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1. 发明申请

US20060252035A1 Sphks as modifiers of the p53 pathway and methods of use 审中-公开
标题翻译： Sphks作为p53途径的修饰物和使用方法
公开(公告)号：US20060252035A1
公开(公告)日：2006-11-09
申请号：US10486306
申请日：2002-08-02
申请人： Lori Friedman , Gregory Plowman , Michael Costa , Danxi Li , Roel Funke , Tak Hung
发明人： Lori Friedman , Gregory Plowman , Michael Costa , Danxi Li , Roel Funke , Tak Hung
IPC分类号： C12Q1/68 , G01N33/574 , C12Q1/48
CPC分类号： G01N33/57449 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5091 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided.
摘要翻译：人SPHK基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。提供了鉴定p53调节剂的方法，包括筛选调节SPHK活性的试剂。

2. 发明申请

US20070160539A1 HPRP4s Modifiers of the p53 Pathway and Methods of Use 失效
标题翻译： HPRP4s p53途径和使用方法的修饰符
公开(公告)号：US20070160539A1
公开(公告)日：2007-07-12
申请号：US11627831
申请日：2007-01-26
申请人： Lori Friedman , Gregory Plowman , Tak Hung , Helen Francis-Lang , Danxi Li , Roel Funke , Michael Costa
发明人： Lori Friedman , Gregory Plowman , Tak Hung , Helen Francis-Lang , Danxi Li , Roel Funke , Michael Costa
IPC分类号： A61K49/00 , C12Q1/68 , G01N33/567 , G01N33/574
CPC分类号： G01N33/57449 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5091 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.
摘要翻译：人hPRP4基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。提供了鉴定p53调节剂的方法，包括筛选调节hPRP4活性的试剂。

3. 发明授权

US07993829B2 HPRP4s modifiers of the p53 pathway and methods of use 失效
标题翻译： HPRP4s p53途径的修饰和使用方法
公开(公告)号：US07993829B2
公开(公告)日：2011-08-09
申请号：US11627831
申请日：2007-01-26
申请人： Lori Friedman , Gregory D. Plowman , Tak Hung , Helen Francis-Lang , Danix Li , Roel P. Funke , Michael Costa
发明人： Lori Friedman , Gregory D. Plowman , Tak Hung , Helen Francis-Lang , Danix Li , Roel P. Funke , Michael Costa
IPC分类号： C12Q1/68
CPC分类号： G01N33/57449 , C12Q1/485 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5091 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/68 , G01N33/6842 , G01N33/6875 , G01N2500/00 , G01N2510/00
摘要： Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.
摘要翻译：人hPRP4基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。提供了鉴定p53调节剂的方法，包括筛选调节hPRP4活性的试剂。

4. 发明申请

US20060084063A1 Rabs as modifiers of the p53 pathway and methods of use 审中-公开
标题翻译： Rabs作为p53途径的修饰剂和使用方法
公开(公告)号：US20060084063A1
公开(公告)日：2006-04-20
申请号：US10520836
申请日：2003-07-09
申请人： Michael Costa , Mark Maxwell , Mark Lackner , Tak Hung , Carol OBrien , Timothy Heuer , Kim Lickteig
发明人： Michael Costa , Mark Maxwell , Mark Lackner , Tak Hung , Carol OBrien , Timothy Heuer , Kim Lickteig
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/53
CPC分类号： G01N33/5743 , C07K14/4702 , G01N33/5011 , G01N33/57438 , G01N2333/4719 , G01N2333/82 , G01N2510/00
摘要： Human RAB genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of RAB are provided.
摘要翻译：人RAB基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。提供了鉴定p53调节剂的方法，包括筛选调节RAB活性的试剂。

5. 发明申请

US20070059698A1 Marks as modifers of the pten pathway and methods of use 失效
标题翻译：标记为pten途径的修改者和使用方法
公开(公告)号：US20070059698A1
公开(公告)日：2007-03-15
申请号：US10556937
申请日：2004-06-18
申请人： Michael Costa , Garth McGrath , Kim Lickteig , Timothy Heuer
发明人： Michael Costa , Garth McGrath , Kim Lickteig , Timothy Heuer
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C12Q1/485 , G01N33/5088 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N2500/00
摘要： Human MARK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that
摘要翻译：人MARK基因被鉴定为PTEN途径的调节剂，因此是与缺陷型PTEN功能相关的疾病的治疗靶点。用于鉴定PTEN调节剂的方法，包括筛选代谢物

