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1. 发明授权

US08712519B1 Closed-loop adaptive adjustment of pacing therapy based on cardiogenic impedance signals detected by an implantable medical device 有权
标题翻译：基于由可植入医疗设备检测到的心源性阻抗信号的起搏治疗的闭环自适应调整
公开(公告)号：US08712519B1
公开(公告)日：2014-04-29
申请号：US11558194
申请日：2006-11-09
申请人： Dorin Panescu , Weiqun Yang , Louis Wong , Nils Holmstrom , Andre Walker
发明人： Dorin Panescu , Weiqun Yang , Louis Wong , Nils Holmstrom , Andre Walker
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/3684
摘要： Techniques are provided for controlling therapy provided by the implantable cardiac stimulation device based on cardiogenic impedance. A cardiogenic impedance signal (or intracardiac impedance signal) is an impedance signal representative of the beating of the heart of the patient in which the device is implanted. The cardiogenic impedance signal is sensed along a sensing vector passing through at least a portion of the heart so that the sensed impedance is affected by the mechanical beating of the heart along that sensing vector. Pacing therapy is automatically and adaptively adjusted based on the cardiogenic impedance signal. For example, pacing timing parameters such as the atrioventricular delay and the inter-ventricular delay may be adjusted. Preferably, the adjustments are adaptive, i.e. the adjustments are performed in a closed-loop so as to adapt the adjustments to changes in the cardiogenic impedance signal so as to optimize therapy. In one particular example, the adjustments are performed so as to reduce a degree of fractionation within a cardiogenic impedance waveform.
摘要翻译：提供技术用于基于心源性阻抗来控制由可植入心脏刺激装置提供的治疗。心源性阻抗信号（或心内阻抗信号）是表示装置植入的患者的心跳的阻抗信号。沿着通过心脏的至少一部分的感测矢量感测心源性阻抗信号，使得感测到的阻抗受到沿着该感测向量的心脏的机械跳动的影响。基于心源阻抗信号自动调整起搏治疗。例如，可以调整起搏定时参数，例如房室延迟和心室间延迟。优选地，调整是自适应的，即，在闭环中进行调整，以使调整适应于心源阻抗信号的变化，以便优化治疗。在一个具体示例中，执行调整以便降低心源阻抗波形内的分级程度。

2. 发明申请

US20100030294A1 IMPLANTABLE CARDIAC DEVICE WITH SATELLITE REFRESH 有权
标题翻译：具有卫星刷新功能的可携带心脏器具
公开(公告)号：US20100030294A1
公开(公告)日：2010-02-04
申请号：US12183438
申请日：2008-07-31
申请人： Louis Wong , Dorin Panescu
发明人： Louis Wong , Dorin Panescu
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/37288 , A61N1/378
摘要： In one embodiment an implantable cardiac device is provided that includes an implantable cardiac stimulation device with an implantable satellite device coupled to it. The implantable satellite device has a charge storage device. The implantable stimulation device having a refresh generator configured to generate a charge and voltage balanced multi-phasic refresh signal with a duration less than a capacitive time constant of an electro-electrolyte interface of the implantable cardiac device and transmit the charge and voltage balanced multi-phasic refresh signal to the implantable satellite device for charging the charge storage device. In various embodiments, the charge and voltage balanced multi-phasic refresh signal having alternating phase signs and null durations between the alternating phases. In some embodiments, the refresh generator is configured to modulate the multi-phasic waveform refresh signal. The multi-phasic waveform refresh signal may be modulated to contain configuration information, status information, or other information.
摘要翻译：在一个实施例中，提供了可植入的心脏装置，其包括可植入的心脏刺激装置，其中可植入的卫星装置与其联接。可植入式卫星装置具有电荷存储装置。该可植入刺激装置具有刷新发生器，其被配置为产生具有小于可植入心脏装置的电解质界面的电容时间常数的持续时间的充电和电压平衡多相刷新信号，相位刷新信号到可植入式卫星装置，用于对电荷存储装置充电。在各种实施例中，充电和电压平衡的多相刷新信号在交替相位之间具有交替的相位符号和空持续时间。在一些实施例中，刷新发生器配置成调制多相波形刷新信号。可以调制多相波形刷新信号以包含配置信息，状态信息或其他信息。

