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1. 发明授权

US5518680A Tissue regeneration matrices by solid free form fabrication techniques 失效
标题翻译：通过固体自由形式制造技术的组织再生基质
公开(公告)号：US5518680A
公开(公告)日：1996-05-21
申请号：US200636
申请日：1994-02-23
申请人： Linda G. Cima , Michael J. Cima
发明人： Linda G. Cima , Michael J. Cima
IPC分类号： A61F2/00 , A61F2/02 , A61F2/10 , A61F2/28 , A61F2/30 , A61K9/00 , A61K9/16 , A61L27/38 , A61L27/40 , A61L27/56 , A61L27/60 , B29C67/00 , B82B1/00 , B29C35/08 , B29C41/02 , B29C67/20
CPC分类号： B29C67/0051 , A61F2/02 , A61F2/022 , A61F2/105 , A61K9/0024 , A61K9/0097 , A61K9/1647 , A61K9/1694 , A61L27/38 , A61L27/3808 , A61L27/40 , A61L27/56 , A61L27/60 , B29C67/0081 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2002/0086 , A61F2002/009 , A61F2002/30011 , A61F2002/30032 , A61F2002/30034 , A61F2002/30062 , A61F2002/3028 , A61F2002/30677 , A61F2002/3093 , A61F2002/30932 , A61F2002/30962 , A61F2210/0004 , A61F2230/0063 , A61F2240/001 , A61F2250/0023 , A61F2250/003 , A61F2250/0031 , A61F2250/0067 , A61F2310/00359 , B29K2995/0064
摘要： Solid free-form techniques for making medical devices for implantation and growth of cells from polymers or polymer/inorganic composites using computer aided design are described. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The devices can incorporate inorganic particles to improve the strength of the walls forming the pores within the matrix and to provide a source of mineral for the regenerating tissue. The devices can contain tissue adhesion peptides, or can be coated with materials which reduce tissue adhesion. The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.
摘要翻译：描述了使用计算机辅助设计制备用于从聚合物或聚合物/无机复合材料植入和生长细胞的医疗装置的固体自由形式技术。 SFF方法的实例包括立体光刻（SLA），选择性激光烧结（SLS），弹道粒子制造（BPM），熔融沉积建模（FDM）和三维印刷（3DP）。该装置可以掺入无机颗粒以提高在基质内形成孔的壁的强度，并为再生组织提供矿物来源。该装置可以包含组织粘附肽，或者可以用减少组织粘附的材料涂覆。可以通过控制打印参数来操纵装置的宏观结构和孔隙度。最重要的是，可以使用计算机辅助设计（CAD）为个别患者设计和量身定制这些功能，以优化治疗。

2. 发明授权

US5490962A Preparation of medical devices by solid free-form fabrication methods 失效
标题翻译：通过固体自由形式制备方法制备医疗器械
公开(公告)号：US5490962A
公开(公告)日：1996-02-13
申请号：US138345
申请日：1993-10-18
申请人： Linda G. Cima , Michael J. Cima
发明人： Linda G. Cima , Michael J. Cima
IPC分类号： A61F2/00 , A61F2/02 , A61F2/10 , A61F2/28 , A61F2/30 , A61K9/00 , A61K9/16 , A61L27/38 , A61L27/40 , A61L27/56 , A61L27/60 , B29C67/00 , B82B1/00 , B29C35/08 , B29C41/02 , B29C67/20
CPC分类号： A61F2/022 , A61F2/105 , A61F2/28 , A61K9/0024 , A61K9/0097 , A61K9/1647 , A61K9/1694 , A61L27/34 , A61L27/38 , A61L27/40 , A61L27/56 , A61L27/60 , B29C67/0081 , A61F2/30756 , A61F2/3094 , A61F2002/0086 , A61F2002/009 , A61F2002/30011 , A61F2002/30032 , A61F2002/30034 , A61F2002/30062 , A61F2002/3028 , A61F2002/30677 , A61F2002/3093 , A61F2002/30932 , A61F2002/30962 , A61F2210/0004 , A61F2230/0063 , A61F2240/001 , A61F2250/0023 , A61F2250/003 , A61F2250/0031 , A61F2250/0067 , B29K2995/0064 , Y10S623/901 , Y10T428/249953 , Y10T428/249954 , Y10T428/249961 , Y10T428/249978 , Y10T428/249986 , Y10T428/249994 , Y10T428/249999
摘要： Solid free-form techniques for making medical devices for controlled release of bioactive agent and implantation and growth of Cells are described using computer aided design. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.
摘要翻译：使用计算机辅助设计来描述用于制造用于控制释放生物活性剂和植入和生长细胞的医疗装置的固体自由形式技术。 SFF方法的实例包括立体光刻（SLA），选择性激光烧结（SLS），弹道粒子制造（BPM），熔融沉积建模（FDM）和三维印刷（3DP）。可以通过控制打印参数来操纵装置的宏观结构和孔隙度。最重要的是，可以使用计算机辅助设计（CAD）为个别患者设计和量身定制这些功能，以优化治疗。

