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1. 发明申请

US20050059999A1 Delivering genetic material to a stimulation site 审中-公开
标题翻译：将遗传物质提供给刺激部位
公开(公告)号：US20050059999A1
公开(公告)日：2005-03-17
申请号：US10663570
申请日：2003-09-15
申请人： Luc Mongeon , Jesus Casas-Bejar , H. Markowitz , Daisy Cross , Janelle Blum , Michael Ebert , Timothy Laske
发明人： Luc Mongeon , Jesus Casas-Bejar , H. Markowitz , Daisy Cross , Janelle Blum , Michael Ebert , Timothy Laske
IPC分类号： A61K48/00 , A61N1/05 , A61N1/362
CPC分类号： A61N1/0568 , A61K48/0008 , A61K48/0041 , A61K48/0083
摘要： Delivery of genetic material to a stimulation site causes transgene expression by tissue at the stimulation site. In some embodiments, the delivered genetic material causes increased expression of proteins, such as connexins, gap junctions, and ion channels, to increase the conductivity of the tissue at the stimulation site. In some embodiments, the delivered genetic material causes expression of a metalloproteinase, an anti-inflammatory agent, or an immunosuppressant agent. Genetic material is delivered to the stimulation site via a stimulation lead. A stimulation lead for delivering genetic material to a stimulation site includes a chamber that contains a polymeric matrix. The matrix absorbs the genetic material and elutes the genetic material to the stimulation site.
摘要翻译：将遗传物质递送至刺激部位会在刺激部位引起组织的转基因表达。在一些实施方案中，递送的遗传物质导致蛋白质（例如连接蛋白，间隙连接和离子通道）的表达增加，以增加刺激部位组织的电导率。在一些实施方案中，递送的遗传物质导致金属蛋白酶，抗炎剂或免疫抑制剂的表达。遗传物质通过刺激引线输送到刺激部位。用于将遗传物质递送至刺激部位的刺激引线包括含有聚合物基质的腔室。基质吸收遗传物质并将遗传物质洗脱到刺激部位。

2. 发明申请

US20070282259A1 SLEEVE VALVE CATHETERS 审中-公开
标题翻译：套管阀
公开(公告)号：US20070282259A1
公开(公告)日：2007-12-06
申请号：US11754759
申请日：2007-05-29
申请人： Mary Morris , Timothy Laske , Kenneth Heruth , Michael Ujhelyi , Jesus Casas , David Olson
发明人： Mary Morris , Timothy Laske , Kenneth Heruth , Michael Ujhelyi , Jesus Casas , David Olson
IPC分类号： A61M25/14
CPC分类号： A61M25/0075
摘要： A catheter body includes an exit port over which a pressure responsive sleeve is formed that allows material to exit a lumen of the catheter body at a given pressure. In one embodiment, a surface of the sleeve is approximately flush with a surface of the catheter body.
摘要翻译：导管主体包括出口，在该出口处形成压力响应套筒，其允许材料在给定压力下离开导管体的内腔。在一个实施例中，套筒的表面与导管主体的表面大致齐平。

3. 发明申请

US20050245972A1 Apparatus and methods for treating arrhythmia and lowering defibrillation threshold 审中-公开
标题翻译：用于治疗心律失常并降低除颤阈值的装置和方法
公开(公告)号：US20050245972A1
公开(公告)日：2005-11-03
申请号：US10834473
申请日：2004-04-29
申请人： Chike Onyekaba , Timothy Laske , Rick McVenes
发明人： Chike Onyekaba , Timothy Laske , Rick McVenes
IPC分类号： A61M5/142 , A61M5/172 , A61N1/39
CPC分类号： A61N1/3962 , A61M5/14276 , A61M5/1723
摘要： A method for treating cardiac arrhythmia includes infusing an agent, adapted to facilitate treating the arrhythmia, directly into a cardiac vein and delivering a defibrillating shock between two electrodes.
摘要翻译：用于治疗心律失常的方法包括将适于促进心律失常治疗的药物直接注入心静脉并在两个电极之间递送去纤颤性休克。

