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1. 发明授权

US11925806B2 Brain stimulation therapy 有权
公开(公告)号：US11925806B2
公开(公告)日：2024-03-12
申请号：US16941085
申请日：2020-07-28
申请人： Medtronic, Inc.
发明人： Jonathon E. Giftakis , Paul H. Stypulkowski
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0534 , A61N1/36082 , A61N1/36096 , A61N1/36171
摘要： Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.

2. 发明申请

US20220266041A1 MEDICAL DEVICE PATIENT ALERT USING HOUSING STIMULATION BASED ON SENSED EVENT 有权
公开(公告)号：US20220266041A1
公开(公告)日：2022-08-25
申请号：US17645682
申请日：2021-12-22
申请人： Medtronic, Inc.
发明人： Jonathon E. Giftakis , Scott R. Stanslaski , William C. Harding , Ryan Gertenbach , Brian L. Bechard , Nathan A. Torgerson
IPC分类号： A61N1/372 , A61N1/02 , A61N1/08 , A61N1/05 , A61N1/36
摘要： An implantable medical device that includes a memory, stimulation circuitry configured to deliver electrical stimulation to a patient, and processing circuitry operably coupled to the memory. The processing circuitry is configured to: control the stimulation circuitry to output electrical stimulation therapy to a patient via a first electrode combination and control the stimulation circuitry to output a notification stimulation via a second electrode combination and interleaved with the electrical stimulation therapy. The notification stimulation may include an intensity above a perception level of the patient, and the second electrode combination may include an electrode disposed at an implant site of the implantable medical device.

3. 发明申请

US20220266039A1 MEDICAL DEVICE PATIENT TWO-WAY COMMUNICATION BASED ON SENSED EVENT 有权
公开(公告)号：US20220266039A1
公开(公告)日：2022-08-25
申请号：US17645661
申请日：2021-12-22
申请人： Medtronic, Inc.
发明人： Jonathon E. Giftakis , Scott R. Stanslaski , William C. Harding , Ryan Gertenbach , Brian L. Bechard , Nathan A. Torgerson
IPC分类号： A61N1/372 , A61N1/36
摘要： A system that includes a movement sensor configured to be implanted within a patient and generate a movement signal and processing circuitry configured to be implanted within the patient and configured to: receive the movement signal from the movement sensor and determine that the movement signal is representative of a communication from the patient. Responsive to determining that the movement signal is representative of the communication, the processing circuitry may cause an alert associated with the communication to be output to the patient. The processing circuitry may also perform an action requested by the communication.

4. 发明授权

US11077305B2 Identification of compromised components in a medical system 有权
公开(公告)号：US11077305B2
公开(公告)日：2021-08-03
申请号：US15699873
申请日：2017-09-08
申请人： MEDTRONIC, INC.
发明人： Jonathon E. Giftakis , Timothy J. Denison , Paul H. Stypulkowski , Scott R. Stanslaski , Robert S. Raike , Mae Eng , David E. Linde , Thomas Adamski
IPC分类号： A61N1/36 , A61N1/05 , A61N1/08
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.

5. 发明申请

US20180326217A1 BRAIN STIMULATION THERAPY 审中-公开
公开(公告)号：US20180326217A1
公开(公告)日：2018-11-15
申请号：US16036439
申请日：2018-07-16
申请人： Medtronic, Inc.
发明人： Jonathon E. Giftakis , Paul H. Stypulkowski
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0534 , A61N1/36082 , A61N1/36096 , A61N1/36171
摘要： Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.

6. 发明申请

US20140194945A1 TARGET THERAPY DELIVERY SITE SELECTION 审中-公开
标题翻译：目标治疗交付网站选择
公开(公告)号：US20140194945A1
公开(公告)日：2014-07-10
申请号：US14207926
申请日：2014-03-13
申请人： Medtronic, Inc.
发明人： Paul H. Stypulkowski , Jonathon E. Giftakis
IPC分类号： A61N1/36
CPC分类号： A61N1/36064 , A61N1/0534 , A61N1/36135 , A61N1/36171 , A61N1/36185
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
摘要翻译：在选择用于治疗患者状况的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域（例如，丘脑的前核）内的至少两个区域并且确定响应于递送的刺激的患者脑的第二区域（例如，海马）中的脑活动（例如，由生物电脑信号所示）的变化。可以基于脑活动的变化来选择靶治疗递送部位，电极组合或两者。

