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1. 发明申请

US20120070411A1 SUBSTITUTED NUCLEOTIDE ANALOGS 审中-公开
标题翻译：取代核苷类似物
公开(公告)号：US20120070411A1
公开(公告)日：2012-03-22
申请号：US13236450
申请日：2011-09-19
申请人： Leonid Beigelman , Lawrence Blatt , Guangyi Wang , Vivek Kumar Rajwanshi , Natalia Dyatkina , David Bernard Smith
发明人： Leonid Beigelman , Lawrence Blatt , Guangyi Wang , Vivek Kumar Rajwanshi , Natalia Dyatkina , David Bernard Smith
IPC分类号： A61K38/21 , C07H19/10 , A61K31/7076 , A61K31/708 , A61K31/7068 , A61P31/22 , C12N9/99 , C12N5/071 , A61P31/14 , A61P31/12 , A61P31/20 , C07H19/207 , A61K31/7072
CPC分类号： C07H19/067 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K45/06 , C07H19/167 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are phosphoroamidate nucleotide analogs, methods of synthesizing phosphoroamidate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphoroamidate nucleotide analogs.
摘要翻译：本文公开了磷酰胺酸核苷酸类似物，合成氨基磷酸酯核苷酸类似物的方法和用氨基磷酸酯核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。

2. 发明申请

US20120070415A1 AZIDO NUCLEOSIDES AND NUCLEOTIDE ANALOGS 有权
标题翻译： AZIDO核苷酸和核苷类似物
公开(公告)号：US20120070415A1
公开(公告)日：2012-03-22
申请号：US13236486
申请日：2011-09-19
申请人： Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
发明人： Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
IPC分类号： A61K38/21 , C07H19/073 , A61K31/7072 , C07H19/067 , A61K31/708 , C07H19/167 , C07H19/10 , C07H19/09 , A61K31/7076 , C07H19/20 , C07H19/11 , C07H19/056 , A61K31/7056 , C07H19/19 , C12N5/071 , A61P31/12 , A61P31/14 , A61P31/16 , A61K39/42 , A61K31/7105 , A61K38/47 , A61K31/7068
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K45/06 , C07H19/056 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/167 , C07H19/19 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
摘要翻译：本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。本文还公开了改善和/或治疗疾病和/或病症（包括副粘病毒和/或正粘病毒的感染）与其核苷，核苷酸和类似物的方法。病毒感染的实例包括呼吸道合胞病毒（RSV）和流感感染。

3. 发明授权

US08877731B2 Azido nucleosides and nucleotide analogs 有权
标题翻译：叠氮核苷和核苷酸类似物
公开(公告)号：US08877731B2
公开(公告)日：2014-11-04
申请号：US13236486
申请日：2011-09-19
申请人： Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
发明人： Leonid Beigelman , Jerome Deval , David Bernard Smith , Guangyi Wang , Vivek Kumar Rajwanshi
IPC分类号： A61K31/70 , A01N43/04 , C07H19/00 , C07H19/04 , C07H19/10 , C07H19/048 , C07H19/20 , C07H19/167 , C07H19/173 , A61K31/7068 , C07H19/056 , C07H19/09 , A61K31/7056 , A61K45/06 , A61K31/7072 , A61K31/708 , A61K31/7105 , C07H19/11 , C07H19/067 , C07H19/19 , A61K31/7076 , C07H19/073
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K45/06 , C07H19/056 , C07H19/067 , C07H19/073 , C07H19/09 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/167 , C07H19/19 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
摘要翻译：本文公开了核苷，核苷酸及其类似物，包括核苷，核苷酸及其类似物中的一种或多种的药物组合物及其合成方法。本文还公开了改善和/或治疗疾病和/或病症（包括副粘病毒和/或正粘病毒的感染）与其核苷，核苷酸和类似物的方法。病毒感染的实例包括呼吸道合胞病毒（RSV）和流感感染。

