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1. 发明申请

US20070254945A1 AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF 有权
标题翻译： AMINOCYCLOHEXYL醚化合物及其用途
公开(公告)号：US20070254945A1
公开(公告)日：2007-11-01
申请号：US11690361
申请日：2007-03-23
申请人： Grace Jung , Bertrand Plouvier , Yuzhong Liu , Jeff Zhu , Tao Sheng , Anthony Barrett , Lewis Choi , Doug Chou
发明人： Grace Jung , Bertrand Plouvier , Yuzhong Liu , Jeff Zhu , Tao Sheng , Anthony Barrett , Lewis Choi , Doug Chou
IPC分类号： A61K31/075 , A61K31/4015 , C07C41/01 , C07C41/14 , C07D207/12
CPC分类号： A61K31/40 , A61K31/455 , A61K31/4965 , A61K31/519 , C07D207/12
摘要： Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
摘要翻译：公开了氨基环己基醚化合物。本发明的化合物可以掺入组合物和试剂盒中。本发明还公开了化合物和组合物的用途，包括治疗心律失常。

2. 发明申请

US20080021005A1 Pegylated Ion Channel Modulating Compounds 有权
标题翻译：聚乙二醇化离子通道调节化合物
公开(公告)号：US20080021005A1
公开(公告)日：2008-01-24
申请号：US11547419
申请日：2005-03-31
申请人： Elizabeth Cheu , Lewis Choi , Doug Chou , Allen Davidoff , Alan Ezrin , Grace Jung , Bertrand Plouvier , Aregahegn Yifru
发明人： Elizabeth Cheu , Lewis Choi , Doug Chou , Allen Davidoff , Alan Ezrin , Grace Jung , Bertrand Plouvier , Aregahegn Yifru
IPC分类号： C07D207/12 , A61K31/4015 , A61K31/4025 , A61K31/4155 , A61K31/427 , A61K31/4439 , A61K31/497 , C07D277/20 , C07D401/02 , C07D487/02 , C07D487/00 , C07D403/14 , C07D403/02 , C07D401/04 , C07D281/00 , C07D209/82 , A61K31/501 , A61K31/519 , A61K31/55 , A61K31/58 , A61P9/00
CPC分类号： C07H15/203 , A61K47/54 , A61K47/555 , A61K47/60 , A61K51/04 , C07B2200/05 , C07C257/06 , C07D207/12 , C07D209/88 , C07D209/94 , C07F9/572
摘要： This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also disclosed
摘要翻译：本发明涉及某些离子通道调节化合物的PEG衍生物，药物偶联物和同位素衍生物。还公开了药物组合物和使用方法

3. 发明申请

US20050197383A1 Quaternary ammonium compounds and their use as anti-tussive agents 审中-公开
标题翻译：第四季铵化合物及其作为抗呕吐剂的用途
公开(公告)号：US20050197383A1
公开(公告)日：2005-09-08
申请号：US11115633
申请日：2005-04-26
申请人： Lewis Choi , Gregory Beatch , Clive Page
发明人： Lewis Choi , Gregory Beatch , Clive Page
IPC分类号： A61K31/404 , A61K31/135 , A61K31/14 , A61P11/14 , C07C215/40 , C07C217/14 , C07C217/18 , C07C217/30 , C07D209/08 , C07D211/14 , A61K31/4025 , A61K31/40
CPC分类号： C07D209/08 , C07C217/18 , C07C217/30
摘要： In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment aid/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula Y-J-EAn− (I), wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).
摘要翻译：一方面，本发明涉及某些季铵化合物作为活性成分在制备用于治疗辅助剂或预防包括人在内的温血动物（例如式YJ化合物）中的咳嗽的药物中的用途其中J独立地选自式（II），（III）和（IV）之一表示的基团。

4. 发明申请

US20050038256A1 Synthetic process for trans-aminocyclohexyl ether compounds 审中-公开
公开(公告)号：US20050038256A1
公开(公告)日：2005-02-17
申请号：US10862157
申请日：2004-06-04
申请人： Anthony Barrett , Lewis Choi
发明人： Anthony Barrett , Lewis Choi
IPC分类号： A61K31/40 , A61K31/455 , A61K31/4965 , A61K31/519 , C07D207/12 , C07D211/20 , C07D207/46
CPC分类号： A61K31/519 , A61K31/40 , A61K31/455 , A61K31/4965 , C07D207/12
摘要： A method of stereoselectively making an aminocyclohexyl ether comprises, for example, reacting to form the aminocyclohexyl ether having the formula respectively, wherein independently at each occurrence, R1 and R2 are independently hydrogen, C1-C8alkyl, C3-C8alkoxyalkyl, C1-C8hydroxyalkyl, or C7-C12aralkyl; or R1 and R2 are independently C3-C8alkoxyalkyl, C1-C8hydroxyalkyl, and C7-C12aralkyl; or R1 and R2, when taken together with the nitrogen atom to which they are directly attached in formula (57) or (75), form a ring denoted by formula (I): wherein the ring of formula (I) is formed from the nitrogen as shown as well as three to nine additional ring atoms independently carbon, nitrogen, oxygen, or sulfur; where any two adjacent ring atoms may be joined together by single or double bonds, and where any one or more of the additional carbon ring atoms may be substituted with one or two substituents selected from the group consisting of hydrogen, hydroxy, C1-C3hydroxyalkyl, oxo, C2-C4acyl, C1-C3alkyl, C2-C4alkylcarboxy, C1-C3alkoxy, and C1-C20alkanoyloxy, or may be substituted to form a spiro five- or six-membered heterocyclic ring containing one or two oxygen and/or sulfur heteroatoms; or any two adjacent additional carbon ring atoms may be fused to a C3-C8carbocyclic ring, and any one or more of the additional nitrogen ring atoms may be substituted with substituents selected from the group consisting of hydrogen, C1-C6alkyl, C2-C4acyl, C2-C4hydroxyalkyl and C3-C8alkoxyalkyl; or R1 and R2, when taken together with the nitrogen atom to which they are directly attached in formula (I), may form a bicyclic ring system selected from the group consisting of 3-azabicyclo[3.2.2]nonan-3-yl, 2-azabicyclo[2.2.2]octan-2-yl, 3-azabicyclo[3.1.0]hexan-3-yl, and 3-azabicyclo[3.2.0]heptan-3-yl; and wherein R3, R4 and R5 are independently bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, cyano, sulfamyl, trifluoromethyl, C2-C7alkanoyloxy, C1-C6alkyl, C1-C6alkoxy, C2-C7alkoxycarbonyl, C1-C6thioalkyl, aryl or N(R6,R7) where R6 and R7 are independently hydrogen, acetyl, methanesulfonyl or C1-C6alkyl; or R3, R4 and R5 are independently hydrogen, hydroxy or C1-C6alkoxy; with the proviso that R3, R4 and R5 cannot all be hydrogen; and wherein O-J is a leaving group. Methods of making intermediates are also disclosed.

