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1. 发明申请

US20120265198A1 RENAL NERVE DETECTION AND ABLATION APPARATUS AND METHOD 审中-公开
标题翻译：肾脏神经检测和消融装置及方法
公开(公告)号：US20120265198A1
公开(公告)日：2012-10-18
申请号：US13299932
申请日：2011-11-18
申请人： Loren M. Crow , Mark L. Jenson , Scott Smith
发明人： Loren M. Crow , Mark L. Jenson , Scott Smith
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/36007 , A61N7/022
摘要： Stimulation energy is delivered to one or more renal artery sites in accordance with a predetermined energy delivery protocol. The stimulation energy is sufficient to elicit a physiologic response from the patient but insufficient to ablate renal nerves. Target renal artery sites that elicit a physiologic response are identified, and renal nerve tissue at or proximate the target sites is ablated.
摘要翻译：根据预定的能量递送方案，将刺激能量递送至一个或多个肾动脉部位。刺激能量足以引起患者的生理反应，但不足以消融肾神经。确定引起生理反应的目标肾动脉部位，消除靶点位置或其附近的肾神经组织。

2. 发明申请

US20120265066A1 GUIDE-COMPATIBLE LARGE-ELECTRODE CATHETER FOR RENAL NERVE ABLATION WITH REDUCED ARTERIAL INJURY 有权
标题翻译：指导兼容的大电极导管，用于神经退化，减少肢体损伤
公开(公告)号：US20120265066A1
公开(公告)日：2012-10-18
申请号：US13353948
申请日：2012-01-19
申请人： Loren M. Crow , Mark L. Jenson
发明人： Loren M. Crow , Mark L. Jenson
IPC分类号： A61B6/00 , A61B18/14
CPC分类号： A61B18/1492 , A61B90/39 , A61B2017/00473 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/0808
摘要： A first catheter is dimensioned for deployment within a renal artery. A second catheter has a shaft with an outer diameter smaller than an inner diameter of the first catheter's open lumen. A gap is formed between the shaft and the first catheter when the second catheter is situated within the first catheter. The gap facilitates transport of a fluid, such as imaging contrast media, along the first catheter. An electrode arrangement at the distal end of the shaft is configured to deliver ablative energy to perivascular renal nerves, and has an outer diameter about the same size as the inner diameter of the first catheter such that a fit therebetween substantially blocks fluid flow within the gap yet provides for relative movement between the electrode arrangement and the luminal wall. A conductor extends between the proximal and distal ends of the shaft and is coupled to electrode arrangement.
摘要翻译：第一个导管的尺寸用于部署在肾动脉内。第二导管具有外径小于第一导管开口腔内径的轴。当第二导管位于第一导管内时，在轴和第一导管之间形成间隙。该间隙便于沿着第一导管输送诸如成像造影剂的流体。在轴的远端处的电极布置被配置为将消融能量递送至血管周围肾神经，并且具有与第一导管的内径大致相同尺寸的外径，使得其间的配合基本上阻挡在间隙内的流体流动而是提供电极装置和腔壁之间的相对运动。导体在轴的近端和远端之间延伸并耦合到电极装置。

