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1. 发明授权

US08888675B2 Apparatus and methods for supporting cardiac ischemic tissue 有权
标题翻译：用于支持心脏缺血组织的装置和方法
公开(公告)号：US08888675B2
公开(公告)日：2014-11-18
申请号：US12855469
申请日：2010-08-12
申请人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
发明人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
IPC分类号： A61F2/00 , A61N1/362 , A61B17/12 , A61B17/064 , A61F2/24 , A61B17/068
CPC分类号： A61F2/2487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12181 , A61B17/12186 , A61B17/12195 , A61B2017/0647 , A61L2430/20
摘要： Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds that may be placed within the heart percutaneously. A scaffold assembly may include a layer of biocompatible material detachably secured to a placement rod, such that the placement rod may be used to urge the layer of biocompatible material through a catheter to adjacent an area of ischemic tissue. Anchors may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco-elastic foam, around an inflatable member inflated within a ventricle.
摘要翻译：公开了用于支持心脏的缺血组织的装置和方法，所述支架可以经皮放置在心脏内的支架。支架组件可以包括可拆卸地固定到放置杆的生物相容性材料层，使得放置杆可以用于通过导管将生物相容性材料层推动到邻近缺血组织的区域。锚固体可以将材料层固定到心肌。可以将多层生物相容性材料分别放置在心室中以形成支架。在一些实施方案中，通过将聚合物（例如粘弹性泡沫）注射到在心室内膨胀的可充气构件的周围形成或增强支架。

2. 发明申请

US20120041257A1 APPARATUS AND METHODS FOR SUPPORTING CARDIAC ISCHEMIC TISSUE 有权
标题翻译：用于支持心脏组织化学组织的装置和方法
公开(公告)号：US20120041257A1
公开(公告)日：2012-02-16
申请号：US12855469
申请日：2010-08-12
申请人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
发明人： John J. Stankus , Barbara E. Stamberg , Pamela A. Kramer-Brown , Jesus Magana , Shubhayu Basu , Yuet Mei Khong , Florian N. Ludwig
IPC分类号： A61F2/00
CPC分类号： A61F2/2487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12181 , A61B17/12186 , A61B17/12195 , A61B2017/0647 , A61L2430/20
摘要： Apparatus and methods are disclosed for supporting ischemic tissue of the heart using scaffolds that may be placed within the heart percutaneously. A scaffold assembly may include a layer of biocompatible material detachably secured to a placement rod, such that the placement rod may be used to urge the layer of biocompatible material through a catheter to adjacent an area of ischemic tissue. Anchors may secure the layer of material to the myocardium. Multiple layers of biocompatible material may be placed in the ventricle separately to form the scaffold. In some embodiments, a scaffold is formed or reinforced by injecting a polymer, such as a visco-elastic foam, around an inflatable member inflated within a ventricle.
摘要翻译：公开了用于支持心脏的缺血组织的装置和方法，所述支架可以经皮放置在心脏内的支架。支架组件可以包括可拆卸地固定到放置杆的生物相容性材料层，使得放置杆可以用于通过导管将生物相容性材料层推动到邻近缺血组织的区域。锚固体可以将材料层固定到心肌。可以将多层生物相容性材料分别放置在心室中以形成支架。在一些实施方案中，通过将聚合物（例如粘弹性泡沫）注射到在心室内膨胀的可充气构件的周围形成或增强支架。

