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1. 发明授权

US09034644B2 Compositions for repair of defects in osseous tissues, and methods of making the same 有权
公开(公告)号：US09034644B2
公开(公告)日：2015-05-19
申请号：US13174266
申请日：2011-06-30
申请人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
发明人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
IPC分类号： A61K9/00 , C12N5/00 , A61K35/32 , A61L27/36
CPC分类号： A61L27/3608 , A61K35/32 , A61L27/3604 , A61L2400/06 , A61L2430/02
摘要： Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.

2. 发明授权

US07498041B2 Composition for repair of defects in osseous tissues 有权
标题翻译：用于修复骨组织缺陷的组合物
公开(公告)号：US07498041B2
公开(公告)日：2009-03-03
申请号：US11247230
申请日：2005-10-12
申请人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
发明人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
IPC分类号： A61K9/00 , C12N5/08 , C12N5/00
CPC分类号： A61K35/32 , A61L27/3604 , A61L27/3608 , A61L2400/06 , A61L2430/02
摘要： Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.
摘要翻译：组织修复组合物，特别是骨修复组合物，其含有软化骨碎片和匀浆结缔组织。组合物可以以可注射凝胶，可注射糊剂，糊剂，油灰或可再水化的冷冻干燥形式的形式使用。

3. 发明授权

US07977094B2 Compositions for repair of defects in osseous tissues, and methods of making the same 有权
标题翻译：用于修复骨组织缺陷的组合物及其制备方法
公开(公告)号：US07977094B2
公开(公告)日：2011-07-12
申请号：US11898053
申请日：2007-09-07
申请人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
发明人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
IPC分类号： C12N5/02 , C12N5/071
CPC分类号： A61L27/3608 , A61K35/32 , A61L27/3604 , A61L2400/06 , A61L2430/02
摘要： Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.
摘要翻译：组织修复组合物，特别是含有软骨骨碎片和匀浆结缔组织的骨修复组合物及其制备方法。组合物可以以可注射凝胶，可注射糊剂，糊剂，油灰或可再水化的冷冻干燥形式的形式使用。

4. 发明授权

US08309106B2 Composition for repair of defects in osseous tissues 有权
标题翻译：用于修复骨组织缺陷的组合物
公开(公告)号：US08309106B2
公开(公告)日：2012-11-13
申请号：US12394629
申请日：2009-02-27
申请人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
发明人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
IPC分类号： A61K9/00 , C12N5/00
CPC分类号： A61K35/32 , A61L27/3604 , A61L27/3608 , A61L2400/06 , A61L2430/02
摘要： Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.
摘要翻译：组织修复组合物，特别是骨修复组合物，其含有软化骨碎片和匀浆结缔组织。组合物可以以可注射凝胶，可注射糊剂，糊剂，油灰或可再水化的冷冻干燥形式的形式使用。

5. 发明授权

US09005646B2 Compositions for repair of defects in tissues, and methods of making the same 有权
标题翻译：用于修复组织缺陷的组合物及其制备方法
公开(公告)号：US09005646B2
公开(公告)日：2015-04-14
申请号：US12732974
申请日：2010-03-26
申请人： Leila Masinaei , Lloyd Wolfinbarger, Jr. , Silvia S. Chen , Alyce Linthurst Jones , Jingsong Chen
发明人： Leila Masinaei , Lloyd Wolfinbarger, Jr. , Silvia S. Chen , Alyce Linthurst Jones , Jingsong Chen
IPC分类号： A61K9/00 , C12N5/00 , A61L27/36 , A61L27/56 , A61F2/28 , A61F2/30
CPC分类号： A61K35/35 , A61F2/28 , A61F2/30756 , A61F2310/00359 , A61K35/32 , A61K47/22 , A61L27/28 , A61L27/3604 , A61L27/3608 , A61L27/56 , A61L2300/30 , A61L2300/606 , A61L2430/02
摘要： Tissue repair compositions, particularly bone repair compositions, containing (a) bone fragments and (b) homogenized connective tissue, and methods for making the same are provided. Some of the inventive tissue repair compositions contain a radioprotectant. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form. Kits for using such tissue repair compositions are also provided.
摘要翻译：提供了包含（a）骨碎片和（b）匀浆结缔组织的组织修复组合物，特别是骨修复组合物及其制备方法。一些本发明的组织修复组合物含有放射防护剂。组合物可以以可注射凝胶，可注射糊剂，糊剂，油灰或可再水化的冷冻干燥形式的形式使用。还提供了使用这种组织修复组合物的试剂盒。