3. 发明授权

US09220561B2 Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury 有权
标题翻译：导管相容的大电极导管用于肾神经消融，减少动脉损伤
公开(公告)号：US09220561B2
公开(公告)日：2015-12-29
申请号：US13353948
申请日：2012-01-19
申请人： Loren M. Crow , Mark L. Jenson
发明人： Loren M. Crow , Mark L. Jenson
IPC分类号： A61B18/14 , A61B19/00 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B90/39 , A61B2017/00473 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/0808
摘要： A first catheter is dimensioned for deployment within a renal artery. A second catheter has a shaft with an outer diameter smaller than an inner diameter of the first catheter's open lumen. A gap is formed between the shaft and the first catheter when the second catheter is situated within the first catheter. The gap facilitates transport of a fluid, such as imaging contrast media, along the first catheter. An electrode arrangement at the distal end of the shaft is configured to deliver ablative energy to perivascular renal nerves, and has an outer diameter about the same size as the inner diameter of the first catheter such that a fit therebetween substantially blocks fluid flow within the gap yet provides for relative movement between the electrode arrangement and the luminal wall. A conductor extends between the proximal and distal ends of the shaft and is coupled to electrode arrangement.
摘要翻译：第一个导管的尺寸用于部署在肾动脉内。第二导管具有外径小于第一导管开口腔内径的轴。当第二导管位于第一导管内时，在轴和第一导管之间形成间隙。该间隙便于沿着第一导管输送诸如成像造影剂的流体。在轴的远端处的电极布置被配置为将消融能量递送至血管周围肾神经，并且具有与第一导管的内径大致相同尺寸的外径，使得其间的配合基本上阻挡在间隙内的流体流动而是提供电极装置和腔壁之间的相对运动。导体在轴的近端和远端之间延伸并耦合到电极装置。

4. 发明授权

US09254124B2 Self-orientating suture wound closure device 有权
标题翻译：自定向缝合伤口闭合装置
公开(公告)号：US09254124B2
公开(公告)日：2016-02-09
申请号：US12026207
申请日：2008-02-05
申请人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
发明人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
IPC分类号： A61B17/04 , A61B17/00 , A61B17/34 , A61B19/00
CPC分类号： A61B17/0057 , A61B17/0469 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/047 , A61B2017/0472 , A61B2017/3484 , A61B2090/067 , A61B2090/0811
摘要： A device is disclosed for providing an indication as to the relative position of a vessel or artery opening thereby facilitating the choice of which several closure techniques to use. A disclosed device includes an outer tube and a collapsible foot slidably disposed within a distal end of the outer tube. The device may further include one or more threaded suture needles, a biodegradable plug or other wound closing device that is connected to another shaft. The collapsed or folded foot is pushed distally out of the tube and through the opening in the vessel whereupon the foot expands. Pulling the expanded foot in the proximal direction provides an indication as to the orientation of the opening in the vessel, which assists in determining the type of closing procedure to be carried out.
摘要翻译：公开了一种用于提供关于血管或动脉开口的相对位置的指示的装置，从而便于选择使用哪些闭合技术。所公开的装置包括外管和可滑动地设置在外管的远端内的可折叠的脚。该装置还可以包括一个或多个螺纹缝合针，可生物降解的塞子或其它连接到另一轴的闭合装置。折叠或折叠的脚从管中向远侧推出并穿过容器中的足部膨胀的开口。沿着近端方向拉动扩张的脚提供关于容器中的开口的取向的指示，这有助于确定要执行的关闭程序的类型。

5. 发明授权

US09044350B2 Alignment sheath apparatus and method 有权
标题翻译：对准护套装置及方法
公开(公告)号：US09044350B2
公开(公告)日：2015-06-02
申请号：US11507103
申请日：2006-08-21
申请人： Mark L. Jenson , William J. Drasler , Tracee Eidenschink
发明人： Mark L. Jenson , William J. Drasler , Tracee Eidenschink
IPC分类号： A61F2/954 , A61F2/856 , A61F2/86 , A61F2/852 , A61F2/06
CPC分类号： A61F2/856 , A61F2/852 , A61F2/86 , A61F2/954 , A61F2002/067 , A61F2220/005 , A61F2220/0058 , A61F2230/001 , A61F2230/0043 , A61F2250/006
摘要： The invention is direction to an alignment apparatus comprising a central sheath, an alignment sheath, and at least one stent. The central sheath and the alignment sheath each have a wall and a distal end where the wall of the alignment sheath is engaged to the wall of the central sheath. The wall of the central sheath defines a central lumen that has a central guide wire extending therethrough and the wall of the alignment sheath defines an alignment lumen that has an alignment guide wire extending therethrough. The distal end of the alignment sheath is positioned proximally to the distal end of the central sheath. The alignment apparatus has at least one stent disposed about one of the alignment guide wire or the central guide wire. The at least one stent has a pre-delivered state so that when the at least one stent is in the pre-delivered state, it is contained within at least one of the central sheath and the alignment sheath.
摘要翻译：本发明是包括中心护套，对准护套和至少一个支架的对准装置的方向。中心护套和对准护套均具有壁和远端，其中对准护套的壁与中心护套的壁接合。中心护套的壁限定了具有延伸穿过其中的中心导丝的中心管，并且对准护套的壁限定了具有延伸穿过其中的对准导丝的对准内腔。对准护套的远端位于中央护套的远端的近侧。对准装置具有至少一个支架，其布置在对准引导线或中心引导线之一附近。至少一个支架具有预输送状态，使得当至少一个支架处于预输送状态时，其被包含在至少一个中心护套和对准护套中。

