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1. 发明申请

US20070072171A1 Solid surface for biomolecule delivery and high-throughput assay 失效
标题翻译：用于生物分子递送和高通量测定的固体表面
公开(公告)号：US20070072171A1
公开(公告)日：2007-03-29
申请号：US11527134
申请日：2006-09-26
申请人： Lei Yu , Kenji Matsumoto , Shouping Ji , Fusheng Du
发明人： Lei Yu , Kenji Matsumoto , Shouping Ji , Fusheng Du
IPC分类号： C12Q1/00 , C12N5/06 , C12N5/04 , C12N15/82 , C12N15/09
CPC分类号： C12N15/87 , A61K47/644 , A61K47/645 , A61K48/00
摘要： The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules.
摘要翻译：本发明涉及通过在被转染试剂和生物分子包被的固体表面上培养细胞而将生物分子如核酸引入细胞的方法。

2. 发明申请

US20070020761A1 Solid surface for biomolecule delivery and high-throughput assay 审中-公开
公开(公告)号：US20070020761A1
公开(公告)日：2007-01-25
申请号：US11526927
申请日：2006-09-26
申请人： Lei Yu , Kenji Matsumoto , Shouping Ji , Fusheng Du
发明人： Lei Yu , Kenji Matsumoto , Shouping Ji , Fusheng Du
IPC分类号： C12N15/87 , C12N5/06
CPC分类号： C12N15/87 , A61K47/644 , A61K47/645 , A61K48/00
摘要： The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules.

3. 发明申请

US20060147376A1 Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier 审中-公开
公开(公告)号：US20060147376A1
公开(公告)日：2006-07-06
申请号：US11364596
申请日：2006-02-27
申请人： Lei Yu , Fusheng Du , Shouping Ji , Kenji Matsumoto
发明人： Lei Yu , Fusheng Du , Shouping Ji , Kenji Matsumoto
IPC分类号： C40B40/02 , G01N33/53 , A61K49/00
CPC分类号： C08G73/02 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/645 , A61K48/0041
摘要： The present invention provides a controllably degradable cationic polymer for delivery of biomolecules (nucleic acids, peptides, etc.), drugs, molecules used in medical imaging applications, sensitizing agents used in cancer treatments, and molecules used in tissue engineering. The present invention also provides a method for synthesizing the polymer according to the present invention.

4. 发明授权

US08192989B2 Solid surface for biomolecule delivery and high-throughput assay 失效
标题翻译：用于生物分子递送和高通量测定的固体表面
公开(公告)号：US08192989B2
公开(公告)日：2012-06-05
申请号：US11527134
申请日：2006-09-26
申请人： Lei Yu , Kenji Matsumoto , Shouping Ji , Fusheng Du
发明人： Lei Yu , Kenji Matsumoto , Shouping Ji , Fusheng Du
IPC分类号： C12N15/00
CPC分类号： C12N15/87 , A61K47/644 , A61K47/645 , A61K48/00
摘要： The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules.
摘要翻译：本发明涉及通过在被转染试剂和生物分子包被的固体表面上培养细胞而将生物分子如核酸引入细胞的方法。

5. 发明申请

US20050191746A1 Compositions and methods for biodegradable polymer-peptide mediated transfection 失效
标题翻译：可生物降解聚合物 - 肽介导的转染的组合物和方法
公开(公告)号：US20050191746A1
公开(公告)日：2005-09-01
申请号：US10789589
申请日：2004-02-27
申请人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Kenji Matsumoto , Lei Yu
发明人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Kenji Matsumoto , Lei Yu
IPC分类号： A61K47/48 , A61K48/00 , C08L59/00 , C12N15/87 , C12N15/85 , C08G63/48
CPC分类号： C08L59/00 , A61K47/59 , A61K47/645 , A61K48/00 , C12N15/87
摘要： Complexes are disclosed which are a combination of a polynucleotide and a biodegradable polyacetal-peptide. The disclosed complexes are useful for cell transfection.
摘要翻译：公开了多核苷酸和生物可降解聚缩醛肽的组合的复合物。所公开的复合物可用于细胞转染。

6. 发明授权

US06878374B2 Biodegradable polyacetals 失效
标题翻译：可生物降解聚缩醛
公开(公告)号：US06878374B2
公开(公告)日：2005-04-12
申请号：US10375705
申请日：2003-02-25
申请人： Lei Yu , Sang Van , Shouping Ji , Kenji Matsumoto
发明人： Lei Yu , Sang Van , Shouping Ji , Kenji Matsumoto
IPC分类号： A61K47/48 , C08G65/00 , C08G73/02 , A61K39/44 , C08F283/00
CPC分类号： C08G73/0213 , A61K47/59 , C08G65/002
摘要： A polymer comprising recurring units represented by formula (I): wherein X is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VZ, where R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl, where V is a labile linker group, and where Z is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, and hexadecaamine dendrimer; and wherein Y is selected from the group consisting of —(CH2)2—, —(CH2)2—O—(CH2)2—, —(CH2)2—O—(CH2)2—, and —(CH2)3—NHC(O)—(CH2)6—C(O)NH—(CH2)3— is useful in nucleic acid delivery applications. Polyacetals of the formula (I) are preferably made by reacting appropriate diols and divinyl ethers. In preferred embodiments, complexes formed between polyacetals of the formula (I) and polynucleotides are useful as transfection reagents.
摘要翻译：一种包含由式（I）表示的重复单元的聚合物：其中X选自C（O）OR 1，C（O）SR 1，C（O）NR 1 R 2 >和VZ，其中R 1和R 2各自独立地选自氢，C 1至C 10烷基和C 6至C 10芳基，其中V是不稳定的连接基团，并且其中Z被选择由聚（乙烯亚胺），聚（丙烯亚胺），聚（赖氨酸），PAMAM树枝状聚合物，八胺树枝状聚合物和十六胺树枝状聚合物组成的组中; 其中Y选自 - （CH 2）2 - ， - （CH 2）2 -O-（CH 2）2 - ， - （CH 2）2 -O-（CH 2）2 - 和 - （CH 2） 3-NHC（O） - （CH 2）6 -C（O）NH-（CH 2）3 - 可用于核酸递送应用。式（I）的聚缩醛优选通过使适当的二醇和二乙烯基醚反应来制备。在优选的实施方案中，在式（I）的聚缩醛和多核苷酸之间形成的络合物可用作转染试剂。

