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1. 发明授权

US08168201B2 Vaccines 有权
标题翻译：疫苗
公开(公告)号：US08168201B2
公开(公告)日：2012-05-01
申请号：US11696131
申请日：2007-04-03
申请人： Leslie Hickle , Abraham Anderson , Robert C. Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
发明人： Leslie Hickle , Abraham Anderson , Robert C. Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
IPC分类号： A61K39/295 , A61K48/00 , A61K39/02 , C12N15/117 , A61K38/00
CPC分类号： A61K39/385 , A61K39/012 , A61K39/08 , A61K2039/552 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C07K2319/55 , C12N2720/10034 , C12N2760/18434 , C12N2770/20034 , Y02A50/489
摘要： The present invention relates to compositions for inducing immune responses, including an antigen and a promiscuous T-cell epitope. Also provided are methods of inducing immune responses in hosts, comprising administering compositions comprising antigens and promiscuous T-cell epitopes to the host.
摘要翻译：本发明涉及用于诱导免疫应答的组合物，包括抗原和混杂T细胞表位。还提供了在宿主中诱导免疫应答的方法，包括向宿主施用包含抗原和混杂的T细胞表位的组合物。

2. 发明申请

US20070286871A1 VACCINES 有权
标题翻译：疫苗
公开(公告)号：US20070286871A1
公开(公告)日：2007-12-13
申请号：US11696131
申请日：2007-04-03
申请人： Leslie Hickle , Abraham Anderson , Robert Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
发明人： Leslie Hickle , Abraham Anderson , Robert Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
IPC分类号： A61K39/295 , A61K39/116 , C07H21/04
CPC分类号： A61K39/385 , A61K39/012 , A61K39/08 , A61K2039/552 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C07K2319/55 , C12N2720/10034 , C12N2760/18434 , C12N2770/20034 , Y02A50/489
摘要： The present invention relates to compositions for inducing immune responses, including an antigen and a promiscuous T-cell epitope. Also provided are methods of inducing immune responses in hosts, comprising administering compositions comprising antigens and promiscuous T-cell epitopes to the host.
摘要翻译：本发明涉及用于诱导免疫应答的组合物，包括抗原和混杂T细胞表位。还提供了在宿主中诱导免疫应答的方法，包括向宿主施用包含抗原和混杂的T细胞表位的组合物。

3. 发明授权

US08945550B2 Antibodies and methods for making and using them 有权
标题翻译：用于制造和使用它们的抗体和方法
公开(公告)号：US08945550B2
公开(公告)日：2015-02-03
申请号：US12487422
申请日：2009-06-18
申请人： Gerhard Frey , Bruce E. Kimmel , Abraham Anderson
发明人： Gerhard Frey , Bruce E. Kimmel , Abraham Anderson
IPC分类号： A61K39/395
CPC分类号： C07K16/2887 , C07K16/2803 , C07K16/2809 , C07K2317/24 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic anti-bodies, and the nucleic acids encoding them, and methods for making and using these immunoglobulins. The invention provides recombinant and synthetic polypeptide and nucleic acid embodiments of these polypeptides and/or antibodies. The invention also provides polypeptides comprising, or consisting of, consensus human framework regions, or “Independently Consensused Frameworks (ICFs)”, nucleic acids encoding them, and libraries and kits comprising these ICFs and/or antibodies of the invention, individually and in combinatorial libraries and combinations.
摘要翻译：本发明提供抗体，包括嵌合人抗体，重组抗体，合成抗体和编码它们的核酸，以及制备和使用这些免疫球蛋白的方法。本发明提供这些多肽和/或抗体的重组和合成多肽和核酸实施方案。本发明还提供了包含共有人框架区或“独立共有框架（ICF）”的编码它们的核酸或包含本发明的这些ICF和/或抗体的文库和试剂盒的多肽，并且组合的多肽图书馆和组合。

4. 发明授权

US08465741B2 Antibodies and methods for making and using them 有权
标题翻译：用于制造和使用它们的抗体和方法
公开(公告)号：US08465741B2
公开(公告)日：2013-06-18
申请号：US11855943
申请日：2007-09-14
申请人： Gerhard Frey , Bruce E. Kimmel , Abraham Anderson
发明人： Gerhard Frey , Bruce E. Kimmel , Abraham Anderson
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , C07K16/18
CPC分类号： C07K16/2887 , C07K16/2803 , C07K16/2809 , C07K2317/24 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic antibodies, and the nucleic acids encoding them, and methods for making and using these immunoglobulins. The invention provides recombinant and synthetic polypeptide and nucleic acid embodiments of these polypeptides and/or antibodies. The invention also provides polypeptides comprising, or consisting of, consensus human framework regions, or “Independently Consensused Frameworks (ICFs)”, nucleic acids encoding them, and libraries and kits comprising these ICFs and/or antibodies of the invention, individually and in combinatorial libraries and combinations.
摘要翻译：本发明提供抗体，包括嵌合人抗体，重组抗体，合成抗体和编码它们的核酸，以及制备和使用这些免疫球蛋白的方法。本发明提供这些多肽和/或抗体的重组和合成多肽和核酸实施方案。本发明还提供了包含共有人框架区或“独立共有框架（ICF）”的编码它们的核酸或包含本发明的这些ICF和/或抗体的文库和试剂盒的多肽，并且组合的多肽图书馆和组合。