6. 发明授权

US07498040B2 Compositions for repair of defects in osseous tissues, and methods of making the same 有权
标题翻译：用于修复骨组织缺陷的组合物及其制备方法
公开(公告)号：US07498040B2
公开(公告)日：2009-03-03
申请号：US11247229
申请日：2005-10-12
申请人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
发明人： Leila Masinaei , Lloyd Wolfinbarger, Jr.
IPC分类号： A61K9/00 , C12N5/02
CPC分类号： A61L27/3608 , A61K35/32 , A61L27/3604 , A61L2400/06 , A61L2430/02
摘要： Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.
摘要翻译：组织修复组合物，特别是含有软骨骨碎片和匀浆结缔组织的骨修复组合物及其制备方法。组合物可以以可注射凝胶，可注射糊剂，糊剂，油灰或可再水化的冷冻干燥形式的形式使用。

7. 发明授权

US06569200B2 Plasticized soft tissue grafts, and methods of making and using same 有权
公开(公告)号：US06569200B2
公开(公告)日：2003-05-27
申请号：US09874862
申请日：2001-06-05
申请人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
发明人： Lloyd Wolfinbarger, Jr. , Robert K. O'Leary , Billy G. Anderson
IPC分类号： A61F208
CPC分类号： A61L27/362 , A61F2/02 , A61F2/4644 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30535 , A61F2002/4646 , A61F2002/4649 , A61F2250/0058 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/502 , A61L2430/02
摘要： The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.

8. 发明授权

US06432712B1 Transplantable recellularized and reendothelialized vascular tissue graft 有权
标题翻译：可移植的细胞和内皮细胞血管组织移植物
公开(公告)号：US06432712B1
公开(公告)日：2002-08-13
申请号：US09595717
申请日：2000-06-16
申请人： Lloyd Wolfinbarger, Jr.
发明人： Lloyd Wolfinbarger, Jr.
IPC分类号： C12N500
CPC分类号： A61F2/062 , A61L27/38 , A61L27/3895 , A61L27/507 , A61L2430/20 , C12M21/08 , C12M25/14 , C12M29/12 , C12M29/14 , Y10S623/916 , Y10S623/921
摘要： The invention provides a device and process for recellularizing essentially acellular or devitalized tissue grafts, including for example essentially acellular or devitalized vascular tissue grafts, derived from human or animal sources, or as constructed using any number of tissue engineering methodologies. The process includes repopulating and reendothelializing an essentially acellular or devitalized tissue graft. The device is useful for producing a repopulated tissue graft from an essentially acellular or devitalized tissue, as well as for producing an essentially acellular or devitalized tissue graft.
摘要翻译：本发明提供了一种装置和方法，用于基本上使细胞或失活的组织移植物（包括例如来源于人或动物来源的基本上是细胞的或失活的血管组织移植物）或使用任何数量的组织工程方法来构建。该过程包括基本上无细胞或失活的组织移植物的再填充和再内皮化。该装置可用于从基本上无细胞或失活的组织产生重新植入的组织移植物，以及用于产生基本上无细胞或失活的组织移植物。