6. 发明授权

US5094506A Child's safety car seat windshield 失效
标题翻译：儿童安全车座椅挡风玻璃
公开(公告)号：US5094506A
公开(公告)日：1992-03-10
申请号：US735495
申请日：1991-07-25
申请人： Michael Costa
发明人： Michael Costa
IPC分类号： B60N2/28
CPC分类号： B60N2/2839 , B60N2/2806 , B60N2/286
摘要： This invention relates to a new and improved windshield assembly for use with a conventional child safety car seat in a motor vehicle with an open top. The invention also relates to a means of securing the windshield to the child safety car seat using its existing automobile safety belt attachment slots. The object of the invention is to protect the child from harsh direct wind, pebbles, insects and exposure to excessive sunlight while the child is riding in a motor vehicle with an open top. The windshield envisioned is made of a rigid transparent photosensitive material which either changes sun screening characteristics in response to a change in light intensity or is composed of transparent tinted plastic which decreases or otherwise filters incident light. The windshield is designed to allow the child to enjoy the view by enabling him or her to see clearly through the device and likewise to enable adults to see the child.
摘要翻译：本发明涉及一种新的和改进的挡风玻璃组件，其用于具有敞开顶部的机动车辆中的常规儿童安全车座。本发明还涉及使用其现有的汽车安全带附接槽将挡风玻璃固定到儿童安全座椅的装置。本发明的目的是为了保护孩子免受恶劣的直接风，鹅卵石，昆虫和暴露于过度阳光的照射，同时孩子骑在具有开放顶部的机动车辆中。设想的挡风玻璃由刚性透明感光材料制成，其可以响应于光强度的变化而改变遮阳特性，或由透明有色塑料组成，其减少或以其他方式过滤入射光。挡风玻璃的设计是为了让孩子能够通过设备清楚地看到孩子，同样能让大人看到孩子。

7. 发明授权

US08335590B2 System and method for adjusting an image capturing device attribute using an unused degree-of-freedom of a master control device 有权
标题翻译：使用主控设备的未使用自由度来调整图像捕获设备属性的系统和方法
公开(公告)号：US08335590B2
公开(公告)日：2012-12-18
申请号：US12342230
申请日：2008-12-23
申请人： Michael Costa , David Robinson , Michael L. Hanuschik , Randal P. Goldberg , Paul Millman
发明人： Michael Costa , David Robinson , Michael L. Hanuschik , Randal P. Goldberg , Paul Millman
IPC分类号： G05B21/00
CPC分类号： B25J9/1697 , A61B34/30 , A61B34/37 , A61B34/76 , A61B90/361
摘要： An image capturing device is robotically positioned and oriented in response to operator manipulation of a master control device. An unused degree-of-freedom of the master control device is used to adjust an attribute such as focusing of the image capturing device relative to a continually updated set-point. A deadband is provided to avoid inadvertent adjusting of the image capturing device attribute and haptic feedback is provided back to the master control device so that the operator is notified when adjusting of the attribute is initiated.
摘要翻译：响应于主控制装置的操作者操纵，图像捕获装置被机器人定位和定向。使用主控制装置的未使用的自由度来调整诸如图像捕获装置相对于不断更新的设定点的聚焦的属性。提供死区以避免图像捕获设备属性的无意的调整，并且将触觉反馈提供给主控设备，使得在启动属性的调整时通知操作者。

8. 发明申请

US20120191175A1 Tubular Stent with Rotatable Connections and Method of Making 审中-公开
标题翻译：具有可旋转连接的管状支架和制造方法
公开(公告)号：US20120191175A1
公开(公告)日：2012-07-26
申请号：US13010599
申请日：2011-01-20
申请人： Michael Costa , Lance Ensign , John Richardson , Justin Goshgarian , Mark Hoff , Rui Lam , John Imschweiler
发明人： Michael Costa , Lance Ensign , John Richardson , Justin Goshgarian , Mark Hoff , Rui Lam , John Imschweiler
IPC分类号： A61F2/82 , B21F45/06
CPC分类号： B21F15/06 , A61F2/88 , A61F2/90 , A61F2002/91558 , A61F2002/91591 , A61F2220/0033 , A61F2250/0071 , B21F15/08 , B21F45/008
摘要： A tubular stent includes a plurality of bands aligned generally along a common longitudinal axis. A first band has a plurality of first crowns and a second band adjacent to the first band has a plurality of second crowns. A connecting ring connects the first band to the second band, wherein one of the first crowns is rotatably disposed through a lumen of the connecting ring and one of the second crowns is fused to the wall of the connecting ring outside of the lumen of the connecting ring. Methods of making tubular stents with rotatable connections are also disclosed.
摘要翻译：管状支架包括大致沿着共同的纵向轴线排列的多个带。第一带具有多个第一冠，并且与第一带相邻的第二带具有多个第二冠。连接环将第一带连接到第二带，其中第一冠中的一个可旋转地设置穿过连接环的内腔，并且第二冠中的一个将熔接到连接环的壁在连接的内腔外部环。还公开了具有可旋转连接的管状支架的制造方法。

