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1. 发明授权

US08956346B2 Reflectance-facilitated ultrasound treatment and monitoring 有权
标题翻译：反射促进超声治疗和监测
公开(公告)号：US08956346B2
公开(公告)日：2015-02-17
申请号：US13015951
申请日：2011-01-28
申请人： Liat Tsoref , Yossi Gross
发明人： Liat Tsoref , Yossi Gross
IPC分类号： A61B18/00 , A61B8/08 , A61N7/02 , A61B8/00 , A61B17/00 , A61N7/00
CPC分类号： A61B34/20 , A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/481 , A61B8/5223 , A61B17/320016 , A61B17/320092 , A61B2017/00026 , A61B2017/00084 , A61B2017/00106 , A61B2017/00243 , A61B2017/320052 , A61B2018/00285 , A61B2034/2063 , A61B2090/3784 , A61N7/022 , A61N2007/0052 , A61N2007/0056 , A61N2007/0069 , A61N2007/0091
摘要： A method comprising providing a reflective region at a far side of tissue of a subject is provided. The method includes assessing whether the reflective region is in a desired location, by means of acoustic sensing; and in response to assessing that the reflective region is in the desired location, activating an ultrasound transducer to ablate the tissue by applying ultrasound energy to a near side of the tissue, such that at least a portion of the transmitted energy is reflected by the reflective region onto the tissue of the subject. Other embodiments are also described.
摘要翻译：提供了一种方法，包括在受试者的组织的远侧提供反射区域。该方法包括通过声学感测来评估反射区域是否在期望的位置; 并且响应于评估反射区域处于所需位置，激活超声换能器以通过向组织的近侧施加超声能量来消融组织，使得至少一部分透射能量被反射区域到受试者的组织上。还描述了其它实施例。

2. 发明申请

US20140058294A1 TISSUE TREATMENT AND MONITORING BY APPLICATION OF ENERGY 审中-公开
标题翻译：通过应用能源组织治疗和监测
公开(公告)号：US20140058294A1
公开(公告)日：2014-02-27
申请号：US14003130
申请日：2012-03-04
申请人： Yossi Gross , Michael Kardosh , Gideon Meiry , Liat Tsoref , Leonid Kushkuley , Yaron Assaf
发明人： Yossi Gross , Michael Kardosh , Gideon Meiry , Liat Tsoref , Leonid Kushkuley , Yaron Assaf
IPC分类号： A61N7/02 , A61B8/00 , A61B5/00 , A61B8/12
CPC分类号： A61N7/022 , A61B5/4836 , A61B8/12 , A61B8/445 , A61B8/546 , A61B2017/22069 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61N2007/0043 , A61N2007/0078 , A61N2007/0086 , A61N2007/0091
摘要： Apparatus is provided, which includes at least one ultrasound transducer. The ultrasound transducer is configured to be positioned within a lumen of a subject and to ablate tissue surrounding a wall of the lumen without ablating the wall of the lumen, by focusing ultrasound energy on a focal zone that is outside of the wall of the lumen. A transluminal delivery tool is configured to position the ultrasound transducer in the lumen, and a control unit is configured to drive the ultrasound transducer. Other embodiments are also described.
摘要翻译：提供了包括至少一个超声换能器的装置。超声换能器被配置为定位在受试者的内腔内，并且通过将超声能量聚焦在位于管腔壁外部的聚焦区域上而消融内腔壁周围的组织，而不会消融内腔壁。经腔递送工具被配置为将超声换能器定位在内腔中，并且控制单元被配置为驱动超声换能器。还描述了其它实施例。

