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1. 发明授权

US07639494B2 Electronic apparatus 失效
标题翻译：电子仪器
公开(公告)号：US07639494B2
公开(公告)日：2009-12-29
申请号：US12021861
申请日：2008-01-29
申请人： Jin-Jen Lin
发明人： Jin-Jen Lin
IPC分类号： G06F1/16
CPC分类号： F16M11/10 , F16M11/2021 , F16M2200/08 , G06F1/162 , G06F1/1679 , G06F1/1681
摘要： An electronic apparatus includes a first machine assembly, a second machine assembly having a pushing part and a first locking part, and a connection mechanism. The connection mechanism connecting the first and the second machine assemblies includes a body, a driven element having a second locking part and a third locking part, and a fourth locking part disposed on the body. Two ends of the body are pivoted to the first assembly and the second assembly respectively. The driven element is movably disposed on the body. When the second assembly is at a first position and the connection mechanism is at a second position, the second assembly is located above the first assembly, the pushing part and the first locking part are far from the connection mechanism, and the fourth locking part locks the third locking part to restrict the relative movement between the driven element and the body.
摘要翻译：电子设备包括第一机器组件，具有推动部分和第一锁定部分的第二机器组件和连接机构。连接第一和第二机器组件的连接机构包括主体，具有第二锁定部件和第三锁定部件的从动元件以及设置在主体上的第四锁定部件。主体的两端分别枢转到第一组件和第二组件。从动元件可移动地设置在主体上。当第二组件处于第一位置并且连接机构处于第二位置时，第二组件位于第一组件的上方，推动部分和第一锁定部分远离连接机构，并且第四锁定部件锁定第三锁定部分限制从动元件和主体之间的相对运动。

2. 发明授权

US07468425B2 p40 protein acts as an oncogene 有权
标题翻译： p40蛋白作为致癌基因
公开(公告)号：US07468425B2
公开(公告)日：2008-12-23
申请号：US10274874
申请日：2002-10-22
申请人： David Sidransky , Jin Jen , Barry Trink , Edward A. Ratovitski
发明人： David Sidransky , Jin Jen , Barry Trink , Edward A. Ratovitski
IPC分类号： C07K5/00
CPC分类号： C07K14/82 , A61K38/00 , C07K14/4746
摘要： We have discovered p40, the shortest variant of a new human p53 homologue (p40/p51/p63/p73H). We have also found that it plays a role in cancer. Low level amplification of the p40 locus accompanied by RNA and protein overexpression was observed in primary lung cancers, and head and neck cancer cell lines. P40 protein overexpression in primary lung tumors was limited to squamous cell carcinoma, tumors known to harbor a high frequency of p53 mutations. Overexpression of p40 in Rat 1a cells led to an increase in soft agar growth and tumor size in mice. We searched for p40 binding proteins using the yeast two-hybrid system. P53 was the most common binding target of the 1.6×106 clones screened from a mouse embryonic library. Moreover, coexpression of p40 and p53 led to a decrease in p53 transcriptional activity. Our results support the notion that p40 plays an oncogenic role in human cancer.
摘要翻译：我们已经发现了p40，一种新的人p53同源物（p40 / p51 / p63 / p73H）的最短变体。我们还发现它在癌症中发挥作用。在原发性肺癌和头颈癌细胞系中观察到p40基因座伴随RNA和蛋白质过表达的低水平扩增。 P40蛋白在原发性肺肿瘤中的过表达仅限于鳞状细胞癌，已知具有高频率p53突变的肿瘤。大鼠1a细胞中p40的过表达导致小鼠软琼脂生长和肿瘤大小增加。我们使用酵母双杂交系统搜索p40结合蛋白。 P53是从小鼠胚胎文库筛选的1.6×106克隆的最常见的结合靶标。此外，p40和p53的共表达导致p53转录活性的降低。我们的研究结果支持p40在人类癌症中发挥致癌作用的观念。

