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1. 发明申请

US20110230865A1 SUSTAINED DELIVERY OF AN ACTIVE AGENT USING AN IMPLANTABLE SYSTEM 有权
标题翻译：使用可植入系统可持续地提供活性剂
公开(公告)号：US20110230865A1
公开(公告)日：2011-09-22
申请号：US13116970
申请日：2011-05-26
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Bonnie J. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Bonnie J. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61M37/00
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译：本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。不可渗透的储存器分为水溶胀剂室和活性剂配制室。来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。交付期限达2年。

2. 发明授权

US06395292B2 Sustained delivery of an active agent using an implantable system 有权
标题翻译：使用可植入系统持续递送活性剂
公开(公告)号：US06395292B2
公开(公告)日：2002-05-28
申请号：US09848211
申请日：2001-05-04
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61F200
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译：本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。不可渗透的储存器分为水溶胀剂室和活性剂配制室。来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。交付期限达2年。

3. 发明授权

US06180129B2 Polyurethane-containing delivery systems 失效
标题翻译：含聚氨酯的输送系统
公开(公告)号：US06180129B2
公开(公告)日：2001-01-30
申请号：US08956424
申请日：1997-10-23
申请人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery
发明人： Judy A. Magruder , James B. Eckenhoff , Richard Cortese , Jeremy C. Wright , John R. Peery
IPC分类号： A61K914
CPC分类号： A61K9/0004 , A61M31/002
摘要： A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.
摘要翻译：公开了用于将有益剂递送到动物的递送系统。递送系统包括围绕内腔的壁，所述壁包括限制流体进入系统的组合物和允许流体进入系统的组合物。管腔包括有益剂和可膨胀构件。递送系统包括用于递送有益剂的出口装置。

4. 发明授权

US6156331A Sustained delivery of an active agent using an implantable system 有权
公开(公告)号：US6156331A
公开(公告)日：2000-12-05
申请号：US310149
申请日：1999-05-12
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff, deceased , Felix A. Landrau , Scott D. Lautenbach , Judy A Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff, deceased , Felix A. Landrau , Scott D. Lautenbach , Judy A Magruder , Jeremy C. Wright
IPC分类号： A61K38/09 , A61F13/00 , A61F2/00 , A61K9/22
CPC分类号： A61K38/09
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.

5. 发明授权

US5985305A Sustained delivery of an active agent using an implantable system 失效
公开(公告)号：US5985305A
公开(公告)日：1999-11-16
申请号：US943007
申请日：1997-10-02
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61K9/00 , A61K38/00 , A61K38/09 , A61K45/00 , A61M5/145 , A61F13/00
CPC分类号： A61K9/0004 , A61K38/09 , A61K9/0024 , A61M5/14526 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.

6. 发明授权

US5972370A Peptide/protein suspending formulations 有权
公开(公告)号：US5972370A
公开(公告)日：1999-10-26
申请号：US238159
申请日：1999-01-28
申请人： James B. Eckenhoff, deceased , Leslie A. Holladay , John Joseph Leonard, Jr. , Iris K. M. Leung , Sally A. Tao , Judy A. Magruder , John P. Carr , Jeremy C. Wright
发明人： James B. Eckenhoff, deceased , Leslie A. Holladay , John Joseph Leonard, Jr. , Iris K. M. Leung , Sally A. Tao , Judy A. Magruder , John P. Carr , Jeremy C. Wright
IPC分类号： A61K9/10 , A61K9/00 , A61K38/21 , A61K47/10 , A61K47/32 , A61K47/38 , A61F2/00 , A61K9/14 , A61K38/00 , C07K17/02
CPC分类号： A61K9/0004 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The present invention provides improved compositions for improving the chemical and physical stability of peptides and proteins. The invention provides a liquid beneficial agent formulation containing a liquid suspension comprising at least 5% by weight beneficial agent and having a viscosity and beneficial agent size which minimizes settling of the agent in suspension over the extended delivery period.

7. 发明授权

US5916582A Aqueous formulations of peptides 失效
公开(公告)号：US5916582A
公开(公告)日：1999-06-29
申请号：US874694
申请日：1997-06-13
申请人： Cynthia L. Stevenson , Sally A. Tao , Steven J. Prestrelski , James B. Eckenhoff, deceased , Jeremy C. Wright , John J. Leonard, Jr.
发明人： Cynthia L. Stevenson , Sally A. Tao , Steven J. Prestrelski , James B. Eckenhoff, deceased , Jeremy C. Wright , John J. Leonard, Jr.
IPC分类号： A61K47/16 , A61K9/00 , A61K9/08 , A61K38/00 , A61K38/04 , A61K38/08 , A61K38/09 , A61K38/22 , A61K38/24 , A61K38/27 , A61K38/38 , A61K47/02 , A61K47/08 , A61K47/18 , A61K47/20 , A61P35/00 , A61P43/00 , A61F2/02
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/08 , A61K47/20
摘要： This invention relates to stable liquid aqueous formulations of peptide compounds at high concentrations. These stable formulations comprise at least about 10% peptide in water. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.

