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1. 发明申请

US20120158004A1 STEERABLE AND CURVABLE VERTEBROPLASTY SYSTEM WITH CLOG-RESISTANT EXIT PORTS 审中-公开
标题翻译：具有耐高温出口口的可转动和可弯曲的VERTEBROPLASTY系统
公开(公告)号：US20120158004A1
公开(公告)日：2012-06-21
申请号：US13182335
申请日：2011-07-13
申请人： Keith Burger , Joshua Cheatwood , Shixin Chen
发明人： Keith Burger , Joshua Cheatwood , Shixin Chen
IPC分类号： A61B17/88
CPC分类号： A61B17/8811 , A61B17/8827
摘要： Methods and devices for augmenting bone, such as in performing vertebroplasty are disclosed. A bone cement injection needle is provided, having a laterally deflectable distal end. The distal end may be provided with one or two or more cavity creation elements, such as a bevel or diamond tip or inflatable balloons. A cavity creation element may include one or more filament layers. Systems are also disclosed, including the steerable and curvable injection needle, introducer and stylet. The system can also include various exit ports that can be configured with clog-resistant features. Methods are also disclosed.
摘要翻译：公开了用于增加骨骼的方法和装置，例如执行椎体成形术。提供骨粘固剂注射针，其具有可横向偏转的远端。远端可以设置有一个或两个或更多个空腔创建元件，例如斜面或金刚石尖端或可充气气球。空腔产生元件可以包括一个或多个细丝层。还公开了系统，包括可转向和可调节的注射针，导引器和探针。该系统还可以包括可配置防堵塞功能的各种出口。还公开了方法。

2. 发明申请

US20080154254A1 Dermal and Transdermal Cryogenic Microprobe Systems and Methods 有权
标题翻译：皮肤和透皮低温微探针系统和方法
公开(公告)号：US20080154254A1
公开(公告)日：2008-06-26
申请号：US11614887
申请日：2006-12-21
申请人： Keith Burger , Ronald Williams , Lisa Elkins
发明人： Keith Burger , Ronald Williams , Lisa Elkins
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00747 , A61B2018/00452 , A61B2018/0262 , A61B2018/0293
摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-toleranced lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.
摘要翻译：医疗装置，系统和方法可任选地治疗皮肤病和/或美容缺陷，和/或广泛的其它靶组织。实施例用至少一个小的组织穿透探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入的尺寸的针而不留下可见的瘢痕。治疗可以沿着细长针的大部分或全部可插入长度施加，任选地通过将低温冷却流体通过熔融二氧化硅流体供应管的小的，紧密公差的管腔引入针内腔，供应管内腔经常计量冷却液。可以通过经由有限的总排气量空间耦合到针内腔的简单的压力释放阀来增强治疗温度和/或时间控制。

3. 发明授权

US08715275B2 Pain management using cryogenic remodeling 有权
标题翻译：疼痛管理采用低温重塑
公开(公告)号：US08715275B2
公开(公告)日：2014-05-06
申请号：US13615059
申请日：2012-09-13
申请人： Keith Burger , Lisa Elkins , Ronald Williams
发明人： Keith Burger , Lisa Elkins , Ronald Williams
IPC分类号： A61B18/18
CPC分类号： A61F7/12 , A61B18/0218 , A61B2018/00452 , A61B2018/0293 , A61F7/00 , A61F2007/0056 , A61F2007/0063 , A61F2007/0087 , A61F2007/0094 , A61F2007/0285 , A61F2007/126
摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.
摘要翻译：用于疼痛管理和其它应用的医疗装置，系统和方法可以用至少一个穿过皮肤暴露的皮肤表面插入的探针施加冷却。冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

