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1. 发明授权

US06566341B1 Derivative of isoindigo, indigo and indirubin for the treatment of cancer 有权
标题翻译：靛蓝，靛蓝和靛玉红衍生物治疗癌症
公开(公告)号：US06566341B1
公开(公告)日：2003-05-20
申请号：US10021589
申请日：2001-12-13
申请人： Longgui Wang , Xiaomei Liu , Ruihuan Chen
发明人： Longgui Wang , Xiaomei Liu , Ruihuan Chen
IPC分类号： C07D29502
CPC分类号： C07H19/04
摘要： A compound called NATURA, which is a derivative of Isoindigo is useful in aiding the general health of a patient and specifically is beneficial in preventing or treating cancer. This compound and other related Isoindigo, Indigo and Indirubin derivatives are designed such that the bioactivity or bioavailability of the compound is increased. Also, pharmaceutical compositions that include a therapeutically effective amount of at least one of these derivatives and a pharmaceutically acceptable carrier. A method for the use of these pharmaceutical compositions and compounds is taught, wherein a therapeutically effective amount is administered to an animal. The pharmaceutical composition or compound can be re-administered to the animal until a desired treatment or result is accomplished.
摘要翻译：称为NATURA的化合物是Isoindigo的衍生物，可用于帮助患者的一般健康，具体有益于预防或治疗癌症。该化合物和其它相关的Isoindigo，Indigo和Indirubin衍生物被设计成使得化合物的生物活性或生物利用度增加。而且，包括治疗有效量的这些衍生物和药学上可接受的载体中的至少一种的药物组合物。教导了使用这些药物组合物和化合物的方法，其中向动物施用治疗有效量。药物组合物或化合物可以重新施用于动物直到达到所需的治疗或结果。

2. 发明授权

US06933315B2 Derivatives of isoindigo, indigo and indirubin and methods of treating cancer 有权
标题翻译：异靛素，靛蓝和靛玉红的衍生物和治疗癌症的方法
公开(公告)号：US06933315B2
公开(公告)日：2005-08-23
申请号：US10864458
申请日：2004-06-10
申请人： Longgui Wang , Xiaomei Liu , Ruihuan Chen
发明人： Longgui Wang , Xiaomei Liu , Ruihuan Chen
IPC分类号： C07H17/02 , A61K31/404 , A61K31/7056 , A61K45/06 , A61P35/00 , C07D209/34 , C07H19/02 , C07H19/23 , C07D43/04
CPC分类号： C07H19/23 , C07D209/34
摘要： A compound called NATURA, which is a derivative of Isoindigo is useful in aiding the general health of a patient and specifically is beneficial in preventing or treating cancer. This compound and other related Isoindigo, Indigo and Indirubin derivatives are designed such that the bioactivity or bioavailability of the compound is increased. Methods of synthesizing these derivatives is also taught. In addition, pharmaceutical compositions that include a therapeutically effective amount of at least one of these derivatives and a pharmaceutically acceptable carrier. A method for the use of these pharmaceutical compositions and compounds is taught, wherein a therapeutically effective amount is administered to an animal having solid tumor cancer. The pharmaceutical composition or compound can be re-administered to the animal until a desired treatment or result is accomplished.
摘要翻译：称为NATURA的化合物是Isoindigo的衍生物，可用于帮助患者的一般健康，具体有益于预防或治疗癌症。该化合物和其它相关的Isoindigo，Indigo和Indirubin衍生物被设计成使得化合物的生物活性或生物利用度增加。还教导了合成这些衍生物的方法。另外，包括治疗有效量的这些衍生物和药学上可接受的载体中的至少一种的药物组合物。教导了使用这些药物组合物和化合物的方法，其中向具有实体肿瘤癌症的动物施用治疗有效量。药物组合物或化合物可以重新施用于动物直到达到所需的治疗或结果。

