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1. 发明授权

US06979543B2 Method for detecting biological agents 失效
标题翻译：检测生物制剂的方法
公开(公告)号：US06979543B2
公开(公告)日：2005-12-27
申请号：US10412568
申请日：2003-04-10
申请人： Liaohai Chen , Duncan W. McBranch , Hsing-Lin Wang , David G. Whitten
发明人： Liaohai Chen , Duncan W. McBranch , Hsing-Lin Wang , David G. Whitten
IPC分类号： C07C319/14 , C07C323/12 , G01N33/543 , C12Q1/68
CPC分类号： G01N33/54373 , C07B2200/05 , C07C319/14 , G01N33/5438 , G01N33/54386 , Y10S435/808 , Y10S435/966 , Y10S436/805 , Y10S436/806 , Y10S436/808 , Y10S436/823 , Y10S530/811 , Y10S530/812 , C07C323/12
摘要： A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-altering element bound thereto and capable of altering the measurable property, the intermediate combination adapted for subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the intermediate combination from the polymer results in a detectable change in the alterable measurable property, and, detecting said detectable change in the alterable measurable property.
摘要翻译：提供了一种传感器，其包括能够从发光和导电性组中具有可改变的可测量性质的聚合物，所述聚合物具有识别元件，束缚元件和结合到其上的改变属性的元件的中间组合，并且能够改变可测量的性质，适于在暴露于具有与识别元件结合的亲和力的试剂之后随后与聚合物分离的中间体组合，因此中间体组合与聚合物的分离导致可改变的可测量性质的可检测变化，检测可变的可测量性质中的所述可检测变化。

2. 发明授权

US06589731B1 Method for detecting biological agents 失效
标题翻译：检测生物制剂的方法
公开(公告)号：US06589731B1
公开(公告)日：2003-07-08
申请号：US09565589
申请日：2000-05-04
申请人： Liaohai Chen , Duncan W. McBranch , Hsing-Lin Wang , David G. Whitten
发明人： Liaohai Chen , Duncan W. McBranch , Hsing-Lin Wang , David G. Whitten
IPC分类号： G01N3353
CPC分类号： G01N33/5438 , G01N33/542 , G01N33/54373 , G01N33/54386 , Y10S435/808 , Y10S435/966 , Y10S436/805 , Y10S436/806 , Y10S436/808 , Y10S436/823
摘要： A sensor element is provided including a polymer exhibiting a measurable property from the group of luminescence and electrical conductivity, the polymer being complexed with a unit including a recognition element, a tethering element and a property-altering element bound thereto so as to alter the measurable property, the unit being susceptible of subsequent separation from the polymer upon exposure to an agent having an affinity for binding to the recognition element whereupon the separation of the unit from the polymer results in a detectable change in the measurable property.
摘要翻译：提供了一种传感器元件，其包括从发光和导电性组中显示可测量性质的聚合物，所述聚合物与包括识别元件，系链元件和结合到其上的改变属性的单元复合，以便改变可测量的性质，该单元易于暴露于具有与识别元件结合的亲和性的试剂后随后与聚合物分离，因此单元与聚合物的分离导致可测量性质的可检测变化。