4. 发明申请

US20080200910A1 Replaceable and/or Easily Removable Needle Systems for Dermal and Transdermal Cryogenic Remodeling 有权
标题翻译：用于皮肤和透皮低温重塑的可更换和/或易于移除的针系统
公开(公告)号：US20080200910A1
公开(公告)日：2008-08-21
申请号：US11675886
申请日：2007-02-16
申请人： Keith Burger , Lisa Elkins , Ronald Williams
发明人： Keith Burger , Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02 , A61M5/31
CPC分类号： A61B18/0218 , A61B18/02 , A61B2017/00747 , A61B2018/00023 , A61B2018/00458 , A61B2018/0262 , A61B2018/0293
摘要： The present invention generally provides improved medical devices, systems, and methods. Embodiments may be particularly well suited for the treatment of dermatological and/or cosmetic defects, and alternative embodiments may be configured for treatment of a wide range of target tissues. Some embodiments of the present invention apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments make use of replaceable needle probes supported by a probe body handle, with small needle probes often being replaced during treatment of a single patient. Unlike the large format cryogenic cooling systems of the past, small cryogenic cooling needle probes may dull or be damaged by insertion. Careful control over the control of cryogenic cooling fluid into a needle probe can allow the length of the active cooling to be controlled through depletion of liquid from an evaporating cryogenic cooling flow. Hence, even needles having similar external structures may provide differing lengths of an iceball along the needle axis. Surprisingly, small cryogenic cooling needles and/or other cryogenic cooling probes having a lubricious coating will allow safe removal of the probe from the treatment region while at a least a portion of the tissue remains frozen, significantly decreasing the overall time for a procedure involving many insertion/freeze/removal cycles.
摘要翻译：本发明通常提供改进的医疗装置，系统和方法。实施方案可以特别适用于治疗皮肤病和/或美容缺陷，并且替代实施方案可以被配置用于治疗大范围的靶组织。本发明的一些实施方案用至少一个小的穿透组织的探针进行冷却，所述探针通常包括适于穿过患者皮肤的暴露表面插入的尺寸的针，而不留下可见的瘢痕。冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。示例性实施例使用由探针主体手柄支撑的可替换的针探针，在单个患者的治疗期间经常更换小的针头探针。与过去的大型低温冷却系统不同，小型低温冷却针探针可能会沉没或被插入而损坏。将低温冷却液控制到针头探针中的仔细控制可以通过从蒸发的低温冷却流中消耗液体来控制主动冷却的长度。因此，即使具有相似外部结构的针也可以沿针轴提供不同长度的冰球。令人惊讶的是，具有光滑涂层的小型低温冷却针和/或其它低温冷却探针将允许从处理区域安全地移除探针，同时在组织的至少一部分保持冷冻，显着降低涉及许多方法的程序的总体时间插入/冻结/去除循环。

5. 发明授权

US06648879B2 Safety cryotherapy catheter 有权
公开(公告)号：US06648879B2
公开(公告)日：2003-11-18
申请号：US09953464
申请日：2001-09-14
申请人： James Joye , Keith Burger , Michael Fourkas , Timothy Holland
发明人： James Joye , Keith Burger , Michael Fourkas , Timothy Holland
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B18/0218 , A61B2017/00292 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： Improved devices, systems, and methods for inhibiting hyperplasia in blood vessels provide controlled and safe cryotherapy treatment of a target portion within a body lumen of a patient. One embodiment of the cryotherapy catheter comprises a catheter body having a proximal end and a distal end with a cooling fluid supply lumen and an exhaust lumen extending therebetween. A first balloon is disposed near the distal end of the catheter body in fluid communication with the supply and exhaust lumens. A second balloon is disposed over the first balloon with a barrier therebetween.

