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1. 发明授权

US08417316B2 MRI imaging and contrast method 有权
标题翻译： MRI成像和对比方法
公开(公告)号：US08417316B2
公开(公告)日：2013-04-09
申请号：US11661975
申请日：2005-09-08
申请人： Dina Carasso , Uzi Eliav , Gil Navon
发明人： Dina Carasso , Uzi Eliav , Gil Navon
IPC分类号： A61B5/055
CPC分类号： G01R33/4828 , A61B5/055 , A61B18/04 , G01R33/4804 , G01R33/4814 , G01R33/56 , G01R33/5605
摘要： A novel MRI contrast technique enables to observe tissue properties not observable by previously known MRI methods. A difference between two disclosed pulse sequences is used to measure magnetization exchange time between water molecules and macromolecules such as proteins, thereby producing a measure highly sensitive to tissue changes resulting from coagulation, yet relatively insensitive to temperature fluctuations. This result is applied to an imaging method and provides direct visualization of the effects of surgical thermal ablation procedures.
摘要翻译：一种新颖的MRI对比技术能够观察到以前已知的MRI方法不可观察到的组织特性。使用两个公开的脉冲序列之间的差异来测量水分子和大分子如蛋白质之间的磁化交换时间，从而产生对凝结产生的组织变化高度敏感的测量，但对温度波动相对不敏感。该结果被应用于成像方法，并且提供了手术热消融程序的效果的直接可视化。

2. 发明授权

US07390671B2 Method of selective excitation for improving contrast in magnetic resonance imaging 有权
标题翻译：用于改善磁共振成像对比度的选择性激发方法
公开(公告)号：US07390671B2
公开(公告)日：2008-06-24
申请号：US10450838
申请日：2001-11-19
申请人： Uzi Eliav , Gil Navon , Arnon Neufeld
发明人： Uzi Eliav , Gil Navon , Arnon Neufeld
IPC分类号： G01N24/00 , A61B5/05
CPC分类号： G01R33/4608 , G01R33/465 , Y10T436/24
摘要： A method of magnetic resonance analysis of at least one type of molecules present in a solvent, the method comprises (a) applying a first radiofrequency pulse sequence selected so as to initially select a coherence of an order n for the at least one type of molecules in the solvent, wherein n is zero, a positive or a negative integer other than ±1, and thereafter to select an exclusive excitation of the at least one type of molecules in the solvent; (b) measuring at least one magnetic resonance parameter of the solvent; and (c) using the at least one magnetic resonance parameter of the solvent for calculating at least one magnetic resonance parameter of the at least one molecule.
摘要翻译：一种对存在于溶剂中的至少一种类型的分子进行磁共振分析的方法，所述方法包括：（a）施加选择的第一射频脉冲序列，以便最初选择所述至少一种类型的分子的阶数n的相干性在溶剂中，其中n为零，除±1之外的正整数或负整数，之后选择溶剂中至少一种类型的分子的排他性激发; （b）测量溶剂的至少一个磁共振参数; 和（c）使用溶剂的至少一个磁共振参数来计算至少一个分子的至少一个磁共振参数。

3. 发明申请

US20090167303A1 Method and Apparatus for Magnetic Resonance Analysis 有权
标题翻译：磁共振分析方法与装置
公开(公告)号：US20090167303A1
公开(公告)日：2009-07-02
申请号：US12223397
申请日：2007-02-04
申请人： Uzi Eliav , Gil Navon , Arnon Neufeld
发明人： Uzi Eliav , Gil Navon , Arnon Neufeld
IPC分类号： G01R33/48
CPC分类号： G01R33/4828 , G01R33/5605 , G01R33/5607
摘要： A method of magnetic resonance analysis of a body having therein at least one molecular species and water is disclosed. The method comprises, subtracting magnetic resonance signals induced by a second radiofrequency pulse sequence from magnetic resonance signals induced by a first radiofrequency pulse sequence followed by a evolution period. The first radiofrequency pulse sequence is selected so as to suppress magnetization for the water while preserving a generally longitudinal magnetization to the at least one molecular species. The second radiofrequency pulse sequence being selected so as to suppress transverse and longitudinal magnetization for both the water and the at least one molecular species.
摘要翻译：公开了一种其中具有至少一种分子种类和水的物体的磁共振分析方法。该方法包括：从由第一射频脉冲序列感应的磁共振信号，随后的演化周期减去由第二射频脉冲序列感应的磁共振信号。选择第一射频脉冲序列以便抑制水的磁化，同时保持对至少一种分子种类的大致纵向磁化。选择第二射频脉冲序列以便抑制水和至少一种分子种类的横向和纵向磁化。

4. 发明授权

US07795867B2 Method, apparatus and system for magnetic resonance analysis based on water magnetization transferred from other molecules 有权
标题翻译：基于从其他分子转移的水磁化的磁共振分析的方法，装置和系统
公开(公告)号：US07795867B2
公开(公告)日：2010-09-14
申请号：US12223397
申请日：2007-02-04
申请人： Uzi Eliav , Gil Navon , Arnon Neufeld
发明人： Uzi Eliav , Gil Navon , Arnon Neufeld
IPC分类号： G01V3/00
CPC分类号： G01R33/4828 , G01R33/5605 , G01R33/5607
摘要： A method of magnetic resonance analysis of a body having therein at least one molecular species and water is disclosed. The method comprises, subtracting magnetic resonance signals induced by a second radiofrequency pulse sequence from magnetic resonance signals induced by a first radiofrequency pulse sequence followed by a evolution period. The first radiofrequency pulse sequence is selected so as to suppress magnetization for the water while preserving a generally longitudinal magnetization to the at least one molecular species. The second radiofrequency pulse sequence being selected so as to suppress transverse and longitudinal magnetization for both the water and the at least one molecular species.
摘要翻译：公开了一种其中具有至少一种分子种类和水的物体的磁共振分析方法。该方法包括：从由第一射频脉冲序列感应的磁共振信号，随后的演化周期减去由第二射频脉冲序列感应的磁共振信号。选择第一射频脉冲序列以便抑制水的磁化，同时保持对至少一种分子种类的大致纵向磁化。选择第二射频脉冲序列以便抑制水和至少一种分子种类的横向和纵向磁化。