3. 发明申请

US20120190918A1 APPARATUS AND METHODS FOR SUPPORTING CARDIAC ISCHEMIC TISSUE BY MEANS OF EMBEDDED STRUCTURES 审中-公开
标题翻译：通过嵌入式结构支持心脏组织分析的装置和方法
公开(公告)号：US20120190918A1
公开(公告)日：2012-07-26
申请号：US13011850
申请日：2011-01-21
申请人： Randolf Von Oepen , Travis R. Yribarren , William E. Webler, JR. , Barbara E. Stamberg , Florian N. Ludwig , John J. Stankus , Yuet Mei Khong
发明人： Randolf Von Oepen , Travis R. Yribarren , William E. Webler, JR. , Barbara E. Stamberg , Florian N. Ludwig , John J. Stankus , Yuet Mei Khong
IPC分类号： A61F2/04
CPC分类号： A61F2/2478 , A61F2002/249 , A61F2210/0004 , A61F2210/0014
摘要： Systems and methods are disclosed for reinforcing ischemic tissue of a heart. A reinforcing element is initially positioned within a lumen of a delivery needle. The delivery needle is urged into the ischemic tissue and the reinforcing element is urged out of the needle into the ischemic tissue. The reinforcing element may be embodied as a coiled, undulating, or arcuate spring and may include a shape-memory material. A bioabsorbable material may maintain the reinforcing element in a deformed state. The reinforcing element may be tensioned as it is positioned within the myocardium in order to provide a cinching force by means of a cord lock selectively releasing the reinforcing element. The reinforcing element may be embodied as a number of spiral portions secured to a hub and urged outwardly by rotation of the hub.
摘要翻译：公开了用于增强心脏缺血组织的系统和方法。加强元件最初位于输送针的内腔内。递送针被推入缺血组织中，并且增强元件被推出针头进入缺血组织。加强元件可以被实施为卷绕的，起伏的或弓形的弹簧，并且可以包括形状记忆材料。生物可吸收材料可以将增强元件保持在变形状态。加强元件可以在其位于心肌内的状态下被张紧，以便通过选择性地释放加强元件的帘线锁提供收紧力。加强元件可以被实施为固定到毂的多个螺旋部分并且通过轮毂的旋转而被向外推动。

4. 发明授权

US08703180B1 Multiple growth factor compositions, methods of fabrication, and methods of treatment 失效
标题翻译：多重生长因子组合物，制备方法和治疗方法
公开(公告)号：US08703180B1
公开(公告)日：2014-04-22
申请号：US11877635
申请日：2007-10-23
申请人： John J. Stankus , Florian N. Ludwig , Evgenia Mandrusov , Liangxuan Zhang , Hong Ma , Jinping Wan , Shubhayu Basu
发明人： John J. Stankus , Florian N. Ludwig , Evgenia Mandrusov , Liangxuan Zhang , Hong Ma , Jinping Wan , Shubhayu Basu
IPC分类号： A61K9/127 , A61F2/00 , A61K9/14 , C12N5/071
CPC分类号： A61K38/30 , A61K9/06 , A61K9/127 , A61K35/34 , A61K38/18 , A61K38/1825 , A61K38/1833 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/193 , A61K38/57 , A61K45/06 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/604 , A61L2300/626 , A61L2430/20 , A61K2300/00
摘要： Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.
摘要翻译：公开了具有与至少两种不同类型的生长因子相关联的持续释放载体的组合物及其制备和处理方法。在一些实施方案中，生长因子的同时释放可以是优选的，而在其它实施方案中，生长因子的顺序释放可能是优选的。至少两个生长因子施加到损伤部位，例如由心肌梗塞或缺血性心力衰竭引起的受损的心脏组织可以更好地模拟和诱导改善心脏功能所必需的复合生长因子信号传导途径。当在心肌梗死或缺血性心力衰竭后应用于患者时，持续释放载体平台或平台内的多个生长因子可能对旨在减轻左心室重塑的注射细胞产生协同效应。治疗方法包括使用导管和/或注射器的经皮，亚剑虫和胸部开胸方法。

5. 发明授权

US08038991B1 High-viscosity hyaluronic acid compositions to treat myocardial conditions 有权
标题翻译：高粘度透明质酸组合物治疗心肌病症
公开(公告)号：US08038991B1
公开(公告)日：2011-10-18
申请号：US11933922
申请日：2007-11-01
申请人： John J. Stankus , Eugene Michal , Mikael Trollsas , Brandon Katz , Shubhayu Basu
发明人： John J. Stankus , Eugene Michal , Mikael Trollsas , Brandon Katz , Shubhayu Basu
IPC分类号： C12N5/00
CPC分类号： A61K31/00 , A61K9/0024 , A61K31/728 , A61K31/78 , A61K31/79 , A61K35/16 , A61K35/28 , A61K35/34 , A61K35/35 , A61K38/40 , A61K45/06 , A61K47/36 , A61L27/26 , A61L27/3804 , A61L27/3839 , A61L2430/20 , A61K2300/00 , C08L5/08
摘要： Embodiments of single component bioscaffolding systems formed of a hydrogel such as hyaluronic acid or salt thereof are described. The hyaluronic acid or salt thereof may be dissolved in a buffer, plasma, or combination thereof to minimize adverse immunogenic responses when applied to a treatment site. Additionally, the hydrogel component includes stem cells to facilitate angiogenesis or facilitate tissue repair and/or regeneration of ischemic tissue, particularly in compromised cardiac tissue. The bioscaffolding may also be formed on a stent or a cardiac medical device.
摘要翻译：描述了由诸如透明质酸或其盐的水凝胶形成的单组分生物支架系统的实施方案。透明质酸或其盐可以溶解在缓冲液，血浆或其组合中，以在施用于治疗部位时使不利的免疫原性反应最小化。此外，水凝胶组分包括促进血管发生的干细胞，或促进缺血组织的组织修复和/或再生，特别是在受损的心脏组织中。生物支架也可以形成在支架或心脏医疗装置上。