6. 发明申请

US20120265186A1 STEERABLE CURVABLE ABLATION CATHETER FOR VERTEBROPLASTY 审中-公开
标题翻译：用于VERTEBROPLASTY的可弯曲的弯曲导管
公开(公告)号：US20120265186A1
公开(公告)日：2012-10-18
申请号：US13219445
申请日：2011-08-26
申请人： Keith Burger , John Stalcup , Michael T. Lyster , Gerard von Hoffmann , Arvind Soni
发明人： Keith Burger , John Stalcup , Michael T. Lyster , Gerard von Hoffmann , Arvind Soni
IPC分类号： A61B18/14 , A61B18/02 , A61B18/18
CPC分类号： A61B18/1477 , A61B17/8811 , A61B17/8819 , A61B17/8827 , A61B17/8836 , A61B17/8855 , A61B18/02 , A61B18/18 , A61B2017/003 , A61B2018/0044 , A61B2018/00565 , A61B2018/0212 , A61B2018/0262 , A61M25/0138 , A61M25/0147 , A61M25/0152 , A61M25/1011 , A61M2025/0092 , A61N2007/025
摘要： Disclosed herein is a steerable, curvable catheter with one, two, or more ablation elements that can be used for various applications including vertebroplasty. The catheter can include an elongate, tubular body, having a proximal end, a distal end, and a central lumen extending therethrough; a deflectable zone on the distal end of the tubular body, deflectable through an angular range; a handle on the proximal end of the tubular body; and a deflection control on the handle; an energy delivery control on the handle; and one or more energy delivery elements on the distal end of the device for ablating tissue within bone. The energy delivery elements could be RF heating electrodes in a monopole or dipole arrangement although other energy delivery modalities are also contemplated. For example, the energy delivery elements include cryoprobes. Systems and methods involving the ablation catheter are also disclosed.
摘要翻译：本发明公开了一种可转向的可旋转导管，其具有一个，两个或更多个消融元件，其可用于包括椎体成形术的各种应用。导管可以包括细长的管状体，其具有近端，远端和延伸穿过其中的中心腔; 在管状体的远端上的可偏转区域，其可偏转通过角度范围; 在管状体的近端处的手柄; 和手柄上的偏转控制; 手柄上的能量传递控制; 以及在装置的远端上用于消融骨内的组织的一个或多个能量递送元件。能量传递元件可以是单极或偶极子布置中的RF加热电极，但是也可以考虑其它能量传递模式。例如，能量传递元件包括冷冻探针。还公开了涉及消融导管的系统和方法。

7. 发明申请

US20120191095A1 STEERABLE CURVABLE VERTEBROPLASTY DRILL 审中-公开
标题翻译：可弯曲的VERTEBROPLASTY DRILL
公开(公告)号：US20120191095A1
公开(公告)日：2012-07-26
申请号：US13215098
申请日：2011-08-22
申请人： Keith Burger , Shixin Chen , Joshua Cheatwood
发明人： Keith Burger , Shixin Chen , Joshua Cheatwood
IPC分类号： A61B17/16
CPC分类号： A61B17/1671 , A61B17/1642 , A61B17/8811 , A61B17/8819 , A61B17/8827 , A61B17/8855 , A61B2017/00557
摘要： Disclosed herein is a steerable and curvable drill that can be used for various applications including vertebroplasty. The drill can include an elongate, tubular body, having a proximal end, a distal end, and a central lumen extending therethrough; a deflectable zone on the distal end of the tubular body including one or more laser cuts, deflectable through an angular range; an insertable wire insertable into at least a portion of the central lumen of the elongate, tubular body; a handle on the proximal end of the tubular body; a deflection control on the handle; a drill control on the handle; a drive shaft within the elongate tubular body having a proximal end and a distal end; and a boring element on the distal end of the device for creating a cavity within bone. The boring element can be operably connected to the distal end of the drive shaft via a crimping mechanism. Systems and methods involving the drill are also disclosed.
摘要翻译：本文公开了一种可转向和可调的钻头，可用于包括椎体成形术在内的各种应用。钻头可以包括细长的管状主体，其具有近端，远端和延伸穿过其中的中心腔; 所述管状主体的远端上的可偏转区域包括可通过角度范围偏转的一个或多个激光切割; 可插入的线，其可插入到细长管状体的中心腔的至少一部分中; 在管状体的近端处的手柄; 手柄上的偏转控制; 手柄上的钻头控制; 细长管状体内的驱动轴具有近端和远端; 以及在所述装置的远端上的用于在骨内形成腔的无孔元件。钻孔元件可以通过压接机构可操作地连接到驱动轴的远端。还公开了涉及钻头的系统和方法。