9. 发明授权

US06305379B1 Process for producing osteoinductive bone, and osteoinductive bone produced thereby 有权
标题翻译：用于生产骨诱导骨的方法和由此产生的骨诱导性骨
公开(公告)号：US06305379B1
公开(公告)日：2001-10-23
申请号：US09547888
申请日：2000-04-12
申请人： Lloyd Wolfinbarger, Jr.
发明人： Lloyd Wolfinbarger, Jr.
IPC分类号： A61B1900
CPC分类号： A61L27/3687 , A61F2/28 , A61F2/3094 , A61F2/4644 , A61L27/3608 , A61L27/365 , A61L2430/02 , A61L2430/40 , B01D11/0257 , Y10S623/901 , Y10S623/923
摘要： A process is disclosed for producing osteoinductive bone using a controlled-flow apparatus. The present apparatus allows for the controlled extraction of undesirable constituents from a body tissue. The present invention provides for the demineralization of ground bone particles or pieces of cancellous or cortical bone which permits the controlled and reproducible demineralization of bone to produce bone which is maximally osteoinductive. It has been demonstrated that ground cadaveric bone which is demineralized to a residual calcium level approximating 2% by dry weight of bone is optimally osteoinductive as assayed using in vivo and in vitro assays of osteoinductivity. The present controlled-flow apparatus includes one or more solution containers which supply solutions to be pumped into one or more vessels filled with tissue samples to be extracted. Solvent outflowing from the vessels can be monitored for pH, calcium ion concentration or conductivity as a basis for determining when extraction is complete. Using the present invention, a linear relationship has been shown to exist between eluent pH and percent residual calcium in the bone being demineralized. Thus, the current invention permits the reproducible demineralization of bone which is optimally osteoinductive. The invention also describes a means of correcting the percent residual calcium in bone which is overly demineralized, returning it to a state of being optimally osteoinductive.
摘要翻译：公开了一种使用受控流动装置生产骨诱导骨的方法。本装置允许从身体组织控制提取不需要的成分。本发明提供了研磨骨颗粒或松质骨或皮层骨的脱矿质，其允许骨的控制和可重复的去矿物质以产生最大骨诱导的骨。已经证明，通过使用体内和体外测定骨诱导力测定，被软化至残余钙水平接近于骨干重2％的残留钙水平的地骨质骨是最佳的骨诱导。本控制流量装置包括一个或多个溶液容器，其提供待泵送到一个或多个填充有待提取的组织样本的容器的溶液。可以监测从容器流出的溶剂的pH，钙离子浓度或电导率，作为确定提取完成时的基础。使用本发明，在洗脱剂pH与被软化骨骼中的残留钙百分比之间存在线性关系。因此，本发明允许骨的可重现的去矿物质，其是最佳的骨诱导性的。本发明还描述了一种矫正过度去矿化的骨中百分比残余钙的方法，使其恢复到最佳的骨诱导状态。

10. 发明授权

US06189537B1 Process for producing osteoinductive bone, and osteoinductive bone produced thereby 失效
标题翻译：用于生产骨诱导骨的方法和由此产生的骨诱导性骨
公开(公告)号：US06189537B1
公开(公告)日：2001-02-20
申请号：US08706707
申请日：1996-09-06
申请人： Lloyd Wolfinbarger, Jr.
发明人： Lloyd Wolfinbarger, Jr.
IPC分类号： A61B1900
CPC分类号： A61L27/3687 , A61F2/28 , A61F2/3094 , A61F2/4644 , A61L27/3608 , A61L27/365 , A61L2430/02 , A61L2430/40 , B01D11/0257 , Y10S623/901 , Y10S623/923
摘要： The invention produces osteoinductive bone using a controlled-flow apparatus. The apparatus allows for the controlled extraction of undesirable constituents from a body tissue. The invention provides for the demineralization of ground bone particles or pieces of cancellous or cortical bone which permits the controlled and reproducible demineralization of bone to produce bone which is maximally osteoinductive. It has been demonstrated that ground cadaveric bone which is demineralized to a residual calcium level approximating 2% by dry weight of bone is optimally osteoinductive as assayed using in vivo and in vitro assays of osteoinductivity. The controlled-flow apparatus includes one or more solution containers which supply solutions to be pumped into one or more vessels filled with tissue samples to be extracted. Solvent outflowing from the vessels can be monitored for pH, calcium ion concentration or conductivity as a basis for determining when extraction is complete. Using the invention, a linear relationship has been shown to exist between eluent pH and percent residual calcium in the bone being demineralized. Thus, the invention permits the reproducible demineralization of bone which is optimally osteoinductive. The invention also corrects the percent residual calcium in bone which is overly demineralized, returning it to a state of being optimally osteoinductive.
摘要翻译：本发明使用受控流动装置产生骨诱导骨。该装置允许从身体组织控制提取不需要的成分。本发明提供了研磨骨颗粒或松质骨或皮质骨的软化物，其允许骨的受控和可重复的去矿物质以产生最大骨诱导的骨。已经证明，通过使用体内和体外测定骨诱导力测定，被软化至残余钙水平接近于骨干重2％的残留钙水平的地骨质骨是最佳的骨诱导。受控流动装置包括一个或多个解决方案容器，其将待泵送到一个或多个容纳有待提取的组织样本的容器的溶液提供。可以监测从容器流出的溶剂的pH，钙离子浓度或电导率，作为确定提取完成时的基础。使用本发明，在脱矿质骨中洗脱液pH与残留钙百分比之间存在线性关系。因此，本发明允许骨的可重现的去矿物质，其是最佳的骨诱导性的。本发明还校正过度去矿物质的骨中残留的百分比百分数，使其恢复到最佳的骨诱导状态。

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