6. 发明授权

US08556966B2 Annuloplasty device 有权
标题翻译：瓣膜成形术装置
公开(公告)号：US08556966B2
公开(公告)日：2013-10-15
申请号：US13070059
申请日：2011-03-23
申请人： Mark L. Jenson
发明人： Mark L. Jenson
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2451 , A61F2002/30042 , A61F2002/30583 , A61F2210/0085
摘要： Devices, systems, and methods associated with annuloplasty are described herein. One or more annuloplasty devices include a number of longitudinal filaments moveable between an introductory configuration and a deployed configuration, wherein the number of longitudinal filaments are one or more lengths, and a shell, wherein the shell contains the number of longitudinal filaments and a curable polymer to maintain the annuloplasty device in a deployed configuration.
摘要翻译：本文描述了与瓣环成形术相关联的装置，系统和方法。一个或多个瓣膜成形术装置包括在介绍构型和展开构型之间可移动的多个纵向长丝，其中纵向长丝的数量是一个或多个长度，以及壳，其中壳包含多个纵向长丝和可固化聚合物以将瓣环成形术装置维持在部署的配置中。

7. 发明申请

US20120296349A1 Percutaneous Mitral Annulus Mini-Plication 审中-公开
标题翻译：经皮二尖瓣环微球
公开(公告)号：US20120296349A1
公开(公告)日：2012-11-22
申请号：US13240921
申请日：2011-09-22
申请人： Scott R. Smith , Mark L. Jenson
发明人： Scott R. Smith , Mark L. Jenson
IPC分类号： A61B17/08 , A61B17/10
CPC分类号： A61B17/00234 , A61B17/0644 , A61B17/1227 , A61B17/1285 , A61B2017/00243 , A61B2017/081 , A61F2/2442
摘要： A plication clip comprises a first end portion; a second end portion; and a central portion connecting the first end portion to the second end portion. The first end portion is curved toward the second end portion, and the second end portion is curved toward the first end portion. The central portion has a curvilinear profile such that when the clip is deployed, a shorter length between the first end portion and the second end portion is formed. A delivery catheter and methods for deploying the plication clip are also provided.
摘要翻译：折叠夹包括第一端部; 第二端部; 以及将第一端部连接到第二端部的中心部。第一端部朝向第二端部弯曲，第二端部朝向第一端部弯曲。中心部分具有曲线轮廓，使得当夹子展开时，在第一端部和第二端部之间形成较短的长度。还提供了输送导管和用于展开折叠夹的方法。

