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    • 3. 发明授权
    • Wavefront characterization of corneas
    • 角膜的波前表征
    • US06578964B2
    • 2003-06-17
    • US10176600
    • 2002-06-24
    • Leonard John Otten, IIIGavin R. G. ErrySimon C. WoodsPaul Harrison
    • Leonard John Otten, IIIGavin R. G. ErrySimon C. WoodsPaul Harrison
    • A61B310
    • A61B3/1015A61B3/107A61F2/142G01J9/00
    • Apparatus for determining if a cornea (whether in vitro or in vivo) has been modified (either surgically or otherwise). The method includes the steps of: passing a beam of collimated light a (either coherent or incoherent) through the cornea to produce a distorted wavefront; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The analysis of the distorted wavefront can be for the presence of higher order aberrations, or Gausian characteristics which are indicative of modifications. More particularly, the method includes the steps of providing an optical system that has a pupil plane and an image plane at a detector; positioning the cornea in the pupil plane; passing a collimated beam of light through the cornea to produce at least two images in the image plane; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The apparatus includes: a source of collimated light: an optical system including a distorted grating and an imaging lens (which have a pupil plane, first and second virtual planes, and an image plane); structure for positioning the cornea in the pupil plane; and a computer. The structure for positioning the cornea (which is immersed in a suitable storage fluid) includes first and second plano/plano lenses. The first and second plano lens, which are substantially and perpendicular to and centered with respect to the axis, have less than total distortions.
    • 用于确定角膜(无论是体外或体内)是否已被修改(手术或其他方式)的装置。 该方法包括以下步骤:将准直光束(相干或非相干)通过角膜以产生畸变的波前; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 畸变波阵面的分析可以是高阶像差的存在,或表示修改的高斯特性。 更具体地说,该方法包括以下步骤:提供在检测器处具有瞳孔平面和图像平面的光学系统; 将角膜定位在瞳孔平面中; 使准直的光束通过角膜,在图像平面中产生至少两个图像; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 该装置包括:准直光源:包括失真光栅和成像透镜(其具有瞳孔平面,第一和第二虚拟平面以及像平面)的光学系统; 用于将角膜定位在瞳孔平面中的结构; 和电脑。 用于定位角膜(其浸入合适的储存液体中)的结构包括第一和第二平面/平视镜片。 基本上和垂直于和相对于轴居中的第一和第二平面透镜具有小于总失真。
    • 5. 发明授权
    • Wavefront characterization of corneas
    • 角膜的波前表征
    • US07104649B2
    • 2006-09-12
    • US10115355
    • 2002-04-02
    • Leonard John Otten, IIIGavin R. G. ErrySimon C. WoodsPaul Harrison
    • Leonard John Otten, IIIGavin R. G. ErrySimon C. WoodsPaul Harrison
    • A61B3/10
    • A61B3/1015A61B3/107A61F2/142G01J9/00
    • Apparatus for determining if a cornea (whether in vitro or in vivo) has been modified (either surgically or otherwise). The method includes the steps of: passing a beam of collimated light a (either coherent or incoherent) through the cornea to produce a distorted wavefront; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The analysis of the distorted wavefront can be for the presence of higher order aberrations, or Gausian characteristics which are indicative of modifications. More particularly, the method includes the steps of providing an optical system that has a pupil plane and an image plane at a detector; positioning the cornea in the pupil plane; passing a collimated beam of light through the cornea to produce at least two images in the image plane; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The apparatus includes: a source of collimated light: an optical system including a distorted grating and an imaging lens (which have a pupil plane, first and second virtual planes, and an image plane); structure for positioning the cornea in the pupil plane; and a computer. The structure for positioning the cornea (which is immersed in a suitable storage fluid) includes first and second plano/plano lenses. The first and second plano lens, which are substantially and perpendicular to and centered with respect to the axis, have less than λ/10 total distortions.