3. 发明申请

US20100274161A1 IMPLOSION TECHNIQUES FOR ULTRASOUND 审中-公开
标题翻译：超声波腐蚀技术
公开(公告)号：US20100274161A1
公开(公告)日：2010-10-28
申请号：US12682748
申请日：2008-10-22
申请人： Haim Azhari , Liat Tsoref , Yossi Gross , Jacob Benarie
发明人： Haim Azhari , Liat Tsoref , Yossi Gross , Jacob Benarie
IPC分类号： A61B17/225
CPC分类号： A61N7/02 , A61B2017/22008 , A61B2017/22024 , A61B2017/308 , A61B2090/378 , A61N2007/0008 , A61N2007/0078
摘要： A housing (50) is placed on skin of a subject, and draws at least a portion of the skin within at least a part of the housing. The housing includes at least first and second support structures (34), placed in contact with a surface of skin surrounding the portion of the skin, the first support structure having a first concave surface (153) and the second support structure having a second concave surface (153) that faces the first concave surface. The apparatus includes one or more first ultrasound transducers (160) coupled to the first support structure and one or more second ultrasound transducers coupled to the second support structure. The apparatus also includes a control unit which drives the first and second ultrasound transducers to induce an implosion wave in a target region of the skin. Other embodiments are also described.
摘要翻译：将壳体（50）放置在受试者的皮肤上，并且在壳体的至少一部分内吸取皮肤的至少一部分。壳体包括至少第一和第二支撑结构（34），放置成与围绕皮肤部分的皮肤表面接触，第一支撑结构具有第一凹面（153），第二支撑结构具有第二凹面面（153）面向第一凹面。该装置包括耦合到第一支撑结构的一个或多个第一超声换能器（160）和耦合到第二支撑结构的一个或多个第二超声换能器。该装置还包括控制单元，其驱动第一和第二超声换能器以在皮肤的目标区域中引起内爆波。还描述了其它实施例。

4. 发明申请

US20130103028A1 REFLECTANCE-FACILITATED ULTRASOUND TREATMENT AND MONITORING 有权
标题翻译：反射辅助超声治疗和监测
公开(公告)号：US20130103028A1
公开(公告)日：2013-04-25
申请号：US13697831
申请日：2011-05-12
申请人： Liat Tsoref , Yossi Gross , Michael Kardosh
发明人： Liat Tsoref , Yossi Gross , Michael Kardosh
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B18/1492 , A61B2017/00084 , A61B2017/00106 , A61B2017/00247 , A61B2017/00256 , A61B2018/00285 , A61B2018/0212 , A61B2019/4054 , A61B2090/0454 , A61N7/00 , A61N7/022 , A61N2007/0021 , A61N2007/003 , A61N2007/0043 , A61N2007/0065 , A61N2007/0069 , A61N2007/0078 , A61N2007/0091 , A61N2007/027
摘要： Apparatus comprising an ultrasound ablation system (10), which comprises a reflection-facilitation element (12), configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultra-sound tool (20), which comprises at least one ultrasound transducer (40) configured to be positioned within a heart chamber of the subject. The ultrasound transducer (40) is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.
摘要翻译：包括超声消融系统（10）的装置，其包括被配置为放置在受试者的心肌外部位置处的反射促进元件（12），并且提供心外膜反射区域; 和超声工具（20），其包括构造成定位在受试者的心室内的至少一个超声换能器（40）。超声换能器（40）被配置为通过向心肌组织施加超声能量来消融心肌组织，使得至少一部分透射能量被反射区域反射到心肌组织上。还描述了其它实施例。

5. 发明申请

US20110251524A1 DEVICE FOR ULTRASOUND TREATMENT AND MONITORING TISSUE TREATMENT 审中-公开
标题翻译：超声治疗和监测组织治疗装置
公开(公告)号：US20110251524A1
公开(公告)日：2011-10-13
申请号：US13063567
申请日：2009-09-13
申请人： Haim Azhari , Liat Tsoref , Yossi Gross , Jacob Benarie
发明人： Haim Azhari , Liat Tsoref , Yossi Gross , Jacob Benarie
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B2018/00994 , A61B2090/378 , A61F2007/029 , A61N2007/0008 , A61N2007/0065 , A61N2007/0078
摘要： Apparatus is provided, including first and second support structures for placement on skin of a subject. At least one of the first and second structures is moveable with respect to the other so as to draw a portion of the skin and underlying tissue of the subject between respective lateral surfaces of the support structures. At least one ultrasound transducer is moveably coupled to the first support structure along an axis of the structure that is not parallel to the lateral surface of the structure. The ultrasound transducer is configured to transmit toward the portion of skin and underlying tissue one or more forms of acoustic radiation energy, including treatment energy. At least one acoustic element is coupled to the second support structure. Other applications are also described.
摘要翻译：提供了包括用于放置在受试者皮肤上的第一和第二支撑结构的装置。第一和第二结构中的至少一个可以相对于另一个结构移动，以便在支撑结构的相应侧表面之间画出被摄体的一部分皮肤和下面的组织。至少一个超声换能器沿着不平行于结构的侧表面的结构的轴线可移动地联接到第一支撑结构。超声换能器被配置为向皮肤和下面的组织的一部分传递一种或多种形式的声辐射能量，包括治疗能量。至少一个声学元件耦合到第二支撑结构。还描述了其它应用。

