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1. 发明申请

US20130120757A1 METHODS, SYSTEMS AND APPLICATIONS OF VARIABLE IMAGING DEPTH IN FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：方法，系统和可变成像深度在FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY中的应用
公开(公告)号：US20130120757A1
公开(公告)日：2013-05-16
申请号：US13354066
申请日：2012-01-19
申请人： Lingfeng YU , Matthew J. Everett , Mary K. Durbin , Utkarsh Sharma
发明人： Lingfeng YU , Matthew J. Everett , Mary K. Durbin , Utkarsh Sharma
IPC分类号： A61B3/10 , G01B9/02
CPC分类号： A61B3/102 , G01B9/02004 , G01B9/02069 , G01B9/02091 , G01N21/4795
摘要： Systems, methods and applications for adjusting the imaging depth of a Fourier Domain optical coherence tomography system without impacting the axial resolution of the system are presented. One embodiment of the invention involves changing the sweep rate of a swept-source OCT system while maintaining the same data acquisition rate and spectral bandwidth of the source. Another embodiment involves changing the data acquisition rate of a SS-OCT system while maintaining the same sweep rate over the same spectral bandwidth. Several applications of variable imaging depth in the field of ophthalmic imaging are described.
摘要翻译：提出了一种用于调整傅立叶域光学相干断层扫描系统的成像深度而不影响系统轴向分辨率的系统，方法和应用。本发明的一个实施例涉及改变扫频源OCT系统的扫描速率，同时维持源的相同的数据采集速率和光谱带宽。另一实施例涉及改变SS-OCT系统的数据采集速率，同时在相同的光谱带宽上保持相同的扫描速率。描述了眼科成像领域可变成像深度的几种应用。

2. 发明授权

US08801187B1 Methods to reduce variance in OCT analysis of the macula 有权
标题翻译：减少黄斑OCT分析方法的方法
公开(公告)号：US08801187B1
公开(公告)日：2014-08-12
申请号：US13250699
申请日：2011-09-30
申请人： Robert W. Knighton , Matthew J. Everett , Mary K. Durbin , Jonathan D. Oakley
发明人： Robert W. Knighton , Matthew J. Everett , Mary K. Durbin , Jonathan D. Oakley
IPC分类号： A61B3/12 , G06F17/00 , A61B3/10
CPC分类号： A61B3/102 , A61B3/0025 , G06T7/0012 , G06T7/12 , G06T7/162 , G06T7/60 , G06T2207/10101 , G06T2207/30041
摘要： Methods for analyzing optical coherence tomography (OCT) images of the macula to reduce variance and improve disease diagnosis are presented. One embodiment of the invention is directed towards selecting analysis locations and data segmentation techniques to take advantage of structural homogeneities. Another embodiment is directed towards reducing the variance in a collection of normative data by transforming the individual members of the database to correspond to a Standard Macula. Variations in foveal size are corrected by radial transformation. Variations in layer thickness are corrected by axial shifting. Diagnosis is performed by comparing OCT images from a patient to the improved normative database.
摘要翻译：提出了分析黄斑的光学相干断层扫描（OCT）图像以减少变异并改善疾病诊断的方法。本发明的一个实施例涉及选择分析位置和数据分割技术以利用结构均匀性。另一个实施例旨在通过将数据库的各个成员变换为对应于标准黄疸来减少规范数据集合中的差异。通过径向变换校正中心凹大小的变化。通过轴向移动来校正层厚度的变化。通过比较患者的OCT图像和改进的规范数据库来进行诊断。

3. 发明授权

US08128229B2 RNFL measurement analysis 有权
标题翻译： RNFL测量分析
公开(公告)号：US08128229B2
公开(公告)日：2012-03-06
申请号：US12859727
申请日：2010-08-19
申请人： Scott A. Meyer , Mary K. Durbin , Paul F. Stetson , Bagrat Amirbekian
发明人： Scott A. Meyer , Mary K. Durbin , Paul F. Stetson , Bagrat Amirbekian
IPC分类号： A61B3/10
CPC分类号： A61B3/12 , A61B3/1241
摘要： One embodiment of the present invention accounts for individual anatomical variation when evaluating optical nerve fiber measurements. In one aspect, contextual information is used to compensate or correct measurement data. In another aspect, reference coordinates are remapped for improved comparison or visualization. In one embodiment of this latter aspect, the method uses measurements of nerve fiber capacity and maps of nerve fiber retinal service to improve sensitivity and specificity in eye function metrics. In one instance, we use the birefringence of nerve fibers to determine the orientation of the fibers within the RNFL. Orientation of the fibers about the ONH is indicative of the service provided by the fibers and is used to improve the interpretation of thickness measurements of the nerve fiber layer. Normalized nerve fiber measurements about the optic nerve head improve specificity and sensitivity as compared to the standard model. These improvements are a result of partitioning the normative database or modifying the measurement data prior to comparison. Statistics on normalized measurements of nerve fiber bundles also show improvements in specificity and sensitivity.
摘要翻译：评估光学神经纤维测量时，本发明的一个实施例解释了个体解剖学变化。在一个方面，使用上下文信息来补偿或校正测量数据。在另一方面，重新映射参考坐标以改善比较或可视化。在后一方面的一个实施例中，该方法使用神经纤维能力的测量和神经纤维视网膜服务的图来提高眼睛功能度量中的灵敏度和特异性。在一种情况下，我们使用神经纤维的双折射来确定RNFL内纤维的取向。关于ONH的纤维的取向指示由纤维提供的服务，并且用于改善对神经纤维层的厚度测量的解释。与标准模型相比，关于视神经头的规范化神经纤维测量提高了特异性和灵敏度。这些改进是在比较之前划分规范性数据库或修改测量数据的结果。关于神经纤维束的归一化测量的统计数据也显示出特异性和灵敏度的改善。

