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1. 发明申请

US20100136089A1 LOCATION OF FATTY ACID ESTERS ON TAMPONS AND TOXIN INHIBITING EFFICACY 有权
标题翻译：脂肪酸酯在AMP。。。。。。。。。。。。。。。。。。
公开(公告)号：US20100136089A1
公开(公告)日：2010-06-03
申请号：US12622482
申请日：2009-11-20
申请人： Linda M. PIERSON , Susan K. Brown-Skrobot , Ching-Yun M. Yang
发明人： Linda M. PIERSON , Susan K. Brown-Skrobot , Ching-Yun M. Yang
IPC分类号： A61K31/23 , A61K9/70 , A61K31/22 , A61P31/04
CPC分类号： A61F13/8405 , A61F13/2074 , A61L15/46 , A61L15/60 , A61L2300/21
摘要： The application of active ingredients, exemplified by GML, to absorbent fibers, such as rayon fibers, used in tampon manufacture at very low levels has been found to maintain efficacy in the inhibition of the production of toxic shock syndrome toxin one (TSST-1) produced by S. aureus without overtly killing the microorganism to achieve the desired reduction while avoiding undesired test results that suggest the presence of “impurities” in some jurisdictions.
摘要翻译：已经发现以非常低的水平将用于棉塞制造中的吸收性纤维（例如人造纤维）应用于GML中的活性成分（例如GML）用于抑制中毒性休克综合征毒素（TSST-1）的产生的功效，由金黄色葡萄球菌产生，而不会明显杀死微生物以实现所需的还原，同时避免在一些管辖区域中存在“杂质”的不期望的测试结果。

2. 发明申请

US20100130951A1 COATING COMPOSITIONS AND COATED SUBSTRATES FOR ARTICLES OF MANUFACTURE USED IN CONTACT WITH HUMAN BODY SURFACES 有权
标题翻译：用于与人体表面接触使用的制品文章的涂料组合物和涂层基材
公开(公告)号：US20100130951A1
公开(公告)日：2010-05-27
申请号：US12621681
申请日：2009-11-19
申请人： Linda M. PIERSON , Susan K. Brown-Skrobot , Ching-Yun M. Yang
发明人： Linda M. PIERSON , Susan K. Brown-Skrobot , Ching-Yun M. Yang
IPC分类号： A61F13/20 , C09D191/00
CPC分类号： A61K9/0036 , C09D191/00 , C09D191/06
摘要： A composition of matter includes a flexible substrate and a coating disposed on the substrate. The coating comprises about 10-60 wt-% of a waxy compound and about 90-40 wt-% of a diluent. The coating forms a stable liquid mixture at a temperature between about 35° C. and about 100° C., has a liquefaction temperature of at least about 30° C., and has a contact angle with a flat surface of the substrate of less than about 35° when measured at a temperature of 60° C.
摘要翻译：物质组合物包括柔性基底和设置在基底上的涂层。涂层包含约10-60重量％的蜡状化合物和约90-40重量％的稀释剂。涂层在约35℃至约100℃之间的温度下形成稳定的液体混合物，具有至少约30℃的液化温度，并且与基材的平坦表面的接触角较小在温度为60℃时测量时约为35度

3. 发明授权

US08425480B2 Location of fatty acid esters on tampons and toxin inhibiting efficacy 有权
标题翻译：脂肪酸酯在棉塞上的位置和毒素的抑制作用
公开(公告)号：US08425480B2
公开(公告)日：2013-04-23
申请号：US12622482
申请日：2009-11-20
申请人： Linda M. Pierson , Susan K. Brown-Skrobot , Ching-Yun M. Yang
发明人： Linda M. Pierson , Susan K. Brown-Skrobot , Ching-Yun M. Yang
IPC分类号： A61F13/15 , A61F13/20
CPC分类号： A61F13/8405 , A61F13/2074 , A61L15/46 , A61L15/60 , A61L2300/21
摘要： The application of active ingredients, exemplified by GML, to absorbent fibers, such as rayon fibers, used in tampon manufacture at very low levels has been found to maintain efficacy in the inhibition of the production of toxic shock syndrome toxin one (TSST-1) produced by S. aureus without overtly killing the microorganism to achieve the desired reduction while avoiding undesired test results that suggest the presence of “impurities” in some jurisdictions.
摘要翻译：已经发现以非常低的水平将用于棉塞制造中的吸收性纤维（例如人造纤维）应用于GML中的活性成分（例如GML）用于抑制中毒性休克综合征毒素（TSST-1）的产生的功效，由金黄色葡萄球菌产生，而不会明显杀死微生物以实现所需的还原，同时避免在一些管辖区域中存在“杂质”的不期望的测试结果。