4. 发明授权

US08871737B2 Substituted nucleotide analogs 有权
标题翻译：取代的核苷酸类似物
公开(公告)号：US08871737B2
公开(公告)日：2014-10-28
申请号：US13236435
申请日：2011-09-19
申请人： David Bernard Smith , Jerome Deval , Natalia Dyatkina , Leonid Beigelman , Guangyi Wang
发明人： David Bernard Smith , Jerome Deval , Natalia Dyatkina , Leonid Beigelman , Guangyi Wang
IPC分类号： A61K31/70 , C07H19/04 , C07H19/10 , C07H19/20 , C07H19/06 , A61K31/7072 , C07H19/16 , A61K45/06 , A61K31/7076
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/06 , C07H19/16 , C07H19/20 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate prodrugs and thiophosphates (including α-thiomonophosphates, α-thiodiphosphates, and α-thiotriphosphates), methods of synthesizing phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates and methods of treating viral infections, such as HCV, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs, such as thiophosphoramidate prodrugs, and thiophosphates.
摘要翻译：本文公开了硫代磷酸酯核苷酸类似物，例如硫代磷酰胺酸酯前药和硫代磷酸酯（包括α-硫代磷酸酯，α-硫代二磷酸酯和α-硫代三磷酸酯），合成硫代磷酸酯核苷酸类似物如硫代磷酰胺酸酯前药和硫代磷酸酯的方法和治疗病毒感染的方法，例如具有硫代磷酸酯核苷酸类似物的HCV，癌症和/或寄生虫病，例如硫代磷酰胺酸酯前药和硫代磷酸酯。

5. 发明申请

US20120071434A1 SUBSTITUTED NUCLEOTIDE ANALOGS 有权
标题翻译：取代核苷类似物
公开(公告)号：US20120071434A1
公开(公告)日：2012-03-22
申请号：US13236435
申请日：2011-09-19
申请人： David Bernard Smith , Jerome Deval , Natalia Dyatkina , Leonid Beigelman , Guangyi Wang
发明人： David Bernard Smith , Jerome Deval , Natalia Dyatkina , Leonid Beigelman , Guangyi Wang
IPC分类号： A61K31/7072 , C07H19/20 , A61K31/7076 , A61P31/12 , C12N5/071 , A61P31/22 , A61P31/18 , A61P31/16 , A61P31/20 , C07H19/10 , A61P31/14
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/06 , C07H19/16 , C07H19/20 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs.
摘要翻译：本文公开了硫代磷酸酯核苷酸类似物，合成硫代磷酸酯核苷酸类似物的方法和用硫代磷酸酯核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。

6. 发明授权

US08772474B2 Cyclic nucleotide analogs 有权
标题翻译：环状核苷酸类似物
公开(公告)号：US08772474B2
公开(公告)日：2014-07-08
申请号：US13332068
申请日：2011-12-20
申请人： Leonid Beigelman , David Bernard Smith , Jerome Deval , Vivek Kumar Rajwanshi
发明人： Leonid Beigelman , David Bernard Smith , Jerome Deval , Vivek Kumar Rajwanshi
IPC分类号： C07H19/00 , C07H19/20 , C07H19/04 , A01N43/04 , A61K31/70
CPC分类号： C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
摘要翻译：本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。

7. 发明申请

US20120165286A1 CYCLIC NUCLEOTIDE ANALOGS 有权
标题翻译：循环核素类似物
公开(公告)号：US20120165286A1
公开(公告)日：2012-06-28
申请号：US13332068
申请日：2011-12-20
申请人： Leonid Beigelman , David Bernard Smith , Jerome Deval , Vivek Kumar Rajwanshi
发明人： Leonid Beigelman , David Bernard Smith , Jerome Deval , Vivek Kumar Rajwanshi
IPC分类号： A61K31/7076 , C12N5/02 , A61K31/7072 , A61K31/7064 , A61P31/12 , A61K31/7068 , C07H19/11 , C07H19/213 , A61P31/22 , C12N9/99 , A61K31/708
CPC分类号： C07H19/20 , A61K31/14 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07F9/65744 , C07H17/02 , C07H19/10 , C07H19/11 , C07H19/213 , Y02A50/414 , Y02A50/465 , A61K2300/00
摘要： Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with cyclic nucleotide analogs.
摘要翻译：本文公开了环状核苷酸类似物，合成环状核苷酸类似物的方法和用环状核苷酸类似物治疗疾病和/或病症如病毒感染，癌症和/或寄生虫病的方法。