8. 发明申请

US20120232570A1 APPARATUS AND METHOD FOR TREATING OCCLUDED VASCULATURE 审中-公开
标题翻译：用于治疗闭塞性血管的装置和方法
公开(公告)号：US20120232570A1
公开(公告)日：2012-09-13
申请号：US13481309
申请日：2012-05-25
申请人： Mark L. Jenson , William J. Drasler
发明人： Mark L. Jenson , William J. Drasler
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B2017/00398 , A61B2017/22044 , A61B2017/22077 , A61B2017/22094 , A61M25/0084 , A61M25/0138 , A61M2025/0046 , A61M2025/0063 , A61M2025/1093
摘要： Occluded vasculature such as occluded arterial vasculature can be recanalized using a device that is configured to penetrate an occlusion, while limiting a distance that said penetration structure can extend in order to limit inadvertent vascular damage. The device can include an elongate shaft of a guidewire and a stylet disposed within a lumen of the elongate shaft such that the stylet is selectively actuatable within the elongate shaft.
摘要翻译：封闭的脉管系统如闭塞的动脉脉管系统可以使用被配置为穿透闭塞的装置再次通气，同时限制所述穿透结构可以延伸的距离，以限制无意的血管损伤。该装置可以包括导丝的细长轴和设置在细长轴的内腔中的探针，使得探针可以在细长轴内选择性地致动。

9. 发明申请

US20120123303A1 Minimally Invasive Access for Renal Nerve Ablation 有权
标题翻译：微创获取肾神经消融
公开(公告)号：US20120123303A1
公开(公告)日：2012-05-17
申请号：US13243134
申请日：2011-09-23
申请人： David Sogard , Scott Smith , Mark L. Jenson
发明人： David Sogard , Scott Smith , Mark L. Jenson
IPC分类号： A61B18/18 , A61B18/04 , A61N7/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2018/00875 , A61B2018/0212 , A61N5/062 , A61N7/022 , A61N2005/067 , A61N2007/003
摘要： An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.
摘要翻译：细长的柔性医疗装置通过自然孔插入患者体内，并通过自然孔推进到影响肾交感神经活动的靠近神经组织的位置。医疗装置可以进入身体器官和靠近神经组织的器官内的位置。器官可以包括胃肠道或泌尿道的器官。医疗装置可以前进穿过器官壁中的进入孔并且位于邻近神经组织的位置处。成像和消融能量中的一个或两个从医疗装置的远端传送到神经组织。可以使用各种形式的能量消融内源性肾组织，包括射频能量，超声能量，光能和热能。

10. 发明申请

US20120059286A1 Self-Powered Ablation Catheter for Renal Denervation 审中-公开
标题翻译：自吸式消融导管用于肾去神经
公开(公告)号：US20120059286A1
公开(公告)日：2012-03-08
申请号：US13227446
申请日：2011-09-07
申请人： Roger Hastings , Dave Sogard , Kevin Edmunds , Mark L. Jenson
发明人： Roger Hastings , Dave Sogard , Kevin Edmunds , Mark L. Jenson
IPC分类号： A61N7/00 , A61B18/18 , A61B18/12
CPC分类号： A61B18/1206 , A61B5/0002 , A61B18/1492 , A61B34/25 , A61B2017/00734 , A61B2018/00011 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00678 , A61B2018/00708 , A61B2018/00744 , A61B2018/00821 , A61B2018/00875 , A61B2018/00916 , A61B2018/00994 , A61B2018/1226 , A61B2018/1861 , A61N7/022
摘要： An ablation catheter includes a flexible shaft having length sufficient to access a patient's renal artery. An electrode arrangement is provided at the distal end of the shaft. A handle unit includes a housing configured for hand-held manipulation and is coupled to the catheter. A battery and one or both of a high frequency AC generator and ultrasound generator are provided in the housing. The battery serves as the sole source of power for the generator. The generator is configured to generate energy sufficient to ablate perivascular renal nerve tissue using energy stored in the battery. The catheter may be disposable and the housing re-usable. Both the catheter and the housing may be disposable.
摘要翻译：消融导管包括具有足以接近患者肾动脉的长度的柔性轴。电极布置设置在轴的远端。手柄单元包括构造成用于手持操作的壳体并且联接到导管。电池和高频交流发电机和超声波发生器中的一个或两个设置在壳体中。电池是发电机的唯一电源。发生器被配置为产生足以使用存储在电池中的能量消融血管周围肾神经组织的能量。导管可以是一次性的并且壳体可重新使用。导管和外壳都可以是一次性的。

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