3. 发明授权

US09354813B1 Data storage system modeling 有权
标题翻译：数据存储系统建模
公开(公告)号：US09354813B1
公开(公告)日：2016-05-31
申请号：US13729680
申请日：2012-12-28
申请人： Sean C. Dolan , Sachin More , Hui Wang , Xiaomei Liu , Marik Marshak
发明人： Sean C. Dolan , Sachin More , Hui Wang , Xiaomei Liu , Marik Marshak
IPC分类号： G06F3/06 , G06F17/50 , G06F11/34
CPC分类号： G06F3/061 , G06F3/0631 , G06F3/0647 , G06F3/0653 , G06F3/0655 , G06F3/0685 , G06F11/3419 , G06F11/3466 , G06F11/3485 , G06F17/5009
摘要： Described are modeling techniques. In accordance with one or more criteria, a determination may be made as to whether to use a dynamic model or a static model to model performance of components, such as storage devices, of a data storage system. A system may include first and second data storage systems where the first data storage system includes a computer readable medium with first code that performs processing in connection with data storage movement optimizations using one or more models including a dynamic model, and second code that generates and maintains the dynamic model used to model performance of storage devices. The second code may include code for performing first processing to determine device sets each of which does not share back-end resources of the second data storage system with any other device sets, and performing second processing to determine sets of performance curves corresponding to the device sets.
摘要翻译：描述的是建模技术。根据一个或多个标准，可以确定是否使用动态模型或静态模型来建模数据存储系统的组件（诸如存储设备）的性能。系统可以包括第一和第二数据存储系统，其中第一数据存储系统包括具有第一代码的计算机可读介质，第一代码使用包括动态模型的一个或多个模型与数据存储移动优化相结合执行处理，第二代码生成和维护用于建模存储设备性能的动态模型。第二代码可以包括用于执行第一处理以确定每个不与任何其他设备组共享第二数据存储系统的后端资源的设备组的代码，并且执行第二处理以确定与该设备相对应的性能曲线集合套。

4. 发明授权

US08972694B1 Dynamic storage allocation with virtually provisioned devices 有权
标题翻译：动态存储分配与虚拟设备
公开(公告)号：US08972694B1
公开(公告)日：2015-03-03
申请号：US13429622
申请日：2012-03-26
申请人： Sean Dolan , Alex Veprinsky , Owen Martin , Marik Marshak , Hui Wang , Xiaomei Liu
发明人： Sean Dolan , Alex Veprinsky , Owen Martin , Marik Marshak , Hui Wang , Xiaomei Liu
IPC分类号： G06F12/00 , G06F13/00 , G06F13/28
CPC分类号： G06F13/28 , G06F3/0608 , G06F3/0665 , G06F3/0685 , G06F12/0646
摘要： A write operation writes first data to a target logical address range included in a first logical address range of a virtually provisioned device. It is determined that physical storage is not allocated for the target logical address range. First processing is performed to allocate a first portion of physical storage having a first corresponding logical address subrange that includes the target logical address range. The first portion is allocated from a physical device included in a first storage tier. The first processing includes selecting the first storage tier from multiple storage tiers in accordance with selection criteria including metrics characterizing an expected workload or level of activity for the first corresponding logical address subrange of the virtually provisioned device. Mapping information is updated to indicate that the first corresponding logical address subrange of the virtually provisioned device maps to the first portion of physical storage.
摘要翻译：写入操作将第一数据写入包含在虚拟设备的第一逻辑地址范围内的目标逻辑地址范围。确定没有为目标逻辑地址范围分配物理存储。执行第一处理以分配具有包括目标逻辑地址范围的第一对应逻辑地址子范围的物理存储器的第一部分。第一部分从包括在第一存储层中的物理设备分配。第一处理包括根据选择标准来选择来自多个存储层的第一存储层，所述选择标准包括表征虚拟提供设备的第一对应逻辑地址子范围的预期工作负载或活动级别的度量。更新映射信息以指示虚拟供应设备的第一对应逻辑地址子范围映射到物理存储的第一部分。

