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1. 发明授权

US5443461A Segmented device for simultaneous delivery of multiple beneficial agents 失效
标题翻译：用于同时传送多个有益试剂的分段装置
公开(公告)号：US5443461A
公开(公告)日：1995-08-22
申请号：US114800
申请日：1993-08-31
申请人： Linda E. Atkinson , John T. Dunn , Robert M. Gale , David L. Rivera
发明人： Linda E. Atkinson , John T. Dunn , Robert M. Gale , David L. Rivera
IPC分类号： A61K9/22 , A61K9/48
CPC分类号： A61K9/4808
摘要： Diffusional delivery devices are constructed in two or more compartments, each containing a separate drug or other beneficial agent, and each arranged to permit diffusion of the agent out of the device through an individually-characterized agent-permeable wall segment. The diffusion rates of the various agents relative to one another are set and controlled by the parameters of the individual wall segments, such as the surface area of the wall segment, the average thickness of the wall segment, and the permeability of the wall segment for the particular agent. The permeability may be varied by variations in the chemical composition of the wall segment. Using these parameters rather than blending the agents at calculated ratios in a single formulation for diffusion through a single wall permits a wider range of, and greater flexibility in, variation between the diffusion rates of the different agents. This is of value when the simultaneous administration of agents at a specified ratio is desired.
摘要翻译：扩散递送装置构造在两个或更多个隔室中，每个隔室含有单独的药物或其它有益剂，并且每个隔室布置成允许药剂通过单独表征的药剂可渗透壁段从装置中扩散出设备。各种试剂相对于彼此的扩散速率由单个壁段的参数设定和控制，例如壁段的表面积，壁段的平均厚度和壁段的渗透率特定的代理。渗透率可以通过壁段的化学组成的变化而变化。使用这些参数而不是以单一制剂计算的比例混合试剂以通过单个壁扩散，允许不同试剂的扩散速率之间的变化范围更宽且更大的灵活性。当需要以特定比例同时施用药剂时，这是有价值的。

2. 发明授权

US5609885A Osmotic membrane and delivery device 失效
标题翻译：渗透膜和输送装置
公开(公告)号：US5609885A
公开(公告)日：1997-03-11
申请号：US387967
申请日：1995-02-10
申请人： David L. Rivera , Sonya Merrill , James B. Eckenhoff , Jeremy C. Wright , James L. Osborne
发明人： David L. Rivera , Sonya Merrill , James B. Eckenhoff , Jeremy C. Wright , James L. Osborne
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.
摘要翻译：本发明涉及渗透输送装置的改进，其中该装置包括包含乙酸丁酸纤维素的半透壁，并包围含有有益剂或药物制剂的内部隔室，流体活化的可膨胀驱动构件，试剂配方和驱动构件，以及任选的密封构件和在半透壁中的出口装置; 并且其中改进包括具有差示扫描量热法（“DSC”）轮廓的半透膜的乙酸丁酸纤维素成分，其中主DSC或DSC主峰具有在228℃以上的最小温度峰，并且二次DSC峰面积相等小于或等于初级和次级DSC峰的总合合面积的约30％。本发明还涉及由具有差示扫描量热法（“DSC”）分布的醋酸丁酸纤维素制备的改进的半透膜，其中主DSC峰值高于228℃，二次DSC峰面积等于或小于超过了主要和次要DSC峰总面积的约30％，半透膜对于渗透输送装置提供了显着改进的均匀快速启动性能。

3. 发明授权

US4731122A Process for manufacturing a thermoplastic molding composition 失效
标题翻译：制造热塑性模塑组合物的方法
公开(公告)号：US4731122A
公开(公告)日：1988-03-15
申请号：US31824
申请日：1987-03-30
申请人： Richard Cortese , Jeremy C. Wright , James B. Eckenhoff , David L. Rivera
发明人： Richard Cortese , Jeremy C. Wright , James B. Eckenhoff , David L. Rivera
IPC分类号： C08L1/12 , A61K9/20 , C08K5/11 , C08L1/00 , C08L1/10 , C08L1/14 , C08L71/02 , C08L1/08
CPC分类号： A61K9/2054 , C08L1/10
摘要： The invention concerns a process for producing a thermoplastic composition comprising a cellulose ester.
摘要翻译：本发明涉及一种生产包含纤维素酯的热塑性组合物的方法。

4. 发明授权

US5783213A Osmotic membrane and delivery device 失效
标题翻译：渗透膜和输送装置
公开(公告)号：US5783213A
公开(公告)日：1998-07-21
申请号：US811812
申请日：1997-03-06
申请人： David L. Rivera , Sonya Merrill , James B. Eckenhoff , Jeremy C. Wright , James L. Osborne
发明人： David L. Rivera , Sonya Merrill , James B. Eckenhoff , Jeremy C. Wright , James L. Osborne
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.
摘要翻译：本发明涉及渗透输送装置的改进，其中该装置包括包含乙酸丁酸纤维素的半透壁，并包围含有有益剂或药物制剂的内部隔室，流体活化的可膨胀驱动构件，试剂配方和驱动构件，以及任选的密封构件和在半透壁中的出口装置; 并且其中改进包括具有差示扫描量热法（“DSC”）轮廓的半透膜的乙酸丁酸纤维素成分，其中主DSC或DSC主峰具有在228℃以上的最小温度峰，并且二次DSC峰面积相等小于或等于初级和次级DSC峰的总合合面积的约30％。本发明还涉及由具有差示扫描量热法（“DSC”）分布的醋酸丁酸纤维素制备的改进的半透膜，其中主DSC峰值高于228℃，二次DSC峰面积等于或小于超过了主要和次要DSC峰总面积的约30％，半透膜对于渗透输送装置提供了显着改进的均匀快速启动性能。

5. 发明授权

US5607696A Osmotic membrane and delivery device 失效
公开(公告)号：US5607696A
公开(公告)日：1997-03-04
申请号：US441888
申请日：1995-05-16
申请人： David L. Rivera , Sonya Merrill , James B. Eckenhoff , Jeremy C. Wright , James L. Osborne
发明人： David L. Rivera , Sonya Merrill , James B. Eckenhoff , Jeremy C. Wright , James L. Osborne
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.

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