4. 发明授权

US08237011B2 Coating compositions and coated substrates for articles of manufacture used in contact with human body surfaces 有权
标题翻译：用于与人体表面接触的制品的涂料组合物和涂覆的基材
公开(公告)号：US08237011B2
公开(公告)日：2012-08-07
申请号：US12621681
申请日：2009-11-19
申请人： Linda M. Pierson , Susan K. Brown-Skrobot , Ching-Yun M. Yang
发明人： Linda M. Pierson , Susan K. Brown-Skrobot , Ching-Yun M. Yang
IPC分类号： A61F13/15 , A61F13/20
CPC分类号： A61K9/0036 , C09D191/00 , C09D191/06
摘要： A composition of matter includes a flexible substrate and a coating disposed on the substrate. The coating comprises about 10-60 wt-% of a waxy compound and about 90-40 wt-% of a diluent. The coating forms a stable liquid mixture at a temperature between about 35° C. and about 100° C., has a liquefaction temperature of at least about 30° C., and has a contact angle with a flat surface of the substrate of less than about 35° when measured at a temperature of 60° C.
摘要翻译：物质组合物包括柔性基底和设置在基底上的涂层。涂层包含约10-60重量％的蜡状化合物和约90-40重量％的稀释剂。涂层在约35℃至约100℃之间的温度下形成稳定的液体混合物，具有至少约30℃的液化温度，并且与基材的平坦表面的接触角较小在温度为60℃时测量时约为35度

5. 发明授权

US08318089B2 Method and apparatus of sterilization using monochromic UV radiation source 有权
标题翻译：使用单色紫外线辐射源灭菌的方法和设备
公开(公告)号：US08318089B2
公开(公告)日：2012-11-27
申请号：US13208452
申请日：2011-08-12
申请人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
发明人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
IPC分类号： A61L2/00 , B01J19/00 , B01J19/08 , A62B7/08 , G01N23/00 , B65D85/04 , B65D83/10 , B65D41/00 , A24F15/00 , B65B55/02
CPC分类号： A61L12/063 , A61L2/10 , B65B25/008
摘要： A processes of sterilizing a contact lens, that is immersed in an aqueous liquid and hermetically in a container, using at least 284 mJ/cm2 of UV radiation in the range of 240-280 nm is disclosed herein.
摘要翻译：本文公开了使用在240-280nm范围内的至少284mJ / cm 2的紫外线辐射将隐形眼镜浸入含水液体并气密地在容器中进行灭菌的方法。

6. 发明授权

US5547985A Additives to feminine products 失效
标题翻译：女性产品添加剂
公开(公告)号：US5547985A
公开(公告)日：1996-08-20
申请号：US151593
申请日：1993-11-12
申请人： Susan K. Brown-Skrobot , Mary R. Irving
发明人： Susan K. Brown-Skrobot , Mary R. Irving
IPC分类号： A01N31/02 , A01N37/02 , A01N37/06 , A61K8/37 , A61K9/00 , A61K31/23 , A61Q15/00 , A61Q17/00 , A61Q19/10 , A61K31/22 , A61K31/225
CPC分类号： A61Q19/10 , A61K31/23 , A61K8/375 , A61K9/0034 , A61Q15/00 , A61Q17/005
摘要： Nonabsorbent products and douche compositions for cleansing and placement within the vagina contain an amount of a compound effective to inhibit the production of toxic shock syndrome toxin-1 and Enterotoxins A, B and C when the products are brought into contact with the bacteria. The products and compositions of this invention are also effective in combatting streptococcal pyrogenic exotoxin and hemolysin production by Groups A, B, F and G streptococci. The compound is selected from the group consisting of monoesters of a polyhydric aliphatic alcohol and a C.sub.8 -C.sub.18 fatty acid; diesters of a polyhydric aliphatic alcohol and a C.sub.8 -C.sub.18 fatty acid; and mixtures thereof. The monoesters and diesters have at least one hydroxyl group associated with their aliphatic alcohol residue.
摘要翻译：用于清洁和放置在阴道内的非吸收性产品和冲洗剂组合物含有一定量的化合物，当产品与细菌接触时，该化合物有效地抑制中毒性休克综合征毒素-1和肠毒素A，B和C的产生。本发明的产品和组合物也有效地抵抗A，B，F和G组链球菌产生链球菌热原性外毒素和溶血素。该化合物选自多元脂肪醇和C8-C18脂肪酸的单酯; 多元脂肪醇和C8-C18脂肪酸的二酯; 及其混合物。单酯和二酯具有与其脂族醇残基相关的至少一个羟基。