9. 发明授权

US09296034B2 Apparatus and method for forming a wave form for a stent from a wire 有权
标题翻译：用于从线形成支架的波形的装置和方法
公开(公告)号：US09296034B2
公开(公告)日：2016-03-29
申请号：US13191134
申请日：2011-07-26
申请人： Michael Costa , Lance Ensign , Dustin Thompson , Paul Coates , Rui Lam , Larry Childs , Justin Eckhardt , Jerry Warmerdam , Charlie Dawson , Bob Boldig
发明人： Michael Costa , Lance Ensign , Dustin Thompson , Paul Coates , Rui Lam , Larry Childs , Justin Eckhardt , Jerry Warmerdam , Charlie Dawson , Bob Boldig
IPC分类号： B21F1/04 , B21D7/024 , B21D7/02 , B21F45/00 , A61F2/88
CPC分类号： B21F1/04 , A61F2/82 , A61F2/88 , A61F2240/001 , B21D7/02 , B21D7/024 , B21F45/008
摘要： An apparatus for forming a wave form for a stent from a wire includes a pair of tension wires configured to rotate about an axis. The tension wires and axis are substantially orthogonal to the stent wire disposed in a gap between the tension wires. When the tension wires are rotated, a bend is formed in the portion of the stent wire disposed between the tension wires. The tension wires may be controlled such that the axis of rotation is aligned with the particular tension wire around which the stent wire is to be bent for each particular bend formed in the stent wire, thereby preventing the particular tension wire from translating during rotation such that the tension wire behaves like a rotary pipe bending die around which the stent wire is bent. A feed assembly feeds the stent wire into the forming area between the tension wires.
摘要翻译：用于从电线形成用于支架的波形的装置包括一对构造成围绕轴旋转的张力线。张力线和轴基本上垂直于布置在张力线之间的间隙中的支架线。当张力线旋转时，在设置在张力线之间的支架线的部分中形成弯曲部。可以控制张力线，使得旋转轴线与特定的拉力线对准，对于支架线中形成的每个特定弯曲，支架线将被弯曲，从而防止特定的拉力线在旋转期间平移，使得张力线的行为类似于旋转管弯曲模具，支架线绕其弯曲。进给组件将支架线材馈送到张力线之间的成形区域。

10. 发明申请

US20130025339A1 Apparatus and Method for Forming a Wave Form for a Stent from a Wire 有权
标题翻译：用于从电线形成支架的波形的装置和方法
公开(公告)号：US20130025339A1
公开(公告)日：2013-01-31
申请号：US13191134
申请日：2011-07-26
申请人： Michael Costa , Lance Ensign , Dustin Thompson , Paul Coates , Rui Lam , Larry Childs , Justin Eckhardt , Jerry Warmerdam , Charlie Dawson , Bob Boldig
发明人： Michael Costa , Lance Ensign , Dustin Thompson , Paul Coates , Rui Lam , Larry Childs , Justin Eckhardt , Jerry Warmerdam , Charlie Dawson , Bob Boldig
IPC分类号： B21F1/04
CPC分类号： B21F1/04 , A61F2/82 , A61F2/88 , A61F2240/001 , B21D7/02 , B21D7/024 , B21F45/008
摘要： An apparatus for forming a wave form for a stent from a wire includes a pair of tension wires configured to rotate about an axis. The tension wires and axis are substantially orthogonal to the stent wire disposed in a gap between the tension wires. When the tension wires are rotated, a bend is formed in the portion of the stent wire disposed between the tension wires. The tension wires may be controlled such that the axis of rotation is aligned with the particular tension wire around which the stent wire is to be bent for each particular bend formed in the stent wire, thereby preventing the particular tension wire from translating during rotation such that the tension wire behaves like a rotary pipe bending die around which the stent wire is bent. A feed assembly feeds the stent wire into the forming area between the tension wires.
摘要翻译：用于从电线形成用于支架的波形的装置包括一对构造成围绕轴旋转的张力线。张力线和轴基本上垂直于布置在张力线之间的间隙中的支架线。当张力线旋转时，在设置在张力线之间的支架线的部分中形成弯曲部。可以控制张力线，使得旋转轴线与特定的拉力线对准，对于支架线中形成的每个特定弯曲，支架线将被弯曲，从而防止特定的拉力线在旋转期间平移，使得张力线的行为类似于旋转管弯曲模具，支架线绕其弯曲。进给组件将支架线材馈送到张力线之间的成形区域。

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