3. 发明授权

US06530958B1 Tissue regeneration matrices by solid free-form fabrication techniques 失效
标题翻译：通过固体自由形式制造技术的组织再生基质
公开(公告)号：US06530958B1
公开(公告)日：2003-03-11
申请号：US08463203
申请日：1995-06-05
申请人： Linda G. Cima , Michael J. Cima
发明人： Linda G. Cima , Michael J. Cima
IPC分类号： A61F228
CPC分类号： A61F2/022 , A61F2/105 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2002/0086 , A61F2002/009 , A61F2002/30011 , A61F2002/30032 , A61F2002/30034 , A61F2002/30062 , A61F2002/3028 , A61F2002/30677 , A61F2002/3093 , A61F2002/30932 , A61F2002/30962 , A61F2210/0004 , A61F2230/0063 , A61F2240/001 , A61F2250/0023 , A61F2250/003 , A61F2250/0031 , A61F2250/0067 , A61K9/0024 , A61K9/0097 , A61K9/1647 , A61K9/1694 , A61L27/34 , A61L27/38 , A61L27/40 , A61L27/56 , A61L27/60 , B29C64/165 , B29K2995/0064 , B33Y10/00 , B33Y70/00 , B33Y80/00 , Y10S623/901 , Y10T428/249953 , Y10T428/249954 , Y10T428/249961 , Y10T428/249978 , Y10T428/249986 , Y10T428/249994 , Y10T428/249999
摘要： Solid free-form (SSF) techniques for making medical devices for implantation and growth of cells from polymers or polymer/inorganic composites using computer aided design are described. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The devices can incorporate inorganic particles to improve the strength of the walls forming the pores within the matrix and to provide a source of mineral for the regenerating tissue. The devices can contain tissue adhesion peptides, or can be coated with materials which reduce tissue adhesion. The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.
摘要翻译：描述了使用计算机辅助设计来制备用于从聚合物或聚合物/无机复合材料植入和生长细胞的医疗装置的固体自由形式（SSF）技术。 SFF方法的实例包括立体光刻（SLA），选择性激光烧结（SLS），弹道粒子制造（BPM），熔融沉积建模（FDM）和三维印刷（3DP）。该装置可以掺入无机颗粒以提高在基质内形成孔的壁的强度，并为再生组织提供矿物来源。该装置可以包含组织粘附肽，或者可以用减少组织粘附的材料涂覆。可以通过控制打印参数来操纵装置的宏观结构和孔隙度。最重要的是，可以使用计算机辅助设计（CAD）为个别患者设计和量身定制这些功能，以优化治疗。

