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1. 发明授权

US07530688B2 Decorative magnetic attachments to enhance eyewear 有权
标题翻译：装饰磁性附件，以增强眼镜
公开(公告)号：US07530688B2
公开(公告)日：2009-05-12
申请号：US12082297
申请日：2008-04-10
申请人： Thomas Grogan , Melissa Blais
发明人： Thomas Grogan , Melissa Blais
IPC分类号： G02C11/02
CPC分类号： G02C11/02 , G02C2200/02
摘要： Decorative elements magnetically attachable to, removable from and/or interchangeable with eyewear frames comprise decorative element mounting means having a recess for receiving a magnet and cooperating with a recess on the eyewear frame which receives the mounting means. The two recesses are generally opposed in direction such that the recess on the mounting means and the magnet therein are both received internally by the recess on the eyewear frame with the magnet being sufficiently close to the internal metal or wire reinforcement of the frame to be attracted thereto.
摘要翻译：磁性地可附接到眼镜框架和/或可互换的装饰元件包括装饰元件安装装置，其具有用于容纳磁体的凹部并与接收安装装置的眼镜框架上的凹部配合。两个凹槽通常在方向上相对，使得安装装置上的凹部和其中的磁体两者都被眼镜框架上的凹部内部容纳，其中磁体足够靠近待吸引的框架的内部金属或钢丝网加强件到此。

2. 发明申请

US20060252025A1 Low temperature deparaffinization 审中-公开
标题翻译：低温脱蜡
公开(公告)号：US20060252025A1
公开(公告)日：2006-11-09
申请号：US11319118
申请日：2005-12-21
申请人： Hiro Nitta , Thomas Grogan , Kenji Sonoda , Eiko Munechika
发明人： Hiro Nitta , Thomas Grogan , Kenji Sonoda , Eiko Munechika
IPC分类号： A01N1/02 , G01N1/30
CPC分类号： G01N1/36 , G01N1/30 , G01N1/31 , G01N1/312
摘要： Methods and apparatuses for gently removing embedding media from biological samples at temperatures below the embedding medium melting point with liquid composition using batch methods or automated instruments prior to immunohistochemical (IHC), in situ hybridization (ISH) or other special staining or histochemical or cytochemical manipulations.
摘要翻译：在免疫组织化学（IHC），原位杂交（ISH）或其他特殊染色或组织化学或细胞化学操作之前，使用分批方法或自动化仪器，用液体组合物在低于包埋介质熔点的温度下轻轻地从生物样品中去除包埋介质的方法和装置。

3. 发明申请

US20060246536A1 Xenograft tissue control for histology 审中-公开
公开(公告)号：US20060246536A1
公开(公告)日：2006-11-02
申请号：US11416362
申请日：2006-05-01
申请人： Margaret Hardy , Thomas Grogan , Ray Nagle
发明人： Margaret Hardy , Thomas Grogan , Ray Nagle
IPC分类号： G01N1/30 , C12N5/06 , C12N5/08
CPC分类号： G01N33/5005 , G01N1/30 , G01N1/312 , G01N2001/2893 , G01N2015/1018
摘要： An embodiment of the invention is a method of using a xenograft as a control tissue for histology, comprising staining both a patient and a xenograft-derived control sample under substantially similar staining conditions, and assessing the staining outcomes of the two to determine whether the stain was effective for the patient sample. A xenograft has never been used before in histology as a control, as far as the inventors know. The result of using a xenograft as a control is surprisingly advantageous. First, the cell lines grow and differentiate similarly to a human, taking on the general morphology of a real tissue sample. Second, because the same transformed cell line can be grown limitless times in SCID mice, the xenograft control is highly reproducible, leading to a consistent artificial control that is highly manufacturable and subject to genetic manipulation so that antigens or genetic elements may be embedded in the tissue. Another embodiment of the invention is directed generally to a method of making a tissue control substrate, comprising growing a xenograft from a mammalian transformed cell line in a host animal, removing the xenograft from the host animal, processing the xenograft thereby embedding the xenograft tissue in an embedding medium, and finally affixing the embedded xenograft sample onto a substrate. The substrate is generally a microscope slide. The xenograft control slide can then be stained side-by-side with a specimen sample in an automated slide stainer, and act as a control against which the staining quality can be compared. The xenograft control can also be used as a manual staining control. Determining whether the staining was effective for the patient specimen comprises judging the staining intensity of the xenograft control sample to determine if the expected degree and type of staining were realized in the control. If the expected type (nuclear, membranous, or cytoplasmic) and degree (0-4 scale) of staining are realized during the run, then the xenograft control indicates the staining process and reagents are working properly, and so the result in the patient specimen can be trusted. A further embodiment of the invention is a xenograft-derived control slide for histochemical use, comprising at least one xenograft control sample prepared for histological use, and a sample slide upon which the at least one xenograft control sample is affixed.