    • 用于确定角膜(无论是体外或体内)是否已被修改(手术或其他方式)的装置。 该方法包括以下步骤:将准直光束(相干或非相干)通过角膜以产生畸变的波前; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 畸变波阵面的分析可以是高阶像差的存在,或表示修改的高斯特性。 更具体地说,该方法包括以下步骤:提供在检测器处具有瞳孔平面和图像平面的光学系统; 将角膜定位在瞳孔平面中; 使准直的光束通过角膜,在图像平面中产生至少两个图像; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 该装置包括:准直光源:包括失真光栅和成像透镜(其具有瞳孔平面,第一和第二虚拟平面以及像平面)的光学系统; 用于将角膜定位在瞳孔平面中的结构; 和电脑。 用于定位角膜(其浸入合适的储存液体中)的结构包括第一和第二平面/平视镜片。 基本上和垂直于和相对于轴居中的第一和第二平面透镜具有小于λ/ 10的总失真。
    • 6. 发明授权
    • Wavefront characterization of corneas
    • 角膜的波前表征
    • US06464357B1
    • 2002-10-15
    • US09895309
    • 2001-06-29
    • Leonard John Otten, IIIGavin R. G. ErrySimon C. WoodsPaul Harrison
    • Leonard John Otten, IIIGavin R. G. ErrySimon C. WoodsPaul Harrison
    • A61B310
    • A61B3/1015A61B3/107A61F2/142G01J9/00
    • Apparatus for determining if a cornea (whether in vitro or in vivo) has been modified (either surgically or otherwise). The method includes the steps of: passing a beam of collimated light a (either coherent or incoherent) through the cornea to produce a distorted wavefront; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The analysis of the distorted wavefront can be for the presence of higher order aberrations, or Gausian characteristics which are indicative of modifications. More particularly, the method includes the steps of providing an optical system that has a pupil plane and an image plane at a detector; positioning the cornea in the pupil plane; passing a collimated beam of light through the cornea to produce at least two images in the image plane; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The apparatus includes: a source of collimated light: an optical system including a distorted grating and an imaging lens (which have a pupil plane, first and second virtual planes, and an image plane); structure for positioning the cornea in the pupil plane; and a computer. The structure for positioning the cornea (which is immersed in a suitable storage fluid) includes first and second plano/plano lenses. The first and second plano lens, which are substantially and perpendicular to and centered with respect to the axis, have less than &lgr;/10 total distortions.
    • 用于确定角膜(无论是体外或体内)是否已被修改(手术或其他方式)的装置。 该方法包括以下步骤:将准直光束(相干或非相干)通过角膜以产生畸变的波前; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 畸变波阵面的分析可以是高阶像差的存在,或表示修改的高斯特性。 更具体地说,该方法包括以下步骤:提供在检测器处具有瞳孔平面和图像平面的光学系统; 将角膜定位在瞳孔平面中; 使准直的光束通过角膜,在图像平面中产生至少两个图像; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 该装置包括:准直光源:包括失真光栅和成像透镜(其具有瞳孔平面,第一和第二虚拟平面以及像平面)的光学系统; 用于将角膜定位在瞳孔平面中的结构; 和电脑。 用于定位角膜(其浸入合适的储存液体中)的结构包括第一和第二平面/平视镜片。 第一和第二平面透镜基本上和垂直于并且相对于轴居中,具有小于lambd / 10的总失真。
    • 8. 发明授权
    • Beam splitters for, for instance, high efficiency spectral imagers
    • 光束分离器,例如高效光谱成像仪
    • US07535647B1
    • 2009-05-19
    • US11803398
    • 2007-05-11
    • Leonard John Otten, IIIGavin R. G. Erry
    • Leonard John Otten, IIIGavin R. G. Erry
    • G02B27/14
    • G02B27/1006G02B27/1086G02B27/144G02B27/145
    • Optical instruments having, inter alia, optics to process wavelengths of electromagnetic radiation to produce an interferogram. The instruments include an optical path and optical elements positioned along this path for splitting and recombining the wavelengths which interfere with each other to produce a plurality of different fringes of different wavelengths. The optics include matched gratings which are positioned along the optical path outside of the interferometer optics to produce first and second sets of spectrally dispersed beams. The interferometer optics includes a beam splitter and first and second mirrors. In two embodiments the beam splitter has an internal surface including three zones. The instruments can all include a detector for detecting the interferogram and means for processing the detected interferogram to produce spectral information that is spatially distributed.
