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1. 发明授权

US09993205B2 Cardiac response classification using retriggerable classification windows 有权
公开(公告)号：US09993205B2
公开(公告)日：2018-06-12
申请号：US12818066
申请日：2010-06-17
申请人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
发明人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
IPC分类号： A61N1/08 , A61B5/00 , A61N1/37 , A61B5/0452
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/7217 , A61N1/371
摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response, a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.

2. 发明申请

US20130013020A1 Methods and Systems for Managing Fusion and Noise in Cardiac Pacing Response Classification 有权
标题翻译：心脏起搏反应分类融合与噪声管理方法与系统
公开(公告)号：US20130013020A1
公开(公告)日：2013-01-10
申请号：US13618486
申请日：2012-09-14
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

3. 发明申请

US20120265059A1 IMAGING OF POLARIZATION SCRAMBLING TISSUE 有权
标题翻译：偏振屏障组织成像
公开(公告)号：US20120265059A1
公开(公告)日：2012-10-18
申请号：US13531034
申请日：2012-06-22
申请人： Scott A. Meyer , Xing Wei
发明人： Scott A. Meyer , Xing Wei
IPC分类号： A61B3/14 , A61B6/02
CPC分类号： A61B3/102
摘要： The present invention provides for the detection and display of polarization scrambling tissue without resolving the polarization state of the backscattered imaging beam. In one embodiment, we illuminate the tissue using two different polarizations. A first polarization determines a first image of high intensity while the second polarization determines a second image of low intensity. Comparison and combination of the first and second images determines tissue which scrambles the polarization in neighbouring detection cells.
摘要翻译：本发明提供了偏振加扰组织的检测和显示，而不分辨背散射成像束的偏振状态。在一个实施例中，我们使用两种不同的偏振照亮组织。第一偏振确定高强度的第一图像，而第二偏振确定低强度的第二图像。第一和第二图像的比较和组合确定在相邻检测单元中加扰极化的组织。

4. 发明申请

US20120226328A1 CARDIAC RESYNCHRONIZATION THERAPY PARAMETER OPTIMIZATION 审中-公开
标题翻译： CARDIAC RESYNCHRONIZATION治疗参数优化
公开(公告)号：US20120226328A1
公开(公告)日：2012-09-06
申请号：US13466431
申请日：2012-05-08
申请人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
发明人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/36585 , A61N1/3684
摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.
摘要翻译：系统和方法涉及使用多个CRT优化过程来确定CRT参数。每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。可以基于返回的推荐参数的组合来确定CRT参数。可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

5. 发明申请

US20120165895A1 Non-Captured Intrinsic Discrimination in Cardiac Pacing Response Classification 审中-公开
标题翻译：心脏起搏反应分类中不被捕获的内在歧视
公开(公告)号：US20120165895A1
公开(公告)日：2012-06-28
申请号：US13411852
申请日：2012-03-05
申请人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
发明人： Yanting Dong , Scott A. Meyer , Kevin John Stalsberg
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/371 , A61B5/04525
摘要： Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.
摘要翻译：心脏装置和方法通过将后期心脏信号的特征与与未捕获的应答相关联的预期特征与内在激活进行比较来区分诱发反应检测和分类期间的非捕获固有搏动。利用内在激活的非捕获响应的检测可以基于心脏信号的峰值振幅和定时。该方法可以用于区分融合或捕获节拍和未捕获的固有节拍。对起搏脉冲的可能的心脏反应之间的区分可能是有用的，例如在自动捕获验证和/或捕获阈值测试期间。

6. 发明授权

US08208688B2 Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues 有权
标题翻译：生物图像数据处理方法，用于揭示病变组织的更有意义的解剖特征
公开(公告)号：US08208688B2
公开(公告)日：2012-06-26
申请号：US13283445
申请日：2011-10-27
申请人： Matthew J. Everett , Scott A. Meyer , Paul F. Stetson , Yan Zhou
发明人： Matthew J. Everett , Scott A. Meyer , Paul F. Stetson , Yan Zhou
IPC分类号： G06K9/00 , G11B9/02
CPC分类号： A61B5/0066 , G06T7/0014 , G06T19/00 , G06T2200/24 , G06T2207/10101 , G06T2207/30041 , G06T2210/41
摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.
摘要翻译：本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：找到并分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。

7. 外观设计

USD660372S1 Game board 有权
公开(公告)号：USD660372S1
公开(公告)日：2012-05-22
申请号：US29384662
申请日：2011-02-02
申请人： Scott A. Meyer , David J. Meyer , Michael A. Fry
设计人： Scott A. Meyer , David J. Meyer , Michael A. Fry