4. 发明授权

US06933117B2 Reagents and methods for automated hybridization 有权
标题翻译：用于自动化杂交的试剂和方法
公开(公告)号：US06933117B2
公开(公告)日：2005-08-23
申请号：US10136714
申请日：2002-04-30
申请人： Catherine Wolf , Hiroaki Nitta , Thomas Grogan , Jacques Cavadenti , Lidija Pestic-Dragovich , Anthony Hartman , Angela Sattler , Jennifer Wong
发明人： Catherine Wolf , Hiroaki Nitta , Thomas Grogan , Jacques Cavadenti , Lidija Pestic-Dragovich , Anthony Hartman , Angela Sattler , Jennifer Wong
IPC分类号： G01N33/53 , C07H21/02 , C07H21/04 , C12N1/08 , C12P19/34 , C12Q1/68 , G01N33/543 , G01N37/00
CPC分类号： C12Q1/6837 , C12Q1/6832 , C12Q1/6841 , C12Q2527/137 , C12Q2527/125
摘要： The invention provides novel reagents, reagent kits, and methods for automated hybridization. More particularly, the invention provides reagents, reagent kits, and methods for automated in situ hybridization and automated hybridization on a microarray. The use of automated instruments for in situ hybridization and microarray hybridization dramatically reduces the amount of labor and time involved and also facilitates standardization of protocols and consistency between results.
摘要翻译：本发明提供了用于自动化杂交的新型试剂，试剂盒和方法。更具体地，本发明提供用于微阵列自动原位杂交和自动杂交的试剂，试剂盒和方法。使用自动化仪器进行原位杂交和微阵列杂交显着减少了劳动和时间，并促进了协议的标准化和结果之间的一致性。

5. 发明申请

US20110136130A1 METHOD FOR CHROMOGENIC DETECTION OF TWO OR MORE TARGET MOLECULES IN A SINGLE SAMPLE 有权
标题翻译：用于在单个样品中检测两种或更多种目标分子的方法
公开(公告)号：US20110136130A1
公开(公告)日：2011-06-09
申请号：US13059274
申请日：2009-08-21
申请人： Richard Gniewek , Michael Farrell , Hiroaki Nitta , Megan Lehrkamp , Jerome Kosmeder , Brian Daniel Kelly , Fabien Gaire , Mary Padilla , Thomas Grogan , Christopher Bieniarz
发明人： Richard Gniewek , Michael Farrell , Hiroaki Nitta , Megan Lehrkamp , Jerome Kosmeder , Brian Daniel Kelly , Fabien Gaire , Mary Padilla , Thomas Grogan , Christopher Bieniarz
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6841 , G01N33/53 , G01N33/581 , G01N33/583
摘要： The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule.
摘要翻译：本发明提供了用于检测单个组织样品中两种或更多种靶分子的方法和试剂盒，例如用于单一组织样品中的基因和蛋白质双重检测。方法包括用特异性结合第一靶分子的第一结合部分处理组织样品。方法还包括在使组织样品与半抗原标记的结合部分接触或同时检测第二靶分子之前或同时使用含有可溶于富电子的芳族化合物的溶液处理组织样品。在一个实例中，第一靶分子是蛋白质，第二个是核酸序列，第一个靶分子通过免疫组织化学检测，第二个是原位杂交。所公开的方法由于半抗原标记的特异性结合部分与沉积在第一靶分子附近的不溶性富电子化合物的非特异性结合而减少背景。

