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1. 发明授权

US5157330A Method and apparatus for compensating magnetic field inhomogeneity artifact in MRI 失效
标题翻译：用于补偿MRI中磁场不均匀性伪影的方法和装置
公开(公告)号：US5157330A
公开(公告)日：1992-10-20
申请号：US659181
申请日：1991-02-22
申请人： Leon Kaufman , Joseph W. Carlson , David M. Kramer , James D. Hale , Kingman Yee
发明人： Leon Kaufman , Joseph W. Carlson , David M. Kramer , James D. Hale , Kingman Yee
IPC分类号： G01R33/565
CPC分类号： G01R33/56563
摘要： A measure of magnetic field inhomogeneity along a phase-encoded (e.g. y-axis) dimension is derived in k-space from previously acquired MRI phase-encoded projection data. From this, a measure of MRI data skewing caused by such inhomogeneity is obtained and used to compensate therefor. Since the MRI data is to be multi-dimensionally Fourier Transformed in most instances anyway, a transform in the relevant phase encoded dimension (e.g., y-axis) is taken followed with phase shifting each digitized data point by an amount proportional to the measured magnitude of inhomogeneity and to the datum coordinate in the read-out dimension (e.g., x-axis) and to the datum coordinate in each phase-encode dimension (e.g., y-axis) before the data is further Fourier Transformed with respect to the read-out dimension (e.g., x-axis). If two-dimensional phase encoding is employed (e.g., as in 3DFT), then a second level of similar inhomogeneity compensation can be had in the third dimension (e.g., z-axis) as well.
摘要翻译：在先前获得的MRI相位编码投影数据中，在k空间中导出沿着相位编码（例如y轴）尺寸的磁场不均匀性的度量。由此可以获得由这种不均匀性引起的MRI数据偏移的量度，并用于补偿。由于MRI数据在大多数情况下要进行多维傅立叶变换，所以在相关的相位编码维度（例如，y轴）中进行变换，然后将每个数字化数据点的相移量与测量的幅度成正比在数据进一步相对于读取的傅里叶变换之前，在读出维度（例如，x轴）和每个相位编码维度（例如，y轴）中的基准坐标之间的基准坐标 - 尺寸（例如，x轴）。如果采用二维相位编码（例如，如3DFT中那样），则在第三维度（例如，z轴）中可以具有类似的不均匀性补偿的第二级别。

2. 发明授权

US09358154B2 Presbyopia correction through negative spherical aberration 有权
标题翻译：老花眼矫正通过负球面像差
公开(公告)号：US09358154B2
公开(公告)日：2016-06-07
申请号：US12436743
申请日：2009-05-06
申请人： Seema Somani , Kingman Yee
发明人： Seema Somani , Kingman Yee
IPC分类号： A61F9/01 , A61F9/007 , A61F9/00 , G02C7/04 , A61F9/008
CPC分类号： A61B3/103 , A61B3/1015 , A61F2/164 , A61F9/00 , A61F9/008 , A61F9/00806 , A61F9/00808 , A61F2009/00844 , A61F2009/00872 , A61F2009/0088 , G02C7/041 , G02C7/042 , G02C2202/22
摘要： Devices, systems, and methods for treating and/or determining appropriate prescriptions for one or both eyes of a patient are particularly well-suited for addressing presbyopia, often in combination with concurrent treatments of other vision defects. High-order spherical aberration may be imposed in one or both of a patient's eyes, often as a controlled amount of negative spherical aberration extending across a pupil. A desired presbyopia-mitigating quantity of high-order spherical aberration may be defined by one or more spherical Zernike coefficients, which may be combined with Zernike coefficients generated from a wavefront aberrometer. The resulting prescription can be imposed using refractive surgical techniques such as laser eye surgery, using intraocular lenses and other implanted structures, using contact lenses, using temporary or permanent corneal reshaping techniques, and/or the like.
摘要翻译：用于治疗和/或确定患者的一只眼睛或两只眼睛的适当处方的装置，系统和方法特别适合于解决老花眼，通常与其他视力缺陷的并发治疗相结合。高次球面像差可以施加在患者眼睛的一个或两个中，通常作为延伸穿过瞳孔的受控量的负球面像差。可以通过一个或多个球形Zernike系数来定义所需的老花眼减轻量的高阶球面像差，该Zernike系数可以与从波前像差计产生的Zernike系数组合。所得到的处方可以使用屈光手术技术如激光眼科手术，使用眼内透镜和其它植入结构，使用隐形眼镜，使用临时或永久角膜重塑技术等来实施。