4. 发明授权

US07865005B2 Iterative reconstruction of multiple-peak isotope images 有权
标题翻译：多峰同位素图像的迭代重建
公开(公告)号：US07865005B2
公开(公告)日：2011-01-04
申请号：US11627087
申请日：2007-01-25
申请人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
发明人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/408 , G06T2211/424
摘要： In an imaging method, estimated data is iteratively projected and backprojected. The iterative projecting and backprojecting includes projecting or backprojecting the estimated data along parallel paths each employing energy-dependent parameters appropriate for a different energy. During each iteration, the estimated data is adjusted based on comparison of the estimated data with measured data.
摘要翻译：在成像方法中，估计数据被迭代地投影并反向投影。迭代投影和反向投影包括沿着并行路径投影或反投影估计数据，每个并行路径采用适用于不同能量的能量相关参数。在每次迭代期间，基于估计数据与测量数据的比较来调整估计数据。

5. 发明申请

US20090232375A1 ITERATIVE RECONSTRUCTION WITH ENHANCED NOISE CONTROL FILTERING 有权
标题翻译：具有增强噪声控制滤波的迭代重建
公开(公告)号：US20090232375A1
公开(公告)日：2009-09-17
申请号：US12067185
申请日：2006-08-21
申请人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
发明人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
IPC分类号： G06K9/00
CPC分类号： G01T1/2985 , A61B6/037 , G06T5/002 , G06T11/006 , G06T2207/10081 , G06T2207/10104 , G06T2207/10108 , G06T2207/30004 , G06T2211/424
摘要： An imaging system (10) comprises at least one radiation detector (20) disposed adjacent a subject receiving aperture (18) to detect radiation from a subject, receive the radiation and generate measured data. An image processor (38) iteratively reconstructs the detected radiation into image representations, in each reconstruction iteration the image processor (38) applies noise reduction algorithms to at least a difference between the measured data and a portion of a previous iteration image representation.
摘要翻译：成像系统（10）包括邻近对象接收孔（18）设置的至少一个辐射检测器（20），以检测来自对象的辐射，接收辐射并产生测量数据。图像处理器（38）将检测到的辐射重建成图像表示，在每个重建迭代中，图像处理器（38）将噪声降低算法应用于至少测量数据与先前迭代图像表示的一部分之间的差异。

6. 发明授权

US06664542B2 Gamma camera error correction using multiple point sources 有权
公开(公告)号：US06664542B2
公开(公告)日：2003-12-16
申请号：US10026381
申请日：2001-12-20
申请人： Jinghan Ye , Lingxiong Shao , Mary K. Durbin
发明人： Jinghan Ye , Lingxiong Shao , Mary K. Durbin
IPC分类号： G01T1166
CPC分类号： G01T1/1648
摘要： A gamma camera system and method are described which use multiple point sources to detect inaccuracies in detector translational and rotational alignment. In practice of the method of the preferred embodiment, three capillary tubes, each containing a drop of an isotope, are located in different planes and locations with respect to the axis of rotation of the detectors. A SPECT acquisition is performed and the point source projection data is processed to calculate the point source coordinates, from which center-of-rotation correction factors may be calculated. These correction factors are applied by mechanical and software adjustments to the gantry and acquisition systems of the camera to correct for both translational and rotational inaccuracies.

7. 发明授权

US08208599B2 Iterative reconstruction with enhanced noise control filtering 有权
标题翻译：具有增强噪声控制滤波的迭代重建
公开(公告)号：US08208599B2
公开(公告)日：2012-06-26
申请号：US12067185
申请日：2006-08-21
申请人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
发明人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
IPC分类号： G06K9/00
CPC分类号： G01T1/2985 , A61B6/037 , G06T5/002 , G06T11/006 , G06T2207/10081 , G06T2207/10104 , G06T2207/10108 , G06T2207/30004 , G06T2211/424
摘要： An imaging system (10) comprises at least one radiation detector (20) disposed adjacent a subject receiving aperture (18) to detect radiation from a subject, receive the radiation and generate measured data. An image processor (38) iteratively reconstructs the detected radiation into image representations, in each reconstruction iteration the image processor (38) applies noise reduction algorithms to at least a difference between the measured data and a portion of a previous iteration image representation.
摘要翻译：成像系统（10）包括邻近对象接收孔（18）设置的至少一个辐射检测器（20），以检测来自对象的辐射，接收辐射并产生测量数据。图像处理器（38）将检测到的辐射重建成图像表示，在每个重建迭代中，图像处理器（38）将噪声降低算法应用于至少测量数据与先前迭代图像表示的一部分之间的差异。