3. 发明授权

US06743640B2 Fluorescent polymer-QTL approach to biosensing 失效
标题翻译：荧光聚合物 - QTL方法进行生物传感
公开(公告)号：US06743640B2
公开(公告)日：2004-06-01
申请号：US09850074
申请日：2001-05-08
申请人： David G. Whitten , Duncan W. McBranch , Robert Jones , Troy S. Bergstedt
发明人： David G. Whitten , Duncan W. McBranch , Robert Jones , Troy S. Bergstedt
IPC分类号： G01N33543
CPC分类号： G01N33/582 , G01N21/6428 , G01N33/542 , G01N2021/6432 , G01N2021/6439 , Y10S436/808
摘要： A chemical composition including a moiety comprising a quencher (Q), a tethering element (T), and a ligand (L) that associates with and quenches a fluorescent polymer is disclosed. When an analyte sample is introduced, the ligand (L) binds to a target biological agent if it is present, thereby causing the QTL molecule to separate from the fluorescent polymer resulting in an increase in detected fluorescence. The same chemistry is advantageously employed in a competitive assay. An electric field can also be applied to separate the QTL molecule from the fluorescent polymer. A method for detecting targets for these methods are also disclosed.
摘要翻译：公开了一种化学组合物，其包含与猝灭剂（Q），束缚元件（T）和与荧光聚合物缔合并猝灭的配体（L）的部分。当引入分析物样品时，配体（L）如果存在则与目标生物试剂结合，从而使QTL分子与荧光聚合物分离，导致检测到的荧光增加。在竞争性测定中有利地使用相同的化学物质。也可以应用电场以将QTL分子与荧光聚合物分离。还公开了一种用于检测这些方法的靶的方法。

4. 发明授权

US06522447B2 Optical limiting device and method of preparation thereof 失效
公开(公告)号：US06522447B2
公开(公告)日：2003-02-18
申请号：US09872218
申请日：2001-05-31
申请人： Hsing-Lin Wang , Su Xu , Duncan W. McBranch
发明人： Hsing-Lin Wang , Su Xu , Duncan W. McBranch
IPC分类号： G02F103
CPC分类号： A61F7/123 , A61F2007/0054 , A61F2007/126 , Y10T428/24942
摘要： Optical limiting device and method of preparation thereof. The optical limiting device includes a transparent substrate and at least one homogeneous layer of an RSA material in polyvinylbutyral attached to the substrate. The device may be produced by preparing a solution of an RSA material, preferably a metallophthalocyanine complex, and a solution of polyvinylbutyral, and then mixing the two solutions together to remove air bubbles. The resulting solution is layered onto the substrate and the solvent is evaporated. The method can be used to produce a dual tandem optical limiting device.

5. 发明授权

US07125578B1 Photoinduced charge-transfer materials for nonlinear optical applications 失效
标题翻译：用于非线性光学应用的光诱导电荷转移材料
公开(公告)号：US07125578B1
公开(公告)日：2006-10-24
申请号：US09298297
申请日：1999-04-23
申请人： Duncan W. McBranch
发明人： Duncan W. McBranch
IPC分类号： B05D5/06
CPC分类号： G02F1/3618 , B82Y20/00
摘要： A method using polyelectrolyte self-assembly for preparing multi-layered organic molecular materials having individual layers which exhibit ultrafast electron and/or energy transfer in a controlled direction occurring over the entire structure. Using a high molecular weight, water-soluble, anionic form of poly-phenylene vinylene, self-assembled films can be formed which show high photoluminescence quantum efficiency (QE). The highest emission QE is achieved using poly(propylene-imine) (PPI) dendrimers as cationic binders. Self-quenching of the luminescence is observed as the solid polymer film thickness is increased and can be reversed by inserting additional spacer layers of transparent polyelectrolytes between each active conjugated layer, such that the QE grows with thickness. A red shift of the luminescence is also observed as additional PPV layers are added. This effect persists as self-quenching is eliminated. Charge transfer superlattices can be formed by additionally incorporating C60 acceptor layers.
摘要翻译：一种使用聚电解质自组装制备具有单层的多层有机分子材料的方法，其在整个结构上发生在受控方向上表现出超快电子和/或能量传递。使用高分子量的水溶性阴离子形式的聚亚苯基亚乙烯，可以形成显示高光致发光量子效率（QE）的自组装膜。使用聚（丙烯 - 亚胺）（PPI）树枝状大分子作为阳离子粘合剂实现了最高的排放量QE。观察到发光的自熄，因为固体聚合物膜厚度增加，并且可以通过在每个活性共轭层之间插入透明聚电解质的附加间隔层而使其反转，使得QE随厚度增长。当添加额外的PPV层时，也观察到发光的红移。由于消除了自熄，这种效果仍然存在。电荷转移超晶格可以通过另外并入C 60受体层而形成。