6. 发明申请

US20090035381A1 ELECTROSPRAYING METHOD FOR FABRICATION OF PARTICLES AND COATINGS AND TREATMENT METHODS THEREOF 审中-公开
标题翻译：用于制备颗粒和涂层的电喷涂方法及其处理方法
公开(公告)号：US20090035381A1
公开(公告)日：2009-02-05
申请号：US11832257
申请日：2007-08-01
申请人： John J. Stankus , Shubhayu Basu
发明人： John J. Stankus , Shubhayu Basu
IPC分类号： A61K47/30 , A61K38/18 , A61K9/14 , B29B13/08 , B29B9/00
CPC分类号： A61K9/0024 , A61K9/5031 , A61K9/5073 , A61K9/5089 , B05B5/001 , B05B5/025
摘要： Electrospray systems and modified electrospray systems for the fabrication of core-shell particles for controlled-release and/or sustained-release treatment and delivery are herein disclosed. The electrospray system may include between one and a plurality of co-axially situated tubes. Each tube may be electrically connected to a power supply wherein a voltage may be applied thereto. Core-shell particles may be collected on a collection target, which may be a wet or dry collector, and electrically connected to the power supply. Core-shell particles and methods of manufacture are also disclosed. The precursors of the core-shell particles may be polymer- or biomacromolecule-based solutions and may include at least one treatment agent incorporated therein. The number of “core” particle(s) within the “shell” may vary and may provide different treatment agent release profiles depending on the material and/or chemical characteristics of the polymer and/or biomacromolecule used. Methods of treating a condition are also disclosed. A treatment may include delivery of a plurality of core-shell particles which include a treatment agent to a treatment site. Delivery may be performed by a surgical procedure or by a non-invasive procedure such as catheter delivery.
摘要翻译：本文公开了用于制备用于控制释放和/或持续释放处理和递送的核 - 壳颗粒的电喷雾系统和改进的电喷雾系统。电喷雾系统可以包括在一个和多个同轴位于的管之间。每个管可以电连接到电源，其中可以施加电压。核 - 壳颗粒可以收集在收集目标上，其可以是湿的或干的收集器，并且电连接到电源。还公开了核 - 壳颗粒和制造方法。核 - 壳颗粒的前体可以是基于聚合物或生物大分子的溶液，并且可以包括并入其中的至少一种处理剂。 “壳”内的“芯”颗粒的数量可以变化，并且可以根据所使用的聚合物和/或生物大分子的材料和/或化学特性提供不同的处理剂释放曲线。还公开了治疗病症的方法。治疗可以包括将包括治疗剂的多个核 - 壳颗粒递送到治疗部位。可以通过外科手术或非侵入性手术（例如导管递送）进行输送。

7. 发明授权

US06876085B1 Signal layer interconnect using tapered traces 失效
标题翻译：使用锥形迹线的信号层互连
公开(公告)号：US06876085B1
公开(公告)日：2005-04-05
申请号：US10139982
申请日：2002-05-07
申请人： Martin R. Handforth , John J. Stankus
发明人： Martin R. Handforth , John J. Stankus
IPC分类号： H01R9/05 , H05K1/00 , H05K1/02 , H05K1/11 , H05K3/34 , H05K3/36 , H01L23/48 , H01R9/00 , H01R12/04
CPC分类号： H05K1/117 , H01R9/05 , H01R12/52 , H05K1/0219 , H05K1/0237 , H05K1/0298 , H05K3/3405 , H05K3/361 , H05K2201/0919 , H05K2201/09727 , H05K2201/09845 , H05K2201/1034
摘要： An interconnection device has a substrate that includes a conductive trace having an exposed portion at an edge of the substrate. The exposed portion is tapered toward the edge of the substrate. The exposed portion is provided for direct physical contact with a second conductive trace exposed at an edge of a second substrate. A high frequency direct electrical interconnection is thereby provided that reduces the disadvantageous effects of lateral, longitudinal, and co-planar misalignment between the conductive traces.
摘要翻译：互连器件具有衬底，该衬底包括在衬底的边缘处具有暴露部分的导电迹线。暴露部分朝向基板的边缘逐渐变细。暴露部分被提供用于与暴露在第二基底的边缘处的第二导电迹线直接物理接触。由此提供了高频直接电互连，其减少了导电迹线之间的横向，纵向和共平面的未对准的不利影响。