3. 发明授权

US07221977B1 Method and apparatus for measuring battery depletion in implantable medical devices 有权
标题翻译：用于测量可植入医疗器械中电池耗尽的方法和装置
公开(公告)号：US07221977B1
公开(公告)日：2007-05-22
申请号：US10877215
申请日：2004-06-25
申请人： Lyle Weaver , Charles Neder , Louis Wong
发明人： Lyle Weaver , Charles Neder , Louis Wong
IPC分类号： A61N1/00
CPC分类号： A61N1/3708 , A61N1/08
摘要： A method and apparatus for measuring battery depletion in an implantable medical device is presented. The apparatus includes first and second switch pairs disposed in series between the battery and a load, and connected in a parallel arrangement with respect to one another. A capacitor is connected in a first polarity between the battery and the load when only first and fourth switches are closed and in a second polarity when only second and third switches are closed. A comparator circuit causes the switches to reverse the capacitor's polarity based on a comparison of the voltage drop across the capacitor to a threshold value. A counter counts the number of times the capacitor reverses polarity, which is proportional to the amount of charge transferred from the battery during its lifetime in the device and indicative of the battery's level of depletion.
摘要翻译：提出了一种用于测量可植入医疗装置中的电池消耗的方法和装置。该装置包括串联设置在电池和负载之间的第一和第二开关对，并且以相对于彼此并联的方式连接。当仅第一和第四开关闭合时，电容器以电池和负载之间的第一极性连接，并且当仅第二和第三开关闭合时，电容器以第二极性连接。比较器电路使得开关根据电容器两端的电压降与阈值的比较来反转电容器的极性。计数器对电容器反转极性的次数进行计数，这与在器件寿命期间从电池传输的电荷量成比例，并指示电池的耗尽水平。

4. 发明申请

US20160195486A1 Method and Apparatus for Detection, Identification and Quantification of Chemical or Biological Material through Modification of Operating Conditions 审中-公开
标题翻译：用于通过改变操作条件来检测，鉴定和定量化学或生物材料的方法和装置
公开(公告)号：US20160195486A1
公开(公告)日：2016-07-07
申请号：US14590950
申请日：2015-01-06
申请人： Mahmood Anvar , Louis Wong
发明人： Mahmood Anvar , Louis Wong
IPC分类号： G01N27/04 , G01N27/12
CPC分类号： G01N27/14 , G01N27/126 , G01N33/0031
摘要： A sensors reading when exposed to different chemical compounds changes if an operating condition of the sensor such as temperature, pressure, electromagnetic field intensity, light or radiation level is modified and the amount of change is different for different compounds. This invention uses this phenomenon to identify and quantify the concentration of the compound.
摘要翻译：如果传感器的工作状态如温度，压力，电磁场强度，光或辐射水平被修改，并且不同化合物的变化量不同，则暴露于不同化学物质的传感器读数会发生变化。本发明使用这种现象来鉴定和定量化合物的浓度。

5. 发明授权

US08306623B2 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US08306623B2
公开(公告)日：2012-11-06
申请号：US13149507
申请日：2011-05-31
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

6. 发明授权

US07945326B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US07945326B1
公开(公告)日：2011-05-17
申请号：US11684677
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

