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    • 3. 发明申请
      US20050038256A1 Synthetic process for trans-aminocyclohexyl ether compounds 审中-公开
    • Synthetic process for trans-aminocyclohexyl ether compounds
    • US20050038256A1
    • 2005-02-17
    • US10862157
    • 2004-06-04
    • Anthony Barrett , Lewis Choi
    • Anthony Barrett , Lewis Choi
    • A61K31/40 , A61K31/455 , A61K31/4965 , A61K31/519 , C07D207/12 , C07D211/20 , C07D207/46
    • A61K31/519 , A61K31/40 , A61K31/455 , A61K31/4965 , C07D207/12
    • A method of stereoselectively making an aminocyclohexyl ether comprises, for example, reacting to form the aminocyclohexyl ether having the formula respectively, wherein independently at each occurrence, R1 and R2 are independently hydrogen, C1-C8alkyl, C3-C8alkoxyalkyl, C1-C8hydroxyalkyl, or C7-C12aralkyl; or R1 and R2 are independently C3-C8alkoxyalkyl, C1-C8hydroxyalkyl, and C7-C12aralkyl; or R1 and R2, when taken together with the nitrogen atom to which they are directly attached in formula (57) or (75), form a ring denoted by formula (I): wherein the ring of formula (I) is formed from the nitrogen as shown as well as three to nine additional ring atoms independently carbon, nitrogen, oxygen, or sulfur; where any two adjacent ring atoms may be joined together by single or double bonds, and where any one or more of the additional carbon ring atoms may be substituted with one or two substituents selected from the group consisting of hydrogen, hydroxy, C1-C3hydroxyalkyl, oxo, C2-C4acyl, C1-C3alkyl, C2-C4alkylcarboxy, C1-C3alkoxy, and C1-C20alkanoyloxy, or may be substituted to form a spiro five- or six-membered heterocyclic ring containing one or two oxygen and/or sulfur heteroatoms; or any two adjacent additional carbon ring atoms may be fused to a C3-C8carbocyclic ring, and any one or more of the additional nitrogen ring atoms may be substituted with substituents selected from the group consisting of hydrogen, C1-C6alkyl, C2-C4acyl, C2-C4hydroxyalkyl and C3-C8alkoxyalkyl; or R1 and R2, when taken together with the nitrogen atom to which they are directly attached in formula (I), may form a bicyclic ring system selected from the group consisting of 3-azabicyclo[3.2.2]nonan-3-yl, 2-azabicyclo[2.2.2]octan-2-yl, 3-azabicyclo[3.1.0]hexan-3-yl, and 3-azabicyclo[3.2.0]heptan-3-yl; and wherein R3, R4 and R5 are independently bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, cyano, sulfamyl, trifluoromethyl, C2-C7alkanoyloxy, C1-C6alkyl, C1-C6alkoxy, C2-C7alkoxycarbonyl, C1-C6thioalkyl, aryl or N(R6,R7) where R6 and R7 are independently hydrogen, acetyl, methanesulfonyl or C1-C6alkyl; or R3, R4 and R5 are independently hydrogen, hydroxy or C1-C6alkoxy; with the proviso that R3, R4 and R5 cannot all be hydrogen; and wherein O-J is a leaving group. Methods of making intermediates are also disclosed.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 5. 发明申请
      US20110022891A1 Method for the Generation of a Set of Conflicts for Model-Based System Diagnostics, and Corresponding Diagnostic Method 有权
    • Method for the Generation of a Set of Conflicts for Model-Based System Diagnostics, and Corresponding Diagnostic Method
    • 基于模型的系统诊断产生一组冲突的方法及相应的诊断方法
    • US20110022891A1
    • 2011-01-27
    • US12841691
    • 2010-07-22
    • Amir Fijany , Anthony Barrett , Farrokh Vatan
    • Amir Fijany , Anthony Barrett , Farrokh Vatan
    • G06F11/07
    • G06F11/3608
    • A method for the generation of a set of conflicts for model-based system diagnostics is described, with which system a plurality of sensors is associated for the observation of variables indicative of operation conditions.The method starts from generating a complete set of Analytical Redundancy Relations (ARRs) in implicit form and, for each diagnosis instance: it performs a system simulation, computing the expected values for a first subset of Analytical Redundancy Relations (D-ARRs) including the relations involving only one system observation variable; it compares the expected and observed values of the system observation variables to identify the inconsistent variables, i.e. the unsatisfied redundancy relations, indicating a fault in at least one system component; and, when discrepancies are detected, it checks the consistency of each relation belonging to a second subset of Analytical Redundancy Relations (I-ARR), comprising relations involving a plurality of system observation variables, at least one of which exhibits discrepancies between expected and observed values; therefore identifying the support set of the unsatisfied Redundancy Relations as set of system conflicts.
