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1. 发明申请

US20130245591A1 INJECTABLE IBUPROFEN FORMULATION 有权
公开(公告)号：US20130245591A1
公开(公告)日：2013-09-19
申请号：US13422738
申请日：2012-03-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/19 , A61P9/00 , A61J1/10 , A61P29/00
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/192 , A61K47/02
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.

2. 发明申请

US20130245120A1 INJECTABLE IBUPROFEN FORMULATION 有权
公开(公告)号：US20130245120A1
公开(公告)日：2013-09-19
申请号：US13422761
申请日：2012-03-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/19 , A61P29/00 , A61J1/10 , A61J1/00 , B65D30/02 , A61K31/195 , A61P9/00
CPC分类号： A61K47/02 , A61J1/065 , A61J1/10 , A61K31/192
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.

3. 发明授权

US08372877B2 Stabilized statin formulations 有权
公开(公告)号：US08372877B2
公开(公告)日：2013-02-12
申请号：US12762025
申请日：2010-04-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/724 , A61K31/40 , C07D207/34
CPC分类号： A61K31/40 , A61K9/0019 , A61K9/19 , A61K47/40 , A61K47/6951
摘要： The present invention is directed to statin formulations having improved solubility and/or stability and methods for the same.

4. 发明申请

US20110257240A1 STABILIZED STATIN FORMULATIONS 有权
标题翻译：稳定的制剂
公开(公告)号：US20110257240A1
公开(公告)日：2011-10-20
申请号：US12762025
申请日：2010-04-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/40 , A61P29/00 , A61P3/06
CPC分类号： A61K31/40 , A61K9/0019 , A61K9/19 , A61K47/40 , A61K47/6951
摘要： The present invention is directed to statin formulations having improved solubility and/or stability and methods for the same.
摘要翻译：本发明涉及具有改善的溶解度和/或稳定性的他汀类药物制剂及其用途。

5. 发明授权

US09072710B2 Injectable ibuprofen formulation 有权
公开(公告)号：US09072710B2
公开(公告)日：2015-07-07
申请号：US13422761
申请日：2012-03-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/192
CPC分类号： A61K47/02 , A61J1/065 , A61J1/10 , A61K31/192
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.

6. 发明授权

US09072661B2 Injectable ibuprofen formulation 有权
标题翻译：注射布洛芬制剂
公开(公告)号：US09072661B2
公开(公告)日：2015-07-07
申请号：US13422738
申请日：2012-03-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/192 , A61K9/00 , A61K9/08 , A61K47/02
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/192 , A61K47/02
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.
摘要翻译：本发明提供一种药物组合物，其包含布洛芬增溶剂和布洛芬的水溶液，所述布洛芬增溶剂的有效量使得溶液中的布洛芬在100mg / mL至5mg / mL的浓度下保持可溶，而没有正在进行相变。本发明还提供了一种治疗选自疼痛，炎症，发热和/或动脉导管未闭症的病症的方法，包括向有需要的患者施用有效量的布洛芬溶解剂和布洛芬的水溶液，将布洛芬溶解药剂的有效量使得溶液中的布洛芬在100mg / mL至5mg / mL的浓度下保持可溶而不经历相变，以及制备该组合物的方法。

7. 发明申请

US20120309832A1 Acetylcysteine Composition and Uses Thereof 有权
标题翻译：乙酰半胱氨酸组成及用途
公开(公告)号：US20120309832A1
公开(公告)日：2012-12-06
申请号：US13406175
申请日：2012-02-27
申请人： Leo Pavliv
发明人： Leo Pavliv
IPC分类号： A61K31/198 , A61P39/06
CPC分类号： A61K31/198 , A61J1/05 , A61K9/0019 , A61K9/08 , A61K31/195 , A61K31/197 , A61K47/02 , A61K47/26 , B65B7/00
摘要： This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.
摘要翻译：本发明涉及溶液中的新型乙酰半胱氨酸组合物，其包含乙酰半胱氨酸，其基本上不含金属螯合剂，例如EDTA。此外，本发明涉及制备和使用乙酰半胱氨酸组合物的方法。本发明的组合物和方法旨在改善患者耐受性和依从性，同时保持药物制剂的稳定性。本发明的组合物和方法可用于治疗对乙酰氨基酚过量，急性肝衰竭，各种癌症，甲基丙烯腈中毒，心脏旁路手术期间的再灌注损伤和放射性对照诱导的肾病，并且还可用作粘液溶解剂。