5. 发明授权

US06373250B1 Method of magnetic resonance imaging 有权
标题翻译：磁共振成像方法
公开(公告)号：US06373250B1
公开(公告)日：2002-04-16
申请号：US09574241
申请日：2000-05-19
申请人： Liat Tsoref , Uzi Eliav , Gil Navon
发明人： Liat Tsoref , Uzi Eliav , Gil Navon
IPC分类号： G01V300
CPC分类号： G01R33/446 , G01R33/56
摘要： A method of slice selective multiple quantum magnetic resonance imaging of an object is disclosed. The method is effected by implementing the steps of (a) applying a radiofrequency pulse sequence selected so as to select a coherence of an order n to the object, wherein n is zero, a positive or a negative integer other than ±1; (b) applying magnetic gradient pulses, so as to select a slice of the object to be imaged arid to create an image; and (c) acquiring a radiofrequency signal resulting from the object, so as to generate a magnetic resonance slice image of the object. The method provides slice selective multiple quantum magnetic resonance images of yet unprecedented quality in terms of contrast. The method is particularly useful for imaging connective tissues.
摘要翻译：公开了一种对象的切片选择性多量子磁共振成像的方法。该方法通过以下步骤来实现：（a）应用选择以选择n个对象的相干性的射频脉冲序列，其中n为零，除±1之外的正整数或负整数; （b）施加磁梯度脉冲，以便选择待成像对象的切片以产生图像; 以及（c）获取由对象产生的射频信号，以产生该对象的磁共振切片图像。该方法在对比度方面提供了前所未有的质量的切片选择性多量子磁共振图像。该方法对结缔组织成像特别有用。

6. 发明申请

US20080091099A1 Mri Imaging And Contrast Method 有权
标题翻译： Mri成像和对比方法
公开(公告)号：US20080091099A1
公开(公告)日：2008-04-17
申请号：US11661975
申请日：2005-09-08
申请人： Dina Carasso , Uzi Eliav , Gil Navon
发明人： Dina Carasso , Uzi Eliav , Gil Navon
IPC分类号： A61B5/055
CPC分类号： G01R33/4828 , A61B5/055 , A61B18/04 , G01R33/4804 , G01R33/4814 , G01R33/56 , G01R33/5605
摘要： A novel MRI contrast technique enables to observe tissue properties not observable by previously known MRI methods. A difference between two disclosed pulse sequences is used to measure magnetization exchange time between water molecules and macromolecules such as proteins, thereby producing a measure highly sensitive to tissue changes resulting from coagulation, yet relatively insensitive to temperature fluctuations. This result is applied to an imaging method and provides direct visualization of the effects of surgical thermal ablation procedures.
摘要翻译：一种新颖的MRI对比技术能够观察到以前已知的MRI方法不可观察到的组织特性。使用两个公开的脉冲序列之间的差异来测量水分子和大分子如蛋白质之间的磁化交换时间，从而产生对凝结产生的组织变化高度敏感的测量，但对温度波动相对不敏感。该结果被应用于成像方法，并且提供了手术热消融程序的效果的直接可视化。

7. 发明授权

US6144199A Method for imaging vessel wall anatomy and strain 失效
标题翻译：血管壁解剖和应变成像方法
公开(公告)号：US6144199A
公开(公告)日：2000-11-07
申请号：US912783
申请日：1997-08-18
申请人： Yehuda Sharf , Gil Navon , Uzi Eliav , Liat Tsoref
发明人： Yehuda Sharf , Gil Navon , Uzi Eliav , Liat Tsoref
IPC分类号： G01R33/48 , G01R33/483 , G01V3/00
CPC分类号： G01R33/56 , G01R33/485
摘要： A method for depicting the anatomy and quantitative tissue strain of a biological tissue. A spatially resolved, double quantum filtered, nuclear magnetic resonance frequency spectrum is acquired from either .sup.1 H or .sup.2 H nuclei in the tissue. Values in the time domain or frequency domain representations of the free induction decay signal are mapped in 2 spatial dimensions so as to selectively depict histological layers of the tissue anatomy. The residual quadrupolar or dipolar splitting is calculated from the free induction decay signal, and then correlated with a tissue strain value by utilizing a known formula describing the correlation between residual quadrupolar or dipolar splitting and tissue strain. The tissue strain value is then mapped in two spatial dimensions.
摘要翻译：描述生物组织的解剖和定量组织应变的方法。从组织中的1H或2H核获得空间分辨的双量子滤波的核磁共振频谱。将自由感应衰减信号的时域或频域表示中的值映射为2个空间维度，以选择性地描绘组织解剖结构的组织学层。从自由诱导衰减信号计算残余四极或偶极分裂，然后通过利用描述残余四极或偶极分裂和组织应变之间的相关性的已知公式与组织应变值相关。然后将组织应变值映射到两个空间维度。

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