3. 发明授权

US08348425B2 Compound modulation transfer function for laser surgery and other optical applications 有权
公开(公告)号：US08348425B2
公开(公告)日：2013-01-08
申请号：US13523064
申请日：2012-06-14
申请人： Guang-Ming Dai , Kingman Yee
发明人： Guang-Ming Dai , Kingman Yee
IPC分类号： A61B3/10 , A61B3/00
CPC分类号： A61B3/103 , A61B3/0025 , A61B3/1015 , A61F9/00 , A61F9/00802 , A61F9/00808 , A61F9/00812 , A61F2009/00844 , A61F2009/00853 , A61F2009/00872 , A61F2009/00882 , A61F2009/00895 , G02C7/02 , G02C7/028 , G02C7/042
摘要： Methods, devices, and systems establish an optical surface shape that mitigates or treats a vision condition in a patient. An optical surface shape for a particular patient can be determined using a set of patient parameters for the specific patient by using a compound modulation transfer function (CMTF). The compound modulation transfer function can include a combination of modulation transfer functions (MTF's) at a plurality of distinct frequencies.

4. 发明授权

US08182471B2 Intrastromal refractive correction systems and methods 有权
$Intrastromal refractive correction systems and methods$
标题翻译：内镜屈光矫正系统及方法
公开(公告)号：US08182471B2
公开(公告)日：2012-05-22
申请号：US11677504
申请日：2007-02-21
申请人： Kingman Yee
发明人： Kingman Yee
IPC分类号： A61B18/18
CPC分类号： A61F9/00829 , A61F9/00836 , A61F9/00838 , A61F2009/00846 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00895
摘要： Devices, systems, and methods for laser eye surgery selectively ablate tissues within the cornea of an eye along one or more target surfaces, so that corneal tissue bordered by the laser incision surface(s) can be mechanically removed. An appropriate tissue-shaping surface can be selected based on the regular refractive error of the eye, and a shape of the target laser surface(s) can be calculated so as to correct irregular refractive errors of the eye, impose desired additional sphero-cylindrical and/or irregular alterations.
摘要翻译：用于激光眼科手术的装置，系统和方法选择性地消除沿着一个或多个靶表面的眼睛角膜内的组织，从而可以机械地去除由激光切割表面界定的角膜组织。可以基于眼睛的规则折射误差来选择适当的组织成形表面，并且可以计算目标激光表面的形状，以校正眼睛的不规则折射误差，施加期望的附加球晶柱和/或不规则的改变。

5. 发明申请

US20120026460A1 COMPOUND MODULATION TRANSFER FUNCTION FOR LASER SURGERY AND OTHER OPTICAL APPLICATIONS 有权
公开(公告)号：US20120026460A1
公开(公告)日：2012-02-02
申请号：US13246091
申请日：2011-09-27
申请人： George M. Dai , Kingman Yee
发明人： George M. Dai , Kingman Yee
IPC分类号： A61B3/107 , A61B3/00
CPC分类号： A61B3/103 , A61B3/0025 , A61B3/1015 , A61F9/00 , A61F9/00802 , A61F9/00808 , A61F9/00812 , A61F2009/00844 , A61F2009/00853 , A61F2009/00872 , A61F2009/00882 , A61F2009/00895 , G02C7/02 , G02C7/028 , G02C7/042
摘要： Methods, devices, and systems establish an optical surface shape that mitigates or treats a vision condition in a patient. An optical surface shape for a particular patient can be determined using a set of patient parameters for the specific patient by using a compound modulation transfer function (CMTF). The compound modulation transfer function can include a combination of modulation transfer functions (MTF's) at a plurality of distinct frequencies.

