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1. 发明授权

US07884131B2 Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same 失效
标题翻译：来自长链多不饱和脂肪酸的牛痘素及其制备和使用方法
公开(公告)号：US07884131B2
公开(公告)日：2011-02-08
申请号：US11284790
申请日：2005-11-21
申请人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Mary Van Elswyk
发明人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Mary Van Elswyk
IPC分类号： A61K31/22 , C07C59/00 , C07C57/00
CPC分类号： C12P7/6472 , C07C59/42 , C07D303/38 , C12P7/6427
摘要： Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
摘要翻译：公开了衍生自C22多不饱和脂肪酸的新型oxylipin，本文称为多糖类，以及制备和使用这种oxylipin的方法。还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6）作为生产新型oxylipins的底物，以及由此产生的oxylipin。还公开了在治疗和营养或化妆品应用中使用DPAn-6，DPAn-3，DTAn-6和/或衍生自其的oxylipin，和/或衍生自C22脂肪酸结构的新型二十二烷酸，特别是作为抗炎或抗神经变性化合物。本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的LCPUFA衍生的草甘膦脂类，尤其是二十二烷酸。

2. 发明申请

US20110178047A1 Oxylipins From Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same 审中-公开
标题翻译：来自长链多不饱和脂肪酸的Oxylipins及其制备和使用方法
公开(公告)号：US20110178047A1
公开(公告)日：2011-07-21
申请号：US12981261
申请日：2010-12-29
申请人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Mary Van Elswyk
发明人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Mary Van Elswyk
IPC分类号： A61K31/202 , C07C59/42 , A61K31/616 , A61P29/00 , A61P25/28
CPC分类号： C12P7/6472 , C07C59/42 , C07D303/38 , C12P7/6427
摘要： Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
摘要翻译：公开了衍生自C22多不饱和脂肪酸的新型oxylipin，本文称为多糖类，以及制备和使用这种oxylipin的方法。还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6）作为生产新型oxylipins的底物，以及由此产生的oxylipin。还公开了在治疗和营养或化妆品应用中使用DPAn-6，DPAn-3，DTAn-6和/或衍生自其的oxylipin，和/或衍生自C22脂肪酸结构的新型二十二烷酸，特别是作为抗炎或抗神经变性化合物。本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的LCPUFA衍生的草甘膦脂类，尤其是二十二烷酸。

3. 发明申请

US20110190389A1 OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：来自长链多脂脂肪酸的氧化锌及其制备和使用方法
公开(公告)号：US20110190389A1
公开(公告)日：2011-08-04
申请号：US12531344
申请日：2008-02-20
申请人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Dutt Vinjamoori , Mary Van Elswyk
发明人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Dutt Vinjamoori , Mary Van Elswyk
IPC分类号： A61K31/336 , A61K31/202 , C07C57/03 , A61P29/00 , C12P7/64 , C12P17/02 , C07D303/38 , A61P25/28
CPC分类号： A61K31/202 , A23L33/12 , A61K8/361 , A61K31/60 , A61K45/06 , A61Q19/00 , C07C59/42 , C07D303/36 , C07D303/48 , A61K2300/00
摘要： Disclosed are novel oxylipins, referred to herein as docosanoids and eicosanoids, that are derived from C22 polyunsaturated fatty acids and from C20 polyunsaturated fatty acids, respectively, and methods of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6), docosatrienoic acid (C22:3n-3) (DTrAn-3), docosadienoic acid (C22:2n-6) (DDAn-6), eicosatrienoic acid (C20:3n-3) (ETrAn-3) eicosapentaenoic acid and arachidonic acid as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of LCPUF A-derived oxylipins, and particularly, docosanoids.
摘要翻译：公开了分别衍生自C22多不饱和脂肪酸和C20多不饱和脂肪酸的新型牛脂素，本文称为二十二烷酸类和类二十烷酸，以及制备和使用这些牛脂素的方法。还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6），二十二碳三烯酸（C22：3n-3）（DTrAn-3），二十二碳烯酸（C22：2n-6）（DDAn-6），二十碳三烯酸（C20：3n-3）（ETrAn-3）二十碳五烯酸和花生四烯酸作为生产新型oxylipins的底物，以及由此产生的oxylipin。还公开了在治疗和营养或美容应用中使用DPAn-6，DPAn-3，DTAn-6和/或由其衍生的oxylipin，和/或衍生自C22脂肪酸结构的新型二醇类，特别是作为抗炎或抗神经变性化合物。本发明还涉及生产长链多不饱和酸（LCPUF A）的油和组合物的新方法，其含有增强和有效量的LCPUF A衍生的草甘膦脂类，特别是二十二烷酸。