7. 发明授权

US08706237B2 Brain stimulation response profiling 有权
标题翻译：脑刺激反应剖析
公开(公告)号：US08706237B2
公开(公告)日：2014-04-22
申请号：US13766006
申请日：2013-02-13
申请人： Medtronic, Inc.
发明人： Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Scott R. Stanslaski
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36139 , A61N1/3615 , A61N1/36167 , A61N1/372
摘要： Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
摘要翻译：各种实施例涉及在多个不同水平的刺激参数下向大脑递送电刺激，并且感测脑的生物电响应以递送刺激参数的多个不同级别中的每一个的电刺激。刺激参数的抑制窗口可以基于感测的生物电响应被识别为具有作为下边界的抑制阈值和放电后阈值作为上边界。刺激参数的治疗水平可以设置为基于抑制窗口的治疗输送。刺激参数的治疗水平可以设定为比抑制窗口内的放电后阈值更接近抑制阈值。提出海马刺激的数据表明抑制窗口。

8. 发明申请

US20130197944A1 Techniques for Data Reporting in an Implantable Medical Device 审中-公开
标题翻译：可植入医疗器械数据报告技术
公开(公告)号：US20130197944A1
公开(公告)日：2013-08-01
申请号：US13803462
申请日：2013-03-14
申请人： MEDTRONIC, INC.
发明人： Touby A. Drew , Jonathon E. Giftakis
IPC分类号： G06F19/00
CPC分类号： G16H15/00 , A61B5/0006 , A61B5/0031 , A61B5/0205 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/4076 , A61B5/4094 , A61B5/7232 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F19/3418 , G06F19/3468 , G06F19/3481 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。植入装置获取数据并将数据存储在基于年龄的第一数据结构中的数据记录中。在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。

9. 发明授权

US12036410B2 Multi-target adaptive neurostimulation therapy control 有权
公开(公告)号：US12036410B2
公开(公告)日：2024-07-16
申请号：US17062213
申请日：2020-10-02
申请人： Medtronic, Inc.
发明人： David E. Linde , Benjamin P. Isaacson , Nicholas D. Buse , Duane L. Bourget , Robert S. Raike , Jonathon E. Giftakis , Caleb C. Zarns , Thomas L. Chouinard
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61N1/0534 , A61N1/36067 , A61N1/36171 , A61N1/36175 , A61N1/36192 , A61N1/36071
摘要： A medical device or system of medical devices can be configured to detect an indicator of a symptom in a patient; in response to detecting the indicator of the symptom in the patient, deliver to the patient a first stimulation therapy; and in response to determining that the indicator of the symptom has been present for more than a threshold amount of time after beginning to deliver the first stimulation therapy a second stimulation therapy different than the first stimulation therapy.

10. 发明授权

US12036401B2 Seizure detection algorithm adjustment 有权
公开(公告)号：US12036401B2
公开(公告)日：2024-07-16
申请号：US16773719
申请日：2020-01-27
申请人： Medtronic, Inc.
发明人： Jonathon E. Giftakis , Nathan A. Torgerson
IPC分类号： A61N1/05 , A61B5/00 , A61B5/03 , A61N1/36
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： A medical system implements a seizure detection algorithm to detect a seizure based on a first patient parameter. The medical system monitors a second patient parameter to adjust the seizure detection algorithm. In some examples, the medical system determines whether a seizure for which therapy delivery is desirable occurred based on a second patient parameter. If a target seizure occurred, and the seizure detection algorithm did not detect the target seizure, the medical system adjusts the seizure detection algorithm to detect the target seizure. For example, the medical system may determine a first patient parameter characteristic indicative of the target seizure detected based on the second patient parameter and store the first patient parameter characteristic as part of the seizure detection algorithm. In some examples, the first patient parameter is an electrical brain signal and the second patient parameter is patient activity (e.g., patient motion or posture).

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