3. 发明授权

US07709202B2 Molecular characteristics of non-small cell lung cancer 失效
标题翻译：非小细胞肺癌的分子特征
公开(公告)号：US07709202B2
公开(公告)日：2010-05-04
申请号：US11829483
申请日：2007-07-27
申请人： Mariana Nacht , Tatiana Dracheva , David Sidransky , Stephen L Madden , Jin Jen
发明人： Mariana Nacht , Tatiana Dracheva , David Sidransky , Stephen L Madden , Jin Jen
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung cancers (NSCLC). Separation of normal and tumor samples, as well as histopathological subtypes, was evident using the 3,921 most abundant transcript tags. This distinction remained when just 115 highly differentially expressed transcript tags were used. Furthermore, these 115 transcript tags clustered into groups that were suggestive of the unique biological and pathological features of the different tissues examined. Adenocarcinomas were characterized by high-level expression of small airway-associated or immunologically related proteins, while squamous cell carcinomas overexpressed genes involved in cellular detoxification or antioxidation. The messages of two p53-regulated genes, p21WAF1/CIP1 and 14-3-3σ, were consistently under-expressed in the adenocarcinomas, suggesting that the p53 pathway itself might be compromised in this cancer type. Gene expression observed by SAGE were consistent with the results obtained by quantitative real-time PCR or cDNA array analyses using 43 additional lung tumor and normal samples. Thus, although derived from only a few tissue libraries, molecular signatures of non-small cell lung cancer derived from SAGE most likely represent an unbiased yet distinctive molecular signature for human lung cancer.
摘要翻译：我们使用层次聚类来检查在总共九个正常肺上皮细胞和非小细胞肺癌（NSCLC）中通过基因表达（SAGE）的连续分析产生的基因表达谱。正常和肿瘤样本的分离以及组织病理学亚型，使用3,921个最丰富的转录标签是明显的。当仅使用115种高度差异表达的转录标记时，这种区别仍然存在。此外，这115个转录标签聚集成组，提示所检测的不同组织的独特的生物学和病理学特征。腺癌的特征在于高水平表达小气道相关或免疫相关蛋白，而鳞状细胞癌过表达涉及细胞解毒或抗氧化的基因。两个p53调控基因p21WAF1 / CIP1和14-3-3＆sgr的信息在腺癌中一贯低表达，表明p53途径本身可能在这种癌症类型中受损。通过SAGE观察到的基因表达与通过使用43个额外的肺肿瘤和正常样品的定量实时PCR或cDNA阵列分析获得的结果一致。因此，尽管仅来自少数组织文库，但从SAGE衍生的非小细胞肺癌的分子特征最可能代表人类肺癌的无偏差但独特的分子特征。

4. 发明申请

US20090270265A1 Molecular Characteristics of Non-Small Cell Lung Cancer 失效
标题翻译：非小细胞肺癌的分子特征
公开(公告)号：US20090270265A1
公开(公告)日：2009-10-29
申请号：US11829483
申请日：2007-07-27
申请人： Mariana NACHT , Tatiana Dracheva , David Sidransky , Stephen Madden , Jin Jen
发明人： Mariana NACHT , Tatiana Dracheva , David Sidransky , Stephen Madden , Jin Jen
IPC分类号： C40B30/04 , C12Q1/68 , C12Q1/26 , C12Q1/02
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung cancers (NSCLC). Separation of normal and tumor samples, as well as histopathological subtypes, was evident using the 3,921 most abundant transcript tags. This distinction remained when just 115 highly differentially expressed transcript tags were used. Furthermore, these 115 transcript tags clustered into groups that were suggestive of the unique biological and pathological features of the different tissues examined. Adenocarcinomas were characterized by high-level expression of small airway-associated or immunologically related proteins, while squamous cell carcinomas overexpressed genes involved in cellular detoxification or antioxidation. The messages of two p53-regulated genes, p21WAF1/CIP1 and 14-3-3α, were consistently under-expressed in the adenocarcinomas, suggesting that the p53 pathway itself might be compromised in this cancer type. Gene expression observed by SAGE were consistent with the results obtained by quantitative real-time PCR or cDNA array analyses using 43 additional lung tumor and normal samples. Thus, although derived from only a few tissue libraries, molecular signatures of non-small cell lung cancer derived from SAGE most likely represent an unbiased yet distinctive molecular signature for human lung cancer.
摘要翻译：我们使用层次聚类来检查在总共九个正常肺上皮细胞和非小细胞肺癌（NSCLC）中通过基因表达（SAGE）的连续分析产生的基因表达谱。正常和肿瘤样本的分离以及组织病理学亚型，使用3,921个最丰富的转录标签是明显的。当仅使用115种高度差异表达的转录标记时，这种区别仍然存在。此外，这115个转录标签聚集成组，提示所检测的不同组织的独特的生物学和病理学特征。腺癌的特征在于高水平表达小气道相关或免疫相关蛋白，而鳞状细胞癌过表达涉及细胞解毒或抗氧化的基因。两个p53调控基因p21WAF1 / CIP1和14-3-3alpha的信息在腺癌中一直低表达，表明p53途径本身可能在这种癌症类型中受损。通过SAGE观察到的基因表达与通过使用43个额外的肺肿瘤和正常样品的定量实时PCR或cDNA阵列分析获得的结果一致。因此，尽管仅来自少数组织文库，但从SAGE衍生的非小细胞肺癌的分子特征最可能代表人类肺癌的无偏差但独特的分子特征。