8. 发明授权

US08116870B2 Capture detection for multi-chamber pacing 有权
标题翻译：捕获检测多腔起搏
公开(公告)号：US08116870B2
公开(公告)日：2012-02-14
申请号：US12214852
申请日：2008-06-23
申请人： Yanting Dong , Scott A. Meyer , Kevin John Stahlsberg
发明人： Yanting Dong , Scott A. Meyer , Kevin John Stahlsberg
IPC分类号： A61N1/368
CPC分类号： A61N1/3712 , A61N1/3684
摘要： Multi-chamber pacing may result in capture of one chamber, capture of multiple chambers, fusion, or non-capture. Approaches for detecting various capture conditions during multi-chamber pacing are described. Pacing pulses are delivered to left and right heart chambers during a cardiac cycle. A cardiac electrogram signal is sensed following the delivery of the pacing pulses. Left chamber capture only, right chamber capture only, and bi-chamber capture may be distinguished based on characteristics of the cardiac electrogram signal. Multi-chamber capture detection may be implemented using detection windows having dimensions of time and amplitude. The detection windows are associated with expected features, such as expected signal peaks, under a particular capture condition. The cardiac electrogram signal features are compared to detection windows to determine the capture condition.
摘要翻译：多腔起搏可能导致一个腔室的捕获，多个腔室的捕获，融合或非捕获。描述了在多室起搏期间检测各种捕获条件的方法。在心动周期期间，起搏脉冲被传送到左心室和右心室。在起搏脉冲输送之后感测心电图信号。仅左室捕获，右室捕获，双室捕获可以基于心电图信号的特征来区分。可以使用具有时间和幅度尺寸的检测窗来实现多室捕获检测。检测窗口与特定捕获条件下的预期特征（例如期望的信号峰值）相关联。将心电图信号特征与检测窗口进行比较以确定捕获条件。

9. 发明申请

US20110224751A1 CAPTURE DETECTION BASED ON PROPAGATED DEPOLARIZATION FROM A PACING SITE 审中-公开
标题翻译：基于从PACING站点传播分解的捕获检测
公开(公告)号：US20110224751A1
公开(公告)日：2011-09-15
申请号：US13104437
申请日：2011-05-10
申请人： Alok S. Sathaye , M. Jason Brooke , Scott A. Meyer
发明人： Alok S. Sathaye , M. Jason Brooke , Scott A. Meyer
IPC分类号： A61N1/362
CPC分类号： A61N1/371
摘要： A methods and devices for capture detection are based on sensing a propagated depolarization from a contralateral cardiac chamber. An intersite sensing interval is determined based on an intersite pacing delay and an intersite conduction delay associated with first and second pacing sites. Pacing pulses are delivered to the first pacing site and the second pacing site, the pacing pulses separated in time by the intersite pacing delay. An intersite sensing interval is timed. The process includes sensing, during the intersite sensing interval, at the first pacing site for a depolarization propagated to the first pacing site from the second pacing site. It a depolarization propagated from the second pacing site is not sensed, then capture of the first and second pacing sites is detected.
摘要翻译：用于捕获检测的方法和装置基于感测来自对侧心室的传播的去极化。基于场间起搏延迟和与第一和第二起搏部位相关联的间歇间传导延迟确定位置间感测间隔。起搏脉冲被传送到第一起搏部位和第二起搏部位，起搏脉冲及时地通过位置间起搏延迟分开。站间感知间隔是定时的。该过程包括在第一起搏部位期间在站间感测间隔期间感测到从第二起搏部位传播到第一起搏部位的去极化。从第二起搏部位传播的去极化不被感测，然后检测到第一和第二起搏部位的捕获。

10. 发明授权

US07979113B2 Multi channel approach to capture verification 有权
标题翻译：捕获验证的多渠道方法
公开(公告)号：US07979113B2
公开(公告)日：2011-07-12
申请号：US12435896
申请日：2009-05-05
申请人： Yanting Dong , Scott A. Meyer , Qingsheng Zhu
发明人： Yanting Dong , Scott A. Meyer , Qingsheng Zhu
IPC分类号： A61B5/04
CPC分类号： A61N1/371 , A61B5/04525 , A61B5/7217 , A61B5/7264
摘要： Methods and systems involve classifying the cardiac response to pacing using a multi-channel approach. Multiple cardiac response signals are sensed via multiple sense channels. Each sense channel comprises a distinct combination of electrodes and sensing circuitry. The cardiac response to the pacing pulse is classified based on the morphology of the cardiac response signals. Classifying the cardiac response involves discriminating between capture, fusion, non-capture, and non-capture with intrinsic activity.
摘要翻译：方法和系统包括使用多通道方法对心脏起搏应答进行分类。通过多个感测通道感测多个心脏反应信号。每个感测通道包括电极和感测电路的不同组合。基于心脏反应信号的形态对起搏脉搏的心脏反应进行分类。分类心脏反应包括区分捕获，融合，非捕获和非捕获与内在活动。

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