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1. 发明申请

US20110251093A1 ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US20110251093A1
公开(公告)日：2011-10-13
申请号：US13084869
申请日：2011-04-12
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： C40B30/04
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

2. 发明授权

US07526114B2 Analysis, secure access to, and transmission of array images 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US07526114B2
公开(公告)日：2009-04-28
申请号：US10714203
申请日：2003-11-14
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

3. 发明申请

US20060222226A1 Analysis, secure access to, and transmission of array images 审中-公开
公开(公告)号：US20060222226A1
公开(公告)日：2006-10-05
申请号：US11439598
申请日：2006-05-23
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

4. 发明授权

US08712123B2 Analysis, secure access to, and transmission of array images 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US08712123B2
公开(公告)日：2014-04-29
申请号：US13084869
申请日：2011-04-12
申请人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
发明人： Xiongwu Xia , Michael Seul , Chiu Chau , Scott Determan
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

5. 发明授权

US07940968B2 Analysis, secure access to, and transmission of array images 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US07940968B2
公开(公告)日：2011-05-10
申请号：US11439599
申请日：2006-05-23
申请人： Michael Seul , Xiongwu Xia , Chiu Chau
发明人： Michael Seul , Xiongwu Xia , Chiu Chau
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

6. 发明申请

US20060222227A1 Analysis, secure access to, and transmission of array images 有权
公开(公告)号：US20060222227A1
公开(公告)日：2006-10-05
申请号：US11439599
申请日：2006-05-23
申请人： Michael Seul , Xiongwu Xia , Chiu Chau
发明人： Michael Seul , Xiongwu Xia , Chiu Chau
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

7. 发明申请

US20110077167A1 AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TARGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 审中-公开
标题翻译：多重探测目标相互作用模式的自动分析：模式匹配与识别
公开(公告)号：US20110077167A1
公开(公告)日：2011-03-31
申请号：US12961086
申请日：2010-12-06
申请人： Xiongwu Xia , Michael Seul
发明人： Xiongwu Xia , Michael Seul
IPC分类号： C40B30/04
CPC分类号： C12Q1/6827 , G16B20/00 , G16B30/00
摘要： Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement (“redaction”) of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment (“AAA”) program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portable database to permit visualizing, importing, exporting and creating customizable summary reports; system configuration (“Set-up”) including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and “cut-and-paste” editing, generating “warning” statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string (“reaction pattern”) setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.
摘要翻译：公开的方法和算法（及其实现）支持在集成软件环境中进行自动化等位基因分配的自动分析和交互式审查和细化（“编辑”）分析。优选地使用软件系统和称为自动等位基因分配（“AAA”）程序的程序的实现提供了多种功能，包括：通过与便携式数据库的集成接口的数据管理，以允许可视化，导入，出口和创建可定制的汇总报告; 系统配置（“设置”），包括用户授权，训练集分析和探测屏蔽; 模式分析包括字符串匹配和探针翻转; 和Interactive Redaction将实时数据库计算和“剪切和粘贴”编辑相结合，生成“警告”语句和支持注释。它还包括阈值功能，设置阈值的方法，通过匹配用于该探针的实验二进制串（“反应模式”）设置来精确化阈值的方法，探针对由探针产生的信号进行探针掩蔽，所述探针不对显着区别于等位基因

8. 发明申请

US20060025930A1 Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification 有权
标题翻译：多重探针 - 目标相互作用模式的自动分析：模式匹配和等位基因识别
公开(公告)号：US20060025930A1
公开(公告)日：2006-02-02
申请号：US10909638
申请日：2004-08-02
申请人： Xiongwu Xia , Michael Seul
发明人： Xiongwu Xia , Michael Seul
IPC分类号： G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6827 , G06F19/18 , G06F19/22
摘要： Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement (“redaction”) of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment (“AAA”) program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portable database to permit visualizing, importing, exporting and creating customizable summary reports; system configuration (“Set-up”) including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and “cut-and-paste” editing, generating “warning” statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string (“reaction pattern”) setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.
摘要翻译：公开的方法和算法（及其实现）支持在集成软件环境中进行自动化等位基因分配的自动分析和交互式审查和细化（“编辑”）分析。优选地使用软件系统和称为自动等位基因分配（“AAA”）程序的程序的实现提供了多种功能，包括：通过与便携式数据库的集成接口的数据管理，以允许可视化，导入，出口和创建可定制的汇总报告; 系统配置（“设置”），包括用户授权，训练集分析和探测屏蔽; 模式分析包括字符串匹配和探针翻转; 和Interactive Redaction将实时数据库计算和“剪切和粘贴”编辑相结合，生成“警告”语句和支持注释。它还包括阈值功能，设置阈值的方法，通过匹配用于该探针的实验二进制串（“反应模式”）设置来精确化阈值的方法，探针对由探针产生的信号进行探针掩蔽，所述探针不对显着区别于等位基因