    • 描述了用于产生用于基于模型的系统诊断的一组冲突的方法，与该系统相关联的多个传感器用于观察指示操作条件的变量。 该方法从隐式形式生成一套完整的分析冗余关系（ARR）开始，对于每个诊断实例，它执行系统仿真，计算分析冗余关系（D-ARR）的第一个子集的期望值，包括 只涉及一个系统观测变量的关系; 它比较系统观测变量的预期值和观测值，以识别指示至少一个系统组件中的故障的不一致变量，即不满足的冗余度关系; 并且当检测到差异时，它检查属于分析冗余关系（I-ARR）的第二子集的每个关系的一致性，其包括涉及多个系统观察变量的关系，其中至少一个呈现预期和观察到的差异 价值观 因此，将不满意​​的冗余关系的支持集确定为系统冲突。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 7. 发明授权
      US08311783B2 Method for the generation of a set of conflicts for model-based system diagnostics, and corresponding diagnostic method 有权
    • Method for the generation of a set of conflicts for model-based system diagnostics, and corresponding diagnostic method
    • 用于生成用于基于模型的系统诊断的一组冲突的方法，以及相应的诊断方法
    • US08311783B2
    • 2012-11-13
    • US12841691
    • 2010-07-22
    • Amir Fijany , Anthony Barrett , Farrokh Vatan
    • Amir Fijany , Anthony Barrett , Farrokh Vatan
    • G06F17/50 , G06F9/45 , G06F11/07
    • G06F11/3608
    • A method for the generation of a set of conflicts for model-based system diagnostics is described, with which system a plurality of sensors is associated for the observation of variables indicative of operation conditions.The method starts from generating a complete set of Analytical Redundancy Relations (ARRs) in implicit form and, for each diagnosis instance: it performs a system simulation, computing the expected values for a first subset of Analytical Redundancy Relations (D-ARRs) including the relations involving only one system observation variable; it compares the expected and observed values of the system observation variables to identify the inconsistent variables, i.e. the unsatisfied redundancy relations, indicating a fault in at least one system component; and, when discrepancies are detected, it checks the consistency of each relation belonging to a second subset of Analytical Redundancy Relations (I-ARR), comprising relations involving a plurality of system observation variables, at least one of which exhibits discrepancies between expected and observed values; therefore identifying the support set of the unsatisfied Redundancy Relations as set of system conflicts.
    • 描述了用于产生用于基于模型的系统诊断的一组冲突的方法，与该系统相关联的多个传感器用于观察指示操作条件的变量。 该方法从隐式形式生成一套完整的分析冗余关系（ARR）开始，对于每个诊断实例，它执行系统仿真，计算分析冗余关系（D-ARR）的第一个子集的期望值，包括 只涉及一个系统观测变量的关系; 它比较系统观测变量的预期值和观测值，以识别指示至少一个系统组件中的故障的不一致变量，即不满足的冗余度关系; 并且当检测到差异时，它检查属于分析冗余关系（I-ARR）的第二子集的每个关系的一致性，其包括涉及多个系统观察变量的关系，其中至少一个呈现预期和观察到的差异 价值观 因此，将不满意​​的冗余关系的支持集确定为系统冲突。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 8. 发明申请
      US20060094880A9 Synthetic process for trans-aminocyclohexyl ether compounds 审中-公开
    • Synthetic process for trans-aminocyclohexyl ether compounds
    • US20060094880A9
    • 2006-05-04
    • US10862157
    • 2004-06-04
    • Anthony Barrett , Lewis Choi
    • Anthony Barrett , Lewis Choi
    • C07D211/20 , C07D207/46
    • A61K31/519 , A61K31/40 , A61K31/455 , A61K31/4965 , C07D207/12
    • A method of stereoselectively making an aminocyclohexyl ether comprises, for example, reacting to form the aminocyclohexyl ether having the formula respectively, wherein independently at each occurrence, R1 and R2 are independently hydrogen, C1-C8alkyl, C3-C8alkoxyalkyl, C1-C8hydroxyalkyl, or C7-C12aralkyl; or R1 and R2 are independently C3-C8alkoxyalkyl, C1-C8hydroxyalkyl, and C7-C12aralkyl; or R1 and R2, when taken together with the nitrogen atom to which they are directly attached in formula (57) or (75), form a ring denoted by formula (I): wherein the ring of formula (I) is formed from the nitrogen as shown as well as three to nine additional ring atoms independently carbon, nitrogen, oxygen, or sulfur; where any two adjacent ring atoms may be joined together by single or double bonds, and where any one or more of the additional carbon ring atoms may be substituted with one or two substituents selected from the group consisting of hydrogen, hydroxy, C1-C3hydroxyalkyl, oxo, C2-C4acyl, C1-C3alkyl, C2-C4alkylcarboxy, C1-C3alkoxy, and C1-C20alkanoyloxy, or may be substituted to form a spiro five- or six-membered heterocyclic ring containing one or two oxygen and/or sulfur heteroatoms; or any two adjacent additional carbon ring atoms may be fused to a C3-C8carbocyclic ring, and any one or more of the additional nitrogen ring atoms may be substituted with substituents selected from the group consisting of hydrogen, C1-C6alkyl, C2-C4acyl, C2-C4hydroxyalkyl and C3-C8alkoxyalkyl; or R1 and R2, when taken together with the nitrogen atom to which they are directly attached in formula (I), may form a bicyclic ring system selected from the group consisting of 3-azabicyclo[3.2.2]nonan-3-yl, 2-azabicyclo[2.2.2]octan-2-yl, 3-azabicyclo[3.1.0]hexan-3-yl, and 3-azabicyclo[3.2.0]heptan-3-yl; and wherein R3, R4 and R5 are independently bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, cyano, sulfamyl, trifluoromethyl, C2-C7alkanoyloxy, C1-C6alkyl, C1-C6alkoxy, C2-C7alkoxycarbonyl, C1-C6thioalkyl, aryl or N(R6,R7) where R6 and R7 are independently hydrogen, acetyl, methanesulfonyl or C1-C6alkyl; or R3, R4 and R5 are independently hydrogen, hydroxy or C1-C6alkoxy; with the proviso that R3, R4 and R5 cannot all be hydrogen; and wherein O-J is a leaving group. Methods of making intermediates are also disclosed.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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