4. 发明授权

US06176874B1 Vascularized tissue regeneration matrices formed by solid free form fabrication techniques 失效
标题翻译：由固体自由形式制造技术形成的血管化组织再生基质
公开(公告)号：US06176874B1
公开(公告)日：2001-01-23
申请号：US08477226
申请日：1995-06-07
申请人： Joseph P. Vacanti , Linda G. Cima , Michael J. Cima
发明人： Joseph P. Vacanti , Linda G. Cima , Michael J. Cima
IPC分类号： A61F200
CPC分类号： A61F2/105 , A61F2/022 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2002/0086 , A61F2002/009 , A61F2002/30011 , A61F2002/30032 , A61F2002/30034 , A61F2002/30062 , A61F2002/30199 , A61F2002/3028 , A61F2002/30677 , A61F2002/3093 , A61F2002/30932 , A61F2002/30962 , A61F2210/0004 , A61F2230/0063 , A61F2240/001 , A61F2250/0023 , A61F2250/003 , A61F2250/0031 , A61F2250/0067 , A61L27/3808 , A61L27/40 , A61L27/56 , A61L27/60 , B29C64/135 , B29C64/165 , B29K2995/0064 , B33Y10/00 , B33Y30/00 , B33Y80/00 , Y10S623/901 , A61L27/38
摘要： Solid free-form fabrication (SFF) methods are used to manufacture devices for allowing tissue regeneration and for seeding and implanting cells to form organ and structural components, which can additionally provide controlled release of bioactive agents, wherein the matrix is characterized by a network of lumens functionally equivalent to the naturally occurring vasculature of the tissue formed by the implanted cells, and which can be lined with endothelial cells and coupled to blood vessels at the time of implantation to form a vascular network throughout the matrix. The SFF methods can be adapted for use with a variety of polymeric, inorganic and composite materials to create structures with defined compositions, strengths, and densities, using computer aided design (CAD). Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP).
摘要翻译：固体自由形式制造（SFF）方法用于制造用于允许组织再生和用于种植和植入细胞以形成器官和结构组分的装置，其可另外提供生物活性剂的受控释放，其中所述基质的特征在于：流体功能上等同于由植入的细胞形成的组织的天然存在的脉管系统，并且其可以在植入时与内皮细胞排列并耦合到血管，以在整个基质中形成血管网络。 SFF方法可以适用于各种聚合物，无机和复合材料，以使用计算机辅助设计（CAD）创建具有确定的组成，强度和密度的结构。SFF方法的实例包括立体光刻（SLA），选择性激光烧结（SLS），弹道粒子制造（BPM），熔融沉积建模（FDM）和三维打印（3DP）。

