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1. 发明授权

US07078030B2 Oncolytic adenovirus 失效
标题翻译：溶瘤腺病毒
公开(公告)号：US07078030B2
公开(公告)日：2006-07-18
申请号：US10733674
申请日：2003-12-11
申请人： Leisa Johnson , Ali Fattaey , Terry Hermiston , Jerry Yuqiao Shen , Sylvie Laquerre
发明人： Leisa Johnson , Ali Fattaey , Terry Hermiston , Jerry Yuqiao Shen , Sylvie Laquerre
IPC分类号： A61K48/00 , C12N15/00 , C12N15/63 , C12N5/00 , C12N15/86
CPC分类号： C07K14/005 , A61K35/761 , C12N7/00 , C12N9/78 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2830/008
摘要： Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.
摘要翻译：描述了制备这种载体的病毒载体和优先杀死肿瘤而不是正常细胞的方法，优选的载体是在由优选E2F应答的肿瘤特异性启动子取代的E1A和/或E4区域内具有内源性启动子的腺病毒。

2. 发明授权

US07396679B2 Oncolytic adenovirus 失效
标题翻译：溶瘤腺病毒
公开(公告)号：US07396679B2
公开(公告)日：2008-07-08
申请号：US10303598
申请日：2002-11-25
申请人： Leisa Johnson , Ali Fattaey , Terry Hermiston , Yuqiao Shen , Sylvie Laquerre
发明人： Leisa Johnson , Ali Fattaey , Terry Hermiston , Yuqiao Shen , Sylvie Laquerre
IPC分类号： C12N15/00
CPC分类号： C12N7/00 , A61K35/761 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , C12N2830/008
摘要： Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.
摘要翻译：描述了制备这种载体的病毒载体和优先杀死肿瘤而不是正常细胞的方法，优选的载体是在由优选E2F应答的肿瘤特异性启动子取代的E1A和/或E4区域内具有内源性启动子的腺病毒。

3. 发明授权

US07001596B1 Oncolytic adenovirus 失效
公开(公告)号：US07001596B1
公开(公告)日：2006-02-21
申请号：US09714409
申请日：2000-11-14
申请人： Leisa Johnson , Ali Fattaey , Terry Hermiston
发明人： Leisa Johnson , Ali Fattaey , Terry Hermiston
IPC分类号： A61K48/00 , C12N15/00 , C12N15/63
CPC分类号： C12N7/00 , A61K35/76 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , C12N2830/008
摘要： Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters in the E1A and/or E4 regions substituted with a tumor specific promoter which is preferably E2F responsive.

4. 发明授权

US07332281B2 Therapeutic targets in cancer 失效
标题翻译：癌症治疗靶点
公开(公告)号：US07332281B2
公开(公告)日：2008-02-19
申请号：US10833833
申请日：2004-04-27
申请人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
发明人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
摘要翻译：本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。本发明提供了存在于细胞表面上的与癌症相关的CA多肽，并提出了针对癌症的新型治疗靶点。本发明还提供了用于检测癌症的诊断组合物和方法。本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

5. 发明授权

US5876711A Methods and compositions for determining the tumor suppressor status of cells 失效
标题翻译：用于确定细胞的肿瘤抑制状态的方法和组合物
公开(公告)号：US5876711A
公开(公告)日：1999-03-02
申请号：US657828
申请日：1996-05-31
申请人： Ali Fattaey
发明人： Ali Fattaey
IPC分类号： C12N15/09 , A61K51/00 , C12Q1/68 , A01N63/00 , C12Q1/70
CPC分类号： C12Q1/6897
摘要： Methods and compositions for determining the tumor suppressor status of cells are described, preferably as pertaining to the p53 status of tumor cells, and preferably in vivo using a recombinant construct consisting of a first polynucleotide sequence that encodes a reporter molecule and a second p53 binding polynucleotide sequence that is operably linked to the first polynucleotide sequence such that binding of p53 to the second polynucleotide sequence causes the expression of the reporter molecule which can be detected or quantified.
摘要翻译：描述了用于确定细胞的肿瘤抑制状态的方法和组合物，优选与肿瘤细胞的p53状态相关，优选在体内使用由编码报告分子和第二p53结合多核苷酸的第一多核苷酸序列组成的重组构建体序列，其可操作地连接到第一多核苷酸序列，使得p53与第二多核苷酸序列的结合引起可被检测或定量的报道分子的表达。

6. 发明申请

US20060194210A1 Novel therapeutic targets in cancer 失效
公开(公告)号：US20060194210A1
公开(公告)日：2006-08-31
申请号：US10833833
申请日：2004-04-27
申请人： David Morris , Marc Malandro , Albert Lai , Christin Tse , Ali Fattaey
发明人： David Morris , Marc Malandro , Albert Lai , Christin Tse , Ali Fattaey
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