5. 发明申请

US20100104553A1 ANTIBODIES AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：用于制造和使用它们的抗体和方法
公开(公告)号：US20100104553A1
公开(公告)日：2010-04-29
申请号：US11855943
申请日：2007-09-14
申请人： Gerhard FREY , Bruce E. Kimmel , Abraham Anderson
发明人： Gerhard FREY , Bruce E. Kimmel , Abraham Anderson
IPC分类号： A61K39/395 , C07K16/00 , A61P31/00 , A61P37/06 , A61P35/00
CPC分类号： C07K16/2887 , C07K16/2803 , C07K16/2809 , C07K2317/24 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic antibodies, and the nucleic acids encoding them, and methods for making and using these immunoglobulins. The invention provides recombinant and synthetic polypeptide and nucleic acid embodiments of these polypeptides and/or antibodies. The invention also provides polypeptides comprising, or consisting of, consensus human framework regions, or “Independently Consensused Frameworks (ICFs)”, nucleic acids encoding them, and libraries and kits comprising these ICFs and/or antibodies of the invention, individually and in combinatorial libraries and combinations.
摘要翻译：本发明提供抗体，包括嵌合人抗体，重组抗体，合成抗体和编码它们的核酸，以及制备和使用这些免疫球蛋白的方法。本发明提供这些多肽和/或抗体的重组和合成多肽和核酸实施方案。本发明还提供了包含共有人框架区或“独立共有框架（ICF）”的编码它们的核酸或包含本发明的这些ICF和/或抗体的文库和试剂盒的多肽，并且组合的多肽图书馆和组合。

6. 发明申请

US20140234328A1 USE OF C-MET PROTEIN FOR PREDICTING THE EFFICACY OF ANTI-HEPATOCYTE GROWTH FACTOR ("HGF") ANTIBODIES IN ESOPHAGEAL AND GASTRIC CANCER PATIENTS 审中-公开
标题翻译：使用C-MET蛋白质预测抗生殖细胞生长因子（“HGF”）在食管癌和胃癌患者中的作用
公开(公告)号：US20140234328A1
公开(公告)日：2014-08-21
申请号：US14343328
申请日：2012-09-07
申请人： Abraham Anderson , Kelly Oliner , Rui Tang , Elwyn Loh , Sarita Dubey
发明人： Abraham Anderson , Kelly Oliner , Rui Tang , Elwyn Loh , Sarita Dubey
IPC分类号： G01N33/574 , C07K16/22
CPC分类号： C07K16/22 , A61K39/3955 , G01N33/57446 , G01N2333/4753 , G01N2800/52 , A61K2300/00
摘要： The present invention relates to use of the human Met receptor (also known as “c-Met”) for predicting the efficacy of inhibitors of the HGF-Met pathway, and in particular, anti-HGF antibodies, in the treatment of esophageal and gastric cancer patients. The present invention also relates to methods and kits for predicting the usefulness of anti-HGF antibodies in the treatment of esophageal and gastric cancer.
摘要翻译：本发明涉及人Met受体（也称为“c-Met”）用于预测HGF-Met途径抑制剂，特别是抗HGF抗体在治疗食管和胃癌中的功效的用途癌症患者。本发明还涉及用于预测抗HGF抗体在治疗食管癌和胃癌中的用途的方法和试剂盒。

7. 发明授权

US06415453B1 Low temperature thermal insulation garment utilizing the wearer's exhalant 失效
标题翻译：低温隔热服装采用穿戴者的呼气
公开(公告)号：US06415453B1
公开(公告)日：2002-07-09
申请号：US09952109
申请日：2001-09-11
申请人： Abraham Anderson , Anita Sengupta
发明人： Abraham Anderson , Anita Sengupta
IPC分类号： A62B1700
CPC分类号： A62B17/005
摘要： A low-temperature thermal insulation garment is proposed for low-energy requirement, self-sustaining body temperature maintenance. The proposed garment uses the body's expired respiratory gases and natural thermal production capabilities to insulate and maintain a comfortable skin temperature. The garment provides a constant re-supply of heated air with each exhaled breath. The garment has a mouthpiece with a check-valve that shunts exhaled air into a network of channels and bladders that cover the entire body. The garment also consists of a heat reflective lining to reduce radiant heat loss and a neoprene outer layer providing conductive insulation, durability, and waterproofing. Inhaled air is heated prior to entering the mouthpiece due to heat exchange with warmer areas of the garment. This allows residual heat from the exhalant to be transferred to incoming air. The garment can be fitted with artificial air supply, worn as is, or under a pressurized suit.
摘要翻译：提出了一种低温保温服装，用于低能量需求，维持体温维持。所提出的服装使用身体呼出的呼吸气体和自然热生产能力来隔离和保持舒适的皮肤温度。服装提供每次呼气呼吸恒定的加热空气重新供应。衣服具有带止回阀的喉舌，将呼出的空气分流到覆盖整个身体的通道和囊的网络中。该服装还由热反射衬里组成，以减少辐射热损失，并且氯丁橡胶外层提供导电绝缘，耐用性和防水性。吸入空气在进入吹口之前由于与衣物的较暖的区域的热交换而被加热。这样可以将来自呼吸器的剩余热量转移到进入的空气中。服装可以配备人造空气供应，按原样穿戴，或在加压服下。

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