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1. 发明申请

US20100222872A1 Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers 审中-公开
标题翻译：用生物可吸收载体处理病变部位的方法，组成和装置
公开(公告)号：US20100222872A1
公开(公告)日：2010-09-02
申请号：US12782656
申请日：2010-05-18
申请人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica Desnoyer , Florian N. Ludwig
发明人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica Desnoyer , Florian N. Ludwig
IPC分类号： A61F2/82 , A61F2/00
CPC分类号： A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.
摘要翻译：公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响组织和/或器官。另外公开了用包括颗粒的涂层制造的植入式医疗装置或嵌入在医疗装置内的植入式医疗装置。

2. 发明申请

US20110027188A1 Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers 审中-公开
标题翻译：用生物可吸收载体处理病变部位的方法，组成和装置
公开(公告)号：US20110027188A1
公开(公告)日：2011-02-03
申请号：US12901402
申请日：2010-10-08
申请人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian N. Ludwig
发明人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian N. Ludwig
IPC分类号： A61K49/00 , A61K9/00 , A61K38/00 , A61K38/18 , A61K39/395 , A61P9/00 , A61P9/10 , A61F2/86
CPC分类号： A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the device is implanted in a patient. The smaller particles and the larger particles are made of bioabsorbable metal, glass or ceramic. A substance can be associated with the smaller particles. The larger particles can be embedded within at least a portion of the device.
摘要翻译：公开了一种植入式医疗装置，其具有包含在多个较大颗粒中的多个较小颗粒，并且构造成当将该装置植入患者时从较大颗粒释放。较小的颗粒和较大的颗粒由生物可吸收的金属，玻璃或陶瓷制成。物质可以与较小的颗粒相关联。较大的颗粒可以嵌入装置的至少一部分内。

3. 发明授权

US08735344B2 Sustained release of APO A-I mimetic peptides and methods of treatment 有权
标题翻译： APO A-I模拟肽的持续释放和治疗方法
公开(公告)号：US08735344B2
公开(公告)日：2014-05-27
申请号：US13177476
申请日：2011-07-06
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： C07K14/775 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。

4. 发明授权

US08785382B2 Lipid therapy 失效
标题翻译：脂质治疗
公开(公告)号：US08785382B2
公开(公告)日：2014-07-22
申请号：US11694793
申请日：2007-03-30
申请人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
发明人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
IPC分类号： A61K38/00 , A61N1/30 , A61M31/00
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
摘要： A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
摘要翻译：一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

5. 发明授权

US07985728B1 Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
标题翻译：持续释放Apo A-I模拟肽和治疗方法
公开(公告)号：US07985728B1
公开(公告)日：2011-07-26
申请号：US11858862
申请日：2007-09-20
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny , Stephen D. Pacetti , Dariush Davalian , Syed Fayaiz Ahmed Hossainy , Florian N. Ludwig , Jinping Wan , John Stankus , Rachel Bright
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： C07K14/775 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。

6. 发明申请

US20070232539A1 LIPID THERAPY 失效
标题翻译：脂肪疗法
公开(公告)号：US20070232539A1
公开(公告)日：2007-10-04
申请号：US11694793
申请日：2007-03-30
申请人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
发明人： Deborah Kilpatrick , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Florian N. Ludwig , Paul M. Consigny , Jeffrey T. Ellis , Florencia Lim
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
摘要： A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.
摘要翻译：一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。一种组合物，其包含Apo A1和选择用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

7. 发明授权

US08888675B2 Apparatus and methods for supporting cardiac ischemic tissue 有权
标题翻译：用于支持心脏缺血组织的装置和方法
公开(公告)号：US08888675B2
公开(公告)日：2014-11-18
申请号：US12855469
申请日：2010-08-12
申请人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
发明人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
IPC分类号： A61F2/00 , A61N1/362 , A61B17/12 , A61B17/064 , A61F2/24 , A61B17/068
CPC分类号： A61F2/2487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12181 , A61B17/12186 , A61B17/12195 , A61B2017/0647 , A61L2430/20
摘要： Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds that may be placed within the heart percutaneously. A scaffold assembly may include a layer of biocompatible material detachably secured to a placement rod, such that the placement rod may be used to urge the layer of biocompatible material through a catheter to adjacent an area of ischemic tissue. Anchors may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco-elastic foam, around an inflatable member inflated within a ventricle.
摘要翻译：公开了用于支持心脏的缺血组织的装置和方法，所述支架可以经皮放置在心脏内的支架。支架组件可以包括可拆卸地固定到放置杆的生物相容性材料层，使得放置杆可以用于通过导管将生物相容性材料层推动到邻近缺血组织的区域。锚固体可以将材料层固定到心肌。可以将多层生物相容性材料分别放置在心室中以形成支架。在一些实施方案中，通过将聚合物（例如粘弹性泡沫）注射到在心室内膨胀的可充气构件的周围形成或增强支架。