6. 发明授权

US07828734B2 Device for ultrasound monitored tissue treatment 有权
标题翻译：用于超声监测组织治疗的装置
公开(公告)号：US07828734B2
公开(公告)日：2010-11-09
申请号：US11651198
申请日：2007-01-08
申请人： Haim Azhari , Jacob Benarie , Yossi Gross , Liat Tsoref
发明人： Haim Azhari , Jacob Benarie , Yossi Gross , Liat Tsoref
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B2090/378 , A61N2007/0008 , A61N2007/0078
摘要： Apparatus is provided, including a housing, adapted for placement on tissue of a subject, and a plurality of transducers, disposed at respective locations with respect to the housing, and configured to transmit energy towards each other, in a plane defined by the housing.
摘要翻译：提供了一种设备，包括适于放置在对象的组织上的壳体以及设置在相对于壳体的相应位置处的多个换能器，并且被配置成在由壳体限定的平面中朝向彼此传递能量。

7. 发明授权

US07678049B2 Bone age assessment using ultrasound 失效
标题翻译：骨龄评估使用超声波
公开(公告)号：US07678049B2
公开(公告)日：2010-03-16
申请号：US10042735
申请日：2001-10-25
申请人： Liat Tsoref , Dov Furman
发明人： Liat Tsoref , Dov Furman
IPC分类号： A61B8/00 , A61B8/02 , A61B8/06 , A61B8/12 , A61B8/14
CPC分类号： A61B5/4504 , A61B5/107 , A61B5/4514 , A61B5/4528 , A61B8/0858 , A61B8/0875 , A61B8/58
摘要： A method and an apparatus for estimating bone age by at least one acoustic signal in an ossification-actuated skeletal structure. The apparatus includes an acoustic transmitter and an acoustic receiver positioned facing each other so that the structure is positioned between them. The structure has at least two bones. The transmitter is adapted for transmitting a signal to cross the structure transversely. An electronic moveable gantry is provided for adjusting the position of the acoustic transmitter and the acoustic receiver in relation to the structure. A computer system is enabled to perform one or more functions to position the moveable gantry; transmit the signal by the transmitter; control the signal transmitted by the transmitter; receive the transmitted signal by the receiver; and estimate bone age responsive to the received signal by at least one bone age calculation formula.
摘要翻译：一种用于通过骨化致动骨骼结构中的至少一个声信号估计骨龄的方法和装置。该装置包括声发射器和声接收器，它们彼此相对定位，使结构位于它们之间。该结构至少有两个骨头。发射机适于传输信号以横向跨越结构。提供电子可移动台架，用于相对于结构调节声发射器和声接收器的位置。计算机系统能够执行一个或多个功能来定位可移动台架; 由发射机发射信号; 控制发射机发射的信号; 由接收器接收发送的信号; 并且通过至少一个骨龄计算公式估计响应于接收到的信号的骨龄。