7. 发明授权

US5389374A Prevention of toxin production using absorbent products 失效
标题翻译：使用吸收性产品预防毒素生产
公开(公告)号：US5389374A
公开(公告)日：1995-02-14
申请号：US128336
申请日：1993-09-29
申请人： Susan K. Brown-Skrobot
发明人： Susan K. Brown-Skrobot
IPC分类号： A61F13/15 , A61F13/20 , A61F13/472 , A61L15/20 , A61L15/42 , A61L15/44 , A61L15/48 , A61F13/02 , A61L15/16
CPC分类号： A61L15/20 , Y10S604/904
摘要： Absorbent products, especially catemenial tampons, for absorbing body fluids, such as menstrual fluid, blood and wound exudates, comprise an amount of a compound effective to inhibit the production of Enterotoxin A, Enterotoxin B and/or Enterotoxin C by Staphylococcus aureus bacteria when the products are brought into contact with the bacteria. The compositions of this invention are also useful to inhibit production of Streptococcal pyrogenic exotoxins A, B and C, as well as hemolysins produced by Groups A, B, F and G streptococci in solution as well as being expected to be effective to inhibit such toxin and hemolysin production when used in conjunction with absorbent products. The compound is selected from the group consisting of monoesters of a polyhydric aliphatic alcohol and a C.sub.8 -C.sub.18 fatty acid; diesters of a polyhydric aliphatic alcohol and a C.sub.8 -C.sub.18 fatty acid; and mixtures thereof. The monoesters and diesters have at least one hydroxyl group associated with their aliphatic alcohol residue.
摘要翻译：用于吸收体液（例如月经液，血液和伤口渗出物）的吸收制品，特别是儿科卫生棉条包含一定量的有效抑制金黄色葡萄球菌产生肠毒素A，肠毒素B和/或肠毒素C的化合物产品与细菌接触。本发明的组合物还可用于抑制链球菌热原性外毒素A，B和C的产生，以及溶液中由A，B，F和G族链球菌产生的溶血素，并且预期有效抑制这种毒素和与吸收产品结合使用时产生溶血素。该化合物选自多元脂肪醇和C8-C18脂肪酸的单酯; 多元脂肪醇和C8-C18脂肪酸的二酯; 及其混合物。单酯和二酯具有与其脂族醇残基相关的至少一个羟基。

8. 发明申请

US20110293471A1 Method and Apparatus of Sterilization Using Monochromic UV Radiation Source 有权
标题翻译：使用单色紫外线辐射源灭菌的方法和装置
公开(公告)号：US20110293471A1
公开(公告)日：2011-12-01
申请号：US13208452
申请日：2011-08-12
申请人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
发明人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
IPC分类号： A61L2/10
CPC分类号： A61L12/063 , A61L2/10 , B65B25/008
摘要： This invention provides a process of sterilizing a medical device, and preferably the contents of a sealed container which comprises said medical device, comprising the step of exposing said medical device to monochromatic ultraviolet radiation whereby the Dvalue of Bacillus stearothermophilus (ATCC 7953) is at least 23.7 mJ/cm2 monochromatic ultraviolet radiation at 257 nm to the spore. Further, this invention provides a process of sterilizing a medical device comprising the step of subjecting said medical device to monochromatic ultraviolet radiation wherein the minimum total energy density of said monochromatic ultraviolet radiation at 257 nm which reaches the microorganisms present on said medical device is at least 284 mJ/cm2.This invention further provides an apparatus for delivering UV radiation to a medical device for sterilization comprising a laser and a scanner for the laser such that at least 284 mJ/cm2 at 257 nm is applied to a treatment area for said medical device. This invention provides a process and apparatus in which sterilization can be achieved in less than 20 seconds, preferably less than 15 seconds, more preferably in less than 5 seconds. The process and apparatus are efficient and continuous.
摘要翻译：本发明提供了一种对医疗装置进行灭菌的方法，优选包括所述医疗装置的密封容器的内容物，其包括将所述医疗装置暴露于单色紫外线辐射的步骤，由此使嗜热脂肪芽孢杆菌（ATCC 7953）的D值至少为在257nm处的23.7mJ / cm 2单色紫外线辐射对孢子。此外，本发明提供对医疗装置进行灭菌的方法，包括以下步骤：对所述医疗装置进行单色紫外线辐射，其中到达所述医疗装置上存在的微生物的257nm处的所述单色紫外线辐射的最小总能量密度至少为 284mJ / cm 2。本发明还提供一种用于将UV辐射递送到用于灭菌的医疗装置的装置，包括用于激光的激光器和扫描仪，使得在257nm处的至少284mJ / cm 2施加到所述医疗装置的治疗区域。本发明提供一种方法和装置，其中可以在少于20秒，优选小于15秒，更优选在少于5秒内实现灭菌。该方法和设备是有效和连续的。