4. 发明申请

US20060030893A1 Means for increasing implantable medical device electrode surface area 有权
标题翻译：增加植入式医疗器械电极表面积的手段
公开(公告)号：US20060030893A1
公开(公告)日：2006-02-09
申请号：US10914303
申请日：2004-08-09
申请人： Timothy Laske , Gonzalo Martinez , Lea Nygren
发明人： Timothy Laske , Gonzalo Martinez , Lea Nygren
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/3756
摘要： A surface area of an IMD electrode is increased by forming a conductive layer over an external portion of a sidewall of an IMD connector header and electrically coupling the conductive layer of the connector header to a conductive mounting surface of a hermetically sealed IMD housing; wherein the conductive mounting surface is an extension of an external conductive surface of the IMD, which external conductive surface forms the IMD electrode that is increased in surface area by the conductive layer formed over the connector header.
摘要翻译：通过在IMD连接器集管的侧壁的外部部分上形成导电层并将连接器集管的导电层电耦合到密封的IMD壳体的导电安装表面来增加IMD电极的表面积; 其中所述导电安装表面是所述IMD的外部导电表面的延伸部，所述外部导电表面形成所述IMD电极，所述IMD电极通过形成在所述连接器插头上的导电层而在表面积上增加。

5. 发明申请

US20050021091A1 System for the delivery of a biologic therapy with device monitoring and back-up 审中-公开
标题翻译：用于提供设备监测和备份的生物治疗系统
公开(公告)号：US20050021091A1
公开(公告)日：2005-01-27
申请号：US10798613
申请日：2004-03-11
申请人： Timothy Laske , Daniel Sigg , Orhan Soykan
发明人： Timothy Laske , Daniel Sigg , Orhan Soykan
IPC分类号： A61B5/042 , A61B5/0452 , A61B5/0464 , A61B5/07 , A61K48/00 , A61M5/142 , A61M5/172 , A61N1/05 , A61N1/18
CPC分类号： A61M5/14276 , A61B5/042 , A61B5/0452 , A61B5/0464 , A61B5/076 , A61B5/4839 , A61B5/6882 , A61K48/00 , A61M5/1723 , A61M2205/04 , A61M2210/122 , A61M2210/125 , A61M2230/04 , A61N1/0568 , C12N2750/14143
摘要： An implantable medical device (IMD), such as a cardiac monitor and/or pulse generator is implanted during a procedure where a biologic is introduced into a targeted area of the heart. The IMD monitors cardiac performance to determine the efficacy of the biologic. Based on the achieved efficacy, the IMD will either take no action, provide device based therapy, and/or ablate the tissue to destroy the biologic and its effects if the biologic proves unsuccessful.
摘要翻译：在将生物体引入心脏的目标区域的过程中植入可植入医疗装置（IMD），例如心脏监测器和/或脉冲发生器。 IMD监测心脏功能以确定生物制剂的功效。基于实现的功效，如果生物学证明不成功，IMD将不采取行动，提供基于设备的治疗和/或消融组织以破坏生物及其作用。

6. 发明申请

US20060142814A1 Pacing method 有权
公开(公告)号：US20060142814A1
公开(公告)日：2006-06-29
申请号：US10782420
申请日：2004-02-19
申请人： Timothy Laske , Paul Iaizzo
发明人： Timothy Laske , Paul Iaizzo
IPC分类号： A61N1/368
CPC分类号： A61N1/056 , A61N1/0573
摘要： A method for delivering physiological pacing includes selecting an electrode implant site within an interventricular septal zone, which is in proximity to the bundle of His where pacing stimulation results in a rhythm breaking out at an intrinsic location, and wherein a ratio of sensed P-wave amplitude to sensed R-wave amplitude is less than approximately 0.5 and a pacing threshold is less than or equal to approximately 1.5 volts.

