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1. 发明授权

US07329502B2 ZAP-70 expression as a marker for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) 有权
标题翻译： ZAP-70表达作为慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL / SLL）的标记物
公开(公告)号：US07329502B2
公开(公告)日：2008-02-12
申请号：US10309548
申请日：2002-12-03
申请人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
发明人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA mRNA or protein.
摘要翻译：已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。提供了通过确定受试者是否过表达ZAP-70 mRNA mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。

2. 发明申请

US20110236915A1 ZAP-70 EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL) 有权
标题翻译： ZAP-70表达作为慢性淋巴细胞淋巴瘤/小淋巴细胞淋巴瘤（CLL / SLL）的标记物
公开(公告)号：US20110236915A1
公开(公告)日：2011-09-29
申请号：US13155198
申请日：2011-06-07
申请人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
发明人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
IPC分类号： G01N33/53 , C12Q1/48
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA mRNA or protein.
摘要翻译：已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。提供了通过确定受试者是否过表达ZAP-70 mRNA mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。

3. 发明授权

US08748114B2 ZAP-70 expression as a marker for chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL) 有权
标题翻译： ZAP-70表达作为慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL / SLL）的标记物
公开(公告)号：US08748114B2
公开(公告)日：2014-06-10
申请号：US13155198
申请日：2011-06-07
申请人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
发明人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA or protein.
摘要翻译：已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。提供了通过确定受试者是否过表达ZAP-70 mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。

4. 发明授权

US07981610B2 ZAP-70 expression as a marker for chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL) 有权
标题翻译： ZAP-70表达作为慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL / SLL）的标记物
公开(公告)号：US07981610B2
公开(公告)日：2011-07-19
申请号：US11955322
申请日：2007-12-12
申请人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
发明人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
IPC分类号： C12Q1/68
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA or protein.
摘要翻译：已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。提供了通过确定受试者是否过表达ZAP-70 mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。

5. 发明申请

US20080227741A1 ZAP-70 EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL) 有权
标题翻译： ZAP-70表达作为慢性淋巴细胞淋巴瘤/小淋巴细胞淋巴瘤（CLL / SLL）的标记物
公开(公告)号：US20080227741A1
公开(公告)日：2008-09-18
申请号：US11955322
申请日：2007-12-12
申请人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
发明人： Louis M. Staudt , Andreas Rosenwald , Wyndham Wilson , Todd S. Barry , Adrian Wiestner
IPC分类号： A61K31/7088 , C12Q1/68 , A61P35/02
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA or protein.
摘要翻译：已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。提供了通过确定受试者是否过表达ZAP-70 mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。

6. 发明申请

US20120225793A1 METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS 审中-公开
标题翻译：鉴别，诊断和预测淋巴瘤存活的方法
公开(公告)号：US20120225793A1
公开(公告)日：2012-09-06
申请号：US13409416
申请日：2012-03-01
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： C40B30/04
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G16B25/00 , G16B40/00 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

7. 发明授权

US08131475B2 Methods for identifying, diagnosing, and predicting survival of lymphomas 有权
标题翻译：识别，诊断和预测淋巴瘤存活的方法
公开(公告)号：US08131475B2
公开(公告)日：2012-03-06
申请号：US11493387
申请日：2006-07-25
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： G01N33/48 , C12Q1/68 , G06G7/58
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

8. 发明申请

US20150132297A1 SURVIVAL PREDICTOR FOR DIFFUSE LARGE B CELL LYMPHOMA 审中-公开
标题翻译：用于DIFFUSE大型B细胞淋巴瘤的存活预防剂
公开(公告)号：US20150132297A1
公开(公告)日：2015-05-14
申请号：US14540302
申请日：2014-11-13
申请人： Lisa Rimsza , Andrew T. Lister , Wing C. Chan , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaloy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
发明人： Lisa Rimsza , Andrew T. Lister , Wing C. Chan , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaloy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.
摘要翻译：本发明提供了与DLBCL患者的基于表达的生存预测因子相关的方法和材料。

9. 发明申请

US20110195064A1 SURVIVAL PREDICTOR FOR DIFFUSE LARGE B CELL LYMPHOMA 审中-公开
标题翻译：用于DIFFUSE大型B细胞淋巴瘤的生存预后
公开(公告)号：US20110195064A1
公开(公告)日：2011-08-11
申请号：US12996489
申请日：2009-06-05
申请人： Lisa Rimsza , Andrew T. Lister , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaloy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
发明人： Lisa Rimsza , Andrew T. Lister , Dennis Weisenburger , Jan Delabie , Erlend B. Smeland , Harald Holte , Stein Kvaloy , Rita M. Braziel , Richard I. Fisher , Pedro Jares , Armando Lopez-Guillermo , Elias Campo Guerri , Elaine S. Jaffe , Georg Lenz , Wyndham H. Wilson , George Wright , Sandeep S. Dave , Louis M. Staudt , Randy D. Gascoyne , Joseph M. Connors , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , German Ott
IPC分类号： A61K39/395 , C40B30/00 , A61P35/00 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
摘要翻译：本发明提供了与弥漫性大B细胞淋巴瘤（DLBCL）患者的基于基因表达的存活预测因子相关的方法和材料。

10. 发明授权

US07711492B2 Methods for diagnosing lymphoma types 有权
标题翻译：诊断淋巴瘤类型的方法
公开(公告)号：US07711492B2
公开(公告)日：2010-05-04
申请号：US10934930
申请日：2004-09-03
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan
IPC分类号： G01N33/48 , C12Q1/68 , C12N15/00 , C12N15/11
CPC分类号： G06F19/24 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G06F19/20 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

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