9. 发明授权

US08021608B2 Method and apparatus of sterilization using monochromatic UV radiation source 有权
公开(公告)号：US08021608B2
公开(公告)日：2011-09-20
申请号：US12971486
申请日：2010-12-17
申请人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
发明人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
IPC分类号： A61L2/00 , B01J19/00 , B01J19/08 , A62B7/08 , G01N23/00 , B65D85/04 , B65D83/10 , B65D41/00 , B65B55/02
CPC分类号： A61L12/063 , A61L2/10 , B65B25/008
摘要： This invention provides a process of sterilizing a medical device, and preferably the contents of a sealed container which comprises said medical device, comprising the step of exposing said medical device to monochromatic ultraviolet radiation whereby the Dvalue of Bacillus stearothermophilus (ATCC 7953) is at least 23.7 mJ/cm2 monochromatic ultraviolet radiation at 257 nm to the spore. Further, this invention provides a process of sterilizing a medical device comprising the step of subjecting said medical device to monochromatic ultraviolet radiation wherein the minimum total energy density of said monochromatic ultraviolet radiation at 257 nm which reaches the microorganisms present on said medical device is at least 284 mJ/cm2.This invention further provides an apparatus for delivering UV radiation to a medical device for sterilization comprising a laser and a scanner for the laser such that at least 284 mJ/cm2 at 257 nm is applied to a treatment area for said medical device. This invention provides a process and apparatus in which sterilization can be achieved in less than 20 seconds, preferably less than 15 seconds, more preferably in less than 5 seconds. The process and apparatus are efficient and continuous.

10. 发明授权

US07879288B2 Method and apparatus of sterilization using monochromatic UV radiation source 有权
标题翻译：使用单色紫外线辐射源灭菌的方法和设备
公开(公告)号：US07879288B2
公开(公告)日：2011-02-01
申请号：US10939818
申请日：2004-09-13
申请人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
发明人： Susan K. Brown-Skrobot , James A. Ebel , John B. Enns , Gregory A. Hill , Allan W. Kimble
IPC分类号： A61L2/00 , A62B7/08 , A24F15/00 , B01J19/00 , B01J19/08 , B65D85/04 , B65D83/10 , G01N23/00
CPC分类号： A61L12/063 , A61L2/10 , B65B25/008
摘要： This invention provides a process of sterilizing a medical device, and preferably the contents of a sealed container which comprises said medical device, comprising the step of exposing said medical device to monochromatic ultraviolet radiation whereby the Dvalue of Bacillus stearothermophilus (ATCC 7953) is at least 23.7 mJ/cm2 monochromatic ultraviolet radiation at 257 nm to the spore. Further, this invention provides a process of sterilizing a medical device comprising the step of subjecting said medical device to monochromatic ultraviolet radiation wherein the minimum total energy density of said monochromatic ultraviolet radiation at 257 nm which reaches the microorganisms present on said medical device is at least 284 mJ/cm2.This invention further provides an apparatus for delivering UV radiation to a medical device for sterilization comprising a laser and a scanner for the laser such that at least 284 mJ/cm2 at 257 nm is applied to a treatment area for said medical device. This invention provides a process and apparatus in which sterilization can be achieved in less than 20 seconds, preferably less than 15 seconds, more preferably in less than 5 seconds. The process and apparatus are efficient and continuous.
摘要翻译：本发明提供了一种对医疗装置进行灭菌的方法，优选包括所述医疗装置的密封容器的内容物，其包括将所述医疗装置暴露于单色紫外线辐射的步骤，由此使嗜热脂肪芽孢杆菌（ATCC 7953）的D值至少为在257nm处的23.7mJ / cm 2单色紫外线辐射对孢子。此外，本发明提供对医疗装置进行灭菌的方法，包括以下步骤：对所述医疗装置进行单色紫外线辐射，其中到达所述医疗装置上存在的微生物的257nm处的所述单色紫外线辐射的最小总能量密度至少为 284mJ / cm 2。本发明还提供一种用于将UV辐射递送到用于灭菌的医疗装置的装置，包括用于激光的激光器和扫描仪，使得在257nm处的至少284mJ / cm 2施加到所述医疗装置的治疗区域。本发明提供一种方法和装置，其中可以在少于20秒，优选小于15秒，更优选在少于5秒内实现灭菌。该方法和设备是有效和连续的。

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