7. 发明申请

US20050033395A1 Medical electrical lead anchoring 有权
标题翻译：医用电气导线锚定
公开(公告)号：US20050033395A1
公开(公告)日：2005-02-10
申请号：US10664995
申请日：2003-09-17
申请人： Kevin Seifert , Timothy Laske
发明人： Kevin Seifert , Timothy Laske
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N1/059 , A61N2001/0578
摘要： A lead body of a medical electrical lead includes a distal end, a first elongated insulated conductor extending toward the distal end and a first electrode coupled to the conductor. A second elongated insulated conductor includes a first portion extending within the lead body to the distal end and a second portion extending distally from the distal end of the lead body where it is terminated by a tissue anchor on which a second electrode is mounted; the tissue anchor includes a surface for receiving a push force from an insertion tool, which is adapted to insert the anchor within a segment of tissue such that the first electrode of the lead body is in close proximity to the segment of tissue.
摘要翻译：医疗电线的引线体包括远端，朝向远端延伸的第一细长绝缘导体和耦合到导体的第一电极。第二细长绝缘导体包括在引线主体内延伸到远端的第一部分和从引线主体的远端向远端延伸的第二部分，其中第二部分由其上安装有第二电极的组织锚固件终止; 组织锚固件包括用于接收来自插入工具的推力的表面，其适于将锚固件插入组织段内，使得引线主体的第一电极紧邻组织段。

8. 发明申请

US20050015116A1 Variable EGM filtering and fixation prediction 有权
标题翻译：可变EGM过滤和固定预测
公开(公告)号：US20050015116A1
公开(公告)日：2005-01-20
申请号：US10821451
申请日：2004-04-09
申请人： Timothy Laske , Thomas Ahern
发明人： Timothy Laske , Thomas Ahern
IPC分类号： A61N1/08 , A61N1/37
CPC分类号： A61N1/08 , A61N2001/083
摘要： An IMD includes a variable sense amplifier that can be adjusted to counteract the variability created in EGM's due to lead maturation. The effects of lead maturation are either predictively assumed or individually assessed on a given patient. The sense amplifier is then adjusted to assure positive identification of desired events and eliminate unwanted events.
摘要翻译： IMD包括可调节的可变感测放大器，以抵消由于铅成熟引起的EGM中产生的变异性。铅成熟的影响可以在给定的患者中被预测地假定或单独评估。然后调整读出放大器以确保所需事件的正确识别并消除不需要的事件。

9. 发明申请

US20050177220A1 Novel lead fixation means 有权
标题翻译：新型铅固定方式
公开(公告)号：US20050177220A1
公开(公告)日：2005-08-11
申请号：US10772989
申请日：2004-02-05
申请人： Paul Iaizzo , Timothy Laske
发明人： Paul Iaizzo , Timothy Laske
IPC分类号： A61B5/042 , A61N1/05
CPC分类号： A61N1/057 , A61B5/042 , A61B5/6882 , A61B2018/00273
摘要： A medical lead is adhered to a tissue site using a tissue adhesive.
摘要翻译：使用组织粘合剂将医用引线附着在组织部位。

10. 发明申请

US20050148850A1 Clinical tool for structure localization 有权
标题翻译：结构定位临床工具
公开(公告)号：US20050148850A1
公开(公告)日：2005-07-07
申请号：US10987815
申请日：2004-11-12
申请人： Ryan Lahm , Walton Baxter , Josee Morissette , Timothy Laske
发明人： Ryan Lahm , Walton Baxter , Josee Morissette , Timothy Laske
IPC分类号： A61B5/05 , A61B5/06
CPC分类号： A61B5/06 , A61B5/065 , A61B5/7285
摘要： A method for localizing an internal body structure during an image-guided procedure that includes obtaining a three dimensional image of a body portion containing a targeted structure and selected reference structures; determining a set of landmark point coordinates for defining the location of each of the targeted and reference structures; computing triangulation parameters relating the location of the landmark points for the targeted structure and the reference structures; and, during an image-guided procedure, using the computed triangulation parameters to plot an estimated location of the targeted structure on an intra-operative image in which the reference structures have been identified.
摘要翻译：一种用于在图像引导过程中定位内部身体结构的方法，包括获得包含目标结构和所选择的参考结构的身体部分的三维图像; 确定用于定义每个所述目标和参考结构的位置的一组地标点坐标; 计算与目标结构和参考结构的地标点的位置相关的三角测量参数; 并且在图像引导过程期间，使用所计算的三角测量参数来绘制目标结构在已经识别了参考结构的手术中图像上的估计位置。

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