    • 光学仪器尤其具有用于处理电磁辐射波长以产生干涉图的光学装置。 仪器包括沿着该路径定位的光路和光学元件,用于分离和重组彼此干涉的波长,以产生多个不同波长的不同条纹。 光学器件包括沿着干涉仪光学器件外部的光路定位的匹配光栅,以产生第一和第二组光谱分散的光束。 干涉仪光学器件包括分束器和第一和第二反射镜。 在两个实施例中,分束器具有包括三个区域的内表面。 仪器都可以包括用于检测干涉图的检测器和用于处理检测到的干涉图以产生空间分布的光谱信息的装置。
    • 9. 发明授权
    • High resolution, multispectral, wide field of view retinal imager
    • 高分辨率,多光谱,宽视场视网膜成像仪
    • US06331059B1
    • 2001-12-18
    • US09767256
    • 2001-01-22
    • Alexis KudryashovAndrey Viktorovich LarichevLeonard John Otten, III
    • Alexis KudryashovAndrey Viktorovich LarichevLeonard John Otten, III
    • A61B310
    • A61B3/103
    • An ophthalmic instrument (for obtaining high resolution, wide field of area multi-spectral retinal images) including a fundus retinal imager, (which includes optics for illuminating and imaging the retina of the eye); apparatus for generating a reference beam coupled to the fundus optics to form a reference area on the retina; a wavefront sensor optically coupled to the fundus optics for measuring the wavefront produced by optical aberrations within the eye and the imager optics; wavefront compensation optics coupled to the fundus optics for correcting large, low order aberrations in the wavefront; a high resolution detector optically coupled to the imager optics and the wavefront compensation optics; and a computer (which is connected to the wavefront sensor, the wavefront compensation optics, and the high resolution camera) including an algorithm for correcting, small, high order aberrations on the wavefront and residual low order aberrations.
    • 包括眼底视网膜成像仪(其包括用于照射和成像眼睛的视网膜的光学器件)的眼科仪器(用于获得高分辨率,宽范围的多光谱视网膜图像); 用于产生耦合到眼底光学器件以在视网膜上形成参考区域的参考光束的装置; 光学耦合到眼底光学器件的波前传感器,用于测量由眼睛和成像器光学器件内的光学像差产生的波前; 波前补偿光学耦合到眼底光学,用于校正波前的大,低阶像差; 光学耦合到成像器光学器件和波前补偿光学器件的高分辨率检测器; 以及计算机(其连接到波前传感器,波前补偿光学器件和高分辨率相机),其包括用于校正波前的残留低阶像差的小,高阶像差的算法。
    • 10. 发明授权
    • High efficiency spectral imager
    • 高效光谱成像仪
    • US07167249B1
    • 2007-01-23
    • US10723901
    • 2003-11-25
    • Leonard John Otten, III
    • Leonard John Otten, III
    • G01B9/02G01J3/45
    • G01J3/1804G01J3/4532
    • Optical instruments having, inter alia, optics to process wavelengths of electromagnetic radiation to produce an interferogram. The instruments include at least one optical path and optical elements positioned along this path for splitting and recombining the wavelengths which interfere with each other to produce a plurality of different fringes of different wavelengths. In one group, the optics include matched gratings which are positioned along the optical path outside of the interferometer optics to produce first and second sets of spectrally dispersed beams. The interferometer optics also includes a beam splitter and first and second mirrors. The gratings may be positioned in a variety of locations along the optical path. In another group, the optics include a beam splitter having a plurality of surfaces, wherein each of the surfaces is either 100% reflective, 100% transmissive or 50% reflective and 50% transmissive. In a third group, the optics includes the beam splitter having a plurality of reflective and transmissive surfaces and matched gratings. The instruments can all include a detector for detecting the interferogram and means for processing the detected interferogram to produce spectral information.
    • 光学仪器尤其具有用于处理电磁辐射波长以产生干涉图的光学装置。 仪器包括沿着该路径定位的至少一个光路和光学元件,用于分离和重组彼此干涉的波长以产生多个不同波长的不同条纹。 在一组中,光学器件包括沿着干涉仪光学器件外部的光路定位的匹配光栅,以产生第一和第二组光谱分散的光束。 干涉仪光学器件还包括分束器和第一和第二反射镜。 光栅可以沿着光路定位在各种位置。 在另一组中,光学器件包括具有多个表面的分束器,其中每个表面是100%反射,100%透射或50%反射和50%透射。 在第三组中,光学器件包括具有多个反射和透射表面以及匹配光栅的分束器。 仪器都可以包括用于检测干涉图的检测器和用于处理检测到的干涉图以产生光谱信息的装置。