David Sidransky , Jin Jen , Kornelia Polyak , Bert Vogelstein , Kenneth W. Kinzler
IPC分类号： C07H21/00
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： Mitochondrial mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition.
摘要翻译：线粒体突变作为人与环境污染物接触的产物发生。线粒体突变在体液中容易检测到。体液中线粒体突变的测量可用作剂量计来监测对环境污染物的暴露。线粒体突变也可以在癌症患者中检测到。含有突变体线粒体序列的探针和引物可用于监测患者状况。

3. 发明授权

US6040144A Procedure for preparing gene expression libraries enriched for secretory protein genes 失效
标题翻译：制备富集分泌蛋白基因的基因表达文库的方法
公开(公告)号：US6040144A
公开(公告)日：2000-03-21
申请号：US900347
申请日：1997-07-25
申请人： Frank Carter Bancroft , Makiko Fliss
发明人： Frank Carter Bancroft , Makiko Fliss
IPC分类号： C12N15/10 , C12Q1/68 , C12N15/63
CPC分类号： C12N15/1086
摘要： The present invention relates to a method for producing a gene expression library enriched for a particular class of genes comprising (i) a nucleic acid preparation step and (ii) a polyclonal antiserum screening step, wherein both steps define the class of genes of interest. The method of the invention, using selection procedures directed not only at the underlying nucleic acid but also a functional attribute of the target class of proteins, may be used to produce gene expression libraries enriched for genes encoding a desired class of proteins, including, but not limited to, secretory proteins, cell cycle associated proteins, proteins defined by a particular subcellular location, tissue specific proteins, infection-related proteins, and non-infectious disease associated proteins.
摘要翻译：本发明涉及一种富含特定类型基因的基因表达文献的方法，其包括（i）核酸制备步骤和（ii）多克隆抗血清筛选步骤，其中两个步骤限定感兴趣的基因类别。使用本发明的方法，使用不仅在潜在的核酸而不仅指导目标蛋白质类别的功能属性的选择程序，可用于产生富含编码所需类蛋白质的基因的基因表达文库，包括但不限于不限于分泌蛋白，细胞周期相关蛋白，由特定亚细胞定位的蛋白质，组织特异性蛋白质，感染相关蛋白质和非感染性疾病相关蛋白质。

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