4. 发明申请

US20070248586A1 OXYLIPINS FROM STEARIDONIC ACID AND GAMMA-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME 失效
标题翻译：来自硬脂酸和γ-亚麻酸的氧化剂及其制备和使用方法
公开(公告)号：US20070248586A1
公开(公告)日：2007-10-25
申请号：US11669730
申请日：2007-01-31
申请人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Dutt Vinjamoori
发明人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Dutt Vinjamoori
IPC分类号： A61K31/19 , A61K31/35 , A61K38/43 , A61P25/28 , A61P29/00 , C07C53/00 , C07C63/04 , C07D315/00 , C12P7/00
CPC分类号： C12N15/8247 , C07C59/42 , C07D303/38 , C12P7/6427 , C12P7/6472
摘要： Disclosed are novel oxylipins that are derived from γ-linolenic acid (GLA; 18:3n-6) and stearidonic acid (STA or SDA; 18:4n-3), and methods of making and using such oxylipins. Also disclosed is the use of such oxylipins in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. Also disclosed are The invention novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of SDA- and/or GLA-derived oxylipins.
摘要翻译：公开了衍生自γ-亚麻酸（GLA; 18：3n-6）和十八碳四烯酸（STA或SDA; 18：4n-3）的新型oxylipin，以及制备和使用这些oxylipin的方法。还公开了在治疗和营养或化妆品应用中使用这种oxylipin，特别是作为抗炎或抗神经变性化合物。还公开了本发明新颖的生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的SDA和/或GLA衍生的草甘膦。

5. 发明申请

US20060241088A1 Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same 失效
标题翻译：来自长链多不饱和脂肪酸的牛痘素及其制备和使用方法
公开(公告)号：US20060241088A1
公开(公告)日：2006-10-26
申请号：US11284790
申请日：2005-11-21
申请人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Mary Elswyk
发明人： Linda Arterburn , William Barclay , Bindi Dangi , James Flatt , Jung Lee , Mary Elswyk
IPC分类号： A61K31/60 , A61K31/22 , C07C69/02
CPC分类号： C12P7/6472 , C07C59/42 , C07D303/38 , C12P7/6427
摘要： Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
摘要翻译：公开了衍生自C22多不饱和脂肪酸的新型oxylipin，本文称为多糖类，以及制备和使用这种oxylipin的方法。还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6）作为生产新型oxylipins的底物，以及由此产生的oxylipin。还公开了在治疗和营养或化妆品应用中使用DPAn-6，DPAn-3，DTAn-6和/或衍生自其的oxylipin，和/或衍生自C22脂肪酸结构的新型二十二烷酸，特别是作为抗炎或抗神经变性化合物。本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的LCPUFA衍生的草甘膦脂类，尤其是二十二烷酸。