8. 发明授权

US08703180B1 Multiple growth factor compositions, methods of fabrication, and methods of treatment 失效
标题翻译：多重生长因子组合物，制备方法和治疗方法
公开(公告)号：US08703180B1
公开(公告)日：2014-04-22
申请号：US11877635
申请日：2007-10-23
申请人： John J. Stankus , Florian N. Ludwig , Evgenia Mandrusov , Liangxuan Zhang , Hong Ma , Jinping Wan , Shubhayu Basu
发明人： John J. Stankus , Florian N. Ludwig , Evgenia Mandrusov , Liangxuan Zhang , Hong Ma , Jinping Wan , Shubhayu Basu
IPC分类号： A61K9/127 , A61F2/00 , A61K9/14 , C12N5/071
CPC分类号： A61K38/30 , A61K9/06 , A61K9/127 , A61K35/34 , A61K38/18 , A61K38/1825 , A61K38/1833 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/193 , A61K38/57 , A61K45/06 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/604 , A61L2300/626 , A61L2430/20 , A61K2300/00
摘要： Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.
摘要翻译：公开了具有与至少两种不同类型的生长因子相关联的持续释放载体的组合物及其制备和处理方法。在一些实施方案中，生长因子的同时释放可以是优选的，而在其它实施方案中，生长因子的顺序释放可能是优选的。至少两个生长因子施加到损伤部位，例如由心肌梗塞或缺血性心力衰竭引起的受损的心脏组织可以更好地模拟和诱导改善心脏功能所必需的复合生长因子信号传导途径。当在心肌梗死或缺血性心力衰竭后应用于患者时，持续释放载体平台或平台内的多个生长因子可能对旨在减轻左心室重塑的注射细胞产生协同效应。治疗方法包括使用导管和/或注射器的经皮，亚剑虫和胸部开胸方法。

9. 发明申请

US20090181096A1 Method Of Targeting Sustained Release Formulations Of Therapeutic Agents To Treat Lung Diseases 有权
标题翻译：靶向持续释放制剂治疗肺部疾病的方法
公开(公告)号：US20090181096A1
公开(公告)日：2009-07-16
申请号：US12014710
申请日：2008-01-15
申请人： Florian N. Ludwig
发明人： Florian N. Ludwig
IPC分类号： A61K9/14 , A61P11/00
CPC分类号： A61K9/0019 , A61K9/0024 , Y10S514/826 , Y10S514/888 , Y10S514/924 , Y10S514/951
摘要： The present invention relates to method of targeting therapeutic agents for treating lung diseases.
摘要翻译：本发明涉及靶向用于治疗肺部疾病的治疗剂的方法。

10. 发明授权

US09533127B2 Methods for inhibiting reperfusion injury 有权
标题翻译：抑制再灌注损伤的方法
公开(公告)号：US09533127B2
公开(公告)日：2017-01-03
申请号：US11492388
申请日：2006-07-24
申请人： Eugene T. Michal , Peter L. Callas , Florian N. Ludwig
发明人： Eugene T. Michal , Peter L. Callas , Florian N. Ludwig
IPC分类号： A61M31/00 , A61M25/10
CPC分类号： A61M25/104 , A61M2025/1095
摘要： A method that includes introducing a catheter assembly to an obstructed region of a blood vessel lumen and recanalizing the obstructed region with the catheter assembly is disclosed. Prior to or during recanalization, a treatment agent may be delivered through the catheter assembly to a vessel region downstream to the obstructed region. The treatment agent may have a property that will inhibit reperfusion injury. Alternatively, a medical device may be introduced to an obstructed region of a blood vessel lumen and the obstructed region recanalized with the medical device. The treatment agent may be delivered to a vessel region downstream to the obstructed region. The treatment agent may include at least one of an immunosuppresant and an antioxidant. In other methods, a delivery cannula may be introduced to an unperfused region of an occluded vessel without disrupting the occlusion and the treatment agent having a property that will inhibit reperfusion injury may be delivered to the unperfused region through the delivery cannula. After delivering the treatment agent, the occluded vessel may be recanalized by advancing an angioplasty device into the occluded vessel.
摘要翻译：公开了一种方法，其包括将导管组件引入血管内腔的阻塞区域并且用导管组件再通过阻塞区域。在再通之前或期间，处理剂可以通过导管组件递送到阻塞区域下游的血管区域。处理剂可具有抑制再灌注损伤的性质。或者，可以将医疗装置引入血管腔的阻塞区域，并且与医疗装置再通的阻塞区域。处理剂可以被输送到阻塞区域下游的容器区域。处理剂可以包括免疫抑制剂和抗氧化剂中的至少一种。在其他方法中，输送插管可以被引入封闭血管的未灌注区域而不破坏闭塞，并且具有抑制再灌注损伤的性质的治疗剂可通过输送套管输送到未灌注区域。在递送处理剂之后，通过将血管成形术装置推入闭塞的血管中，封闭的血管可以再通。

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