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1. 发明授权

US08249683B2 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US08249683B2
公开(公告)日：2012-08-21
申请号：US12826497
申请日：2010-06-29
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

2. 发明授权

US07774038B2 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US07774038B2
公开(公告)日：2010-08-10
申请号：US11323216
申请日：2005-12-30
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/05 , A61B5/00 , G01N33/50 , G01N33/487
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

3. 发明授权

US09125607B2 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US09125607B2
公开(公告)日：2015-09-08
申请号：US13340562
申请日：2011-12-29
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/1473 , A61B5/1468 , A61B5/1495 , A61B5/1486 , A61B5/00 , A61B5/145 , A61M5/172
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

4. 发明授权

US09125608B2 Real-time self-calibrating sensor system and method 有权
公开(公告)号：US09125608B2
公开(公告)日：2015-09-08
申请号：US13550508
申请日：2012-07-16
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/1495 , A61B5/1468 , A61B5/1486 , A61B5/1473 , A61B5/00 , A61B5/145 , A61M5/172
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.

5. 发明申请

US20120310063A1 REAL-TIME SELF-CALIBRATING SENSOR SYSTEM AND METHOD 有权
公开(公告)号：US20120310063A1
公开(公告)日：2012-12-06
申请号：US13550508
申请日：2012-07-16
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/1473
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.

6. 发明申请

US20100324853A1 REAL-TIME SELF-CALIBRATING SENSOR SYSTEM AND METHOD 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US20100324853A1
公开(公告)日：2010-12-23
申请号：US12826497
申请日：2010-06-29
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： G01D18/00
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

7. 发明申请

US20070163894A1 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US20070163894A1
公开(公告)日：2007-07-19
申请号：US11323216
申请日：2005-12-30
申请人： Lu Wang , Rajiv Shah , Wayne Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne Morgan , Barry Keenan
IPC分类号： G01F1/64 , A61B5/05 , G01N17/00 , G01N31/00 , C12N9/00 , C25B11/00
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

8. 发明授权

US07783442B2 System and methods for calibrating physiological characteristic sensors 有权
标题翻译：用于校准生理特征传感器的系统和方法
公开(公告)号：US07783442B2
公开(公告)日：2010-08-24
申请号：US11931866
申请日：2007-10-31
申请人： John C. Mueller, Jr. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
发明人： John C. Mueller, Jr. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
IPC分类号： G06F17/40 , G06F17/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2560/0223
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered.
摘要翻译：一种校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据，从参考源获取参考葡萄糖值，该参考源在时间上与以预定间隔获得的葡萄糖监测数据相对应，使用参考葡萄糖值和相应的葡萄糖监测数据，以回收所获得的葡萄糖监测数据，并使用校准特征校准获得的葡萄糖监测数据。在另外的实施例中，校准特性的计算包括线性回归，并且在特定实施例中包括最小二乘线性回归。或者，校准特性的计算包括非线性回归。可以验证数据完整性，并且可以对数据进行过滤。

9. 发明申请

US20100268477A1 Systems and Methods for Calibrating Physiological Characteristic Sensors 有权
标题翻译：校准生理特征传感器的系统和方法
公开(公告)号：US20100268477A1
公开(公告)日：2010-10-21
申请号：US12827851
申请日：2010-06-30
申请人： John C. Mueller, JR. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
发明人： John C. Mueller, JR. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
IPC分类号： G12B13/00 , G06F19/00 , G01N33/66
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2560/0223
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered. Further, calibration techniques may be modified during a fast rate of change in the patient's blood glucose level to increase sensor accuracy.
摘要翻译：一种校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据，从参考源获取参考葡萄糖值，该参考源在时间上与以预定间隔获得的葡萄糖监测数据相对应，使用参考葡萄糖值和相应的葡萄糖监测数据，以回收所获得的葡萄糖监测数据，并使用校准特征校准获得的葡萄糖监测数据。在另外的实施例中，校准特性的计算包括线性回归，并且在特定实施例中包括最小二乘线性回归。或者，校准特性的计算包括非线性回归。可以验证数据完整性，并且可以对数据进行过滤。此外，可以在患者血糖水平的快速变化率期间修改校准技术以提高传感器精度。

10. 发明申请

US20090112478A1 Modified Sensor Calibration Algorithm 有权
标题翻译：改进的传感器校准算法
公开(公告)号：US20090112478A1
公开(公告)日：2009-04-30
申请号：US11931866
申请日：2007-10-31
申请人： John C. Mueller, JR. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
发明人： John C. Mueller, JR. , Desmond Barry Keenan , Lu Wang , John J. Mastrototaro
IPC分类号： G01N33/50 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2560/0223
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals, obtaining reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals, calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data, and calibrating the obtained glucose monitor data using the calibration characteristics. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered. Further, calibration techniques may be modified during a fast rate of change in the patient's blood glucose level to increase sensor accuracy.
摘要翻译：一种校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据，从参考源获取参考葡萄糖值，该参考源在时间上与以预定间隔获得的葡萄糖监测数据相对应，使用参考葡萄糖值和相应的葡萄糖监测数据，以回收所获得的葡萄糖监测数据，并使用校准特征校准获得的葡萄糖监测数据。在另外的实施例中，校准特性的计算包括线性回归，并且在特定实施例中包括最小二乘线性回归。或者，校准特性的计算包括非线性回归。可以验证数据完整性，并且可以对数据进行过滤。此外，可以在患者血糖水平的快速变化率期间修改校准技术以提高传感器精度。

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