6. 发明授权

US06761999B2 Nondegenerate four-wave mixing using photoinduced charge-transfer materials 失效
标题翻译：使用光诱导电荷转移材料进行非简并四波混合
公开(公告)号：US06761999B2
公开(公告)日：2004-07-13
申请号：US09973170
申请日：2001-10-04
申请人： Eric S. Maniloff , Duncan W. McBranch , Alan J. Heeger , Dan V. Vacar
发明人： Eric S. Maniloff , Duncan W. McBranch , Alan J. Heeger , Dan V. Vacar
IPC分类号： G03H102
CPC分类号： B82Y30/00 , G02F1/3536 , G02F2202/13 , G03H1/02 , G03H2001/026 , G03H2001/0264 , G03H2222/33 , G03H2260/36
摘要： Charge-transfer materials are demonstrated to be useful for generating femtosecond holographic gratings. Using semiconducting polymers sensitized with varying concentrations of C60, absorption holographic gratings with diffraction efficiencies of 1.6% were recorded with individual ultrafast laser pulses; the diffraction efficiency and time decay of the gratings were measured using nondegenerate four-wave mixing. High quantum efficiency for electron transfer reduces the effects of early recombination which otherwise limits the density of excitations in pure polymers, and the metastability of the charge transfer enables tuning of the decay dynamics by controlling the concentration of acceptors in the mixture.
摘要翻译：电荷转移材料被证明可用于生成飞秒全息光栅。使用用不同浓度C60敏化的半导体聚合物，用单个超快激光脉冲记录衍射效率为1.6％的吸收全息光栅; 使用非衰变四波混频测量光栅的衍射效率和时间衰减。电子传递的高量子效率降低了早期重组的影响，否则限制了纯聚合物中激发的密度，电荷转移的亚稳态可通过控制混合物中受体的浓度来调节衰变动力学。

7. 发明授权

US5741442A Optical limiting materials 失效
标题翻译：光学限制材料
公开(公告)号：US5741442A
公开(公告)日：1998-04-21
申请号：US499888
申请日：1995-07-11
申请人： Duncan W. McBranch , Benjamin R. Mattes , Aaron C. Koskelo , Alan J. Heeger , Jeanne M. Robinson , Laura B. Smilowitz , Victor I. Klimov , Myoungsik Cha , N. Serdar Sariciftci , Jan C. Hummelen
发明人： Duncan W. McBranch , Benjamin R. Mattes , Aaron C. Koskelo , Alan J. Heeger , Jeanne M. Robinson , Laura B. Smilowitz , Victor I. Klimov , Myoungsik Cha , N. Serdar Sariciftci , Jan C. Hummelen
IPC分类号： G02B5/22 , G02F1/35 , F21V9/00
CPC分类号： G02B5/223 , G02F1/3523
摘要： Optical limiting materials. Methanofullerenes, fulleroids and/or other fullerenes chemically altered for enhanced solubility, in liquid solution, and in solid blends with transparent glass (SiO.sub.2) gels or polymers, or semiconducting (conjugated) polymers, are shown to be useful as optical limiters (optical surge protectors). The nonlinear absorption is tunable such that the energy transmitted through such blends saturates at high input energy per pulse over a wide range of wavelengths from 400-1100 nm by selecting the host material for its absorption wavelength and ability to transfer the absorbed energy into the optical limiting composition dissolved therein. This phenomenon should be generalizable to other compositions than substituted fullerenes.
摘要翻译：光学限制材料。化学改性的富含甲醛，富勒烯和/或其他富勒烯在液体溶液中以及与透明玻璃（SiO2）凝胶或聚合物或半导体（共轭）聚合物的固体共混物中的溶解度增强，被用作光学限制器保护者）。非线性吸收是可调谐的，使得通过这种混合物传输的能量在400-1100nm的宽波长范围内以每脉冲的高输入能量饱和，通过选择其吸收波长的主体材料和将吸收的能量转移到光学器件中的能力限制性组合物溶解在其中。这种现象应该可以归因于其他组合物而不是取代的富勒烯。

