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1. 发明授权

US07332281B2 Therapeutic targets in cancer 失效
标题翻译：癌症治疗靶点
公开(公告)号：US07332281B2
公开(公告)日：2008-02-19
申请号：US10833833
申请日：2004-04-27
申请人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
发明人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
摘要翻译：本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。本发明提供了存在于细胞表面上的与癌症相关的CA多肽，并提出了针对癌症的新型治疗靶点。本发明还提供了用于检测癌症的诊断组合物和方法。本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

2. 发明申请

US20090215711A1 Novel compositions and methods in cancer 审中-公开
标题翻译：癌症中的新型成分和方法
公开(公告)号：US20090215711A1
公开(公告)日：2009-08-27
申请号：US10836956
申请日：2004-04-30
申请人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
发明人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
IPC分类号： A61K31/7088 , C12Q1/68 , G01N33/574 , C12N5/00 , C12N5/02 , C12N15/63 , C40B30/00 , C40B40/06 , C40B40/10 , C07K2/00 , C07K16/00 , C07K17/00 , C07H21/04
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
摘要翻译：本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。本发明提供了与癌症相关的CA多肽，其呈递针对癌症的新型治疗靶点。本发明还提供了用于检测癌症的诊断组合物和方法。本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

3. 发明申请

US20080299561A1 Novel therapeutic targets in cancer 审中-公开
标题翻译：癌症中的新型治疗靶点
公开(公告)号：US20080299561A1
公开(公告)日：2008-12-04
申请号：US12005111
申请日：2007-12-21
申请人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
发明人： David W. Morris , Marc S. Malandro , Albert Lai , Christin Tse , Ali Fattaey
IPC分类号： C12Q1/68 , C12Q1/48 , C12Q1/02 , G01N33/574
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
摘要翻译：本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。本发明提供了存在于细胞表面上的与癌症相关的CA多肽，并提出了针对癌症的新型治疗靶点。本发明还提供了用于检测癌症的诊断组合物和方法。本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

4. 发明申请

US20090214546A1 Novel therapeutic targets in cancer 审中-公开
标题翻译：癌症中的新型治疗靶点
公开(公告)号：US20090214546A1
公开(公告)日：2009-08-27
申请号：US11547676
申请日：2005-04-27
申请人： David W. Morris , Marc S. Malandro , Albert Lai , Chistin Tse , Ali Fattaey
发明人： David W. Morris , Marc S. Malandro , Albert Lai , Chistin Tse , Ali Fattaey
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , C07K14/00 , C07K16/18 , A61P35/00
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
摘要翻译：本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。本发明提供了存在于细胞表面上的与癌症相关的CA多肽，并提出了针对癌症的新型治疗靶点。本发明还提供了用于检测癌症的诊断组合物和方法。本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

5. 发明申请

US20080274467A1 Novel Therapeutic Targets in Cancer 审中-公开
标题翻译：癌症中的新型治疗靶点
公开(公告)号：US20080274467A1
公开(公告)日：2008-11-06
申请号：US12034498
申请日：2008-02-20
申请人： David W. Morris , Marc S. Malandro
发明人： David W. Morris , Marc S. Malandro
IPC分类号： C12Q1/68 , C12Q1/02
CPC分类号： C12Q1/6886 , C12Q2565/501 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
摘要翻译：本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。本发明提供了存在于细胞表面上的与癌症相关的CA多肽，并提出了针对癌症的新型治疗靶点。本发明还提供了用于检测癌症的诊断组合物和方法。本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

6. 发明授权

US07816076B2 Therapeutic targets in cancer 失效
标题翻译：癌症治疗靶点
公开(公告)号：US07816076B2
公开(公告)日：2010-10-19
申请号：US11257477
申请日：2005-10-24
申请人： David W. Morris , Marc S. Malandro
发明人： David W. Morris , Marc S. Malandro
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/4748 , A61K39/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/16 , G01N33/57426 , G01N33/57492
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
摘要翻译：本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。本发明提供了存在于细胞表面上的与癌症相关的CA多肽，并提出了针对癌症的新型治疗靶点。本发明还提供了用于检测癌症的诊断组合物和方法。本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

7. 发明申请

US20090214542A1 Novel therapeutic targets in cancer 审中-公开
标题翻译：癌症中的新型治疗靶点
公开(公告)号：US20090214542A1
公开(公告)日：2009-08-27
申请号：US10670914
申请日：2003-09-24
申请人： David W. Morris , Marc S. Malandro
发明人： David W. Morris , Marc S. Malandro
IPC分类号： A61K39/395 , C12N15/11 , C12N5/06 , C12N15/00 , C12Q1/68 , C12Q1/02 , A61P43/00 , A61K31/70 , C40B40/10 , G01N33/574 , C40B40/08 , C07K16/18
CPC分类号： G01N33/5011 , A61K31/70 , C07K14/4748 , C07K16/30 , C12N15/113 , C12N2310/11 , C12Q1/6886 , C12Q2600/136 , G01N33/57426 , G01N33/57488 , G01N33/57496 , G01N2500/00
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.
摘要翻译：本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。本发明提供了存在于细胞表面上的与癌症相关的CA多肽，并提出了针对癌症的新型治疗靶点。本发明还提供了用于检测癌症的诊断组合物和方法。本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