8. 发明申请

US20070183642A1 ITERATIVE RECONSTRUCTION OF MULTIPLE-PEAK ISOTOPE IMAGES 有权
标题翻译：多峰同位素图像的迭代重建
公开(公告)号：US20070183642A1
公开(公告)日：2007-08-09
申请号：US11627087
申请日：2007-01-25
申请人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
发明人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/408 , G06T2211/424
摘要： In an imaging method, estimated data is iteratively projected and backprojected. The iterative projecting and backprojecting includes projecting or backprojecting the estimated data along parallel paths each employing energy-dependent parameters appropriate for a different energy. During each iteration, the estimated data is adjusted based on comparison of the estimated data with measured data.
摘要翻译：在成像方法中，估计数据被迭代地投影并反向投影。迭代投影和反向投影包括沿着并行路径投影或反投影估计数据，每个并行路径采用适用于不同能量的能量相关参数。在每次迭代期间，基于估计数据与测量数据的比较来调整估计数据。

9. 发明授权

US08013307B2 Truncation compensation algorithm for iterative reconstruction 有权
标题翻译：用于迭代重建的截断补偿算法
公开(公告)号：US08013307B2
公开(公告)日：2011-09-06
申请号：US11721722
申请日：2005-12-05
申请人： Jinghan Ye , Mary K. Durbin
发明人： Jinghan Ye , Mary K. Durbin
IPC分类号： G01T1/161 , G01T1/166
CPC分类号： G01T1/1615
摘要： An imaging system (10) includes at least one radiation detector (20) disposed adjacent a subject receiving aperture (18) to detect and measure at least one of emission and transmission radiation from a subject, the detector (20) at a plurality of projection angles. A processor (64) determines which radiation data belong to a field of view of the radiation detector (20) at each projection angle. An image processor (70, 72) iteratively reconstructs the radiation detected only in the determined field of view into image representations. Truncated data is compensated by supplying the untruncated data from the projections taken at different angles at which the truncated data is untruncated.
摘要翻译：成像系统（10）包括邻近被检体接收孔（18）设置的至少一个辐射检测器（20），用于检测和测量来自受检者的发射和透射辐射中的至少一个，所述检测器（20）处于多个投影角度。处理器（64）以每个投影角度确定哪个辐射数据属于辐射检测器（20）的视场。图像处理器（70,72）将仅在所确定的视野中检测到的辐射重建为图像表示。截断的数据通过从截断数据未被截断的不同角度提供未突出数据来补偿。

10. 发明申请

US20110063573A1 RNFL MEASUREMENT ANALYSIS 有权
标题翻译： RNFL测量分析
公开(公告)号：US20110063573A1
公开(公告)日：2011-03-17
申请号：US12859727
申请日：2010-08-19
申请人： Scott A. MEYER , Mary K. Durbin , Paul F. Stetson , Bagrat Amirbekian
发明人： Scott A. MEYER , Mary K. Durbin , Paul F. Stetson , Bagrat Amirbekian
IPC分类号： A61B3/00
CPC分类号： A61B3/12 , A61B3/1241
摘要： One embodiment of the present invention accounts for individual anatomical variation when evaluating optical nerve fiber measurements. In one aspect, contextual information is used to compensate or correct measurement data. In another aspect, reference coordinates are remapped for improved comparison or visualization. In one embodiment of this latter aspect, the method uses measurements of nerve fiber capacity and maps of nerve fiber retinal service to improve sensitivity and specificity in eye function metrics. In one instance, we use the birefringence of nerve fibers to determine the orientation of the fibers within the RNFL. Orientation of the fibers about the ONH is indicative of the service provided by the fibers and is used to improve the interpretation of thickness measurements of the nerve fiber layer. Normalized nerve fiber measurements about the optic nerve head improve specificity and sensitivity as compared to the standard model. These improvements are a result of partitioning the normative database or modifying the measurement data prior to comparison. Statistics on normalized measurements of nerve fiber bundles also show improvements in specificity and sensitivity.
摘要翻译：评估光学神经纤维测量时，本发明的一个实施例解释了个体解剖学变化。在一个方面，使用上下文信息来补偿或校正测量数据。在另一方面，重新映射参考坐标以改善比较或可视化。在后一方面的一个实施例中，该方法使用神经纤维能力的测量和神经纤维视网膜服务的图来提高眼睛功能度量中的灵敏度和特异性。在一种情况下，我们使用神经纤维的双折射来确定RNFL内纤维的取向。关于ONH的纤维的取向指示由纤维提供的服务，并且用于改善对神经纤维层的厚度测量的解释。与标准模型相比，关于视神经头的规范化神经纤维测量提高了特异性和灵敏度。这些改进是在比较之前划分规范性数据库或修改测量数据的结果。关于神经纤维束的归一化测量的统计数据也显示出特异性和灵敏度的改善。

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