5. 发明授权

US6139574A Vascularized tissue regeneration matrices formed by solid free form fabrication techniques 失效
标题翻译：由固体自由形式制造技术形成的血管化组织再生基质
公开(公告)号：US6139574A
公开(公告)日：2000-10-31
申请号：US915409
申请日：1997-08-20
申请人： Joseph P. Vacanti , Linda G. Cima , Michael J. Cima
发明人： Joseph P. Vacanti , Linda G. Cima , Michael J. Cima
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/10 , A61F2/28 , A61F2/30 , A61K9/00 , A61K9/16 , A61L27/38 , A61L27/40 , A61L27/56 , A61L27/60 , B29C67/00 , B82B1/00
CPC分类号： B29C67/0081 , A61F2/022 , A61F2/105 , A61L27/3808 , A61L27/40 , A61L27/56 , A61L27/60 , B29C67/0066 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2002/0086 , A61F2002/009 , A61F2002/30011 , A61F2002/30032 , A61F2002/30034 , A61F2002/30062 , A61F2002/30199 , A61F2002/3028 , A61F2002/30677 , A61F2002/3093 , A61F2002/30932 , A61F2002/30962 , A61F2210/0004 , A61F2230/0063 , A61F2240/001 , A61F2250/0023 , A61F2250/003 , A61F2250/0031 , A61F2250/0067 , B29K2995/0064 , Y10S623/901
摘要： Solid free-form fabrication (SFF) methods are used to manufacture devices for allowing tissue regeneration and for seeding and implanting cells to form organ and structural components, which can additionally provide controlled release of bioactive agents, wherein the matrix is characterized by a network of lumens functionally equivalent to the naturally occurring vasculature of the tissue formed by the implanted cells, and which can be lined with endothelial cells and coupled to blood vessels at the time of implantation to form a vascular network throughout the matrix. The SFF methods can be adapted for use with a variety of polymeric, inorganic and composite materials to create structures with defined compositions, strengths, and densities, using computer aided design (CAD).Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP).
摘要翻译：固体自由形式制造（SFF）方法用于制造用于允许组织再生和用于种植和植入细胞以形成器官和结构组分的装置，其可另外提供生物活性剂的受控释放，其中所述基质的特征在于：流体功能上等同于由植入的细胞形成的组织的天然存在的脉管系统，并且其可以在植入时与内皮细胞排列并耦合到血管，以在整个基质中形成血管网络。 SFF方法可以适用于各种聚合物，无机和复合材料，以使用计算机辅助设计（CAD）创建具有规定组成，强度和密度的结构。 SFF方法的实例包括立体光刻（SLA），选择性激光烧结（SLS），弹道粒子制造（BPM），熔融沉积建模（FDM）和三维印刷（3DP）。

6. 发明授权

US5869170A Preparation of medical devices by solid free-form fabrication methods 失效
标题翻译：通过固体自由形式制备方法制备医疗器械
公开(公告)号：US5869170A
公开(公告)日：1999-02-09
申请号：US464593
申请日：1995-06-05
申请人： Linda G. Cima , Michael J. Cima
发明人： Linda G. Cima , Michael J. Cima
IPC分类号： A61F2/00 , A61F2/02 , A61F2/10 , A61F2/28 , A61F2/30 , A61K9/00 , A61K9/16 , A61L27/38 , A61L27/40 , A61L27/56 , A61L27/60 , B29C67/00 , B82B1/00 , B32B3/26
CPC分类号： A61F2/022 , A61F2/105 , A61F2/28 , A61K9/0024 , A61K9/0097 , A61K9/1647 , A61K9/1694 , A61L27/34 , A61L27/38 , A61L27/40 , A61L27/56 , A61L27/60 , B29C67/0081 , A61F2/30756 , A61F2/3094 , A61F2002/0086 , A61F2002/009 , A61F2002/30011 , A61F2002/30032 , A61F2002/30034 , A61F2002/30062 , A61F2002/3028 , A61F2002/30677 , A61F2002/3093 , A61F2002/30932 , A61F2002/30962 , A61F2210/0004 , A61F2230/0063 , A61F2240/001 , A61F2250/0023 , A61F2250/003 , A61F2250/0031 , A61F2250/0067 , B29K2995/0064 , Y10S623/901 , Y10T428/249953 , Y10T428/249954 , Y10T428/249961 , Y10T428/249978 , Y10T428/249986 , Y10T428/249994 , Y10T428/249999
摘要： Solid free-form techniques for making medical devices for controlled release of bioactive agent and implantation and growth of cells are described using computer aided design. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.
摘要翻译：使用计算机辅助设计描述了用于制造用于控制释放生物活性剂和植入和生长细胞的医疗装置的固体自由形式技术。 SFF方法的实例包括立体光刻（SLA），选择性激光烧结（SLS），弹道粒子制造（BPM），熔融沉积建模（FDM）和三维印刷（3DP）。可以通过控制打印参数来操纵装置的宏观结构和孔隙度。最重要的是，可以使用计算机辅助设计（CAD）为个别患者设计和量身定制这些功能，以优化治疗。