8. 发明申请

US20110150829A1 ANTIVIRAL NUCLEOSIDES 有权
标题翻译：抗性核苷酸
公开(公告)号：US20110150829A1
公开(公告)日：2011-06-23
申请号：US13014022
申请日：2011-01-26
申请人： Han Ma , Keshab Sarma , David Bernard Smith
发明人： Han Ma , Keshab Sarma , David Bernard Smith
IPC分类号： A61K38/20 , C07H19/06 , A61K31/7072 , A61P31/14 , A61K38/21 , A61K38/16
CPC分类号： C07H19/067
摘要： Compounds having the formula I wherein R1, R2 and R3 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译：具有式I的化合物，其中R 1，R 2和R 3如本文所定义，是丙型肝炎病毒NS5b聚合酶抑制剂。还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。

9. 发明授权

US07640797B2 Method and system for increasing safety in chemical application from an aircraft 失效
标题翻译：从飞机上增加化学品应用安全的方法和系统
公开(公告)号：US07640797B2
公开(公告)日：2010-01-05
申请号：US11373820
申请日：2006-03-10
申请人： David Bernard Smith , James Bert Nail
发明人： David Bernard Smith , James Bert Nail
IPC分类号： A63B53/00 , G01W1/00
CPC分类号： G01P13/02 , B64D1/18 , G01P13/025
摘要： This invention relates to a method and system for increasing safety in chemical application from an aircraft. Wind speed, wind direction and other critical flight parameters are measured, calculated, recorded, and visually or audibly announced during the aircraft flight via onboard equipment, which parameters provide a means for the aircraft pilot to control chemical spray application and for unassisted automatic chemical spray cutoff and for limiting spray application outside an application zone or target area. Such parameters also provide a means for indicating the lift reserve of the aircraft and a means for determining atmospheric stability near the ground and providing the pilot with a record of the meteorological conditions at a particular location. The method and system of the present invention also provide a means for predicting appropriate aircraft upwind offset distance to compensate for predicted chemical spray drift.
摘要翻译：本发明涉及一种提高飞机化学应用安全性的方法和系统。风速，风向和其他关键飞行参数通过机载设备在飞机飞行过程中进行测量，计算，记录和视觉或听觉通知，这些参数为飞行员驾驶员控制化学喷雾应用和无辅助自动化学喷雾并且用于限制在施用区域或目标区域之外的喷涂应用。这些参数还提供了一种用于指示飞机的升力储备的手段，以及用于确定地面附近大气稳定性的手段，并向飞行员提供特定位置的气象条件的记录。本发明的方法和系统还提供了一种用于预测适当的飞机逆风偏移距离以补偿预测的化学喷雾漂移的装置。

10. 发明授权

US06984637B2 Cyclic amine derivatives-CCR-3 receptor antagonists 失效
公开(公告)号：US06984637B2
公开(公告)日：2006-01-10
申请号：US10719204
申请日：2003-11-21
申请人： Leyi Gong , Denis John Kertesz , David Bernard Smith , Francisco Xavier Talamas , Robert Stephen Wilhelm
发明人： Leyi Gong , Denis John Kertesz , David Bernard Smith , Francisco Xavier Talamas , Robert Stephen Wilhelm
IPC分类号： A61K31/449 , C07D211/32
CPC分类号： C07D207/325 , C07D207/09 , C07D209/42 , C07D211/18 , C07D211/26 , C07D213/81 , C07D213/82 , C07D215/48 , C07D295/13 , C07D295/135 , C07D307/71 , C07D307/84 , C07D317/68 , C07D333/24 , C07D333/38 , C07D333/68 , C07D401/12 , C07D409/12 , Y02P20/582
摘要： This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

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