6. 发明申请

US20050153453A1 Automated biological reaction apparatus 失效
公开(公告)号：US20050153453A1
公开(公告)日：2005-07-14
申请号：US10991050
申请日：2004-11-17
申请人： Keith Copeland , Thomas Grogan , Charles Hassen , William Humphreys , Charles Lemme , Phillip Miller , William Richards , Wayne Showalter
发明人： Keith Copeland , Thomas Grogan , Charles Hassen , William Humphreys , Charles Lemme , Phillip Miller , William Richards , Wayne Showalter
IPC分类号： B01F5/00 , B01F13/00 , B01F13/02 , G01N1/30 , G01N1/31 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： G01N35/10 , B01F5/0057 , B01F13/0059 , B01F13/02 , B01F13/0272 , B01F2215/0037 , G01N1/312 , G01N35/025 , G01N35/1002 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.

7. 发明申请

US20130034853A1 TWO-COLOR CHROMOGENIC IN SITU HYBRIDIZATION 审中-公开
标题翻译：双色混合中的双色变色
公开(公告)号：US20130034853A1
公开(公告)日：2013-02-07
申请号：US13640301
申请日：2011-04-20
申请人： Brian Kelly , Hiro Nitta , Thomas Grogan , Larry Morrison
发明人： Brian Kelly , Hiro Nitta , Thomas Grogan , Larry Morrison
IPC分类号： G01N21/76
CPC分类号： C12Q1/6841 , C12Q2600/118 , C12Q2600/16 , C12Q2563/131
摘要： The present invention relates to systems and processes for chromogenic in situ hybridization (CISH), and in particular to methods that prevent interference between two or more color detection systems in a single assay. The present invention also relates to processes for scoring assays utilizing break-apart probes.
摘要翻译：本发明涉及用于显色原位杂交（CISH）的系统和方法，特别涉及在单次测定中防止两种或更多种颜色检测系统之间的干扰的方法。本发明还涉及利用断裂探针评分测定法的方法。

8. 发明申请

US20120225793A1 METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS 审中-公开
标题翻译：鉴别，诊断和预测淋巴瘤存活的方法
公开(公告)号：US20120225793A1
公开(公告)日：2012-09-06
申请号：US13409416
申请日：2012-03-01
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： C40B30/04
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G16B25/00 , G16B40/00 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

9. 发明授权

US08131475B2 Methods for identifying, diagnosing, and predicting survival of lymphomas 有权
标题翻译：识别，诊断和预测淋巴瘤存活的方法
公开(公告)号：US08131475B2
公开(公告)日：2012-03-06
申请号：US11493387
申请日：2006-07-25
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： G01N33/48 , C12Q1/68 , G06G7/58
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

10. 发明申请

US20070105136A1 Methods for identifying, diagnosing, and predicting survival of lymphomas 有权
标题翻译：识别，诊断和预测淋巴瘤存活的方法
公开(公告)号：US20070105136A1
公开(公告)日：2007-05-10
申请号：US11493387
申请日：2006-07-25
申请人： Louis Staudt , George Wright , Sandeep Dave , Bruce Tan , John Powell , Wyndham Wilson , Elaine Jaffe , Wing Chan , Timothy Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis Staudt , George Wright , Sandeep Dave , Bruce Tan , John Powell , Wyndham Wilson , Elaine Jaffe , Wing Chan , Timothy Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测因子。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。该信息将有助于开发与特定受试者一起使用的治疗方法。

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