7. 发明授权

US09918656B2 Implantable magnetic relaxation sensors and methods of measuring a sensor's cumulative exposure to a biomarker 有权
公开(公告)号：US09918656B2
公开(公告)日：2018-03-20
申请号：US13806348
申请日：2011-06-27
申请人： Michael J. Cima , Paul Huang , Yibo Ling , Terrence Pong , Christophoros C. Vassiliou
发明人： Michael J. Cima , Paul Huang , Yibo Ling , Terrence Pong , Christophoros C. Vassiliou
IPC分类号： A61B5/055 , A61B5/00 , A61B5/145 , G01R33/56 , G01R33/30 , G01R33/50
CPC分类号： A61B5/055 , A61B5/0031 , A61B5/14546 , A61B2562/0285 , G01R33/302 , G01R33/50 , G01R33/5601
摘要： An implantable magnetic relaxation sensor is provided that comprises superparamagnetic nanoparticies functionalized with one or more agents that bond with a biomarker of interest. The sensor is configured for minimally-invasive implantation into a human or animal, and is configured to indicate the implanted sensor's cumulative exposure to the biomarker of interest by analysis using magnetic resonance relaxometry.

8. 发明授权

US09017312B2 Implantable device for controlled drug delivery 有权
标题翻译：用于受控药物输送的可植入装置
公开(公告)号：US09017312B2
公开(公告)日：2015-04-28
申请号：US12851494
申请日：2010-08-05
申请人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
发明人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
IPC分类号： A61K9/22 , A61M31/00 , A61K9/00 , A61K31/167
CPC分类号： A61K9/0092 , A61K9/0004 , A61K9/0034 , A61K31/167 , A61M31/002
摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.
摘要翻译：提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

9. 发明授权

US08801694B2 Intravesical drug delivery device 有权
标题翻译：膀胱内药物输送装置
公开(公告)号：US08801694B2
公开(公告)日：2014-08-12
申请号：US11463956
申请日：2006-08-11
申请人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61F2/00 , A61M31/00 , A61L29/16 , A61K9/00 , A61L29/06
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

10. 发明授权

US08690840B2 Time-selective bioresorbable or collapsible drug delivery systems and methods 有权
标题翻译：时间选择性生物可吸收或可折叠药物递送系统和方法
公开(公告)号：US08690840B2
公开(公告)日：2014-04-08
申请号：US13267560
申请日：2011-10-06
申请人： Heejin Lee , Michael J. Cima , Cheryl Larrivee-Elkins , Dennis Giesing , Jessica K. Anderson , Sarma Duddu
发明人： Heejin Lee , Michael J. Cima , Cheryl Larrivee-Elkins , Dennis Giesing , Jessica K. Anderson , Sarma Duddu
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61K9/0034 , A61K9/0039 , A61L29/148 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/00
摘要： Implantable medical devices and treatment methods are provided, particularly for use in the bladder. The device is configured for retention in the bladder for at least a portion of the drug delivery period and includes at least one biodegradable component such that following a biodegradation at a selected time, the retention function is lost and the device or portions thereof are resorbed and/or excreted. The method may include deploying into the bladder of a patient a device having a device structure housing a drug formulation comprising at a drug; releasing drug from the device structure into the bladder; and then, changing the composition of urine in the bladder, e.g., by altering the pH, to trigger degradation of at least part of the device structure to enable the device structure or parts thereof to be excreted from the bladder.
摘要翻译：提供了可植入的医疗装置和治疗方法，特别用于膀胱。该装置构造成在膀胱中保留药物递送期的至少一部分，并且包括至少一种可生物降解的组分，使得在选定时间内经过生物降解后，保留功能丧失并且其装置或部分被吸收， /或排泄。该方法可以包括向患者的膀胱中部署具有容纳包含药物的药物制剂的装置结构的装置; 将药物从装置结构释放到膀胱中; 然后，例如通过改变pH来改变膀胱中尿液的组成，以触发装置结构的至少一部分的降解，使装置结构或其部分能够从膀胱排出。

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