7. 发明申请

US20080221477A1 Method and Implantable Medical Device for Measuring an Electrical Bio-Impedance of a Patient 失效
标题翻译：用于测量患者的电生物阻抗的方法和植入式医疗装置
公开(公告)号：US20080221477A1
公开(公告)日：2008-09-11
申请号：US12088996
申请日：2005-10-11
申请人： Allan Olson , Louis Wong
发明人： Allan Olson , Louis Wong
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0538 , A61N1/36521
摘要： In a method and device for measuring an electrical bio-impedance of a patient at least one impedance measurement signal is generated by a current pulse generator, the signal having at least one asymmetric multiphasic impedance measurement waveform that is asymmetric in term of pulse amplitude and/or pulse width relative to the operating voltage of the current pulse generator. The waveform has a DC component that is substantially equal to zero, and is adapted to the available voltage headroom of an implantable device that contains the current pulse generator. The impedance measurement signal with the aforementioned waveform is applied to a patient and a resulting impedance signal is produced thereby, from which at least one impedance value is determined.
摘要翻译：在用于测量患者的电生物阻抗的方法和装置中，至少一个阻抗测量信号由电流脉冲发生器产生，所述信号具有至少一个不对称的多个非对称多相阻抗测量波形，其在脉冲幅度和/ 或相对于电流脉冲发生器的工作电压的脉冲宽度。该波形具有基本上等于零的直流分量，并且适用于包含电流脉冲发生器的可植入装置的可用电压余量。将具有上述波形的阻抗测量信号施加到患者，并且由此产生所得到的阻抗信号，从该阻抗信号确定至少一个阻抗值。

8. 发明申请

US20070288186A1 Methods of use of substrate having properties of keratinous tissue 有权
标题翻译：使用具有角质组织性质的底物的方法
公开(公告)号：US20070288186A1
公开(公告)日：2007-12-13
申请号：US11702404
申请日：2007-02-05
申请人： Saswati Datta , William Belcher , Sandra Murawski , Mannie Clapp , Steven Page , Magda El-Nokaly , Richard Tweddell , Sohini Paldey , Louis Wong , Ronald Warner , Kerstin Nolkrantz , Chitra Laxmanan , Brian Ranade , Jianjun Li , Randall Marsh , Maria Sanchez Pena
发明人： Saswati Datta , William Belcher , Sandra Murawski , Mannie Clapp , Steven Page , Magda El-Nokaly , Richard Tweddell , Sohini Paldey , Louis Wong , Ronald Warner , Kerstin Nolkrantz , Chitra Laxmanan , Brian Ranade , Jianjun Li , Randall Marsh , Maria Sanchez Pena
IPC分类号： G01N33/48 , G01M19/00 , G06G7/58 , G01N19/02
CPC分类号： G01N19/02 , G01N2030/025 , G01N2203/0246
摘要： Method of product evaluation comprising the steps of applying at least one substance to a surface of an artificial substrate to form a substance-coated surface, wherein the substrate surface demonstrates at least one physical property selected from the group consisting of a total surface energy of from about 15 mJ/m2 to about 50 mJ/m2, a polar component of the total surface energy of from about 0 mJ/m2 to about 15 mJ/m2, a zeta-potential at a pH of about 5.0 of from about −30 mV to about 30 mV, and combinations thereof, and performing at least one analysis of the substance-coated surface.
摘要翻译：产品评估方法包括以下步骤：将至少一种物质施加到人造基底的表面以形成物质涂覆的表面，其中所述基底表面显示出至少一种物理性质，所述物理性质选自以下物质的总表面能：约15mJ / m 2至约50mJ / m 2，总表面能的极性分量为约0mJ / m 2 / >约15mJ / m 2，pH约为5.0，约-30mV至约30mV的ζ电位及其组合，并进行至少一种物质分析涂层表面。

9. 发明申请

US20120053470A1 TISSUE CHARACTERIZATION USING INTRACARDIAC IMPEDANCES WITH AN IMPLANTABLE LEAD SYSTEM 有权
标题翻译：使用具有可植入引导系统的入侵者抵抗的组织特征
公开(公告)号：US20120053470A1
公开(公告)日：2012-03-01
申请号：US13149507
申请日：2011-05-31
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
IPC分类号： A61B5/053 , A61B5/085
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

10. 发明授权

US08065005B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
公开(公告)号：US08065005B1
公开(公告)日：2011-11-22
申请号：US11684688
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

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