6. 发明申请

US20080145475A1 Use of DPA(n-6) Oils in Infant Formula 审中-公开
标题翻译：在婴儿配方中使用DPA（n-6）油
公开(公告)号：US20080145475A1
公开(公告)日：2008-06-19
申请号：US11847171
申请日：2007-08-29
申请人： James Flatt , Mary Van Elswyk , Linda Arterburn , William Barclay , Samuel Zeller
发明人： James Flatt , Mary Van Elswyk , Linda Arterburn , William Barclay , Samuel Zeller
IPC分类号： A23K1/18 , A23D7/00
CPC分类号： A23L33/12 , A23L33/40 , A23V2002/00 , A23V2200/30 , A23V2250/187 , A23V2250/1868 , A23V2250/1882
摘要： Infant formula compositions containing docosapentaenoic acid n-6 (“DPA(n-6)”) and other polyunsaturated fatty acids and methods for their preparation and use are provided.
摘要翻译：提供含有二十二碳五烯酸n-6（“DPA（n-6）”）和其他多不饱和脂肪酸的婴儿配方组合物及其制备和使用方法。

7. 发明申请

US20060069159A1 Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation 审中-公开
标题翻译：预防性二十二碳六烯酸治疗亚临床炎症患者
公开(公告)号：US20060069159A1
公开(公告)日：2006-03-30
申请号：US11223128
申请日：2005-09-12
申请人： Linda Arterburn , James Hoffman , Harry Oken , Mary Van Elswyk
发明人： Linda Arterburn , James Hoffman , Harry Oken , Mary Van Elswyk
IPC分类号： A61K31/202
CPC分类号： A61K45/06 , A61K31/202 , A61K31/232 , A61K31/60 , A61K2300/00
摘要： This invention is directed to methods and compositions which impede the development and progression of diseases associated with subclinical inflammation. Subclinical inflammation is commonly associated with atherosclerotic cardiovascular disease, coronary disease or cerebrovascular disease. The methods and compositions of the invention are also particularly suited to providing therapy for subclinical inflammation in diabetic and prediabetic patients. Methods of the invention comprise administration of DHA alone and in combination with antiplatelet drugs.
摘要翻译：本发明涉及妨碍与亚临床炎症相关的疾病的发展和进展的方法和组合物。亚临床炎症通常与动脉粥样硬化性心血管疾病，冠心病或脑血管疾病有关。本发明的方法和组合物还特别适用于在糖尿病和糖尿病患者中提供亚临床炎症的治疗。本发明的方法包括单独给予DHA并与抗血小板药物组合。

8. 发明申请

US20090203655A1 PROPHYLACTIC DOCOSAHEXAENOIC ACID THERAPY FOR PATIENTS WITH SUBCLINICAL INFLAMMATION 审中-公开
标题翻译：丙型肝炎治疗慢性感染患者的临床疗效
公开(公告)号：US20090203655A1
公开(公告)日：2009-08-13
申请号：US12364893
申请日：2009-02-03
申请人： Linda Arterburn , James Hoffman , Harry Oken , Mary Van Elswyk
发明人： Linda Arterburn , James Hoffman , Harry Oken , Mary Van Elswyk
IPC分类号： A61K31/202 , A61P29/00 , A61K31/60 , A61K31/4365 , A61P3/00
CPC分类号： A61K45/06 , A61K31/202 , A61K31/232 , A61K31/60 , A61K2300/00
摘要： This invention is directed to methods and compositions which impede the development and progression of diseases associated with subclinical inflammation. Subclinical inflammation is commonly associated with atherosclerotic cardiovascular disease, coronary disease or cerebrovascular disease. The methods and compositions of the invention are also particularly suited to providing therapy for subclinical inflammation in diabetic and prediabetic patients. Methods of the invention comprise administration of DHA alone and in combination with antiplatelet drugs.
摘要翻译：本发明涉及妨碍与亚临床炎症相关的疾病的发展和进展的方法和组合物。亚临床炎症通常与动脉粥样硬化性心血管疾病，冠心病或脑血管疾病有关。本发明的方法和组合物还特别适用于在糖尿病和糖尿病患者中提供亚临床炎症的治疗。本发明的方法包括单独给予DHA并与抗血小板药物组合。

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