8. 发明授权

US06191861B1 Femtosecond chirp-free transient absorption method and apparatus 失效
标题翻译：飞秒无啁啾的瞬时吸收方法和装置
公开(公告)号：US06191861B1
公开(公告)日：2001-02-20
申请号：US09249726
申请日：1999-02-13
申请人： Duncan W. McBranch , Victor I. Klimov
发明人： Duncan W. McBranch , Victor I. Klimov
IPC分类号： G01N2159
CPC分类号： G01N21/1717
摘要： A method and apparatus for femtosecond transient absorption comprising phase-sensitive detection, spectral scanning and simultaneous controlling of a translation stage to obtain TA spectra information having at least a sensitivity two orders of magnitude higher than that for single-shot methods, with direct, simultaneous compensation for chirp as the data is acquired. The present invention includes a amplified delay translation stage which generates a splittable frequency-doubled laser signal at a predetermined frequency f, a controllable means for synchronously modulating one of the laser signals at a repetition rate of f/2, applying the laser signals to a material to be sample, and acquiring data from the excited sample while simultaneously controlling the controllable means for synchronously modulating.
摘要翻译：一种用于飞秒瞬态吸收的方法和装置，包括相敏检测，光谱扫描和翻译级的同时控制，以获得具有至少比单次方法高两个数量级的灵敏度的TA光谱信息，其具有直接，同时获取数据时对啁啾的补偿。本发明包括放大的延迟转换级，其产生预定频率f的可分开的倍频激光信号，用于以f / 2的重复频率同步调制其中一个激光信号的可控装置，将激光信号施加到要采样的材料，并且从同时控制用于同步调制的可控装置同时获取激发样品的数据。

9. 发明授权

US5420081A Preparation of fullerene/glass composites 失效
标题翻译：富勒烯/玻璃复合材料的制备
公开(公告)号：US5420081A
公开(公告)日：1995-05-30
申请号：US221421
申请日：1994-03-31
申请人： Benjamin R. Mattes , Duncan W. McBranch , Jeanne M. Robinson , Aaron C. Koskelo , Steven P. Love
发明人： Benjamin R. Mattes , Duncan W. McBranch , Jeanne M. Robinson , Aaron C. Koskelo , Steven P. Love
IPC分类号： C03C14/00
CPC分类号： C03C14/008 , C03C2214/32 , Y10T29/49014
摘要： Synthesis of fullerene/glass composites. A direct method for preparing solid solutions of C.sub.60 in silicon dioxide (SiO.sub.2) glass matrices by means of sol-gel chemistry is described. In order to produce highly concentrated fullerene-sol-gel-composites it is necessary to increase the solubility of these "guests" in a delivery solvent which is compatible with the starter sol (receiving solvent). Sonication results in aggregate disruption by treatment with high frequency sound waves, thereby accelerating the rate of hydrolysis of the alkoxide precursor, and the solution process for the C.sub.60. Depending upon the preparative procedure, C.sub.60 dispersed within the glass matrix as microcrystalline domains, or dispersed as true molecular solutions of C.sub.60 in a solid glass matrix, is generated by the present method.
摘要翻译：富勒烯/玻璃复合材料的合成。描述了通过溶胶 - 凝胶化学在二氧化硅（SiO 2）玻璃基质中制备C60固溶体的直接方法。为了生产高度浓缩的富勒烯 - 溶胶 - 凝胶复合材料，有必要将这些“客人”的溶解度提高到与起始溶胶（接收溶剂）相容的输送溶剂中。超声处理通过高频声波处理导致总体破坏，从而加速了醇盐前体的水解速率和C60的溶液过程。根据制备方法，通过本方法产生作为微晶畴分散在玻璃基质内的C60或作为固体玻璃基质中C 60的真实分子溶液分散的C60。

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