5. 发明授权

US07332590B2 Molecular characteristics of non-small cell lung cancer 有权
标题翻译：非小细胞肺癌的分子特征
公开(公告)号：US07332590B2
公开(公告)日：2008-02-19
申请号：US10486844
申请日：2002-08-16
申请人： Mariana Nacht , Tatiana Dracheva , David Sidransky , Stephen Madden , Jin Jen
发明人： Mariana Nacht , Tatiana Dracheva , David Sidransky , Stephen Madden , Jin Jen
IPC分类号： C07H21/02 , C12Q1/68 , C01D15/08
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung cancers (NSCLC). Separation of normal and tumor samples, as well as histopathological subtypes, was evident using the 3,921 most abundant transcript tags. This distinction remained when just 115 highly differentially expressed transcript tags were used. Furthermore, these 115 transcript tags clustered into groups that were suggestive of the unique biological and pathological features of the different tissues examined. Adenocarcinomas were characterized by high-level expression of small airway-associated or immunologically related proteins, while squamous cell carcinomas overexpressed genes involved in cellular detoxification or antioxidation. The messages of two p53-regulated genes, p21WAF1/CIP1 and 14-3-3σ, were consistently under-expressed in the adenocarcinomas, suggesting that the p53 pathway itself might be compromised in this cancer type. Gene expression observed by SAGE were consistent with the results obtained by quantitative real-time PCR or cDNA array analyses using 43 additional lung tumor and normal samples. Thus, although derived from only a few tissue libraries, molecular signatures of non-small cell lung cancer derived from SAGE most likely represent an unbiased yet distinctive molecular signature for human lung cancer.
摘要翻译：我们使用层次聚类来检查在总共九个正常肺上皮细胞和非小细胞肺癌（NSCLC）中通过基因表达（SAGE）的连续分析产生的基因表达谱。正常和肿瘤样本的分离以及组织病理学亚型，使用3,921个最丰富的转录标签是明显的。当仅使用115种高度差异表达的转录标记时，这种区别仍然存在。此外，这115个转录标签聚集成组，提示所检测的不同组织的独特的生物学和病理学特征。腺癌的特征在于高水平表达小气道相关或免疫相关蛋白，而鳞状细胞癌过表达涉及细胞解毒或抗氧化的基因。两种p53调节基因p21 WAF1 / CIP1和14-3-3sigma的信息在腺癌中一直低表达，表明p53途径本身可能在这种癌症类型中受损。通过SAGE观察到的基因表达与通过使用43个额外的肺肿瘤和正常样品的定量实时PCR或cDNA阵列分析获得的结果一致。因此，尽管仅来自少数组织文库，但从SAGE衍生的非小细胞肺癌的分子特征最可能代表人类肺癌的无偏差但独特的分子特征。

6. 发明授权

US06587350B1 Ejection mechanism for modular electronic element 失效
标题翻译：模块化电子元件的排出机构
公开(公告)号：US06587350B1
公开(公告)日：2003-07-01
申请号：US10146052
申请日：2002-05-16
申请人： Jin Jen Lin , Sung Ming Song
发明人： Jin Jen Lin , Sung Ming Song
IPC分类号： H05K500
CPC分类号： H05K7/1411
摘要： An ejection mechanism for modular electronic elements is used for ejecting a modular electronic element housed in a housing chamber of an electronic device. The ejection mechanism is located in the housing chamber. By moving only one driving member, the latching relationship of the modular electronic element may be released and the modular electronic element may be ejected out of the housing chamber to facilitate replacement of various types of modular electronic elements.
摘要翻译：用于模块化电子元件的弹出机构用于弹出容纳在电子设备的容纳室中的模块化电子元件。排出机构位于容纳室中。通过仅移动一个驱动构件，可以释放模块化电子元件的闩锁关系，并且模块化电子元件可以从壳体室排出，以便于更换各种类型的模块化电子元件。