7. 发明授权

US07446099B2 Compositions and methods for biodegradable polymer-peptide mediated transfection 失效
标题翻译：可生物降解聚合物 - 肽介导的转染的组合物和方法
公开(公告)号：US07446099B2
公开(公告)日：2008-11-04
申请号：US10789589
申请日：2004-02-27
申请人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Kenji Matsumoto , Lei Yu
发明人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Kenji Matsumoto , Lei Yu
IPC分类号： A01N43/48
CPC分类号： C08L59/00 , A61K47/59 , A61K47/645 , A61K48/00 , C12N15/87
摘要： Complexes are disclosed which are a combination of a polynucleotide and a biodegradable polyacetal-peptide. The disclosed complexes are useful for cell transfection.
摘要翻译：公开了多核苷酸和生物可降解聚缩醛肽的组合的复合物。所公开的复合物可用于细胞转染。

8. 发明申请

US20060074045A1 Vector for transfection of eukaryotic cells 审中-公开
公开(公告)号：US20060074045A1
公开(公告)日：2006-04-06
申请号：US11286243
申请日：2005-11-23
申请人： Lei Yu , Kenji Matsumoto
发明人： Lei Yu , Kenji Matsumoto
IPC分类号： A61K48/00 , C12N15/88
CPC分类号： C12N15/88 , A61K48/00 , C12N15/87 , C12N2810/6081
摘要： Vectors comprising a nucleic acid, a nucleic acid binding polymer, a vesicle and a membrane active polypeptide are described. Preferred vectors facilitate transfection and/or reduce cytotoxicity. Methods of making the vectors and methods of using the vectors to transfect cells and/or treat a patient in need of gene therapy are described.

9. 发明授权

US08955851B2 Metalannular gasket 有权
标题翻译：金属衬垫
公开(公告)号：US08955851B2
公开(公告)日：2015-02-17
申请号：US12312668
申请日：2007-11-05
申请人： Kenji Matsumoto , Kazuhiro Takahashi
发明人： Kenji Matsumoto , Kazuhiro Takahashi
IPC分类号： F16J15/10 , F16B43/00 , F16B41/00
CPC分类号： F16B43/001 , F16B41/002 , F16J15/104 , Y10S277/937
摘要： A metal annular gasket comprising an annular metal base plate; a compound layer integrally laminated on both surfaces of the annular metal base plate, the compound layer being made of synthetic resin or a rubber material mixed with a fiber material; and an annular seal layer having a circumferential covering portion which covers the inner circumferential edge of the annular metal plate and the inner circumferential edge of both compound layers, the compound layer being made of synthetic resin or a rubber material. The annular seal layer is formed such that the surface of the annular seal layer is so connected to the surfaces of the compound layer as to provide smooth transition in its thickness direction.
摘要翻译：一种金属环形垫片，包括环形金属基板; 在环状金属基板的两面一体层叠的复合层，由合成树脂制成的复合层或与纤维材料混合的橡胶材料; 以及环状密封层，其具有覆盖环状金属板的内周缘和两个复合层的内周边缘的周向覆盖部分，复合层由合成树脂或橡胶材料制成。环形密封层形成为使得环形密封层的表面与化合物层的表面连接，以在其厚度方向上提供平滑的过渡。

10. 发明授权

US08859421B2 Manganese oxide film forming method, semiconductor device manufacturing method and semiconductor device 有权
标题翻译：氧化锰形成方法，半导体器件制造方法和半导体器件
公开(公告)号：US08859421B2
公开(公告)日：2014-10-14
申请号：US13267227
申请日：2011-10-06
申请人： Koji Neishi , Junichi Koike , Kenji Matsumoto
发明人： Koji Neishi , Junichi Koike , Kenji Matsumoto
IPC分类号： H01L21/44 , H01L21/4763 , H01L23/48 , H01L23/52 , H01L29/40 , H01L23/532 , H01L21/768 , C23C16/40
CPC分类号： H01L23/53238 , C23C16/40 , C23C16/401 , C23C16/406 , H01L21/76831 , H01L21/76843 , H01L21/76844 , H01L21/76867 , H01L2924/0002 , H01L2924/12044 , H01L2924/00
摘要： There is provided a manganese oxide film forming method capable of forming a manganese oxide film having high adhesivity to Cu. In the manganese oxide film forming method, a manganese oxide film is formed on an oxide by supplying a manganese-containing gas onto the oxide. A film forming temperature for forming the manganese oxide film is set to be equal to or higher than about 100° C. and lower than about 400° C.
摘要翻译：提供了能够形成对Cu具有高粘合性的氧化锰膜的氧化锰膜形成方法。在氧化锰膜形成方法中，通过向氧化物供给含锰气体，在氧化物上形成氧化锰膜。用于形成氧化锰膜的成膜温度设定为等于或高于约100℃且低于约400℃

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