5. 发明授权

US08578432B2 Policy control over switched delivery networks 有权
标题翻译：交换传送网络的策略控制
公开(公告)号：US08578432B2
公开(公告)日：2013-11-05
申请号：US11952969
申请日：2007-12-07
申请人： Swaminatha Vasudevan , Xiaomei Liu
发明人： Swaminatha Vasudevan , Xiaomei Liu
IPC分类号： H04N7/173 , H04H20/28 , H04N7/16
CPC分类号： H04N21/6408 , H04L12/1886 , H04N21/2385 , H04N21/2402 , H04N21/6125 , H04N21/6405
摘要： A method is described that includes receiving a program request from a transceiver that includes a program request to receive a video program at the transceiver. The method also includes determining an amount of bandwidth on a channel available to the transceiver. The method further includes determining whether to provide a unicast stream or a multicast stream to deliver the requested video program to the transceiver in response to the program request based on a result obtained after implementing a policy control function that considers an amount of bandwidth on the channel to the transceiver. The method further includes formatting and selecting an incoming media stream in accordance with the result of the policy control function to provide a corresponding formatted unicast or multicast media stream that includes video data for the requested video program. The method further includes outputting the associated formatted unicast or multicast media stream on the channel.
摘要翻译：描述了一种方法，其包括从收发器接收包括在收发机处接收视频节目的节目请求的节目请求。该方法还包括确定可用于收发器的信道上的带宽量。该方法还包括根据在实现考虑频道上的带宽量的策略控制功能之后获得的结果来确定是否提供单播流或多播流以将所请求的视频节目传送到收发信机到收发器。该方法还包括根据策略控制功能的结果来格式化和选择传入的媒体流，以提供包括所请求的视频节目的视频数据的对应的格式化的单播或多媒体媒体流。该方法还包括在该信道上输出相关联的格式化单播或多播媒体流。

6. 发明授权

US08335266B2 Expedited splicing of video streams 有权
标题翻译：加速拼接视频流
公开(公告)号：US08335266B2
公开(公告)日：2012-12-18
申请号：US11824452
申请日：2007-06-29
申请人： Xiaomei Liu , Yi Tong Tse
发明人： Xiaomei Liu , Yi Tong Tse
IPC分类号： H04B1/66
CPC分类号： H04N19/00545 , H04N19/46 , H04N21/23406 , H04N21/23424 , H04N21/234381 , H04N21/23655 , H04N21/4344 , H04N21/44004 , H04N21/44016 , H04N21/8547
摘要： In one embodiment, a method is described that includes receiving a conditioned bitstream that includes a digital insertion location and primary network packets that contain compressed video data. The digital insertion location includes replaceable network packets. The method also includes receiving a second bitstream that includes replacement compressed video data. The method also includes determining a location of the digital insertion location. The method further includes adjusting the bitrate of the replacement compressed video data to create adjusted replacement compressed video data. The method further includes providing timestamp information with the replacement compressed video data. The method additionally includes packetizing the adjusted replacement compressed video data and timestamp information into replacement network packets. The method further includes combining the replacement network packets into the digital insertion location in the conditioned bitstream at the network packet level without depacketizing or decompressing the compressed video data in the primary network packets.
摘要翻译：在一个实施例中，描述了一种方法，其包括接收包括数字插入位置和包含压缩视频数据的主网络分组的经调节的比特流。数字插入位置包括可替换的网络分组。该方法还包括接收包括替换压缩视频数据的第二比特流。该方法还包括确定数字插入位置的位置。该方法还包括调整替换压缩视频数据的比特率以创建经调整的替代压缩视频数据。该方法还包括向替换压缩视频数据提供时间戳信息。该方法还包括将经调整的替代压缩视频数据和时间戳信息分组成替换网络分组。该方法还包括将替换网络分组组合到网络分组级别的条件化比特流中的数字插入位置，而不对主网络分组中的压缩视频数据进行解包或解压缩。

7. 发明授权

US07823179B2 System and method for edge resource management 有权
标题翻译：边缘资源管理的系统和方法
公开(公告)号：US07823179B2
公开(公告)日：2010-10-26
申请号：US11109200
申请日：2005-04-18
申请人： Xiaomei Liu , Ashok Bhaskar , Sangeeta Ramakrishnan , Bruce Thompson
发明人： Xiaomei Liu , Ashok Bhaskar , Sangeeta Ramakrishnan , Bruce Thompson
IPC分类号： H04N7/173
CPC分类号： H04N7/17318 , H04L12/66 , H04N21/2385 , H04N21/2402 , H04N21/47202 , H04N21/64738
摘要： The present invention relates generally to a system for managing bandwidth usage in a content delivery system such as a Video on Demand (VOD) network. Specifically, an Edge Resource Manager (ERM) makes use of a number of policies to optimally select a transmission device such as a Quadrature Amplitude Modulation (QAM) device. The policies aid in providing efficient use of the transmission devices particularly when a number of different transmission rates for different media are employed.
摘要翻译：本发明一般涉及用于管理诸如视频点播（VOD）网络的内容传送系统中的带宽使用的系统。具体来说，边缘资源管理器（ERM）利用多个策略来优化诸如正交幅度调制（QAM）设备之类的传输设备。该策略有助于提供传输设备的有效使用，特别是当采用不同媒体的不同传输速率时。