8. 发明授权

US06411758B1 Method and apparatus for aligning a waveguide to a device 有权
标题翻译：用于将波导对准设备的方法和设备
公开(公告)号：US06411758B1
公开(公告)日：2002-06-25
申请号：US09494457
申请日：2000-01-31
申请人： John J. Stankus
发明人： John J. Stankus
IPC分类号： G02B630
CPC分类号： G02B6/422 , G02B6/4206 , G02B6/4212 , G02B6/4225
摘要： An apparatus which aligns a fiber core to a detector on an integrated circuit has a transmission material connecting them which steers the light provided through the fiber core to the detector even in the case of misalignment. The transmission material chosen has a characteristic of being able to have the spatial distribution of its index of refraction altered by electrical means. In this case, an electric field is applied in the area surrounding the path from the fiber core to the detector. Thus, even if the fiber core is not aligned to the detector, the light will be directed from the fiber core to the detector due to the path being surrounded by a lower index of refraction than the path itself. Thus, there is very little loss due to misalignment between the fiber core and the detector.
摘要翻译：将纤维芯与集成电路上的检测器对准的装置具有将它们连接的传输材料，即使在未对准的情况下也将通过纤维芯提供的光转向检测器。所选择的透射材料具有能够通过电气方式改变其折射率的空间分布的特征。在这种情况下，在从光纤芯到检测器的路径周围的区域中施加电场。因此，即使光纤芯不与检测器对准，由于路径被路径自身折射率较低的折射线包围，所以光将从光纤芯线引导到检测器。因此，由于纤维芯和检测器之间的未对准，损失非常小。

9. 发明授权

US4919970A Solder deposition control 失效
标题翻译：焊接沉积控制
公开(公告)号：US4919970A
公开(公告)日：1990-04-24
申请号：US907265
申请日：1986-09-15
申请人： Karl G. Hoebener , John J. Stankus
发明人： Karl G. Hoebener , John J. Stankus
IPC分类号： B23K3/06 , H05K3/12 , H05K3/34
CPC分类号： H05K3/1233 , H05K3/12 , H05K2201/09572 , H05K2203/0139 , H05K2203/163
摘要： A technique for one step solder application through a mask to a printed circuit board (PCB) having pads for surface mountable components and through holes for a leaded components is disclosed wherein the amount of solder deposited on the pads and in the holes is simultaneously, independently controlled as a function of mask thickness, blade hardness and blade to mask angle.

10. 发明授权

US09237945B2 Bioerodible wraps and uses therefor 有权
公开(公告)号：US09237945B2
公开(公告)日：2016-01-19
申请号：US12022430
申请日：2008-01-30
申请人： Mohammed S. El-Kurdl , Yi Hong , Lorenzo Soletti , John J. Stankus , David A. Vorp , William R. Wagner
发明人： Mohammed S. El-Kurdl , Yi Hong , Lorenzo Soletti , John J. Stankus , David A. Vorp , William R. Wagner
IPC分类号： A61F2/06 , D01D5/00 , A61L27/38 , A61L27/36 , A61L27/50 , A61L27/34 , A61L27/54 , A61L27/58 , C12N5/00
CPC分类号： A61F2/06 , A61F2/07 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61L27/18 , A61L27/34 , A61L27/3625 , A61L27/3683 , A61L27/3691 , A61L27/3804 , A61L27/3826 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/604 , A61L2430/22 , C12N5/0068 , C12N2533/40 , D01D5/0007 , D01D5/0076 , D10B2331/10 , D10B2401/12 , D10B2509/06 , C08L67/04
摘要： A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.

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