6. 发明授权

US08016420B2 System and method for illumination and fixation with ophthalmic diagnostic instruments 有权
标题翻译：用眼科诊断仪器照明和固定的系统和方法
公开(公告)号：US08016420B2
公开(公告)日：2011-09-13
申请号：US11750291
申请日：2007-05-17
申请人： Kingman Yee , Seema Somani
发明人： Kingman Yee , Seema Somani
IPC分类号： A61B3/10
CPC分类号： A61B3/0091 , A61B3/103
摘要： An eye measurement system may include a target that moves transverse to an optical path from the target to eye, so as to relax accommodation of the lens of the eye. The target may move transverse to the optical path on a display. The patient may be fogged while the target moves transverse to the optical path, and the target may become smaller such that the patient perceives the target to be moving away from the patient. A pupil camera may measure eye position that can be correlated with the position of the target on the display to determine that the patient has maintained fixation on the moving target. A visible measurement light beam may be pulsed subsequent to and/or during motion of the target that relaxes accommodation of the eye so as to avoid visual interference of the measurement light beam with the target on the display.
摘要翻译：眼睛测量系统可以包括横向于从目标到眼睛的光路移动的目标，以便放松眼睛的镜片的适应。目标可以横向于显示器上的光路移动。当目标物横向于光路移动时，患者可能会起雾，并且目标可能变小，使得患者感知到目标物远离患者。瞳孔照相机可以测量可以与显示器上的目标位置相关联的眼睛位置，以确定患者已经维持在移动目标上的固定。可以在目标的运动之前和/或运动期间脉冲可见的测量光束，其放松眼睛的容纳，以避免测量光束与目标在显示器上的视觉干扰。

7. 发明授权

US07762668B2 Residual accommodation threshold for correction of presbyopia and other presbyopia correction using patient data 有权
标题翻译：使用患者数据修正老花眼和其他老花眼矫正的残留住院阈值
公开(公告)号：US07762668B2
公开(公告)日：2010-07-27
申请号：US12145862
申请日：2008-06-25
申请人： Guangming Dai , Kingman Yee
发明人： Guangming Dai , Kingman Yee
IPC分类号： A61B3/00 , A61B3/10
CPC分类号： A61B3/0025 , A61F2009/00872
摘要： Methods, devices, and systems establish an optical surface shape that mitigates or treats presbyopia in a particular patient. The combination of distance vision and near vision in a patient can be improved, often based on input patient parameters such as pupil size, residual accommodation, and power need. Iterative optimization may generate a customized corrective optical shape for the patient. Threshold residual accommodation is established for presbyopia treatment.
摘要翻译：方法，装置和系统建立光学表面形状，以减轻或治疗特定患者中的老花眼。通常可以根据输入的患者参数（如瞳孔大小，残留调节量和功率需求）来改善患者的距离视力和近视力的组合。迭代优化可以为患者生成定制的校正光学形状。为老花眼治疗建立阈值残留调节。

8. 发明授权

US07652761B2 Methods and systems for laser calibration and eye tracker camera alignment 有权
标题翻译：用于激光校准和眼动仪相机对准的方法和系统
公开(公告)号：US07652761B2
公开(公告)日：2010-01-26
申请号：US12200386
申请日：2008-08-28
申请人： Seema Somani , Kingman Yee , John S. Shimmick
发明人： Seema Somani , Kingman Yee , John S. Shimmick
IPC分类号： G01J1/10
CPC分类号： A61F9/00814 , A61B2017/00725 , A61F9/008 , A61F9/00802 , A61F2009/00846 , A61F2009/00855 , A61F2009/00872 , A61F2009/00897 , B23K26/705 , G01J1/4257 , G01J2001/4261 , G01N21/6456
摘要： The present invention provides methods, systems, and apparatus for calibrating a laser ablation system, such as an excimer laser system for selectively ablating a cornea of a patient's eye. The invention also facilitates alignment of eye tracking cameras that measure a position of the eye during laser eye surgery. A calibration and alignment fixture for a scanning laser beam delivery system having eye tracking cameras may include a structure positionable in a treatment plane. The structure having a feature directing laser energy incident thereon to a calibration energy sensor, at least one reference-edge to determine a characteristic of the laser beam (shape, dimensions, etc.), and an artificial pupil to determine alignment of the eye tracking cameras with the laser system.
摘要翻译：本发明提供了用于校准激光消融系统的方法，系统和装置，例如用于选择性地烧蚀患者眼睛的角膜的准分子激光系统。本发明还有助于在激光眼睛手术期间测量眼睛位置的眼睛跟踪相机的对准。用于具有眼睛跟踪摄像机的扫描激光束传送系统的校准和对准夹具可以包括可在治疗平面中定位的结构。具有将激光能量入射到校准能量传感器的特征的结构，至少一个参考边缘以确定激光束的特性（形状，尺寸等）以及用于确定眼睛跟踪的对准的人造瞳孔相机与激光系统。