5. 发明申请

US20070099983A1 Aminocyclohexyl ether compounds and uses thereof 审中-公开
标题翻译：氨基环己基醚化合物及其用途
公开(公告)号：US20070099983A1
公开(公告)日：2007-05-03
申请号：US10555364
申请日：2003-10-31
申请人： G.M. Barrett , Lewis Choi , Dough Chou , Grace Jung , Bertrand Plouvier , Yuzhong Liu , Jeff Zhu , Tao Sheng
发明人： G.M. Barrett , Lewis Choi , Dough Chou , Grace Jung , Bertrand Plouvier , Yuzhong Liu , Jeff Zhu , Tao Sheng
IPC分类号： A61K31/4015 , C07D207/02
CPC分类号： A61K31/40 , A61K31/455 , A61K31/4965 , A61K31/519 , C07D207/12
摘要： Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
摘要翻译：公开了氨基环己基醚化合物。本发明的化合物可以掺入组合物和试剂盒中。本发明还公开了化合物和组合物的用途，包括治疗心律失常。

6. 发明申请

US20060094880A9 Synthetic process for trans-aminocyclohexyl ether compounds 审中-公开
公开(公告)号：US20060094880A9
公开(公告)日：2006-05-04
申请号：US10862157
申请日：2004-06-04
申请人： Anthony Barrett , Lewis Choi
发明人： Anthony Barrett , Lewis Choi
IPC分类号： C07D211/20 , C07D207/46
CPC分类号： A61K31/519 , A61K31/40 , A61K31/455 , A61K31/4965 , C07D207/12
摘要： A method of stereoselectively making an aminocyclohexyl ether comprises, for example, reacting to form the aminocyclohexyl ether having the formula respectively, wherein independently at each occurrence, R1 and R2 are independently hydrogen, C1-C8alkyl, C3-C8alkoxyalkyl, C1-C8hydroxyalkyl, or C7-C12aralkyl; or R1 and R2 are independently C3-C8alkoxyalkyl, C1-C8hydroxyalkyl, and C7-C12aralkyl; or R1 and R2, when taken together with the nitrogen atom to which they are directly attached in formula (57) or (75), form a ring denoted by formula (I): wherein the ring of formula (I) is formed from the nitrogen as shown as well as three to nine additional ring atoms independently carbon, nitrogen, oxygen, or sulfur; where any two adjacent ring atoms may be joined together by single or double bonds, and where any one or more of the additional carbon ring atoms may be substituted with one or two substituents selected from the group consisting of hydrogen, hydroxy, C1-C3hydroxyalkyl, oxo, C2-C4acyl, C1-C3alkyl, C2-C4alkylcarboxy, C1-C3alkoxy, and C1-C20alkanoyloxy, or may be substituted to form a spiro five- or six-membered heterocyclic ring containing one or two oxygen and/or sulfur heteroatoms; or any two adjacent additional carbon ring atoms may be fused to a C3-C8carbocyclic ring, and any one or more of the additional nitrogen ring atoms may be substituted with substituents selected from the group consisting of hydrogen, C1-C6alkyl, C2-C4acyl, C2-C4hydroxyalkyl and C3-C8alkoxyalkyl; or R1 and R2, when taken together with the nitrogen atom to which they are directly attached in formula (I), may form a bicyclic ring system selected from the group consisting of 3-azabicyclo[3.2.2]nonan-3-yl, 2-azabicyclo[2.2.2]octan-2-yl, 3-azabicyclo[3.1.0]hexan-3-yl, and 3-azabicyclo[3.2.0]heptan-3-yl; and wherein R3, R4 and R5 are independently bromine, chlorine, fluorine, carboxy, hydrogen, hydroxy, hydroxymethyl, methanesulfonamido, nitro, cyano, sulfamyl, trifluoromethyl, C2-C7alkanoyloxy, C1-C6alkyl, C1-C6alkoxy, C2-C7alkoxycarbonyl, C1-C6thioalkyl, aryl or N(R6,R7) where R6 and R7 are independently hydrogen, acetyl, methanesulfonyl or C1-C6alkyl; or R3, R4 and R5 are independently hydrogen, hydroxy or C1-C6alkoxy; with the proviso that R3, R4 and R5 cannot all be hydrogen; and wherein O-J is a leaving group. Methods of making intermediates are also disclosed.

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