8. 发明授权

US5871770A Implantable system for delivery of fluid-sensitive agents to animals 失效
标题翻译：用于向动物输送流体敏感剂的植入系统
公开(公告)号：US5871770A
公开(公告)日：1999-02-16
申请号：US947031
申请日：1997-10-08
申请人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
发明人： Judy A. Magruder , James B. Eckenhoff, deceased , Richard Cortese , Jeremy C. Wright , John R. Peery , James B. Pike , Urano A. Robinson , Jonathan P. Smith , Lyle E. Ziemann
IPC分类号： A61K9/00 , A61K9/52 , A61F2/02 , A61K9/22
CPC分类号： A61K9/0004
摘要： A delivery system (10) is disclosed for delivering a fluid-sensitive beneficial agent (7) such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a wall that surrounds an internal compartment, said wall comprising a first wall section that limits the passage of fluid into the system and a second wall section that permits the passage of fluid into the system. An exit passageway is provided for delivering the beneficial agent an interior compartment (18) to the animal. The exit passageway is sealed with a wax seal (30) which is expelled through the passageway (13) as the internal pressure within the device (10) reaches a predetermined "bursting" pressure. The passageway (13) is preferably sized to compensate for slight variations in the efflux of the beneficial agent and to maintaining a sufficient volumetric outflow rate of beneficial agent in order to minimize influx of biological fluids from the external environment back into the device once the seal (30) is expelled.
摘要翻译：公开了用于将诸如生长激素或其类似物或衍生物的流体敏感有益试剂（7）递送给动物如牛的递送系统（10）。输送系统包括围绕内部隔室的壁，所述壁包括限制流体进入系统的第一壁部分和允许流体进入系统的第二壁部分。提供出口通道用于将有益剂输送到动物的内部隔室（18）。出口通道用蜡密封件（30）密封，当密封件（10）中的内部压力达到预定的“爆裂”压力时，该密封件通过通道（13）排出。通道（13）优选的尺寸适于补偿有益剂的流出中的轻微变化并维持有益剂的足够的体积流出速率，以便最小化生物流体从外部环境流入装置中，一旦密封（30）被排出。

9. 发明授权

US5731001A Locking couplings for osmotic delivery devices 失效
标题翻译：用于渗透输送装置的锁定联轴器
公开(公告)号：US5731001A
公开(公告)日：1998-03-24
申请号：US485877
申请日：1995-06-07
申请人： Judy A. Magruder , James B. Eckenhoff, deceased , Bonnie J. Eckenhoff , Edward V. Bourneuf , Richard Cortese , Jeremy C. Wright , John R. Peery , Ed Bourneuf , James B. Pike , Urano A. Robinson , John M. Sharockman , Jonathan P. Smith
发明人： Judy A. Magruder , James B. Eckenhoff, deceased , Bonnie J. Eckenhoff , Edward V. Bourneuf , Richard Cortese , Jeremy C. Wright , John R. Peery , Ed Bourneuf , James B. Pike , Urano A. Robinson , John M. Sharockman , Jonathan P. Smith
IPC分类号： A61K9/00 , A61K9/52 , A61K9/24
CPC分类号： A61K9/0004
摘要： A delivery system is disclosed for delivering a fluid-sensitive active agent such as a somatotropin, or an analogue or derivative thereof, to an animal such as a bovine. The delivery system comprises a first wall section, a second wall section and a locking coupling therebetween. The coupled wall sections define a compartment, enclosing an active agent and an expandable driving member. Various embodiments of the locking coupling are disclosed.
摘要翻译：公开了用于将诸如生长激素或其类似物或衍生物的流体敏感活性剂递送到动物如牛的递送系统。输送系统包括第一壁部分，第二壁部分和它们之间的锁定联接。耦合的壁部分限定了隔室，包围活性剂和可扩展的驱动构件。公开了锁定联接器的各种实施例。

10. 再颁专利

USRE35601E Delivery device providing beneficial agent stability 失效
标题翻译：输送装置提供有益的药剂稳定性
公开(公告)号：USRE35601E
公开(公告)日：1997-09-02
申请号：US289473
申请日：1994-08-11
申请人： James B. Eckenhoff, deceased
发明人： James B. Eckenhoff, deceased
IPC分类号： A61K9/00 , A61K9/22 , A61K9/20 , A61M31/00
CPC分类号： A61K9/0004
摘要： The present invention is directed to an improved fluid-imbibing dispensing device for delivering a beneficial agent to a biological environment of use, the dispensing device being of the type having a housing which includes a fluid-impermeable first wall section with an open end and a fluid-permeable second wall section with an open end, an internal compartment formed by the first and second wall sections, exit means in the housing, a beneficial agent in that portion of the compartment formed by the first wall section, expandable driving means in that portion of the compartment formed by the second wall section, and a partition layer between the beneficial agent and the expandable driving means; wherein the improvement comprises the first wall section being comprised of an extremely fluid-impermeable material and the open end of each of the first wall section and the second wall section having reciprocally tapered edges one with the other to form a tapered lap joint for mating engagement, the tapered lap joints being bonded together with a pressure-sensitive contact adhesive to form the housing.
摘要翻译：本发明涉及一种改进的流体吸收分配装置，其用于将有益剂递送到生物生物环境中，该分配装置是具有壳体的类型，该壳体包括具有开口端的流体不可渗透的第一壁部分和具有开放端的流体可渗透的第二壁部分，由第一和第二壁部分形成的内部隔室，壳体中的出口装置，在由第一壁部分形成的隔室的该部分中的有益试剂，可扩展驱动装置由所述第二壁部分形成的所述隔室的部分以及所述有益剂和所述可膨胀驱动装置之间的分隔层; 其中所述改进包括第一壁部分由非常不透液体的材料组成，并且每个第一壁部分和第二壁部分的开口端具有往复的锥形边缘，彼此形成锥形搭接部分，用于配合接合，锥形搭接接头用压敏接触粘合剂粘合在一起以形成壳体。

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