7. 发明授权

US5866340A Selective expression of desired genes in cells expressing oncoproteins 失效
公开(公告)号：US5866340A
公开(公告)日：1999-02-02
申请号：US620341
申请日：1996-03-22
申请人： Bert Vogelstein , Kenneth W. Kinzler , Luis da Costa , Jin Jen
发明人： Bert Vogelstein , Kenneth W. Kinzler , Luis da Costa , Jin Jen
IPC分类号： A61K48/00 , C12N15/85 , G01N33/53
CPC分类号： C12N15/85 , A61K48/00
摘要： Over the past decade, it has become clear that tumorigenesis is driven by alterations in genes that control cell growth or cell death. Theoretically, the proteins encoded by these genes provide excellent tools for achieving tumor cell-specific expression. An approach to achieving specific expression of a desired protein in tumor cells is based on the selective expression of such oncoproteins. In outline, an endogenous cellular oncoprotein binds to exogenously introduced gene products, resulting in transcriptional activation of a desired gene. This approach is generally applicable to other diseases in which a particular protein is selectively expressed in disease-affected cells as compared to non-affected cells.

8. 发明申请

US20100100919A1 METHOD FOR REDUCING UPSTREAM INGRESS NOISE IN CABLE DATA SYSTEM 审中-公开
标题翻译：在电缆数据系统中减少上游生态噪声的方法
公开(公告)号：US20100100919A1
公开(公告)日：2010-04-22
申请号：US12642039
申请日：2009-12-18
申请人： Jin-Jen Hsue , Wei-Chih Lu
发明人： Jin-Jen Hsue , Wei-Chih Lu
IPC分类号： H04N7/173
CPC分类号： H04L12/2801 , H04L12/2861 , H04N7/102
摘要： In a method of reducing and diagnosing upstream ingress noise in cable data system utilize a MAC/MAP management messages via a downstream path based on Cable Systems Interface Specification (DOCSIS) to provide precise control of gates deployed near the user side provide a powerful algorithm for CATV operators to mitigate ingress noise problem.
摘要翻译：在减少和诊断电缆数据系统中的上游入口噪声的方法中，利用基于电缆系统接口规范（DOCSIS）的下行路径的MAC / MAP管理消息来提供在用户侧附近部署的门的精确控制，为有线电视运营商减轻进入噪声问题。

9. 发明申请

US20100062443A1 Methods for the Diagnosis and Treatment of Lung Cancer 失效
标题翻译：肺癌诊断与治疗方法
公开(公告)号：US20100062443A1
公开(公告)日：2010-03-11
申请号：US12545028
申请日：2009-08-20
申请人： Jin Jen , Gary A. Beaudry , Stephen L. Madden , Arthur H. Bertlesen , David Sidransky
发明人： Jin Jen , Gary A. Beaudry , Stephen L. Madden , Arthur H. Bertlesen , David Sidransky
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136
摘要： The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.
摘要翻译：本发明提供了帮助诊断肺细胞肿瘤状况的方法以及筛选用于逆转肿瘤病症的潜在治疗剂的方法。

10. 发明申请

US20080168518A1 Method of reducing upstream ingress noise in cable data system 审中-公开
标题翻译：减少电缆数据系统中上游噪声的方法
公开(公告)号：US20080168518A1
公开(公告)日：2008-07-10
申请号：US11649858
申请日：2007-01-05
申请人： Jin-Jen Hsue , Wei-Chih Lu
发明人： Jin-Jen Hsue , Wei-Chih Lu
IPC分类号： H04N7/173
CPC分类号： H04L12/2801
摘要： In a method of reducing upstream ingress noise in cable data system, downstream management messages containing information about user group data uploading time and channel frequency are broadcasted by a headend of the cable data system. The broadcasted downstream management messages are monitored, so as to determine an upstream channel connection time schedule for the user groups. Each user group is connected to an upstream channel of the headend only at a data uploading time scheduled for that user group. As a result, ingress noise existed in the user group will be uploaded to the headend only when the user group is connected to the headend. Therefore, accumulation of upstream ingress noise at the headend is effectively reduced, and the headend network can maintain good signal quality to ensure best network connection.
摘要翻译：在电缆数据系统中减少上游入口噪声的方法中，包含有关用户组数据上载时间和频道频率的信息的下行管理消息由有线数据系统的前端广播。广播的下游管理消息被监视，以便确定用户组的上行信道连接时间表。每个用户组仅在为该用户组计划的数据上传时间连接到前端的上行信道。因此，只有当用户组连接到头端时，用户组中存在的入口噪声才会上传到头端。因此，前端上游入口噪声的积累有效降低，前端网络可以保持良好的信号质量，确保最佳网络连接。

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