8. 发明授权

US07767387B2 Therapeutic targets in cancer 失效
公开(公告)号：US07767387B2
公开(公告)日：2010-08-03
申请号：US10461862
申请日：2003-06-13
申请人： David W. Morris , Marc S. Malandro
发明人： David W. Morris , Marc S. Malandro
IPC分类号： C12Q1/00 , G01N1/00 , G01N33/48 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136 , G01N33/57426 , G01N33/57492 , Y10T436/25
摘要： The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

9. 发明授权

US07820447B2 Compositions and methods for cancer 失效
标题翻译：癌症的组成和方法
公开(公告)号：US07820447B2
公开(公告)日：2010-10-26
申请号：US10035832
申请日：2001-12-26
申请人： David W. Morris , Eric K. Engelhard
发明人： David W. Morris , Eric K. Engelhard
IPC分类号： G01N33/48 , G01N33/566 , G01N33/567 , G01N33/53 , C12Q1/42
CPC分类号： C12Q1/6886 , C07K14/47 , C12Q2600/136 , G01N33/5011 , G01N33/5023 , G01N33/57407 , G01N33/57484 , Y10S436/813
摘要： The present invention relates to novel sequences for use in diagnosis and treatment of carcinomas, especially lymphoma carcinomas. In addition, the present invention describes the use of novel compositions for use in screening methods.
摘要翻译：本发明涉及用于诊断和治疗癌症，特别是淋巴瘤癌症的新型序列。此外，本发明描述了用于筛选方法的新型组合物的用途。

10. 发明授权

US06210078B1 Methods for the in situ removal of a contaminant from soil 有权
标题翻译：从土壤原位清除污染物的方法
公开(公告)号：US06210078B1
公开(公告)日：2001-04-03
申请号：US09324298
申请日：1999-06-02
申请人： James C. Redwine , David W. Morris , David L. Drummonds
发明人： James C. Redwine , David W. Morris , David L. Drummonds
IPC分类号： A62D300
CPC分类号： B01J39/04 , B01D61/145 , B01D61/147 , B01D61/16 , B01D2311/04 , B01J41/04 , B09C1/02 , B09C1/08 , B09C1/085 , B09C2101/00 , C02F1/24 , C02F1/281 , C02F1/283 , C02F1/32 , C02F1/444 , C02F1/5245 , C02F1/56 , C02F1/66 , C02F1/683 , C02F1/78 , C02F2101/103 , C02F2103/06 , E21B43/40 , B01D2311/12 , B01D2311/16
摘要： The invention relates to a method for removing a contaminant in situ from soil containing the contaminant, by contacting the soil containing the contaminant with a reagent in situ to remove the contaminant from the soil and form a mixture; removing the mixture from the soil; and removing the contaminant from the mixture, wherein the reagent is not citric acid. The invention further relates to a method for removing a contaminant in situ from soil containing the contaminant, by contacting the soil containing the contaminant with a reagent in situ and mobilizing the contaminant by electroremediation to form a mixture containing the contaminant; and removing the contaminant from the mixture. The invention further relates to a method for removing a contaminant from soil in situ containing the contaminant, by contacting the soil containing the contaminant with a chelate in situ to form a mixture containing a contaminant-chelate complex; removing the mixture from the soil; and contacting the mixture with an ion exchange resin, whereby the contaminant-chelate complex is separated from the mixture. The invention further relates to a method of removing a contaminant in situ from soil containing the contaminant, by contacting the soil containing the contaminant in situ with a chelate to form a first mixture containing a contaminant-chelate complex; removing the first mixture from the soil; chemically destroying the contaminant-chelate complex of the first mixture to produce a second mixture containing the contaminant; and removing the contaminant from the second mixture.
摘要翻译：本发明涉及一种从含有污染物的土壤中原位除去污染物的方法，通过使含有污染物的土壤与原位原位接触，从土壤中除去污染物并形成混合物; 从土壤中除去混合物; 并从混合物中除去污染物，其中该试剂不是柠檬酸。本发明还涉及一种通过使含有污染物的土壤与原位原位接触并通过电气调节来移动污染物以形成含有污染物的混合物来从含有污染物的土壤中原位除去污染物的方法; 并从混合物中除去污染物。本发明还涉及通过将含有污染物的土壤与螯合物原位接触以形成含有污染物螯合络合物的混合物，从而将含有污染物的土壤中的污物除去的方法; 从土壤中除去混合物; 并将该混合物与离子交换树脂接触，从而将该杂质螯合物与该混合物分离。本发明还涉及一种通过将含有污染物的土壤与螯合物接触以形成含有污染物螯合络合物的第一混合物，从含有污染物的土壤中原位除去污染物的方法; 从土壤中除去第一个混合物; 化学破坏第一混合物的污染物螯合络合物以产生含有污染物的第二混合物; 并从第二混合物中除去污染物。

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