8. 发明申请

US20060236358A1 System and method for edge resource management 有权
标题翻译：边缘资源管理的系统和方法
公开(公告)号：US20060236358A1
公开(公告)日：2006-10-19
申请号：US11109200
申请日：2005-04-18
申请人： Xiaomei Liu , Ashok Bhaskar , Sangeeta Ramakrishnan , Bruce Thompson
发明人： Xiaomei Liu , Ashok Bhaskar , Sangeeta Ramakrishnan , Bruce Thompson
IPC分类号： H04N7/173
CPC分类号： H04N7/17318 , H04L12/66 , H04N21/2385 , H04N21/2402 , H04N21/47202 , H04N21/64738
摘要： The present invention relates generally to a system for managing bandwidth usage in a content delivery system such as a Video on Demand (VOD) network. Specifically, an Edge Resource Manager (ERM) makes use of a number of policies to optimally select a transmission device such as a Quadrature Amplitude Modulation (QAM) device. The policies aid in providing efficient use of the transmission devices particularly when a number of different transmission rates for different media are employed.
摘要翻译：本发明一般涉及用于管理诸如视频点播（VOD）网络的内容传送系统中的带宽使用的系统。具体来说，边缘资源管理器（ERM）利用多个策略来优化诸如正交幅度调制（QAM）设备之类的传输设备。该策略有助于提供传输设备的有效使用，特别是当采用不同媒体的不同传输速率时。

9. 发明申请

US20050136425A1 DNA molecules encoding human NHL, a DNA helicase 失效
标题翻译：编码人类NHL的DNA分子，DNA解旋酶
公开(公告)号：US20050136425A1
公开(公告)日：2005-06-23
申请号：US10859792
申请日：2004-06-03
申请人： Xiaomei Liu , Chang Bai , Michael Metzker
发明人： Xiaomei Liu , Chang Bai , Michael Metzker
IPC分类号： C12N1/21 , C12N9/90 , C12Q1/68 , C07H21/04 , C12N9/22
CPC分类号： C12N9/90
摘要： The present invention disclosed isolated nucleic acid molecules (polynucleotides) which encode NHL, a putative DNA helicase. The present invention in turn relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding NHL, substantially purified forms of associated NHL, associated mutant proteins, and methods associated with identifying compounds which modulate NHL, which will be useful in the treatment of various neoplastic disorders. Both a genomic clone containing regulatory and intron sequences, as well as the exon structure and open reading frame of human NHL are disclosed.
摘要翻译：本发明公开了编码NHL的分离的核酸分子（多核苷酸），即推定的DNA解旋酶。本发明又涉及重组载体和重组宿主，其含有编码NHL的DNA片段，基本上纯化的相关NHL形式，相关的突变型蛋白质，以及与识别调节NHL的化合物相关的方法，其可用于各种治疗肿瘤性疾病。公开了含有调节和内含子序列的基因组克隆，以及人NHL的外显子结构和开放阅读框。

10. 发明授权

US09965381B1 Indentifying data for placement in a storage system 有权
公开(公告)号：US09965381B1
公开(公告)日：2018-05-08
申请号：US13135261
申请日：2011-06-30
申请人： Adnan Sahin , Alexandr Veprinsky , Marik Marshak , Hui Wang , Xiaomei Liu , Owen Martin , Sean C. Dolan
发明人： Adnan Sahin , Alexandr Veprinsky , Marik Marshak , Hui Wang , Xiaomei Liu , Owen Martin , Sean C. Dolan
IPC分类号： G06F12/00 , G06F13/00 , G06F13/28 , G06F12/02 , G06F3/06
CPC分类号： G06F12/023 , G06F3/0605 , G06F3/0647 , G06F3/0683 , G06F3/0685
摘要： Identifying data for placement in a storage system having a plurality of storage classes includes subdividing the data into portions, for each of the portions, independently determining at least one score for a particular portion based on a metric corresponding to access of the particular portion, where the at least one score for the particular portion is independent of scores for other ones of the portions, and identifying sub-portions of data for placement in a particular storage class based on the at least one score of a portion of data corresponding to the sub-portions. The at least one score may be based on short term access statistics and long term access statistics. The access statistics may include read misses, writes, and prefetches.

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