9. 发明授权

US07648238B2 Presbyopia correction using patient data 有权
标题翻译：老花眼矫正使用患者资料
公开(公告)号：US07648238B2
公开(公告)日：2010-01-19
申请号：US12207432
申请日：2008-09-09
申请人： Guangming Dai , Kingman Yee
发明人： Guangming Dai , Kingman Yee
IPC分类号： A61B3/10
CPC分类号： A61F9/00808 , A61B3/0025 , A61F9/00 , A61F9/00812 , A61F2009/00844 , A61F2009/00853 , A61F2009/00872 , A61F2009/00882 , A61F2009/00895
摘要： Methods, devices, and systems establish an optical surface shape that mitigates or treats presbyopia in a particular patient. The combination of distance vision and near vision in a patient can be improved, often based on input patient parameters such as pupil size, residual accommodation, and power need. Iterative optimization may generate a customized corrective optical shape for the patient.
摘要翻译：方法，装置和系统建立光学表面形状，以减轻或治疗特定患者中的老花眼。通常可以根据输入的患者参数（如瞳孔大小，残留调节量和功率需求）来改善患者的距离视力和近视力的组合。迭代优化可以为患者生成定制的校正光学形状。

10. 发明申请

US20090234336A1 PRESBYOPIA CORRECTION USING PATIENT DATA 审中-公开
标题翻译：使用患者数据的PRESBYOPIA校正
公开(公告)号：US20090234336A1
公开(公告)日：2009-09-17
申请号：US12474144
申请日：2009-05-28
申请人： Dimitri Chernyak , Guangming Dai , Kingman Yee
发明人： Dimitri Chernyak , Guangming Dai , Kingman Yee
IPC分类号： A61F9/008 , A61B18/20
CPC分类号： A61F9/008 , A61F9/00808 , A61F2009/00844 , A61F2009/00872 , A61F2009/00895
摘要： Methods and systems for treating presbyopia involve ablating a corneal surface of a first eye of a patient to enhance vision of near objects through a central zone of the first eye and ablating a second eye of the patient to enhance vision of near objects through a peripheral zone of the second eye. In the first eye, a peripheral zone is used primarily for distance vision. In the second eye, a central zone is used primarily for distance vision. Methods, devices, and systems establish an optical surface shape that mitigates or treats presbyopia in a particular patient. The combination of distance vision and near vision in a patient can be improved, often based on input patient parameters such as pupil size, residual accommodation, and power need. Iterative optimization may generate a customized corrective optical shape for the patient.
摘要翻译：用于治疗老花眼的方法和系统涉及消融患者的第一只眼睛的角膜表面，以增强邻近物体通过第一只眼睛的中心区域的视力，并消融患者的第二只眼睛，以通过周边区域增强邻近物体的视力的第二只眼睛。在第一只眼睛中，外围区域主要用于远视。在第二只眼睛中，中心区主要用于远视。方法，装置和系统建立光学表面形状，以减轻或治疗特定患者中的老花眼。通常可以根据输入的患者参数（如瞳孔大小，残留调节量和功率需求）来改善患者的距离视力和近视力的组合。迭代优化可以为患者生成定制的校正光学形状。

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