专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100267578A1 PROBE DENSITY SELF-CONSIDERATIONS AND ELONGATION OF COMPLEMENTARY LOOPED PROBES WHERE PROBES ARE ATTACHED TO A SOLID PHASE 有权
标题翻译：探索密度自我考虑和延伸的复杂循环探测器，其中探测器连接到固相
公开(公告)号：US20100267578A1
公开(公告)日：2010-10-21
申请号：US12708362
申请日：2010-02-18
申请人： MICHAEL SEUL , Yi Zhang , Sukanta Banerjee , Jiacheng Yang , Chiu Chau
发明人： MICHAEL SEUL , Yi Zhang , Sukanta Banerjee , Jiacheng Yang , Chiu Chau
IPC分类号： C40B30/04
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q1/6827 , C12Q2565/1015 , C12Q2537/143 , C12Q2533/101 , C12Q2535/125 , C12Q2525/301
摘要： In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps:adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.
摘要翻译：在溶液中进行的多重测定方法中，其中溶液含有核酸靶，并且其中使用几个不同类型的寡核苷酸探针，每个类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸目标，所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加有效通过一种或多种以下方法可用于结合探针的靶的浓度：（i）在珠的表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

2. 发明申请

US20070243534A1 Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase 审中-公开
标题翻译：探头密度考虑和探针附着在固相上的自互补环状探针的伸长率
公开(公告)号：US20070243534A1
公开(公告)日：2007-10-18
申请号：US11403100
申请日：2006-04-12
申请人： Michael Seul , Yi Zhang , Sukanta Banerjee , Jiacheng Yang , Chiu Chau
发明人： Michael Seul , Yi Zhang , Sukanta Banerjee , Jiacheng Yang , Chiu Chau
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q1/6827 , C12Q2565/1015 , C12Q2537/143 , C12Q2533/101 , C12Q2535/125 , C12Q2525/301
摘要： In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps: adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.
摘要翻译：在溶液中进行的多重测定方法中，其中溶液含有核酸靶，并且其中使用几个不同类型的寡核苷酸探针，每个类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸目标，所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加有效通过一种或多种以下方法可用于结合探针的靶的浓度：（i）在珠的表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

3. 发明授权

US08795966B2 Probe density self-considerations and elongation of complementary looped probes where probes are attached to a solid phase 有权
标题翻译：探针密度自我考虑和互补环状探针的伸长，其中探针连接到固相
公开(公告)号：US08795966B2
公开(公告)日：2014-08-05
申请号：US12708362
申请日：2010-02-18
申请人： Michael Seul , Yi Zhang , Sukanta Banerjee , Jiacheng Yang , Chiu Chau
发明人： Michael Seul , Yi Zhang , Sukanta Banerjee , Jiacheng Yang , Chiu Chau
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q1/6827 , C12Q2565/1015 , C12Q2537/143 , C12Q2533/101 , C12Q2535/125 , C12Q2525/301
摘要： In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps:adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.
摘要翻译：在溶液中进行的多重测定方法中，其中溶液含有核酸靶，并且其中使用几个不同类型的寡核苷酸探针，每个类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸目标，所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加有效通过一种或多种以下方法可用于结合探针的靶的浓度：（i）在珠的表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

4. 发明申请

US20070231825A1 Multianalyte molecular analysis using application-specific random particle arrays 审中-公开
标题翻译：使用应用特异性随机粒子阵列进行多分析分析
公开(公告)号：US20070231825A1
公开(公告)日：2007-10-04
申请号：US11743719
申请日：2007-05-03
申请人： Sukanta Banerjee , Michael Seul , Alice Li , Kariali Podual , Chiu Chau , Zhi Li
发明人： Sukanta Banerjee , Michael Seul , Alice Li , Kariali Podual , Chiu Chau , Zhi Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了用于以生物测定形式应用颗粒阵列以在两类分子（分析物和结合剂）之间进行定性和/或定量分子相互作用分析的方法和装置。本文公开的方法和装置允许确定结合剂和分析物分子之间的结合相互作用的存在或不存在，缔合的强度，和/或缔合速率和解离速率。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