9. 发明授权

US07970553B2 Concurrent optimization in selection of primer and capture probe sets for nucleic acid analysis 有权
标题翻译：选择引物和捕获探针组进行核酸分析的并发优化
公开(公告)号：US07970553B2
公开(公告)日：2011-06-28
申请号：US12502725
申请日：2009-07-14
申请人： Michael Seul , Tatiana Vener , Xiongwu Xia
发明人： Michael Seul , Tatiana Vener , Xiongwu Xia
IPC分类号： G01N33/48
CPC分类号： C12Q1/6876 , C12Q2600/16 , G06F19/20 , G06F19/22
摘要： Disclosed is a method of iteratively optimizing two (or more) interrelated sets of probes for the multi-step analysis of sets of designated sequences, each such sequence requiring, for conversion, at least one conversion probe (“primer”), and each converted sequence requiring, for detection, at least one capture probe. The iterative method disclosed herein for the concurrent optimization of primer and probe selection invokes fast logical string matching functions to perform a complete cross-correlation of probe sequences and target sequences. The score function assigns to each probe-target alignment a “degree of matching” score on the basis of position-weighted Hamming distance functions introduced herein. Pairs of probes in the final selection may differ in several positions, while other pairs of probes may differ in only a single position. Not all such positions are of equal importance, and a score function is introduced, reflecting the position of the mismatch within the probe sequence.
摘要翻译：公开了一种迭代优化两个（或多个）相互关联的探针组的方法，用于多步分析指定序列集合，每个这样的序列需要转化至少一个转化探针（“引物”），并且每个转化用于检测至少一个捕获探针的序列。本文公开的用于并行优化引物和探针选择的迭代方法调用快速逻辑串匹配函数来执行探针序列和靶序列的完全互相关。得分函数根据本文介绍的位置加权汉明距离函数将每个探针 - 目标对准分配给“匹配度”得分。最终选择中的一对探针在几个位置可能有所不同，而其他探针对只能在一个位置上不同。并不是所有这样的位置都是同等重要的，并且引入了分数函数，反映了探针序列内不匹配的位置。

10. 发明申请

US20120065099A1 AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TARGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 有权
标题翻译：多重探测目标相互作用模式的自动分析：模式匹配与识别
公开(公告)号：US20120065099A1
公开(公告)日：2012-03-15
申请号：US13297487
申请日：2011-11-16
申请人： Xiongwu Xia , Michael Seul
发明人： Xiongwu Xia , Michael Seul
IPC分类号： C40B30/04
CPC分类号： C12Q1/6827 , G06F19/18 , G06F19/22
摘要： Methods and algorithms for automated allele assignments within an integrated software environment are provided. These methods and algorithms offer a multiplicity of functionalities including: data management; system configuration including user authorization, training set analysis and probe masking; pattern analysis including string matching and probe flipping; and interactive redaction of data. The methods and algorithms further include methods of setting thresholds, refining thresholds, and probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.
摘要翻译：提供了集成软件环境中自动等位基因分配的方法和算法。这些方法和算法提供了多种功能，包括：数据管理; 系统配置包括用户授权，训练集分析和探测屏蔽; 模式分析包括字符串匹配和探针翻转; 和数据的交互式修改。所述方法和算法还包括设置阈值，精确阈值和由探针产生的信号的探针掩蔽的方法，这些信号对于等位基因之间的区分不起重要作用。

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