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    • 2. 发明授权
    • Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
    • 来自长链多不饱和脂肪酸的牛痘素及其制备和使用方法
    • US07884131B2
    • 2011-02-08
    • US11284790
    • 2005-11-21
    • Linda ArterburnWilliam BarclayBindi DangiJames FlattJung LeeMary Van Elswyk
    • Linda ArterburnWilliam BarclayBindi DangiJames FlattJung LeeMary Van Elswyk
    • A61K31/22C07C59/00C07C57/00
    • C12P7/6472C07C59/42C07D303/38C12P7/6427
    • Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
    • 公开了衍生自C22多不饱和脂肪酸的新型oxylipin,本文称为多糖类,以及制备和使用这种oxylipin的方法。 还公开了二十二碳五烯酸(C22:5n-6)(DPAn-6),二十二碳五烯酸(C22:5n-3)(DPAn-3)和二十二碳四烯酸(DTAn-6:C22:4n-6) 作为生产新型oxylipins的底物,以及由此产生的oxylipin。 还公开了在治疗和营养或化妆品应用中使用DPAn-6,DPAn-3,DTAn-6和/或衍生自其的oxylipin,和/或衍生自C22脂肪酸结构的新型二十二烷酸,特别是 作为抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸(LCPUFA)的油和组合物的新方法,其含有增强和有效量的LCPUFA衍生的草甘膦脂类,尤其是二十二烷酸。
    • 10. 发明申请
    • Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
    • 来自长链多不饱和脂肪酸的牛痘素及其制备和使用方法
    • US20060241088A1
    • 2006-10-26
    • US11284790
    • 2005-11-21
    • Linda ArterburnWilliam BarclayBindi DangiJames FlattJung LeeMary Elswyk
    • Linda ArterburnWilliam BarclayBindi DangiJames FlattJung LeeMary Elswyk
    • A61K31/60A61K31/22C07C69/02
    • C12P7/6472C07C59/42C07D303/38C12P7/6427
    • Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
    • 公开了衍生自C22多不饱和脂肪酸的新型oxylipin,本文称为多糖类,以及制备和使用这种oxylipin的方法。 还公开了二十二碳五烯酸(C22:5n-6)(DPAn-6),二十二碳五烯酸(C22:5n-3)(DPAn-3)和二十二碳四烯酸(DTAn-6:C22:4n-6) 作为生产新型oxylipins的底物,以及由此产生的oxylipin。 还公开了在治疗和营养或化妆品应用中使用DPAn-6,DPAn-3,DTAn-6和/或衍生自其的oxylipin,和/或衍生自C22脂肪酸结构的新型二十二烷酸,特别是 作为抗炎或抗神经变性化合物。 本发明还涉及生产长链多不饱和酸(LCPUFA)的油和组合物的新方法,其含有增强和有效量的LCPUFA衍生的草甘膦脂类,尤其是二十二烷酸。