5. 发明申请

US20050277128A1 Looped probe design to control hybridization stringency 审中-公开
标题翻译：环路探针设计，以控制杂交严格性
公开(公告)号：US20050277128A1
公开(公告)日：2005-12-15
申请号：US11018545
申请日：2004-12-21
申请人： Sukanta Banerjee , Michael Seul , Alice Li , Kairali Podual , Chiu Chau , Zhi Li
发明人： Sukanta Banerjee , Michael Seul , Alice Li , Kairali Podual , Chiu Chau , Zhi Li
IPC分类号： G01N21/64 , B01J19/00 , C12M1/34 , C12Q1/68 , C12Q1/6837 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/58 , G01N35/00
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub- libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了一种用于通过产生磁性纳米颗粒和编码颗粒的新型亚文库从子文库产生编码磁性颗粒的新文库的方法。子库根据需要进行功能化在数组的形成中是有用的。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

6. 发明申请

US20110251093A1 ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US20110251093A1
公开(公告)日：2011-10-13
申请号：US13084869
申请日：2011-04-12
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： C40B30/04
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

7. 发明授权

US07940968B2 Analysis, secure access to, and transmission of array images 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US07940968B2
公开(公告)日：2011-05-10
申请号：US11439599
申请日：2006-05-23
申请人： Michael Seul , Xiongwu Xia , Chiu Chau
发明人： Michael Seul , Xiongwu Xia , Chiu Chau
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

8. 发明申请

US20050288870A1 Number coding for identification of subtypes of coded types of solid phase carriers 有权
标题翻译：用于识别编码类型的固相载体亚型的编号
公开(公告)号：US20050288870A1
公开(公告)日：2005-12-29
申请号：US10943760
申请日：2004-09-17
申请人： Michael Seul , Enqing Tan , Chiu Chau
发明人： Michael Seul , Enqing Tan , Chiu Chau
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/543 , G01N33/68 , H03M20060101 , G06F19/00
CPC分类号： G01N33/6845 , G01N33/543 , G01N33/54313 , G01N33/564
摘要： Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a C-code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, in multiplexed nucleic acid or protein analysis.
摘要翻译：公开了固相载波的对（“双”）或小集（“多重”）的数字编码提供了给定类型的这种载波的可区分的子类型，其中每个载波类型基于C码可区分。这种数字编码对于增加诸如颜色代码的编码系统是有用的，从而有效地乘以“颜色”的数量（可区分的子类型）。它可以应用于例如多重核酸或蛋白质分析中。

9. 发明授权

US07927796B2 Number coding for identification of subtypes of coded types of solid phase carriers 有权
标题翻译：用于识别编码类型的固相载体亚型的编号
公开(公告)号：US07927796B2
公开(公告)日：2011-04-19
申请号：US10943760
申请日：2004-09-17
申请人： Michael Seul , Enqing Tan , Chiu Chau
发明人： Michael Seul , Enqing Tan , Chiu Chau
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04 , G01N33/543 , G01N15/06 , G01N33/48
CPC分类号： G01N33/6845 , G01N33/543 , G01N33/54313 , G01N33/564
摘要： Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.
摘要翻译：披露了提供给定类型的这种载体的可区分子类型的固相载体的对（“双”）或小集（“多重”）的数字编码，其中每种载体类型基于不同的代码可区分。这种数字编码对于增加诸如颜色代码的编码系统是有用的，从而有效地乘以“颜色”的数量（可区分的子类型）。例如，它可以应用于确定样品在两个不同等位基因之一的多个不同位点是纯合的还是杂合的，其中针对两个等位基因中的每一个应用相同的颜色代码，并且具有相同的等位基因通过知道多少载体与检测每个不同等位基因的分子相关联来区分颜色代码。

10. 发明授权

US07526114B2 Analysis, secure access to, and transmission of array images 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US07526114B2
公开(公告)日：2009-04-28
申请号：US10714203
申请日：2003-11-14
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式