8. 发明申请

US20100234465A1 Administration of Intravenous Ibuprofen 有权
标题翻译：静脉注射布洛芬
公开(公告)号：US20100234465A1
公开(公告)日：2010-09-16
申请号：US12722682
申请日：2010-03-12
申请人： Leo Pavliv
发明人： Leo Pavliv
IPC分类号： A61K31/19 , A61P29/00 , A61P41/00
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/192 , A61K31/485 , A61K2300/00
摘要： An effective dose of intravenous ibuprofen administered every 6 hours in surgery patients is a safe and effective way to reduce both pain and the need for morphine. In preferred embodiments, the administration of intravenous ibuprofen starts with the onset of anesthesia.
摘要翻译：在手术患者中每6小时施用一次静脉注射布洛芬的有效剂量是减轻疼痛和吗啡需求的安全有效的方法。在优选的实施方案中，静脉注射布洛芬的施用开始于麻醉开始。

9. 发明授权

US06727286B2 Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid 有权
标题翻译： 2-（4-异丁基苯基）丙酸的药物组合物
公开(公告)号：US06727286B2
公开(公告)日：2004-04-27
申请号：US09985246
申请日：2001-11-02
申请人： Leo Pavliv
发明人： Leo Pavliv
IPC分类号： A61K31195
CPC分类号： A61K31/192 , A61K9/19 , A61K31/198 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of arginine and ibuprofen, wherein the molar ratio of arginine to ibuprofen is less than 1:1, as well as a method of making the same. The present invention also provides a method of treating a condition chosen from pain, inflammation, fever, and/or other conditions alleviated by ibuprofen comprising administering a pharmaceutical composition comprising an aqueous solution of arginine and ibuprofen, wherein the molar ratio of arginine to ibuprofen is less than 1:1.
摘要翻译：本发明提供了包含精氨酸和布洛芬的水溶液的药物组合物，其中精氨酸与布洛芬的摩尔比小于1:1，以及其制备方法。本发明还提供了治疗选自由布洛芬缓解的疼痛，炎症，发热和/或其他病症的病症的方法，其包括给药包含精氨酸和布洛芬的水溶液的药物组合物，其中精氨酸与布洛芬的摩尔比为小于1：1。

10. 发明授权

US08871810B2 Treating critically ill patients with intravenous ibuprofen 有权
标题翻译：治疗重症患者静脉注射布洛芬
公开(公告)号：US08871810B2
公开(公告)日：2014-10-28
申请号：US12646499
申请日：2009-12-23
申请人： Leo Pavliv , Amy Dix Rock
发明人： Leo Pavliv , Amy Dix Rock
IPC分类号： A01N37/10 , A61K31/19 , A61K31/197 , A61K31/192
CPC分类号： A61K31/192 , A61K9/0019 , A61K9/08 , A61K31/197 , A61K45/06 , A61K47/183
摘要： Methods of treating at least one condition chosen from pain, inflammation, and fever in a critically ill patient in need thereof, comprising administering to the critically ill patient an intravenous pharmaceutical composition comprising ibuprofen using a first dosage regimen, wherein the first dosage regimen produces a first pharmacokinetic profile in critically ill patients that is about equivalent to a second pharmacokinetic profile produced by administration of the intravenous pharmaceutical composition using a second dosage regimen of ibuprofen to non-critically ill patients, wherein the at least one condition of the critically ill patient is thereby treated.
摘要翻译：在有需要的危重病人中治疗选自疼痛，炎症和发烧的至少一种病症的方法，包括使用第一剂量方案向危重患者施用包含布洛芬的静脉内药物组合物，其中所述第一剂量方案产生危重症患者的第一药代动力学特征，其大致相当于使用静脉注射药物组合物使用布洛芬的第二剂量方案给予非危重患者的第二药代动力学特征，其中危重患者的至少一种状况是从而进行治疗。

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