8. 发明授权

US6144199A Method for imaging vessel wall anatomy and strain 失效
标题翻译：血管壁解剖和应变成像方法
公开(公告)号：US6144199A
公开(公告)日：2000-11-07
申请号：US912783
申请日：1997-08-18
申请人： Yehuda Sharf , Gil Navon , Uzi Eliav , Liat Tsoref
发明人： Yehuda Sharf , Gil Navon , Uzi Eliav , Liat Tsoref
IPC分类号： G01R33/48 , G01R33/483 , G01V3/00
CPC分类号： G01R33/56 , G01R33/485
摘要： A method for depicting the anatomy and quantitative tissue strain of a biological tissue. A spatially resolved, double quantum filtered, nuclear magnetic resonance frequency spectrum is acquired from either .sup.1 H or .sup.2 H nuclei in the tissue. Values in the time domain or frequency domain representations of the free induction decay signal are mapped in 2 spatial dimensions so as to selectively depict histological layers of the tissue anatomy. The residual quadrupolar or dipolar splitting is calculated from the free induction decay signal, and then correlated with a tissue strain value by utilizing a known formula describing the correlation between residual quadrupolar or dipolar splitting and tissue strain. The tissue strain value is then mapped in two spatial dimensions.
摘要翻译：描述生物组织的解剖和定量组织应变的方法。从组织中的1H或2H核获得空间分辨的双量子滤波的核磁共振频谱。将自由感应衰减信号的时域或频域表示中的值映射为2个空间维度，以选择性地描绘组织解剖结构的组织学层。从自由诱导衰减信号计算残余四极或偶极分裂，然后通过利用描述残余四极或偶极分裂和组织应变之间的相关性的已知公式与组织应变值相关。然后将组织应变值映射到两个空间维度。

9. 发明申请

US20110282249A1 REFLECTANCE-FACILITATED ULTRASOUND TREATMENT 有权
标题翻译：反射辅助超声治疗
公开(公告)号：US20110282249A1
公开(公告)日：2011-11-17
申请号：US12780240
申请日：2010-05-14
申请人： Liat Tsoref , Yossi Gross
发明人： Liat Tsoref , Yossi Gross
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B2017/00084 , A61B2017/00106 , A61B2018/00285 , A61N7/022 , A61N2007/0069 , A61N2007/0091
摘要： Apparatus is provided that includes an ultrasound ablation system, which includes a reflection-facilitation element, configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region. The system further includes an ultrasound tool, which comprises at least one ultrasound transducer configured to be positioned within a heart chamber of the subject, and to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.
摘要翻译：提供了包括超声消融系统的装置，其包括被配置为放置在受试者的心肌外部位置处的反射促进元件，并且提供心外膜反射区域。该系统还包括超声波工具，该超声波工具包括至少一个超声波换能器，其被配置为定位在受试者的心室内，并且通过向心肌组织施加超声能量来消融心肌组织，使得至少一部分透射能量被反射区域反射到心肌组织上。还描述了其它实施例。

10. 发明申请

US20110184322A1 METHOD AND DEVICE FOR TREATMENT OF KELOIDS AND HYPERTROPHIC SCARS USING FOCUSED ULTRASOUND 审中-公开
标题翻译：使用聚焦超声治疗克洛伊病和高血压病的方法和装置
公开(公告)号：US20110184322A1
公开(公告)日：2011-07-28
申请号：US13010555
申请日：2011-01-20
申请人： Solli Brawer , Haim Azhari , Liat Tsoref
发明人： Solli Brawer , Haim Azhari , Liat Tsoref
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2017/00106 , A61B2018/00023 , A61N2007/0034 , A61N2007/0069 , A61N2007/0078 , A61N2007/0091
摘要： A method for treating a scar on a skin surface of a subject is provided. A subject is identified as having a skin surface with scar tissue. In response to identifying the subject as having the scar tissue, a housing comprising at least one acoustic transducer is placed on the skin surface with the scar tissue and the acoustic transducer is activated to apply high intensity focused ultrasound energy to a portion of the scar tissue. Other embodiments are also described.
摘要翻译：提供了一种用于治疗受试者皮肤表面上的瘢痕的方法。受试者被鉴定为具有瘢痕组织的皮肤表面。响应于将受试者识别为具有瘢痕组织，包含至少一个声换能器的壳体被放置在皮肤表面上，其中瘢痕组织被激活，并且将声学换能器激活以将高强度聚焦的超声能量施加到瘢痕组织的一部分。还描述了其它实施例。

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