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1. 发明申请

US20130245591A1 INJECTABLE IBUPROFEN FORMULATION 有权
公开(公告)号：US20130245591A1
公开(公告)日：2013-09-19
申请号：US13422738
申请日：2012-03-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/19 , A61P9/00 , A61J1/10 , A61P29/00
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/192 , A61K47/02
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.

2. 发明申请

US20130245120A1 INJECTABLE IBUPROFEN FORMULATION 有权
公开(公告)号：US20130245120A1
公开(公告)日：2013-09-19
申请号：US13422761
申请日：2012-03-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/19 , A61P29/00 , A61J1/10 , A61J1/00 , B65D30/02 , A61K31/195 , A61P9/00
CPC分类号： A61K47/02 , A61J1/065 , A61J1/10 , A61K31/192
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.

3. 发明授权

US08372877B2 Stabilized statin formulations 有权
公开(公告)号：US08372877B2
公开(公告)日：2013-02-12
申请号：US12762025
申请日：2010-04-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/724 , A61K31/40 , C07D207/34
CPC分类号： A61K31/40 , A61K9/0019 , A61K9/19 , A61K47/40 , A61K47/6951
摘要： The present invention is directed to statin formulations having improved solubility and/or stability and methods for the same.

4. 发明申请

US20110257240A1 STABILIZED STATIN FORMULATIONS 有权
标题翻译：稳定的制剂
公开(公告)号：US20110257240A1
公开(公告)日：2011-10-20
申请号：US12762025
申请日：2010-04-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/40 , A61P29/00 , A61P3/06
CPC分类号： A61K31/40 , A61K9/0019 , A61K9/19 , A61K47/40 , A61K47/6951
摘要： The present invention is directed to statin formulations having improved solubility and/or stability and methods for the same.
摘要翻译：本发明涉及具有改善的溶解度和/或稳定性的他汀类药物制剂及其用途。

5. 发明授权

US09072710B2 Injectable ibuprofen formulation 有权
公开(公告)号：US09072710B2
公开(公告)日：2015-07-07
申请号：US13422761
申请日：2012-03-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/192
CPC分类号： A61K47/02 , A61J1/065 , A61J1/10 , A61K31/192
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.

6. 发明授权

US09072661B2 Injectable ibuprofen formulation 有权
标题翻译：注射布洛芬制剂
公开(公告)号：US09072661B2
公开(公告)日：2015-07-07
申请号：US13422738
申请日：2012-03-16
申请人： Leo Pavliv , Andrew Vila
发明人： Leo Pavliv , Andrew Vila
IPC分类号： A61K31/192 , A61K9/00 , A61K9/08 , A61K47/02
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/192 , A61K47/02
摘要： The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.
摘要翻译：本发明提供一种药物组合物，其包含布洛芬增溶剂和布洛芬的水溶液，所述布洛芬增溶剂的有效量使得溶液中的布洛芬在100mg / mL至5mg / mL的浓度下保持可溶，而没有正在进行相变。本发明还提供了一种治疗选自疼痛，炎症，发热和/或动脉导管未闭症的病症的方法，包括向有需要的患者施用有效量的布洛芬溶解剂和布洛芬的水溶液，将布洛芬溶解药剂的有效量使得溶液中的布洛芬在100mg / mL至5mg / mL的浓度下保持可溶而不经历相变，以及制备该组合物的方法。

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