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1. 发明申请

US20050191746A1 Compositions and methods for biodegradable polymer-peptide mediated transfection 失效
标题翻译：可生物降解聚合物 - 肽介导的转染的组合物和方法
公开(公告)号：US20050191746A1
公开(公告)日：2005-09-01
申请号：US10789589
申请日：2004-02-27
申请人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Kenji Matsumoto , Lei Yu
发明人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Kenji Matsumoto , Lei Yu
IPC分类号： A61K47/48 , A61K48/00 , C08L59/00 , C12N15/87 , C12N15/85 , C08G63/48
CPC分类号： C08L59/00 , A61K47/59 , A61K47/645 , A61K48/00 , C12N15/87
摘要： Complexes are disclosed which are a combination of a polynucleotide and a biodegradable polyacetal-peptide. The disclosed complexes are useful for cell transfection.
摘要翻译：公开了多核苷酸和生物可降解聚缩醛肽的组合的复合物。所公开的复合物可用于细胞转染。

2. 发明授权

US07446099B2 Compositions and methods for biodegradable polymer-peptide mediated transfection 失效
标题翻译：可生物降解聚合物 - 肽介导的转染的组合物和方法
公开(公告)号：US07446099B2
公开(公告)日：2008-11-04
申请号：US10789589
申请日：2004-02-27
申请人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Kenji Matsumoto , Lei Yu
发明人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Kenji Matsumoto , Lei Yu
IPC分类号： A01N43/48
CPC分类号： C08L59/00 , A61K47/59 , A61K47/645 , A61K48/00 , C12N15/87
摘要： Complexes are disclosed which are a combination of a polynucleotide and a biodegradable polyacetal-peptide. The disclosed complexes are useful for cell transfection.
摘要翻译：公开了多核苷酸和生物可降解聚缩醛肽的组合的复合物。所公开的复合物可用于细胞转染。

3. 发明授权

US07048925B2 Acid-sensitive polyacetals and methods 失效
标题翻译：酸敏聚缩醛和方法
公开(公告)号：US07048925B2
公开(公告)日：2006-05-23
申请号：US10651394
申请日：2003-08-28
申请人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Lei Yu
发明人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Lei Yu
IPC分类号： A61K39/44 , C08F283/00
CPC分类号： C08G4/00 , C07C229/22 , C08G73/028
摘要： Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II): wherein A comprises at least one acetal group; B is selected from the group consisting of —CH—, —CH(CH3)—, CH2CH—, —CH2C(CH3)—, —CH(CH3)CH—, and —CHCH(CH3)CH(CH3)—; Z is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VU; V is a linker group; U is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, hexadecaamine dendrimer, enhancer, and targeting receptor; R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl; D is a linkage selected from the group consisting of carboxylic amide, carboxylic ester, urea, and urethane; and G is selected from the group consisting of C4 to C20 alkyl, C6-C10 aryl, and —(OCH2CH2)n—, where n is in the range of 1 to about 250, are useful in nucleic acid delivery applications. In preferred embodiments, complexes formed between polyacetals of the formulae (I) or (II) and polynucleotides are useful as transfection reagents.
摘要翻译：包含由选自式（I）和（II）的式所表示的重复单元的聚缩醛：其中A包含至少一个缩醛基; B选自-CH-，-CH（CH 3 CH 3） - ，CH 2 CH-，-CH 2 C （CH 3） - ， - CH（CH 3 CH 3）CH - 和-CHCH（CH 3 CH 3）CH（CH 3）） - ; Z选自C（O）OR 1，C（O）SR 1，C（O）NR 1 R ^{2和VU; V是连接基团; U选自聚（亚乙基亚胺），聚（丙烯亚胺），聚（赖氨酸），PAMAM树枝状聚合物，八胺树枝状聚合物，十六胺树枝状聚合物，增强剂和靶向受体; R 1和R 2各自各自独立地选自氢，C 1至C 10烷基和C 6至C 10芳基; D是选自羧酸酰胺，羧酸酯，脲和氨基甲酸酯的连接体; 并且G选自C 4〜C 20烷基，C 6 -C 10芳基，C 6〜和 - （OCH 2 CH 2 CH 2）n - ，其中n在1至约250的范围内，可用于核酸交付应用程序。在优选的实施方案中，在式（I）或（II）的聚缩醛和多核苷酸之间形成的络合物可用作转染试剂。}

4. 发明申请

US20050049387A1 ACID-SENSITIVE POLYACETALS AND METHODS 失效
标题翻译：酸敏感聚合物和方法
公开(公告)号：US20050049387A1
公开(公告)日：2005-03-03
申请号：US10651394
申请日：2003-08-28
申请人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Lei Yu
发明人： Sang Van , Nitnara Viroonchatapan , Shouping Ji , Lei Yu
IPC分类号： C07C229/22 , C08G4/00 , C08G73/02 , C08G63/02
CPC分类号： C08G4/00 , C07C229/22 , C08G73/028
摘要： Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II): wherein A comprises at least one acetal group; B is selected from the group consisting of —CH—, —CH(CH3)—, CH2CH—, —CH2C(CH3)—, —CH(CH3)CH—, and —CHCH(CH3)CH(CH3)—; Z is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VU; V is a linker group; U is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, hexadecaamine dendrimer, enhancer, and targeting receptor; R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl; D is a linkage selected from the group consisting of carboxylic amide, carboxylic ester, urea, and urethane; and G is selected from the group consisting of C4 to C20 alkyl, C6-C10 aryl, and —(OCH2CH2)n—, where n is in the range of 1 to about 250, are useful in nucleic acid delivery applications. In preferred embodiments, complexes formed between polyacetals of the formulae (I) or (II) and polynucleotides are useful as transfection reagents.
摘要翻译：包含由选自式（I）和（II）的式所表示的重复单元的聚缩醛：其中A包含至少一个缩醛基; B选自-CH-，-CH（CH 3） - ，CH 2 CH - ， - CH 2 C（CH 3） - ， - CH（CH 3）CH-和-CHCH（CH 3）CH（CH 3） Z选自C（O）OR 1，C（O）SR 1，C（O）NR 1 R 2和VU; V是连接基团; U选自聚（亚乙基亚胺），聚（丙烯亚胺），聚（赖氨酸），PAMAM树枝状聚合物，八胺树枝状聚合物，十六胺树枝状聚合物，增强剂和靶向受体; R 1和R 2各自独立地选自氢，C 1至C 10烷基和C 6至C 10芳基; D是选自羧酸酰胺，羧酸酯，脲和氨基甲酸酯的连接体; 并且G选自C 4 -C 20烷基，C 6 -C 10芳基和 - （OCH 2 CH 2）n - ，其中n在1至约250的范围内，可用于核酸递送应用。在优选的实施方案中，在式（I）或（II）的聚缩醛和多核苷酸之间形成的络合物可用作转染试剂。

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