7. 发明授权

US06391630B1 Plasmids that encode green fluorescent protein 有权
标题翻译：编码绿色荧光蛋白的质粒
公开(公告)号：US06391630B1
公开(公告)日：2002-05-21
申请号：US09260420
申请日：1999-03-01
申请人： Ali Fattaey
发明人： Ali Fattaey
IPC分类号： C12N1500
CPC分类号： C12Q1/6897
摘要： Methods and compositions for determining the tumor suppressor status of cells are described, preferably as pertaining to the p53 status of tumor cells, and preferably in vivo using a recombinant construct consisting of a first polynucleotide sequence that encodes a reporter molecule and a second p53 binding polynucleotide sequence that is operably linked to the first polynucleotide sequence such that binding of p53 to the second polynucleotide sequence causes the expression of the reporter molecule which can be detected or quantified.
摘要翻译：描述了用于确定细胞的肿瘤抑制状态的方法和组合物，优选与肿瘤细胞的p53状态相关，优选在体内使用由编码报告分子和第二p53结合多核苷酸的第一多核苷酸序列组成的重组构建体序列，其可操作地连接到第一多核苷酸序列，使得p53与第二多核苷酸序列的结合引起可被检测或定量的报道分子的表达。

8. 发明申请

US20060024677A1 Novel therapeutic targets in cancer 审中-公开
公开(公告)号：US20060024677A1
公开(公告)日：2006-02-02
申请号：US10895974
申请日：2004-07-20
申请人： David Morris , Marc Malandro , Albert Lai , Christin Tse , Ali Fattaey
发明人： David Morris , Marc Malandro , Albert Lai , Christin Tse , Ali Fattaey
IPC分类号： C12Q1/68 , C40B50/02
CPC分类号： G01N33/574 , C07K14/4748 , C07K16/30 , C12Q1/6837 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/10
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

9. 发明授权

US06498163B1 Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation 失效
标题翻译：吡啶并[2,3-D]嘧啶和4-氨基嘧啶作为细胞增殖抑制剂
公开(公告)号：US06498163B1
公开(公告)日：2002-12-24
申请号：US09355681
申请日：1999-08-02
申请人： Diane Harris Boschelli , Annette Marian Doherty , Ali Fattaey , David William Fry , Susanne Andrea Trumpp-Kallmeyer , Zhipei Wu , Ellen Myra Dobrusin , Mark Robert Barvian
发明人： Diane Harris Boschelli , Annette Marian Doherty , Ali Fattaey , David William Fry , Susanne Andrea Trumpp-Kallmeyer , Zhipei Wu , Ellen Myra Dobrusin , Mark Robert Barvian
IPC分类号： A61K31519
CPC分类号： C07D239/47 , C07D239/48 , C07D471/04
摘要： This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferative disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2-(amino and thio)pyrido[2,3-d]pyrimidines and 2,4-diaminopyrimidines that are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention provides compounds of Formula I: and Formula II: where W is NH, S, SO, or SO2, R1 includes phenyl and substituted phenyl, R2 includes alkyl and cycloalkyl, R3 includes alkyl and hydrogen, R8 and R9 include hydrogen and alkyl, and Z is carboxy. This invention also provides pharmaceutical formulations comprising a compound of Formula I or II together with a pharmaceutically acceptable carrier, diluent, or excipient therefor.
摘要翻译：本发明提供可用于治疗细胞增殖性疾病如癌症和再狭窄的吡啶并嘧啶和4-氨基嘧啶。我们现在已经发现了一组7,8-二氢-2-（氨基和硫代）吡啶并[2,3-d]嘧啶和2,4-二氨基嘧啶，其是细胞周期蛋白依赖性激酶（cdks）和生长因子的有效抑制剂介导的激酶。这些化合物很容易合成，并且可以通过多种途径施用，包括口服，并具有足够的生物利用度。本发明提供式I化合物和式II化合物：其中W是NH，S，SO或SO 2，R 1包括苯基和取代的苯基，R 2包括烷基和环烷基，R 3包括烷基和氢，R 8和R 9包括氢和烷基，并且Z是羧基。本发明还提供了包含式I或II化合物及其药学上可接受的载体，稀释剂或赋形剂的药物制剂。

10. 发明申请

US20090215711A1 Novel compositions and methods in cancer 审中-公开
标题翻译：癌症中的新型成分和方法
公开(公告)号：US20090215711A1
公开(公告)日：2009-08-27
申请号：US10836956
申请日：2004-04-30
申请人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
发明人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
IPC分类号： A61K31/7088 , C12Q1/68 , G01N33/574 , C12N5/00 , C12N5/02 , C12N15/63 , C40B30/00 , C40B40/06 , C40B40/10 , C07K2/00 , C07K16/00 , C07K17/00 , C07H21/04
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
摘要翻译：本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。本发明提供了与癌症相关的CA多肽，其呈递针对癌症的新型治疗靶点。本发明还提供了用于检测癌症的诊断组合物和方法。本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

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