8. 发明授权

US09254162B2 Dermal and transdermal cryogenic microprobe systems 有权
标题翻译：皮肤和透皮低温微探针系统
公开(公告)号：US09254162B2
公开(公告)日：2016-02-09
申请号：US11614887
申请日：2006-12-21
申请人： Keith Burger , Ronald Williams , Lisa Elkins
发明人： Keith Burger , Ronald Williams , Lisa Elkins
IPC分类号： A61B18/02 , A61B17/00 , A61B18/00
CPC分类号： A61B18/02 , A61B2017/00747 , A61B2018/00452 , A61B2018/0262 , A61B2018/0293
摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-toleranced lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.
摘要翻译：医疗装置，系统和方法可任选地治疗皮肤病和/或美容缺陷，和/或广泛的其它靶组织。实施例用至少一个小的组织穿透探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入的尺寸的针而不留下可见的瘢痕。治疗可以沿着细长针的大部分或全部可插入长度施加，任选地通过将低温冷却流体通过熔融二氧化硅流体供应管的小的，紧密公差的管腔引入针内腔，供应管内腔经常计量冷却液。可以通过经由有限的总排气量空间耦合到针内腔的简单的压力释放阀来增强治疗温度和/或时间控制。

9. 发明申请

US20140316413A1 STEERABLE CURVABLE VERTEBROPLASTY DRILL 审中-公开
标题翻译：可弯曲的VERTEBROPLASTY DRILL
公开(公告)号：US20140316413A1
公开(公告)日：2014-10-23
申请号：US14139372
申请日：2013-12-23
申请人： Keith Burger , Joshua Cheatwood , Shixin Chen
发明人： Keith Burger , Joshua Cheatwood , Shixin Chen
IPC分类号： A61B17/16 , A61B17/88
CPC分类号： A61B17/1671 , A61B17/1642 , A61B17/8811 , A61B17/8819 , A61B17/8827 , A61B17/8855 , A61B2017/00557
摘要： Disclosed herein is a steerable and curvable drill that can be used for various applications including vertebroplasty. The drill can include an elongate, tubular body, having a proximal end, a distal end, and a central lumen extending therethrough; a deflectable zone on the distal end of the tubular body including one or more laser cuts, deflectable through an angular range; an insertable wire insertable into at least a portion of the central lumen of the elongate, tubular body; a handle on the proximal end of the tubular body; a deflection control on the handle; a drill control on the handle; a drive shaft within the elongate tubular body having a proximal end and a distal end; and a boring element on the distal end of the device for creating a cavity within bone. The boring element can be operably connected to the distal end of the drive shaft via a crimping mechanism. Systems and methods involving the drill are also disclosed.
摘要翻译：本文公开了一种可转向和可调的钻头，可用于包括椎体成形术在内的各种应用。钻头可以包括细长的管状主体，其具有近端，远端和延伸穿过其中的中心腔; 所述管状主体的远端上的可偏转区域包括可通过角度范围偏转的一个或多个激光切割; 可插入的线，其可插入到细长管状体的中心腔的至少一部分中; 在管状体的近端处的手柄; 手柄上的偏转控制; 手柄上的钻头控制; 细长管状体内的驱动轴具有近端和远端; 以及在所述装置的远端上的用于在骨内形成腔的无孔元件。钻孔元件可以通过压接机构可操作地连接到驱动轴的远端。还公开了涉及钻头的系统和方法。

10. 发明申请

US20130218148A1 Pain Management Using Cryogenic Remodeling 有权
标题翻译：使用低温重塑的疼痛管理
公开(公告)号：US20130218148A1
公开(公告)日：2013-08-22
申请号：US13615059
申请日：2012-09-13
申请人： Keith Burger , Lisa Elkins , Ronald Williams
发明人： Keith Burger , Lisa Elkins , Ronald Williams
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/0218 , A61B2018/00452 , A61B2018/0293 , A61F7/00 , A61F2007/0056 , A61F2007/0063 , A61F2007/0087 , A61F2007/0094 , A61F2007/0285 , A61F2007/126
摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.
摘要翻译：用于疼痛管理和其它应用的医疗装置，系统和方法可以用至少一个穿过皮肤暴露的皮肤表面插入的探针施加冷却。冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

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