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1. 发明授权

US07850683B2 Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) 有权
公开(公告)号：US07850683B2
公开(公告)日：2010-12-14
申请号：US11770185
申请日：2007-06-28
申请人： Lisa Elkins , Ronald Williams
发明人： Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2018/00041 , A61B2018/0262 , A61B2018/0293
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

2. 发明申请

US20090248001A1 Pain management using cryogenic remodeling 有权
标题翻译：疼痛管理采用低温重塑
公开(公告)号：US20090248001A1
公开(公告)日：2009-10-01
申请号：US12271013
申请日：2008-11-14
申请人： Keith Burger , Lisa Elkins , Ronald Williams
发明人： Keith Burger , Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/0218 , A61B2018/00452 , A61B2018/0293 , A61F7/00 , A61F2007/0056 , A61F2007/0063 , A61F2007/0087 , A61F2007/0094 , A61F2007/0285 , A61F2007/126
摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.
摘要翻译：用于疼痛管理和其它应用的医疗装置，系统和方法可以用至少一个穿过皮肤暴露的皮肤表面插入的探针施加冷却。冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

3. 发明授权

US09345526B2 Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) 有权
公开(公告)号：US09345526B2
公开(公告)日：2016-05-24
申请号：US13178451
申请日：2011-07-07
申请人： Lisa Elkins , Ronald Williams
发明人： Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02 , A61M37/00 , A61B18/14 , A61B17/00 , A61B18/00 , A61M5/44
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2017/00792 , A61B2018/00023 , A61B2018/00041 , A61B2018/00452 , A61B2018/00464 , A61B2018/0262 , A61B2018/0293 , A61M5/44 , A61M37/0015 , A61M2037/0023 , A61M2037/003
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

4. 发明授权

US07998137B2 Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) 有权
公开(公告)号：US07998137B2
公开(公告)日：2011-08-16
申请号：US12758686
申请日：2010-04-12
申请人： Lisa Elkins , Ronald Williams
发明人： Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2017/00792 , A61B2018/00023 , A61B2018/00041 , A61B2018/00452 , A61B2018/00464 , A61B2018/0262 , A61B2018/0293 , A61M5/44 , A61M37/0015 , A61M2037/0023 , A61M2037/003
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

5. 发明授权

US07862558B2 Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) 有权
标题翻译：肌肉，神经，结缔组织和/或脂肪组织（脂肪）的皮下低温重塑
公开(公告)号：US07862558B2
公开(公告)日：2011-01-04
申请号：US12399598
申请日：2009-03-06
申请人： Lisa Elkins , Ronald Williams
发明人： Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2018/00041 , A61B2018/0262 , A61B2018/0293
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.
摘要翻译：装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

6. 发明申请

US20100198207A1 SUBDERMAL CRYOGENIC REMODELING OF MUSCLES, NERVES, CONNECTIVE TISSUE, AND/OR ADIPOSE TISSUE (FAT) 有权
标题翻译：肌肉，神经，连接组织和/或ADIPOSE组织（FAT）的低温低温重建
公开(公告)号：US20100198207A1
公开(公告)日：2010-08-05
申请号：US12758686
申请日：2010-04-12
申请人： Lisa Elkins , Ronald Williams
发明人： Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2017/00792 , A61B2018/00023 , A61B2018/00041 , A61B2018/00452 , A61B2018/00464 , A61B2018/0262 , A61B2018/0293 , A61M5/44 , A61M37/0015 , A61M2037/0023 , A61M2037/003
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.
摘要翻译：装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。冷却可改造一个或多个靶组织，以便实现目标组织的组成中所需的变化和/或其行为的改变。冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

7. 发明授权

US07713266B2 Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) 有权
标题翻译：肌肉，神经，结缔组织和/或脂肪组织（脂肪）的皮下低温重塑
公开(公告)号：US07713266B2
公开(公告)日：2010-05-11
申请号：US11295204
申请日：2005-12-05
申请人： Lisa Elkins , Ronald Williams
发明人： Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2017/00792 , A61B2018/00023 , A61B2018/00041 , A61B2018/00452 , A61B2018/00464 , A61B2018/0262 , A61B2018/0293 , A61M5/44 , A61M37/0015 , A61M2037/0023 , A61M2037/003
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.
摘要翻译：装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。冷却可改造一个或多个靶组织，以便实现目标组织的组成中所需的变化和/或其行为的改变。冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

8. 发明申请

US20090171334A1 SUBDERMAL CRYOGENIC REMODELING OF MUSCLES, NERVES, CONNECTIVE TISSUE, AND/OR ADIPOSE TISSUE (FAT) 有权
标题翻译：肌肉，神经，连接组织和/或ADIPOSE组织（FAT）的低温低温重建
公开(公告)号：US20090171334A1
公开(公告)日：2009-07-02
申请号：US12399598
申请日：2009-03-06
申请人： Lisa Elkins , Ronald Williams
发明人： Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2018/00041 , A61B2018/0262 , A61B2018/0293
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.
摘要翻译：装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

9. 发明申请

US20080154254A1 Dermal and Transdermal Cryogenic Microprobe Systems and Methods 有权
标题翻译：皮肤和透皮低温微探针系统和方法
公开(公告)号：US20080154254A1
公开(公告)日：2008-06-26
申请号：US11614887
申请日：2006-12-21
申请人： Keith Burger , Ronald Williams , Lisa Elkins
发明人： Keith Burger , Ronald Williams , Lisa Elkins
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00747 , A61B2018/00452 , A61B2018/0262 , A61B2018/0293
摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-toleranced lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.
摘要翻译：医疗装置，系统和方法可任选地治疗皮肤病和/或美容缺陷，和/或广泛的其它靶组织。实施例用至少一个小的组织穿透探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入的尺寸的针而不留下可见的瘢痕。治疗可以沿着细长针的大部分或全部可插入长度施加，任选地通过将低温冷却流体通过熔融二氧化硅流体供应管的小的，紧密公差的管腔引入针内腔，供应管内腔经常计量冷却液。可以通过经由有限的总排气量空间耦合到针内腔的简单的压力释放阀来增强治疗温度和/或时间控制。

10. 发明授权

US09072498B2 Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) 有权
标题翻译：肌肉，神经，结缔组织和/或脂肪组织（脂肪）的皮下低温重塑
公开(公告)号：US09072498B2
公开(公告)日：2015-07-07
申请号：US12948659
申请日：2010-11-17
申请人： Lisa Elkins , Ronald Williams
发明人： Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02 , A61B5/15 , A61B18/14 , A61B17/00 , A61B18/00
CPC分类号： A61B18/02 , A61B18/14 , A61B2017/00747 , A61B2018/00041 , A61B2018/0262 , A61B2018/0293
摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.
摘要翻译：装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。

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